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Functional Interactions Of Tau, Pin1, P53 And Mrna 3′ Processing Factors In Non-Neuronal Cells, Jorge E. Baquero

Dissertations, Theses, and Capstone Projects

ABSTRACT

mRNA 3’ end processing, an essential step in eukaryotic RNA metabolism, regulates the steady-state levels of different mRNAs and contributes to the cells rapid response to stress. Studies have described potential contributions of mRNA 3’ end processing to numerous human diseases, including cancer and Alzheimer’s disease (AD). Therefore, the main purpose of this dissertation is to further elucidate some of the roles of disease-related factors Pin1, p53 and tau in the regulation mRNA 3’ end processing in non-neuronal cells under different cellular conditions, including during the DNA damage response (DDR).

The results from Chapter II show that the prolyl …

Race, Sexuality, And Masculinity On The Down Low, Stephen Kochenash

Dissertations, Theses, and Capstone Projects

In a so-called post-racial America, a new gay identity has flourished and come into the limelight. However, in recent years, researchers have concluded that not all men who have sex with other men (MSM) self-identify as gay, most noticeably a large population of Black men. It is possible that a tainted history of Black enslavement in this country that is inextricably linked with ideas of space, surveillance, subversion, and survival inform a Black male’s self-identification as being “on the down low” (DL). This begs the question: What does mainstream society view as gay-ness and how is the DL constructed …

Embody: The Transformation Of Intimate Knowledges Through Generations In Liberal Societies, Lisa Kronberg

Dissertations, Theses, and Capstone Projects

This thesis project aims to examine how intimate knowledges[1] are transferred and communicated between generations in Western, liberal societies. By ‘Intimate knowledges’ I mean to encompass diverse knowledge of emotional intelligence, sexual identity, and gender.

Intimate knowledges evolve with human life circle everywhere and at all times, but in Western popular discourse of today, are treated with confusion and repression; they thus emerge as a “loud display of simultaneously silent sexual desire.” (Fine and McClelland, 2006) I explore this tension through a critical, feminist lens that sheds light on the ways in which political economy creates cultural norms that …

Development Of Nanomaterials: Complex Mesoporous Silicas And Highly Functional Multi-Responsive Hybrid Nanogels, Jinhui Yi

Dissertations, Theses, and Capstone Projects

The research work in this dissertation describes the study of the applications of polymers in several important areas. Two synthesis methods for bicontinuous cubic KIT6 silicas with block copolymer Pluronic P123 as templates were developed, expanding the range of available pore size and enchancing mesopore volume. In addition, two types of drug delivery systems were developed based on polymer nanoparticles.

In Chapter 2, it was shown that the addition of a suitable swelling agent at temperatures somewhat lower than those typically used in the syntheses of silicas with cubic Ia3d structure (19−25 °C vs 30−35 °C) allows one to induce …

Multimodal Sensing And Data Processing For Speaker And Emotion Recognition Using Deep Learning Models With Audio, Video And Biomedical Sensors, Farnaz Abtahi

Dissertations, Theses, and Capstone Projects

The focus of the thesis is on Deep Learning methods and their applications on multimodal data, with a potential to explore the associations between modalities and replace missing and corrupt ones if necessary. We have chosen two important real-world applications that need to deal with multimodal data: 1) Speaker recognition and identification; 2) Facial expression recognition and emotion detection.

The first part of our work assesses the effectiveness of speech-related sensory data modalities and their combinations in speaker recognition using deep learning models. First, the role of electromyography (EMG) is highlighted as a unique biometric sensor in improving audio-visual speaker …

Social Influences On Songbird Behavior: From Song Learning To Motion Coordination, Iva Ljubičić

Dissertations, Theses, and Capstone Projects

Social animals learn during development how to integrate successfully into their group. How do social interactions combine to maintain group cohesion? We first review how social environments can influence the development of vocal learners, such as songbirds and humans (Chapter 1). To bypass the complexity of natural social interactions and gain experimental control, we developed Virtual Social Environments, surrounding the bird with videos of manipulated playbacks. This way we were able to design sensory and social scenarios and test how social zebra finches adjust their behavior (Chapters 2 & 3). A serious challenge is that the color output of a …

The Therapeutic Potential Of Natural Products From Vaccinium Berries For Viral And Lung Diseases Through An Improved Lc-Ms-Based Chemometric Approach, Vanya I. Petrova

Dissertations, Theses, and Capstone Projects

Smoking is a global epidemic that creates serious health and economic burden. It is the primary, preventative factor for the majority of causes of death worldwide. Analysis of publicly available data revealed that smoking prevalence rates among the youth in developing countries, especially in Bulgaria, are alarmingly high. The Bulgarian population has one of the highest percentages of smokers and the second highest rate among teenage girls. Consequently, chronic diseases affected by smoking, such as chronic obstructive pulmonary disorder (COPD), have been increasing there in the last five years. Poland, on the other hand, is an exemplary outlier for the …

Biological Signatures Of Emotion Regulation In Children, Sarah Myruski

Dissertations, Theses, and Capstone Projects

Emotion regulation (ER) is a key predictor of positive adjustment throughout the lifespan. Despite decades of research on discrete ER strategy use, ER may be more appropriately measured in terms of the breadth of emotional range, or the degree to which one can flexibly modulate emotional responses. Yet little is known about ER flexibility in childhood. Also, given the crucial role of caregiver support in children’s emotional lives, ER may be most accurately measured in developmentally appropriate and ecologically valid social contexts. Further, few developmental studies have capitalized on the growing evidence base surrounding biological signatures of ER. This study …

Bacterial Lps At The Immune Modulating Component In Juzen-Taiho-To, Diego Montenegro

Dissertations, Theses, and Capstone Projects

Juzen-taiho-to (JTT) is an immune-boosting herbal formulation with an ideal balance of safety and efficacy. For example, JTT is clinically used in Japan to stimulate the immunological functions of cancer patients undergoing chemotherapy and radiation. Although the clinical effects of JTT are recognized, the active compounds and mechanism of action are unknown. The studies conducted previously in our laboratory associated several phytosterols and plant glycolipids with the potent immunostimulatory activity of JTT: namely, β-sitosteryl β-D-glucoside (BSSG), glucocerebroside (GluCer), digalactosyldiacylglycerol (DGDG) and monogalactosyldiacylglycerol (MGDG). However, these compounds, when further purified, exhibited little or no immunostimulatory activity. This suggested that the immunostimulatory …

The Development Of Affect And Defense In Childhood And Adolescence, Kari Gray

Dissertations, Theses, and Capstone Projects

The purpose of this study is to further determine the nature of the relationship between how defense mechanisms affect and are affected by the ways in which feelings are modulated and regulated in children and adolescents. This study has been built upon an IRB-approved research project conducted under primary investigator Steven Tuber, Ph.D. at the Psychological Center and the City College of New York (From Child Assessment to Child Treatment; A Preliminary Investigation). The study data are pre-existing, collected from 5 – 16 year old children and adolescents presenting for treatment and/or assessment at the Psychological Center, a …

Organic Photochemistry: Remote Delivery Of Reactive Oxygen Intermediates Via A Heterogeneous Approach, Niluksha Walalawela Abeykoon

Dissertations, Theses, and Capstone Projects

Photosensitized oxidation reactions produce a number of intermediates species, which are generated in varying amounts over time. This complexity presents major challenges in the study of oxidation processes. Mechanistic efforts to separate and deliver reactive oxygen intermediates enable their controlled use in processes such as bacterial inactivation. This thesis describes a heterogeneous reaction approach taken to control the generation and delivery of reactive oxygen intermediates. The mechanistic details of photosensitized reactions were elucidated via synthetic, materials, and physical organic techniques to optimize the delivery of reactive oxygen intermediates. This thesis contains six chapters as described below.

Chapter 1 gives a …

Conditions Of Personhood And Property, Zachary James Acree

Dissertations, Theses, and Capstone Projects

This paper seeks to demonstrate that a more robust understanding of personhood both reveals flaws in the underlying assumptions of modern property law, and orients that law to a more just application. To do this, the law needs not only a better definition of what persons are, but also a better understanding of how persons function in their society. First, in order to provide some context to the issues at stake, there is a brief historical introduction to some of the problems that personhood inquiries have faced. After the introduction, this paper is divided into four sections. Part I summarizes …

Information Content, Charge Transport Properties, And Computational Capacities Of Proteins, Joseph Murphy Brisendine Jr.

Dissertations, Theses, and Capstone Projects

This thesis is the beginning of an attempt to build a coherent theory of the properties of proteins based in information theory and the duality of information theory and nonequilibrium thermodynamics. Throughout, we will adopt the viewpoint that information can act as a thermodynamic potential, which is necessary to understand how biological processes are both enabled and constrained by the laws of thermodynamics. Understanding information as a form of thermodynamic potential also clarifies the description of proteins and other biological macromolecules as “molecular machines”: meso-scale structures with emergent causal powers which perform work on their environments by irreversibly dissipating energy …

Convergent Evolution Of Biochemical Innovations In Polychaetes: Characterizing The Molecular Basis Of Bioluminescence And Venom Production, Aida E. Verdes Gorín

Dissertations, Theses, and Capstone Projects

The convergent evolution of phenotypic traits is a widespread phenomenon across the tree of life and is explained as the outcome of different taxa facing similar selective forces or environmental conditions. A longstanding question in evolutionary biology is whether the evolution of convergent phenotypes in unrelated lineages is driven by similar or different molecular processes. The research presented here investigates this question by characterizing the molecular basis of two biochemical innovations, bioluminescence and venom production, that have evolved independently in different lineages of polychaetes worms (Annelida). We use an integrative approach, combining next-generation sequencing, phylogenetics and computational tools to evaluate …

Influence Of The Host Plant On The Encyrtid Aenasius Bambawalei, A Parasitoid Used To Control The Cotton Mealybug, Phenacoccus Solenopsis, In Pakistan, Hayat Badshah, Farman Ullah, Paul André Calatayud, Hidayat Ullah, Bashir Ahmad

All Peer-Reviewed Publications

The mealybug Phenacoccus solenopsis Tinsley (Sternorrhyncha: Pseudococcidae) is a highly polyphagous pest of fruits, vegetables, crops and ornamentals in Pakistan. Biological control approach by using Aenasius bambawalei Hayat (Hymenoptera: Encyrtidae) has been developed recently to control this pest. However, the efficiency of this parasitoid is variable according to the locality and the plants on which P. solenopsis is feeding. In this context, this experiment investigated under field and laboratory conditions the influence of the host plant of P. solenopsis on the parasitism success and the female fitness of A. bambawalei, Five plant species, commonly found to be host of P. …

Multi-Omics Reveals The Lifestyle Of The Acidophilic, Mineral-Oxidizing Model Species Leptospirillum Ferriphilum T, S Christel, M Herold, S Bellenberg, M El Hajjami, Et Al

School of Biomedical Sciences

Leptospirillum ferriphilum plays a major role in acidic, metal-rich environments, where it represents one of the most prevalent iron oxidizers. These milieus include acid rock and mine drainage as well as biomining operations. Despite its perceived importance, no complete genome sequence of the type strain of this model species is available, limiting the possibilities to investigate the strategies and adaptations that Leptospirillum ferriphilum DSM 14647T (here referred to as Leptospirillum ferriphilumT) applies to survive and compete in its niche. This study presents a complete, circular genome of Leptospirillum ferriphilumT obtained by PacBio single-molecule real-time (SMRT) long-read sequencing for use as …

Genomic And Cellular Studies Establish The Pathogenesis And Cellular Mechanisms Of Disease-Causing Mutations In Families With Autosomal Recessive Disorders, Nesreen Khalid Ahmad Al Jezawi

Dissertations

The majority of the reported genetic disorders in the UAE population are of the autosomal recessive type, which is mainly due to high rates of consanguinity within the UAE national population, and within a significant proportion of other UAE expatriate communities; such as Arabs and Pakistanis. It is estimated that more than 50% of all marriages among Emiratis occur between biologically related couples, with first cousin marriages being the highest. That could be attributed to sociocultural values in the region. Successful management of genetic diseases can be achieved by the implementation of effective preventative programs that could help reduce the …

Carbon Nanofiber Versus Graphene‐Based Stretchable Capacitive Touch Sensors For Artificial Electronic Skin, P Cataldi, S Dussoni, L Ceseracciu, M Maggiali, Et Al

School of Engineering, Computing and Mathematics

Stretchable capacitive devices are instrumental for new-generation multifunctional haptic technologies particularly suited for soft robotics and electronic skin applications. A majority of elongating soft electronics still rely on silicone for building devices or sensors by multiple-step replication. In this study, fabrication of a reliable elongating parallel-plate capacitive touch sensor, using nitrile rubber gloves as templates, is demonstrated. Spray coating both sides of a rubber piece cut out of a glove with a conductive polymer suspension carrying dispersed carbon nanofibers (CnFs) or graphene nanoplatelets (GnPs) is sufficient for making electrodes with low sheet resistance values (≈10 Ω sq−1). The electrodes based …

Word Co-Occurrence Regularized Non-Negative Matrix Tri-Factorization For Text Data Co-Clustering, Aghiles Salah, Melissa Ailem, Mohamed Nadif

Research Collection School Of Computing and Information Systems

Text data co-clustering is the process of partitioning the documents and words simultaneously. This approach has proven to be more useful than traditional one-sided clustering when dealing with sparsity. Among the wide range of co-clustering approaches, Non-Negative Matrix Tri-Factorization (NMTF) is recognized for its high performance, flexibility and theoretical foundations. One important aspect when dealing with text data, is to capture the semantic relationships between words since documents that are about the same topic may not necessarily use exactly the same vocabulary. However, this aspect has been overlooked by previous co-clustering models, including NMTF. To address this issue, we rely …

The Initiative Of Stem Schools In Egypt: Issues Of Process, Teachers' Compatibility And Governance, Lamis Abdelmeguid

Theses and Dissertations

This study discusses the Science, Technology, Engineering, and Mathematics (STEM) initiative as the latest policy move undertaken by the Egyptian government to improve the education system and prepare future generations of professionals in these fields. The findings of this study are based on a case study of two schools in Egypt. Data was collected using face-to-face and focus group interviewing along with a review of documents. This thesis discusses the role of the different stakeholders, the program structure, the student and teacher selection processes, teaching techniques, curricula, assessments, sustainability plan, and the views of STEM graduates. The study highlights the …

Association Of Interleukin-6 Polymorphisms With Obesity Or Metabolic Traits In Young Mexican-Americans, K. Boeta-Lopez, J. Duran, D. Elizondo, E. Gonzales, Anne R. Rentfro, Andrea E. Schwarzbach, Saraswathy Nair

Health & Biomedical Sciences Faculty Publications

Objective The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans.

Methods The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP).

Results Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-CRP …

Psychological Interventions For Coronary Heart Disease: Cochrane Systematic Review And Meta-Analysis., Suzanne H. Richards, Lindsey Anderson, Caroline E. Jenkinson, Ben Whalley, Karen Rees, Philippa Davies, Paul Bennett, Zulian Liu, Robert West, David R. Thompson, Rod S. Taylor

School of Psychology

Background Although psychological interventions are recommended for the management of coronary heart disease (CHD), there remains considerable uncertainty regarding their effectiveness. Design Systematic review and meta-analysis of randomised controlled trials (RCTs) of psychological interventions for CHD. Methods The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL and PsycINFO were searched to April 2016. Retrieved papers, systematic reviews and trial registries were hand-searched. We included RCTs with at least 6 months of follow-up, comparing the direct effects of psychological interventions to usual care for patients following myocardial infarction or revascularisation or with a diagnosis of angina pectoris or CHD defined …

Impact Of Electrification On Children's Nutritional Status In Rural Bangladesh, Tomoki Fujii, Abu S. Shonchoy, Sijia Xu

Research Collection School Of Economics

Access to electricity has the potential to improve the nutritional status of children by a variety of pathways such as increased wealth, reduced fertility through the change in time use, spread of information through technology such as TV, and improved health care services. Yet, the relationship between electrification and children’s nutritional status is rarely explored in the literature. We attempt to fill this lacuna by offering microeconometric evidence from rural Bangladesh, where a rapid expansion of electrification and significant improvement in children’s nutritional status were observed in the past two decades. We find that access to electricity has a positive …

February 2018 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. February 2018 edition features the article "Recognizing Our Past, Shaping Our Future".

Genetic Differences In The Aryl Hydrocarbon Receptor And Cyp1a2 Affect Sensitivity To Developmental Polychlorinated Biphenyl Exposure In Mice: Relevance To Studies Of Human Neurological Disorders, Kelsey Klinefelter, Molly Kromme Hooven, Chloe Bates, Breann T. Colter, Alexandra Dailey, Smitha Krishnan Infante, Izabela Kania-Korwel, Hans-Joachim Lehmler, Alejandro Lopez-Juarez, Clare Pickering Ludwig, Christine Perdan Curran

Health & Biomedical Sciences Faculty Publications

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human health concern with newly discovered sources of contamination and ongoing bioaccumulation and biomagnification. Children exposed during early brain development are at highest risk of neurological deficits, but highly exposed adults reportedly have an increased risk of Parkinson's disease. Our previous studies found allelic differences in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) affect sensitivity to developmental PCB exposure, resulting in cognitive deficits and motor dysfunction. High-affinity Ahr b Cyp1a2(-/-) mice were most sensitive compared with poor-affinity Ahr d Cyp1a2(-/-) and wild-type Ahr b Cyp1a2(+/+) mice. Our follow-up …

An Investigation Into The Test-Retest Reliability Of The Scale Of Accurate Personality Prediction With A Six Week Interval, Jared Marshall Barrow

Theses and Dissertations

The Scale of Accurate Personality Prediction (SAPP) is a measure to determine the accuracy of an individual’s ability to predict his/her own personality traits. Previous studies have demonstrated the validity of SAPP as a measure, and this study serves as one in a series of study on the reliability of the SAPP. To establish the test-retest reliability of the SAPP, the SAPP scores of 22 participants were calculated from two testing trials separated by a six week interval. A Pearson correlation indicated a significant correlation of moderate strength between the SAPP scores from the two testing trials (r=.572, p<0.01). The implication of these results within the context of the previous test-retest reliability studies and limitations to the current study are discussed.

Reproductive Steroids And Adhd Symptoms Across The Menstrual Cycle, Bethan A. Roberts, Tory Eisenlohr-Moul, Michelle M. Martel

Psychology Faculty Publications

Although Attention-Deficit/Hyperactivity Disorder shows (ADHD) male predominance, females are significantly impaired and exhibit additional comorbid disorders during adolescence. However, no empirical work has examined the influence of cyclical fluctuating steroids on ADHD symptoms in women. The present study examined estradiol (E2), progesterone (P4), and testosterone (T) associations with ADHD symptoms across the menstrual cycle in regularly-cycling young women (N=32), examining trait impulsivity as a moderator. Women completed a baseline measure of trait impulsivity, provided saliva samples each morning, and completed an ADHD symptom checklist every evening for 35 days. Results indicated decreased levels of E2 in the context of increased …

Infrared Heater System For Warming Tropical Forest Understory Plants And Soils, Bruce Kimball, Auro M. Alonso-Rodriguez, Molly A. Cavaleri, Sasha Reed, Grizelle Gonzalez, Tana E. Wood

Michigan Tech Publications, Part 1

The response of tropical forests to global warming is one of the largest uncertainties in predicting the future carbon balance of Earth. To determine the likely effects of elevated temperatures on tropical forest understory plants and soils, as well as other ecosystems, an infrared (IR) heater system was developed to provide in situ warming for the Tropical Responses to Altered Climate Experiment (TRACE) in the Luquillo Experimental Forest in Puerto Rico. Three replicate heated 4‐m‐diameter plots were warmed to maintain a 4°C increase in understory vegetation compared to three unheated control plots, as sensed by IR thermometers. The equipment was …

Eigenstrain As A Mechanical Set-Point Of Cells, Shengmao Lin, Marsha C. Lampi, Cynthia A. Reinhart-King, Gary C.P. Tsui, Jian Wang, Carl A. Nelson, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Cell contraction regulates how cells sense their mechanical environment. We sought to identify the set-point of cell contraction, also referred to as tensional homeostasis. In this work, bovine aortic endothelial cells (BAECs), cultured on substrates with different stiffness, were characterized using traction force microscopy (TFM). Numerical models were developed to provide insights into the mechanics of cell–substrate interactions. Cell contraction was modeled as eigenstrain which could induce isometric cell contraction without external forces. The predicted traction stresses matched well with TFM measurements. Furthermore, our numerical model provided cell stress and displacement maps for inspecting the fundamental regulating mechanism of cell …

Internet Of Underground Things: Sensing And Communications On The Field For Precision Agriculture, Mehmet C. Vuran, Abdul Salam, Rigoberto Wong, Suat Irmak

School of Computing: Conference and Workshop Papers

The projected increases in World population and need for food have recently motivated adoption of information technology solutions in crop fields within precision agriculture approaches. Internet of underground things (IOUT), which consists of sensors and communication devices, partly or completely buried underground for real-time soil sensing and monitoring, emerge from this need. This new paradigm facilitates seamless integration of underground sensors, machinery, and irrigation systems with the complex social network of growers, agronomists, crop consultants, and advisors. In this paper, state-of-the-art communication architectures are reviewed, and underlying sensing technology and communication mechanisms for IOUT are presented. Recent advances in the …