Digital Commons Network^™

Novel Fluconazole Derivatives With Promising Antifungal Activity, Nishad Thamban Chandrika, Sanjib K. Shrestha, Huy X. Ngo, Kaitlind C. Howard, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for new azole antifungal agents for which these problematic characteristics do not exist. The extensive use of azoles has resulted in fungal strains capable of resisting the action of these drugs. Herein, we report the synthesis and antifungal activities of novel fluconazole (FLC) analogues with alkyl-, aryl-, cycloalkyl-, and dialkyl-amino substituents. We evaluated their antifungal activity by MIC determination and time-kill assay as well as their safety profile by hemolytic activity against murine erythrocytes as well as cytotoxicity against …

Contractile Response Of Bovine Lateral Saphenous Vein To Ergotamine Tartrate Exposed To Different Concentrations Of Molecularly Imprinted Polymer, Manoj B. Kudupoje, James L. Klotz, Alexandros Yiannikouris, Karl A. Dawson, Kyle R. Mcleod, Eric S. Vanzant

Animal and Food Sciences Faculty Publications

Ergot alkaloids, in their active isomeric form, affect animal health and performance, and adsorbents are used to mitigate toxicities by reducing bioavailability. Adsorbents with high specificity (molecularly imprinted polymers: MIP) adsorb ergot alkaloids in vitro, but require evaluation for biological implications. Using ex vivo myography, synthetic polymers were evaluated for effects on the bioactivity of ergotamine tartrate (ETA). Polymers were first evaluated using isotherms. Lateral saphenous veins were collected from 17 steers for four independent studies: dose response of ETA, adsorbent dose response, validation of pre-myograph incubation conditions and MIP/ non-molecularly imprinted polymer (NIP) comparison. Norepinephrine normalized percent contractile response …

The Interactive Effect Of Multiple Stressors On Crustacean Zooplankton Communities In Montane Lakes, Jeffrey Thomas Brittain, Angela L. Strecker

Environmental Science and Management Faculty Publications and Presentations

Nonnative fish introductions have altered thousands of naturally fishless montane lakes, resulting in cascading food web repercussions. Nitrogen deposition has been recognized as an anthropogenic contributor to acidification and eutrophication of freshwater ecosystems, which may affect the abundance and composition of planktonic communities. This study identified responses of zooplankton communities from two lakes (fish present versus absent) in Mount Rainier National Park to manipulations simulating an episodic disturbance of acidification and eutrophication via nitrogen addition in mesocosms. Zooplankton communities from lakes with different food web structure (i.e., fish present or absent) responded differently to the singular effects of acid and …

Evolution Of Enzymes With New Specificity By High-Throughput Screening Using Dmpr-Based Genetic Circuits And Multiple Flow Cytometry Rounds, Kil Koang Kwon, Dae-Hee Lee, Su Jin Kim, Su-Lim Choi, Eugene Rha, Soo-Jin Yeom, Bindu Subhadra, Jinhyuk Lee, Ki Jin Jeong, Seung-Goo Lee

Faculty Publications - Biological Sciences

Genetic circuit-based biosensors are useful in detecting target metabolites or in vivo enzymes using transcription factors (Tx) as a molecular switch to express reporter signals, such as cellular fluorescence and antibiotic resistance. Herein, a phenol-detecting Tx (DmpR) was employed as a critical tool for enzyme engineering, specifically for the rapid analysis of numerous mutants with multiple mutations at the active site of tryptophan-indole lyase (TIL, EC 4.1.99.1). Cellular fluorescence was monitored cell-by-cell using flow cytometry to detect the creation of phenolic compounds by a new tyrosine-phenol-lyase (TPL, EC 4.1.99.2). In the TIL scaffold, target amino acids near the indole ring …

In Their Own Words: The Significance Of Participant Perceptions In Assessing Entomology Citizen Science Learning Outcomes Using A Mixed Methods Approach, Louise I. Lynch, Jenny Dauer, Wayne A. Babchuk, Tiffany Heng-Moss, Doug Golick

Department of Entomology: Faculty Publications

A mixed methods study was used to transcend the traditional pre-, post-test approach of citizen science evaluative research by integrating adults’ test scores with their perceptions. We assessed how contributory entomology citizen science affects participants’ science self-efficacy, self-efficacy for environmental action, nature relatedness and attitude towards insects. Pre- and post-test score analyses from citizen scientists (n = 28) and a control group (n = 72) were coupled with interviews (n = 11) about science experiences and entomological interactions during participation. Considering quantitative data alone, no statistically significant changes were evident in adults following participation in citizen science when compared to …

Biob 595.10: St: Ecological Models And Data, Robert Ogden Hall

University of Montana Course Syllabi

No abstract provided.

Biob 160n.01: Principles Of Living Systems, Erick Greene

University of Montana Course Syllabi

No abstract provided.

Biob 468.01: Endocrinology, Creagh W. Breuner

University of Montana Course Syllabi

No abstract provided.

Biom 407.01: Clinical Diagnosis, Pamela K. Shaw

University of Montana Course Syllabi

No abstract provided.

Brain–Computer Interfaces For Augmentative And Alternative Communication: A Tutorial, Jonathan S. Brumberg, Kevin M. Pitt, Alana Mantie-Kozlowski, Jeremy D. Burnison

Department of Special Education and Communication Disorders: Faculty Publications

Purpose--Brain–computer interfaces (BCIs) have the potential to improve communication for people who require but are unable to use traditional augmentative and alternative communication (AAC) devices. As BCIs move toward clinical practice, speech-language pathologists (SLPs) will need to consider their appropriateness for AAC intervention.

Method--This tutorial provides a background on BCI approaches to provide AAC specialists foundational knowledge necessary for clinical application of BCI. Tutorial descriptions were generated based on a literature review of BCIs for restoring communication.

Results--The tutorial responses directly address 4 major areas of interest for SLPs who specialize in AAC: (a) the current state …

Acoustic Surveys Of Bats At Northern Great Plains Parks And Preliminary Results From 2014-16, Daniel S. Licht

United States National Park Service: Publications

Executive Summary

From 2014-16, the Northern Great Plains Inventory & Monitoring Network (Network)—in collaboration with the Midwest Regional Biologist—used acoustic methods to monitor bat populations at 12 Network parks. Six parks were monitored using the nascent North American Bat Monitoring Program (NABat) framework. Six other parks did not meet a priori criteria for inclusion in NABat so they were monitored using similar methods, but a non-systematic sampling frame.

Fifty-five NABat stations were established along with 62 non-NABat stations. Stations were typically monitored for 4-7 nights each year using equipment that records the echolocation calls of bats. Fourteen mobile survey routes …

Beyond The Matrix: The Many Non-Ecm Ligands For Integrins, Bryce Lafoya, Jordan A. Munroe, Alison Miyamoto, Michael A. Detweiler, Jacob J. Crow, Tana Gazdik, Allan R. Albig

Biology Faculty Publications and Presentations

The traditional view of integrins portrays these highly conserved cell surface receptors as mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as coordinators of leukocyte adhesion to the endothelium. These canonical activities are indispensable; however, there is also a wide variety of integrin functions mediated by non-ECM ligands that transcend the traditional roles of integrins. Some of these unorthodox roles involve cell-cell interactions and are engaged to support immune functions such as leukocyte transmigration, recognition of opsonization factors, and stimulation of neutrophil extracellular traps. Other cell-cell interactions mediated by integrins include hematopoietic stem cell …

Comparison Of Beta-Lactamase Genes In Environmental Rahnella Isolates, Katherine D'Angelo, Ray A. Larsen

Honors Projects

Antibiotic resistance is a growing problem in the field of healthcare. Antibiotics are becoming less effective as species of bacteria adapt and share resistance mechanisms. If transmission of mechanisms can be better understood at the molecular level, inhibitors could be developed to lessen the likelihood of antibiotic resistance. In this study, Rahnella spp were isolated from environmental sources on MacConkey plates containing 100 µg ml^-1 ampicillin, and confirmed by 16S rRNA gene sequencing. Whole genomic DNA was extracted from isolates and initial amplifications were performed by polymerase chain reaction (PCR) using primers specific for 16S amplification. New primers were …

Process Safety Management: Optimized Models Influenced By Organization Culture, Taehoon Lee

Graduate Theses - Engineering Management

Companies focus on Process Safety Management (PSM) in order to protect employees and facilities from an accidents, such as explosion and fire. The most elements of PSM are closely related to employees, which determine the organizational culture, and organizational culture directly affects safety culture. Companies put an effort to have a strong safety culture, which is behaviors and responses in regard to emergency and abnormal situation. In this paper, definition and essential theories of PSM were reviewed first, and safety culture in PSM and the safety culture of Indianapolis Power & Light (IPL) were discussed. A method used in IPL …

Role Of Nutritional Factors In Pathogenesis Of Cancer, Anita Patel, Yashwant Pathak, Jayvadan Patel, Vijaykumar B. Sutariya

Pharmacy Faculty Publications

Diet and nutrition are crucial factors throughout the complete life course in the promotion and upholding of good health. It has always been accepted that our defencelessness to infection and disease was influenced by diet and environmental as well as genetic factors. Nutrition is coming to the front position as a principle modifiable determinant of chronic disease, with scientific confirmation with time more supporting the view that alterations in diet have strong effects, equally positive as well as negative, on health throughout life. For the most part notably, nutritional adjustments may not only influence present health but also determine whether …

Use Of 'Eradication' In Hiv Cure-Related Research: A Public Health Debate, Karine Dubé, Stuart Luter, Breanne Lesnar, Luke Newton, Jerome T. Galea, Brandon Brown, Sarah Gianella

Social Work Faculty Publications

Background: The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted their HIV research focus from treatment to cure research. The HIV cure research community often uses the term eradication to describe the science, and talks about eradicating the virus from the body. In public discourse, the term eradication could be conflated with disease eradication at the population level. In this paper, we call for a reframing of HIV cure research as control, as it is a …

When Students Design Their Own Games: A Failed Experiment In A First-Year Seminar, Chad Raymond

Faculty and Staff - Articles & Papers

This paper compares indicators of student engagement across different sections of a first-year seminar taught in Fall 2017. As part of an active learning pedagogy, students in the author’s sections of the course were clustered into teams that designed and played games on refugee migration, aid, and resettlement. Students in seminar sections taught by other faculty members experienced traditional forms of instruction that did not include game design. Data from a survey administered to students in different seminar sections did not indicate an association between game design and student engagement. Further investigation revealed substantial declines in the results of student …

Hyperoxia Causes Mitochondrial Fragmentation In Pulmonary Endothelial Cells By Increasing Expression Of Pro-Fission Proteins, Cui Ma, Andreas M. Beyer, Matthew J. Durand, Anne V. Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D. Ebben, R. Blake Hill, Said H. Audi, Meetha Medhora, Elizabeth R. Jacobs

Biomedical Engineering Faculty Research and Publications

Objective—We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia.

Approach and Results—Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups. The role of mitochondrially derived reactive oxygen species in mt-fragmentation was investigated with mito-TEMPOL and mitochondrial DNA (mtDNA) damage studied by using ENDO III (mt-tat-endonuclease III), a protein that repairs mDNA damage. Drp-1 (dynamin-related …

Consumer Propensity To Adopt Illicit Goods: Theory, Methods, And Results, Sergio Enrique Robles-Avila, Arturo Z. Vasquez-Parraga

Marketing Faculty Publications

The purpose of this study is to examine consumer propensity to adopt illicit goods. The adoption of illicit goods is a worldwide problem that undermines legitimate markets, funds criminal organizations, and harms the most vulnerable in society. International organizations, such as World Economic Forum, have called for the study of the demand of illicit products. Research is crucial to understanding the demand for these products and can contribute to public policy addressing this issue. This research uses two theoretical frameworks: The Theory of Planned Behavior and the Theory of Marketing Ethics. Using the Theory of Planned Behavior, research results suggest …

Biom 403.01: Medical Bacteriology And Mycology Lab, Michael F. Minnick

University of Montana Course Syllabi

No abstract provided.

Bioh 457.80: Cadaver Dissection Ii, Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Anty 413.01: Forensic And Mortuary Archaeology, Kirsten Green

University of Montana Course Syllabi

No abstract provided.

Bioo 433.01: Plant Physiology, Anna Sala

University of Montana Course Syllabi

No abstract provided.

Biob 595.06: St- Concepts In Developmental Biology, Ekaterina Voronina

University of Montana Course Syllabi

No abstract provided.

Anty 426.01: Culture, Health And Healing, Gilbert Quintero

University of Montana Course Syllabi

No abstract provided.

Psyx 356.01: Human Neuropsychology, Robert Stuart Hall

University of Montana Course Syllabi

No abstract provided.

Some Insights Into The Migration Of Double Imaginary Roots Under Small Deviation Of Two Parameters, Dina Alina Irofti, Keqin Gu, Islam Boussaada, Silviu-Iulian Niculescu

SIUE Faculty Research, Scholarship, and Creative Activity

This paper studies the migration of double imaginary roots of the systems’ characteristic equation when two parameters are subjected to small deviations. The proposed approach covers a wide range of models. Under the least degeneracy assumptions, we found that the local stability crossing curve has a cusp at the point that corresponds to the double root, and it divides the neighborhood of this point into an S-sector and a G-sector. When the parameters move into the G-sector, one of the roots moves to the right halfplane, and the other moves to the left half-plane. When the parameters move into the …

Pleiotropic And Novel Phenotypes In The Drosophila Gut Caused By Mutation Of Drop-Dead, Sean Conway, Christine Lynn Sansone, Anika Benske, Kaitlin Kentala, Johan Billen, Jozef Vanden Broeck, Edward M. Blumenthal

Biological Sciences Faculty Research and Publications

Normal gut function is vital for animal survival, and deviations from such function can contribute to malnutrition, inflammation, increased susceptibility to pathogens, diabetes, neurodegenerative diseases, and cancer. In the fruit fly Drosophila melanogaster, mutation of the gene drop-dead (drd) results in defective gut function, as measured by enlargement of the crop and reduced food movement through the gut, and drd mutation also causes the unrelated phenotypes of neurodegeneration, early adult lethality and female sterility. In the current work, adult drd mutant flies are also shown to lack the peritrophic matrix (PM), an extracellular barrier that lines the lumen of the …

International Consensus Statement On Allergy And Rhinology: Allergic Rhinitis, Sarah K. Wise, Sandra Y. Lin, Elina Toskala, Richard R. Orlandi, Cezmi A. Akdis, Jeremiah A. Alt, Antoine Azar, Fuad M. Baroody, Claus Bachert, Helene J. Krouse

School of Medicine Publications

Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document.

Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus …

Incidence Of Dementia In Elderly Latin Americans: Results Of The Maracaibo Aging Study, Gladys E. Maestre, Luis J. Mena, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J. Chacon, Carlos A. Chavez, Luis Falque-Madrid, Ciro A. Gaona

School of Medicine Publications

Introduction—There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study (MAS) to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans.

Methods—The DSM IV-R was used to diagnose dementia, which was classified as Alzheimer’s disease (AD), vascular dementia (VaD), or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years of follow-up (p-y).

Results—The incidence of all dementia diagnoses was 9.10 per 1000 p-y (95% CI 7.13–11.44; 8026 total p-y), 5.18 for AD (95% CI 3.72–7.03; …