Digital Commons Network^™

Development Of Multiple Microemulsion Eye Drops For Sustained Release Of New Glaucoma Drug, Doaa Nabih Ahmed Maria

Theses and Dissertations (ETD)

Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies including several daily dosing, reduced efficacy and systemic side effects all of which resulted in poor patient compliance. Previously we have identified Calcium voltage-gated channel auxiliary subunit Alpha2delta 1 gene (Cacna2d1) as a novel modulator of IOP and confirmed that pregabalin targeted CACNA2D1 in eye tissues (ciliary body and trabecular meshwork) to lower IOP in a …

The Tumor Microenvironment Regulates Retinoblastoma Cell Survival, Zachary K. Goldsmith

Theses and Dissertations (ETD)

Retinoblastoma (Rb) is the most common intraocular malignancy in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing challenges in the management of Rb. Vitreous seeds constitute the greatest challenge in treatment of Rb. The unique location of these seeds within the vitreous makes them difficult to treat. Viable seeds showed reduced proliferative capacity and metabolism. making the majority refractory to current chemotherapeutics. This prompted the development of …

Effective Measures Of Weight Gain Five Years Post-Kidney Transplantation, Tara Calico Cherry

Theses and Dissertations (ETD)

BACKGROUND: Weight gain is commonly observed post-kidney transplantation and is associated with unfavorable health outcomes, such as graft loss, new onset diabetes, and cardiovascular disease. The purpose of this study was to determine the most effective measure for assessing body composition after kidney transplantation.

DESIGN: The study was a descriptive correlational follow-up study from a single kidney transplant site.

SUBJECTS: A total of 45 eligible patients from a 2007-2011 parent study were selected, ages of 37 to 78.

MEASUREMENTS: Body composition was obtained 5–8 years posttransplant via anthropometric measures (waist circumference, body mass index, and dual energy X-ray …

The Role Of Bip Co-Chaperone Sil1 In Marinesco-Sjögren Syndrome Pathogenesis, Viraj Paresh Ichhaporia

Theses and Dissertations (ETD)

Marinesco-Sjögren syndrome (MSS) is a rare, autosomal recessive, multisystem disorder, which is characterized by cerebellar ataxia, early-onset bilateral cataracts, and progressive myopathy amongst other symptoms. MSS has been attributed to mutations in the SIL1 gene, which encodes a nucleotide exchange factor for the endoplasmicreticulum- resident Hsp70 chaperone, BiP. To date, there are 46 MSS-associated mutations that have been reported in SIL1, which occur throughout this gene and are predicted to result in a loss of SIL1’s function. The large majority of these mutations cause deletions of large fractions of the SIL1 protein. Nine MSS-associated mutations are particularly interesting because they …

Signaling Induced By Inflammatory Mediators In The Rodent Pulmonary Microvasculature, Rachel Escue Helms

Theses and Dissertations (ETD)

Acute lung inflammation (ALI), stemming from a disproportionate and detrimental immune response, may arise from or complicate other disease states, leading to the often-fatal acute respiratory distress syndrome (ARDS). Because of the many culpable factors and differing points of induction, pinning down the signaling mechanisms involved in the morbidity of this disorder as well as defining an effective treatment has proved problematic. However, the most detrimental characteristic of this condition is seen regardless of the development of the response: increased microvascular permeability. Because of the architecture and the size of the pulmonary microvascular network, the lungs have a resident, sequestered …

Targeting The Colchicine Binding Site On Tubulin To Overcome Multidrug Resistance And Anticancer Efficacy Of Selective Survivin Inhibitors, Kinsle E. Arnst

Theses and Dissertations (ETD)

Tubulin inhibitors are widely used as chemotherapeutic agents, and their successis attributed to their ability to target microtubule dynamics and disrupt critical cellular functions including cell signaling, motility, intracellular trafficking, and mitosis. Interference with microtubule dynamics consequently disrupts mitotic progression and ultimately leads to apoptosis, validating microtubule dynamics as an excellent target for anticancer agents. While this class of drug has proven to be effective against many cancer types, the clinical efficacy of current tubulin inhibitors is often limited by the development of multidrug resistance. The most common form of resistance to these agents arises from the overexpression of drug …

The Role Of Exosomal Transport Of Viral Agents In Persistent Hiv Pathogenesis, Benjamin J. Patters

Theses and Dissertations (ETD)

Human immunodeficiency virus (HIV) infection, despite great advances in antiretroviral therapy (ART), remains a lifelong affliction. Though current treatment regimens can effectively suppress viral load to undetectable levels and preserve healthy immune function, they cannot fully alleviate all symptoms caused by the presence of the virus, such as HIV-associated neurocognitive disorders (HAND). Exosomes are small vesicles that transport cellular proteins, RNA, and small molecules between cells as a mechanism of intercellular communication. Recent research has shown that HIV proteins and RNA can be packaged into exosomes and transported between cells, to pathogenic effect. This review summarizes the current knowledge on …

Genetic Exploration Of Hereditary Immune Diseases, Cheng Tian

Theses and Dissertations (ETD)

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead to autoimmune diseases that cause the immune system to attack the human body. The mutated genes cause the gene expression levels to change which fail to properly regulate the body's functions, resulting in immune system diseases. I used existing mouse models to improve the understanding of these two diseases.

The first …

Roles Of Cytosolic Nucleic Acid Sensors In Cancer And Infection, Qifan Zhu

Theses and Dissertations (ETD)

Pattern recognition receptors are innate immune sensors that recognize pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) with crucial roles in host defense against microbial infection, autoimmune diseases and cancer. Cytosolic nucleic acids including DNA and RNA originate from pathogens or self-cells, which form major groups of PAMPs and DAMPs. A range of nucleic acid sensors have evolved to sense various types of nucleic acids. How different DNA-sensing pathways regulate microbial infection and cancer is the focus of this dissertation.

Stimulator of IFN genes (STING) is a cytosolic innate immune sensor for cyclic dinucleotides that also serves a dual …

The Effects Of Emotion Socialization On Internalizing Behaviors In Young Adults, Cristina Ramirez

Electronic Theses, Projects, and Dissertations

Parents play a significant role in how children learn to express their emotions as well as their child’s overall emotional well-being. The purpose of this study was to examine the impact of positive and negative emotion socialization experiences on internalizing disorders in young adult males and females. One-hundred and forty-two young adults between the ages of 18-28 years from a southwestern university participated in the current study. It was hypothesized that early negative emotion socialization experiences would be related to higher levels of anxiety and depression in young adulthood (and, conversely, early positive emotion socialization experiences would be related to …

Prioritizing Chemical Constituents In Tobacco Products And Smoke To Predict Developmental Osteotoxicity In Human Embryonic Stem Cells, Joseph Madrid

Electronic Theses, Projects, and Dissertations

Though it is well known that tobacco related products can cause prenatal maldevelopment, very little is known on how tobacco products affect bone tissue as it develops in the embryo. Identifying which chemicals can induce the greatest harm to the prenatal skeletal system is an improbable task as there are over 7,000 chemicals in tobacco smoke alone. We hypothesized that the Toxicological Priority Index (ToxPI) program can be used to rank osteogenic cytotoxicity potential to aid in the assessment of what chemicals out of the thousands can cause osteogenic differentiation inhibition. ToxPI aggregates information from various assays and incorporates them …

Sensor-Based Human Activity Recognition Using Bidirectional Lstm For Closely Related Activities, Arumugam Thendramil Pavai

Electronic Theses, Projects, and Dissertations

Recognizing human activities using deep learning methods has significance in many fields such as sports, motion tracking, surveillance, healthcare and robotics. Inertial sensors comprising of accelerometers and gyroscopes are commonly used for sensor based HAR. In this study, a Bidirectional Long Short-Term Memory (BLSTM) approach is explored for human activity recognition and classification for closely related activities on a body worn inertial sensor data that is provided by the UTD-MHAD dataset. The BLSTM model of this study could achieve an overall accuracy of 98.05% for 15 different activities and 90.87% for 27 different activities performed by 8 persons with 4 …

Evidence For Divergent Patterns Of Local Selection Driving Venom Variation In Mojave Rattlesnakes (Crotalus Scutulatus), Jason L. Strickland, Cara F. Smith, Andrew J. Mason, Drew R. Schield, Miguel Borja, Gamaliel Castañeda-Gaytán, Carol L. Spencer, Lydia L. Smith, Ann Trápaga, Nassima M. Bouzid, Gustavo Campillo-García, Oscar A. Flores-Villela, Daniel Antonio-Rangel, Stephen P. Mackessy, Todd A. Castoe, Darin R. Rokyta, Christopher L. Parkinson

Publications

Snake venoms represent an enriched system for investigating the evolutionary processes that lead to complex and dynamic trophic adaptations. It has long been hypothesized that natural selection may drive geographic variation in venom composition, yet previous studies have lacked the population genetic context to examine these patterns. We leverage range-wide sampling of Mojave Rattlesnakes (Crotalus scutulatus) and use a combination of venom, morphological, phylogenetic, population genetic, and environmental data to characterize the striking dichotomy of neurotoxic (Type A) and hemorrhagic (Type B) venoms throughout the range of this species. We find that three of the four previously identified …

Ucf Libraries Application For The 2019 Acrl Excellence In Academic Libraries Award, Ucf Libraries

Libraries' Documents

No abstract provided.

Changes In The Content, Composition And Localization Of Foliar Phenolic Compounds Of Strawberries As Influenced By Nitrogen Regimen, Ashwini Sushil Narvekar

All Theses

To meet the increasing food demand, conventional agriculture practices emphasizes on quantitative yield and often involves intensification of nitrogen fertilizers. However, owing to the high mobility in the soil, nitrogen leaching imposes serious consequences on environment and subsequently on human health. Although the quantitative yield is predominantly determined by primary metabolism, the secondary metabolism in the plant not only function as response molecules against biotic and abiotic stress but also determines the qualitative composition of the crop. Nitrogen deficiency limits growth more than photosynthesis, leading to accumulation of the carbon based secondary precursors. Nitrogen deficiency or excess is also associated …

Council Of Scientific And Industrial Research (Csir - India) Institutes Website: A Webometric Analysis, Jeyshankar -. Ramalingam -, Nachiappan N

Library Philosophy and Practice (e-journal)

The term ‘webometrics’ was coined for the quantitative analysis of web – related phenomena, content analysis, including links, search engine performances and web technology analysis from an information science perspective. This paper explored into the webometric study of web sites of Council of Scientific and Industrial Research (CSIR) institutions in India. There are 41 CSIR research institutions in India. The study aimed at to establish a kind of ranking of websites of CSIR institutions in India by measuring their WIF. The study of the ranking will help the reader to compare and identify CSIR institutions websites in India by their …

Prairie Reconstruction Unpredictability And Complexity: What Is The Rate Of Reconstruction Failures?, Jack E. Norland, Cami Dixon, Diane Larson, Kristine Askerooth, Benjamin A. Geaumont

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

The outcomes of prairie reconstructions are subject to both unpredictability and complexity. Prairie, tallgrass, and mixed grass reconstruction is defined as the planting of a native herbaceous seed mixture composed of multiple prairie species (10 or more) in an area where the land has been heavily cultivated or anthropogenically disturbed. Because of the unpredictability and complexity inherent in reconstructions, some outcomes end up being failures dominated by exotic species. We propose that these failures follow a fat-tailed distribution as found in other complex systems. Fat-tailed distributions follow the Pareto principle, where 80% of the time reconstructions work as expected but …

Menstrual Hygiene Management And School Absenteeism Among Adolescent Students In Indonesia: Evidence From A Cross-Sectional School-Based Survey, Jessica Davis, Alison Macintyre, Mitsunori Odagiri, Wayan Suriastini, Andreina Cordova, Chelsea Huggett, Paul A. Agius, Anissa Elok Budiyani, Claire Quillet, Stanley Luchters

Population Health, East Africa

Objective: To assess the prevalence of menstrual hygiene management (MHM) knowledge and practices among adolescent schoolgirls in Indonesia, and assess factors associated with poor MHM and school absenteeism due to menstruation.

Methods: A cross-sectional survey enrolled a representative sample of urban and rural school-going girls aged 12-19 years in four provinces of Indonesia. A semi-structured, self-administered questionnaire obtained socio-demographic characteristics, knowledge, practices and attitudes related to menstruation, MHM and school absenteeism. School water, sanitation and hygiene (WASH) facilities were also assessed. Univariate weighted population prevalence was estimated and multivariable logit regression analyses applied to explore associations.

Results: A total of …

Risk Factors And Molecular Features Of Extended-Spectrum Beta-Lactamase Producing Bacteria At Southwest Of Saudi Arabia, Saleh M. Al-Garni, Mabrouk M. Ghonaim, Ali S. Al-Ghamdi, Farooq A. Ganai

Saudi Medical Journal

Objectives: To explore the risk factors, the prevalence rate, and gene types of extended-spectrum beta-lactamase (ESBL)-producing bacteria as the causative agents of infection at King Abdulaziz Specialist Hospital (KAASH), Taif, Kingdom of Saudi Arabia. Methods: This was a retrospective study conducted during the period between February 2017 and January 2018. All samples obtained from the KAASH were analyzed. The MicroScan Walkaway System, bacteriological examination and double disk synergy tests were used to detect ESBL-producing bacteria. To identify ESBL genes, the polymerase chain reaction (PCR) technique was used. Results: The ESBL phenotype was detected in 351 of 1151 isolates (30.5%); Escherichia …

New Variants In Beta Globin Gene Among The Palestinian Refugees With Sickle Cell Disease In Lebanon, Esraa Y. Moussa, Noura M. Yassine, Jamilah M. Borjac

Saudi Medical Journal

Objectives: To examine the association between beta-globin sequence variations and phenotypes of sickle-cell disease (SCD) complications among Palestinian refugees in Lebanon correlating them with chromatographic readings and co-inheritance with β-thalassemia traits. Methods: This cross-sectional study included 47 Palestinian refugees aged 4 to 54 living in different regions in Lebanon during the year 2015. Participant filled a well-designed questionnaire. Deoxyribonucleic acid (DNA) was purified from the blood collected from all participants, followed by polymerase chain reaction (PCR) amplification of exon 1, exon 2, and IVS 1 of hemoglobin beta. Multiple sequence alignment for comparative analysis was performed against normal hemoglobin sequences. …

Trends In The Incidence And Mortality Of Cancer In Saudi Arabia, Mohammad A. Althubiti

Saudi Medical Journal

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016. Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3.5-fold for lung cancer; 3-fold for liver cancer, and 2 folds for lymphoma, leukemia and gastric cancer. …

The Business Of Accelerating The Acceleration Of Startups, David Wai Lun Ng

Dissertations and Theses Collection (Open Access)

The cross-domain and cross-border aspects of the Business Accelerator sector has resulted in an ecosystem that has seen actors in the space jostle for clear and competitive positioning. The evolution of Business Accelerators as a business entity, seeking to supply positive interventions to the journey of start-ups, is common to all growth and innovation orientated ecosystems. The ability for Business Accelerator managers to demonstrably impact their subject acceleratees positively has been an under-researched area. Against this background is the rising volume of capital being channeled into funding startups due to the widespread drive for innovation led growth which is increasingly …

Growing On A Scar: Genetic Variation Of Achillea Millefolium Near Meeker, Colorado, Ace Spitzer

Undergraduate Honors Theses

Mining operations deposit high concentrations of heavy metals such as lead, cadmium, arsenic and vanadium into the topsoil of an ecosystem. These toxic metals can affect flora species health and behavior, causing local extinction and shifts in ecosystem dynamics. However, genetic analyses of some plants growing on toxic soil conditions indicate higher genetic diversity than would be expected in that environment. Determining the effects of soil pollution on plants is important to determine a species’ utility in conservation and restoration. This investigation compared the genetic diversity of western yarrow (Achillea millefolium, Asteraceae), growing near a mine site with vanadium and …

A Data Synthesis Of Melodic Intonation Therapy, Jacqueline Ulfers

Undergraduate Honors Theses

The Baby Boomers, one of the largest (modern) generations, made of 76 million people, is entering the prime age to suffer a stroke, which often leads to aphasia. Melodic Intonation Therapy (MIT)is a current rehabilitation strategy for aphasia. Determining whether MIT is an effective and efficient treatment is vital because millions are at risk to suffer a stroke and effective rehabilitation strategies must be established. This honors thesis was a systematic review of previous studies written on melodic intonation therapy. The articles reviewed were chosen based on criteria including age of the patient, type of stroke, and immediacy of therapy. …

Extreme Cold Consistently Reduces Seedling Growth But Has Species-Specific Effects On Browse Tolerance In Summer, Peter W. Guiden, Brian M. Connolly, John L. Orrock

Biology Faculty Scholarship

Premise of the Study

Extreme weather events can injure plants, causing decreased survival. However, we may underestimate the ecological importance of extreme events if they have strong sublethal effects that manifest after several months. We tested the hypothesis that late-winter extreme-cold events decrease the ability of woody plants to grow and tolerate stem removal in summer.

Methods

Seedlings from four temperate tree species (Abies balsamea, Pinus resinosa, P. strobus, Quercus rubra) were acclimated to winter conditions in growth chambers, and experienced 1 week of warm temperatures before being exposed to one of three 24-h extreme-cold …

Trash Talk: The Effects Of Plastic Pollution On Seabirds In Narragansett Bay, Erin A. O'Neill

Pell Scholars and Senior Theses

Plastic pollution in the ocean is a global concern with more than 8 million tons of plastic dumped into our oceans every year. This policy paper assesses plastic pollution in Narragansett Bay and the negative implications it holds on local seabird populations. Also, essential background information on plastic production and throwaway culture is provided. Moreover, the biological significance of seabirds is described, highlighting the vital role such populations play in local ecosystems such as Narragansett Bay. This paper contributes research to the global issue of plastic pollution by observing declining native wildlife life populations, such as seabirds, on a local …

Hispanic Culture And Machismo: How Hispanics Interpret Transgender And Gender Non-Conforming Identities, Karen R. Rodriguez

Theses and Dissertations

This study examines dynamics linked to normative gender expectations and gender identities within Hispanic culture. Little is known in this regard concerning how Hispanics perceive and interpret transgender and gender non-conforming identities. The analysis provides qualitative assessment using 35 in-depth face-to-face interviews and examines the following research questions: 1) how do life experiences such as marriage, parenthood, and work force participation among Hispanics shape their formation of gender expectations? 2) Among Hispanics, how do class, race/ethnicity, and education shape the construction of gender ideologies.

The present study, in turn adds to the literature by examining gender norm constructs among Mexican-origin …

Varying Dataset Resolution Alters Predictive Accuracy Of Spatially Explicit Ensemble Models For Avian Species Distribution, Claire M. Curry, Jeremy D. Ross, Andrea Contina, Eli S. Bridge

School of Integrative Biological & Chemical Sciences Faculty Publications

Species distribution models can be made more accurate by use of new “Spatiotemporal Exploratory Models” (STEMs), a type of spatially explicit ensemble model (SEEM) developed at the continental scale that averages regional models pixel by pixel. Although SEEMs can generate more accurate predictions of species distributions, they are computationally expensive. We compared the accuracies of each model for 11 grassland bird species and examined whether they improve accuracy at a statewide scale for fine and coarse predictor resolutions. We used a combination of survey data and citizen science data for 11 grassland bird species in Oklahoma to test a spatially …

Is Tpmt Testing A Predictor Of Duration Of Use Or Long-Term Benefit Of Thiopurine Agents?, Shatoya R. Wilson

Masters Theses

Background: Inflammatory Bowel Disease (IBD) affects as many as 1.3 million Americans and includes both ulcerative colitis (UC) and Crohn’s disease (CD). Recent practices have moved towards using immunomodulators early in the course of disease to prevent disease progression. Patients have shown improved outcomes on immunomodulators compared to aminosalicylates, and reduced risk for tachyphylaxis compared to corticosteroid treatment. Thiopurine agents such as azathioprine and 6-mercaptopurine are immunomodulators often used to treat IBD. Unfortunately, many patients experience cytotoxicity from thiopurine use. Recent studies have shown that patients deficient in thiopurine-S-methyltransferase (TMPT), produce an overabundance of the therapeutic end product, 6-thioguanine nucleotide …

Evaluation Of Bioactive Compounds On Different Extracts Of Linum Usitatissimum And Its Antimicrobial Properties Against Selected Oral Pathogens, Ummu A. Fadzir, Khairani I. Mokhtar, Basma E. Mustafa, Deny S. Darnis

Makara Journal of Health Research

Background: Antibacterial agents from natural sources have been suggested as alternatives for treating infectious diseases due to their low side effects. Flaxseed (Linum usitatissimum) exhibits some antibacterial properties, but its effects against oral pathogens are poorly understood. This study investigated flaxseed extracts' antibacterial effects against such pathogens. Methods: Non-polar and polar extracts of flaxseed, with n-hexane, dichloromethane (DCM) and methanol (MeOH), were prepared by sequential Soxhlet extraction. All extracts were qualitatively screened through gas chromatography-mass spectrometry to detect bioactive compounds. Antibacterial activities of flaxseed extracts with different volumes per disc (Oxoid, Badhoevedorp, Netherlands) (5, 7, 10, 12 and 15 µL/disc) …