Digital Commons Network^™

Zika Modulates Arthropod Histone Methylation In Mosquito Cells, Telvin Lee Harrell

Biological Sciences Theses & Dissertations

Epigenetics is the heritable series of covalent modifications that affect chromatin structure, gene expression, and protein function. Methylation is one such epigenetic modification that involves the addition of chemical modifying entities, such as methyl groups, on nucleic acids or proteins. Recent studies have reported that Zika virus (ZIKV) modulates methylation of human and viral RNA important for its replication in vertebrate cells. However, little is known whether ZIKV exerts methylation in arthropod vectors. In this study, I show that ZIKV modulates S-adenosyl methionine (SAMe) synthase, an enzyme involved in the production of SAMe, and histone methylation for its survival in …

Generation Of Large-Volume Diffuse Plasma By An External Ionization Wave From A Single-Electrode Plasma Jet, Seyed Hamid Razavi Barzoki

Electrical & Computer Engineering Theses & Dissertations

A non-thermal transient diffuse plasma can be generated remotely in a nonconductive reduced pressure chamber by an external guided fast ionization wave (FIW). We found that an atmospheric-pressure low-temperature plasma jet (APPJ) can be a source of FIW which transfers an enhanced electric field at the wave front across a reduced pressure Pyrex glass chamber with no electrical connection to the chamber. Here, we studied the formation and propagation of the APPJ plasma, the interaction of atmospheric-pressure guided FIW with a dielectric surface which forms the wall of the reduced-pressure system, and the formation and propagation of the reduce-pressure FIW …

A Stepwise Compression-Relaxation Testing Method For Tissue Characterization And Tumor Detection Via A Two-Dimensional Tactile Sensor, Yichao Yang

Mechanical & Aerospace Engineering Theses & Dissertations

This dissertation presents a stepwise compression-relaxation (SCR) testing method built upon a two-dimensional (2D) tactile sensor for mechanical characterization of soft tissues and tumor detection. The core of the 2D sensor entails one whole polydimethylsiloxane (PDMS) microstructure embedded with a 3×3 sensing-plate/transducer array. A soft sample was compressed by the 2D sensor with a step incremental depth at a ramp speed, and then relaxed for certain hold time. When a soft sample was compressed by the 2D sensor, the sensing-plates translated the sample response at different tissue sites to the sensor deflections, which were registered as resistance changes by the …

Developmental Steps For A Functional Three-Dimensional Cell Culture System For The Study Of Asymmetrical Division Of Neural Stem Cells, Martina Zamponi

Biomedical Engineering Theses & Dissertations

Stem cells are a cell type present during and following development, which possess self- renewal properties, as well as the ability to differentiate into specific cells. Asymmetrical division is the cellular process that allows stem cells to produce one differentiated and one un-differentiated daughter cell during the same mitotic event. Insights in the molecular mechanisms of such process are minimal, due to the absence of effective methods for its targeted study. Currently, traditional methods of investigation include monolayer cell culture and animal models. The first poses structural limitations to the accurate representation of human tissue and cell structures, while animal …

Solid Oxide Electrochemical Cells For High Temperature Hydrogen Production: Theory, Fabrication And Characterization, Can Zhou

Mechanical & Aerospace Engineering Theses & Dissertations

In this dissertation, the concept of water splitting using solid oxide photoelectrochemical cells (SOPCs) at high temperature was introduced and experimentally investigated. High temperature photoelectrochemical water splitting physically broadens the selection of potential applicable semiconductor materials and enables more visible sunlight absorption. This newly conceived concept provides a unique pathway for solar hydrogen production, as compared to conventional photoelectrochemical cells (PECs) that use wide band gap semiconductors in aqueous environments. The theoretical framework of SOPC was elaborated, followed by the experimental investigation to search for appropriate high temperature materials. Selected high temperature Schottky and p-n junction diodes, which were expected …

New Methods To Improve Protein Structure Modeling, Maha Abdelrasoul

Computer Science Theses & Dissertations

Proteins are considered the central compound necessary for life, as they play a crucial role in governing several life processes by performing the most essential biological and chemical functions in every living cell. Understanding protein structures and functions will lead to a significant advance in life science and biology. Such knowledge is vital for various fields such as drug development and synthetic biofuels production.

Most proteins have definite shapes that they fold into, which are the most stable state they can adopt. Due to the fact that the protein structure information provides important insight into its functions, many research efforts …

Potential Interaction Analysis Of Offshore Wind Energy Areas And Breeding Avian Species On The Us Mid-Atlantic Coast, Jeri Lynn Wisman

Biological Sciences Theses & Dissertations

Due to increasing US interest in developing wind energy sites in offshore waters, we synthesized existing data on colonial breeding seabird populations with the potential risk of interacting with lease areas in the mid-Atlantic. Previous efforts by BOEM and NOAA have predicted avian density using at-sea survey data; we seek to complement this work by focusing specifically on birds during the critical and energetically demanding breeding life history stage. We combined colony size and location for each species along the mid-Atlantic coast with buffers around the colonies that correlate with the species’ foraging range. We integrated population size, vulnerability to …

Providing Water For A Forgotten People: A Waterline Assessment Of The Former Bennett Freeze Area, Nikki Rae Tulley

Water Resources Professional Project Reports

The Bennett Freeze was established in 1966 and imposed for 40 years on 1.5 million acres of land within the boundaries of the Western Agency of the Navajo Nation. Bennett Freeze came as a result of the Navajo-Hopi Land Dispute. The “freeze” halted all construction, development, and improvements made to enhance the quality of life within the boundaries of the Bennett Freeze area. Public works were included in the restrictions created by the freeze, which effectively denied residents access to basic sanitation facilities. There are approximately 2,685+ homes (~20,000 residents) within the Former Bennett Freeze Area (FBFA) without access to …

The Strange Career Of The Equal Rights Amendment In New Mexico, Jamie Bronstein

New Mexico Historical Review

No abstract provided.

Book Reviews

New Mexico Historical Review

No abstract provided.

Does Training Multiple Alternative Responses Mitigate Resurgence?, Kelsey Purcell

Theses and Dissertations

Resurgence is a type of treatment relapse that occurs when an extinguished behavior reappears once a more recently reinforced behavior is placed on extinction. Resurgence of problem behavior often occurs when treatment-integrity errors are made during the implementation of differential reinforcement of alternative behavior (DRA). Training multiple alternative responses shows a promise in mitigating resurgence of problem behavior compared to training only a single response. The current study used laboratory methods to systematically replicate previous studies comparing the effects of more typical-DRA training with serial-DRA training on the magnitude of resurgence. Extensions included children as participants, topographically different target and …

Illegitimate Tasks And Employee Silence: A Moderated Mediation Model, Timothy A. Davis

Theses and Dissertations

This study investigated the relationship between illegitimate tasks and employee silence and examined the mediating role of job engagement and the moderating effect of agreeableness and conscientiousness. Grounded in justice theory, stress research, and the engagement literature, this study found illegitimate tasks to positively predict employee silence and negatively predict job engagement. Significant results were not found for the moderation and mediation analysis of personality traits and job engagement, respectively.

Distinguishing Adaptation And Adjustment: Effects On Communication And Safety Performance In Dynamic Work Environments, Kayla Lynne Hoelzel

Theses and Dissertations

People are different in their capacities in adapting and adjusting to dynamic workplaces. Previous literature lacks the distinction between the two constructs, which results in a lack of understanding in how adaptation and adjustment influence other organizational variables such as performance. In the current study, I first summarize the current literature on these two constructs from a few different fields in psychology, discuss the theoretical distinctions of these two constructs, and propose that they should be defined as separate constructs. Then, I establish construct validities for both concepts by developing nomological networks for both adaptation and adjustment based on the …

16pf Couple’S Counseling Report: Gender Differences In Marital Satisfaction, Personality Similarity, And Relationship Adjustment Of Couples In Marital Therapy, Catherine Amelia Mullis

Theses and Dissertations

The present study uses the16 Personality Factor Couple’s Counseling Report (16PF-CCR) to contribute to the current limited understanding of how gender differences, embedded in personality factors, influence marital satisfaction and relationship adjustment. Results were derived from 80 heterosexual couples (160 individuals) seeking marital counseling in a private practice setting. Statistically significant gender differences were found in Primary Personality Factors including Warmth, Sensitivity, Rule-consciousness, Privateness, Emotional Stability, and Tension. Statistical significant gender differences were observed within Global Personality Factors. Toughmindedness, most closely related to the Openness component of the Five Factor Model of Personality, accounted for a substantial amount of the …

An Analysis Of The Relationship Between Orthopedic Drill Bit And Screw Diameter On Drilling Energy And Axial Load Pullout Strength, Scott J. J. Baskerville

Theses and Dissertations

The number of orthopedic procedures performed per year in the United States is expected to grow to 6.6 million by 2020 (1). Most of these surgeries involve some degree of bone drilling and screw fixation, putting many patients at risk of the adverse effects of the heat-induced osteonecrosis which can limit the holding strength of bone screws and the efficacy of the screw-dependent fixtures. Excessive heat-induced osteonecrosis can occur when surgeons prolong the drilling procedure to avoid drill plunge, which can cause damage to soft neurovascular tissues local to the drilling site (2). The SMARTdrill system used in this study …

The Mountain Of A Thousand Holes: Shipwreck Traditions And Treasure Hunting On Oregon's North Coast, Cameron La Follette, Dennis Griffin, Douglas Deur

Anthropology Faculty Publications and Presentations

“Euro-Americans in coastal communities conflated and amplified Native American oral traditions of shipwrecks in Tillamook County, increasingly focusing on buried treasure,” write authors Cameron La Follette, Dennis Griffin and Douglas Deur. In this article, the authors trace the Euro-American blending of Native oral tradition with romances and adventure tales that helped create the “legends contributing to Neahkahnie [Mountain]'s reputation as Oregon's treasure-seeking haven.” They also examine the history of treasure-seeking in the area and describe the escalating conflict between Oregon's treasure-hunting statute and cultural resources protection laws, which led finally to statutory repeal that ended all treasure-hunting on state lands. …

The Galleon Cargo: Accounts In The Colonial Archives, Cameron La Follette, Douglas Deur, Esther González

Anthropology Faculty Publications and Presentations

Much of the debris that has washed up on the shores of the northern Oregon coast for centuries were mainstays of Spanish trade carried as cargo across the world on Manila galleons. Both Native people and Euro-Americans have recovered large beeswax chunks, lending to the lore of the “Beeswax Wreck,” as well as Chinese blue-and-white porcelain fragments. In this article, Cameron La Follette and Douglas Deur describe research findings about cargo on the Santo Cristo de Burgos and similar Manila galleons, including the San Francisco Xavier of 1705, the previous favored candidate for the Oregon wreck. La Follette and Deur …

The Galleon's Final Journey: Accounts Of Ship, Crew, And Passengers In The Colonial Archives, Cameron La Follette, Douglas Deur, Esther González

Anthropology Faculty Publications and Presentations

Through archival research, Cameron La Follette and Douglas Deur document the history of the Santo Cristo de Burgos — the ship thought to be the Beeswax Wreck of Oregon — and its crew and passengers. The Santo Cristo “drew together a multiethnic crew of Spanish, Spanish Basque, Philippine, Mexican, and possibly African men in the most sprawling global trade network of their day.” Research conducted in the Archives of the Indies in Seville, Spain, the National Archives of the Philippines in Manila and the Archivo General de la Nación of Mexico in Mexico City shows that the galleon left the …

No Evidence For Sex-Specific Effects Of The Maternal Social Environment On Offspring Development In Japanese Quail (Coturnix Japonica), E Langen, Nb Von Engelhardt, V Goerlich-Jansson

School of Biological and Marine Sciences

No abstract provided.

Whole Genome Sequencing Of 91 Multiplex Schizophrenia Families Reveals Increased Burden Of Rare, Exonic Copy Number Variation In Schizophrenia Probands And Genetic Heterogeneity, Fayeza F. Khan, Phillip E. Melton, Nina S. Mccarthy, Bharti Morar, John Blangero, Eric K. Moses, Assen Jablensky

School of Medicine Publications

The importance of genomic copy number variants (CNVs) has long been recognized in the etiology of neurodevelopmental diseases. We report here the results from the CNV analysis of whole-genome sequences from 91 multiplex schizophrenia families. Employing four algorithms (CNVnator, Cn.mops, DELLY and LUMPY) to identify CNVs, we find 1231 rare deletions and 287 rare duplications in 300 individuals (77 with schizophrenia (SZ), 32 with schizoaffective disorder (SAD), 82 with another neuropsychiatric diagnosis and 109 unaffected). The size of the CNVs ranges from a few hundred base-pairs to about 1.3Mb. The total burden of CNVs does not differ significantly between affected …

Visual Cycle Proteins: Structure, Function, And Roles In Human Retinal Disease, Andrew T C Tsin, Brandi Betts-Obregon, Jeffery Grigsby

School of Medicine Publications

Here, we seek to summarize the current understanding of the biochemical and molecular events mediated by visual cycle molecules in the eye. The structures and functions of selected visual cycle proteins and their roles in human retinal diseases are also highlighted. Genetic mutations and malfunctions of these proteins provide etiological evidence that many ocular diseases arise from anomalies of retinoid (vitamin A) metabolism and related visual processes. Genetic retinal disorders such as retinitis pigmentosa, Leber's congenital amaurosis, and Stargardt's disease are linked to structural changes in visual cycle proteins. Moreover, recent reports suggest that visual cycle proteins may also play …

Post-Traumatic Stress Disorder And Cardiovascular Diseases: A Cohort Study Of Men And Women Involved In Cleaning The Debris Of The World Trade Center Complex, Molly Remsch, Zoey Laskaris, Janine D. Flory, Consuelo Mora-Mclaughlin, Alfredo Morabia

Publications and Research

BACKGROUND: To determine whether post-traumatic stress disorder (PTSD) is a risk factor for myocardial infarction (MI) and stroke, beyond the expected effects from recognized cardiovascular risk factors and depression.

METHODS AND RESULTS: World Trade Center-Heart is an observational prospective cohort study of 6481 blue-collar first responders nested within the World Trade Center Health Program in New York City. Baseline measures in 2012 and 2013 included blood pressure, weight and height, and blood lipids. PTSD, depression, smoking, and dust exposure during the 2001 cleanup were self-reported. During the 4-year follow-up, outcomes were assessed through (1) interview-based incident, nonfatal MI, and stroke, …

Biotime: A Database Of Biodiversity Time Series For The Anthropocene, Maria Dornelas, Laura H. Antão, Faye Moyes, Amanda E. Bates, Anne E. Magurran, Dušan Adam, Asem A. Akhmetzhanova, Ward Appeltans, José Manuel Arcos, Haley Arnold, Narayanan Ayyappan, Gal Badihi, Andrew H. Baird, Miguel Barbosa, Tiago Egydio Barreto, Claus Bässler, Alecia Bellgrove, Jonathan Belmaker, Lisandro Benedetti-Cecchi, Brian J. Bett, Anne D. Bjorkman, Magdalena Błażewicz, Shane A. Blowes, Christopher P. Bloch, Timothy C. Bonebrake, Susan Boyd, Matt Bradford, Andrew J. Brooks, James H. Brown, Helge Bruelheide, Phaedra Budy, Fernando Carvalho, Edward Castañeda-Moya, Chaolun Allen Chen, John F. Chamblee, Tory J. Chase, Laura Siegwart Collier, Sharon K. Collinge, Richard Condit, Elisabeth J. Cooper, J Hans C. Cornelissen, Unai Cotano, Shannan Kyle Crow, Gabriella Damasceno, Claire H. Davies, Robert A. Davis, Frank P. Day, Steven Degraer, Tim S. Doherty, Timothy E. Dunn, Giselda Durigan, J. Emmett Duffy, Dor Edelist, Graham J. Edgar, Robin Elahi, Sarah C. Elmendorf, Anders Enemar, S. K. Morgan Ernest, Rubén Escribano, Marc Estiarte, Brian S. Evans, Tung-Yung Fan, Fabiano Turini Farah, Luiz Loureiro Fernandes, Fábio Z. Farneda, Alessandra Fidelis, Robert Fitt, Anna Maria Fosaa, Geraldo Antonio Daher Correa Franco, Grace E. Frank, William R. Fraser, Hernando García, Roberto Cazzolla Gatti, Or Givan, Elizabeth Gorgone-Barbosa, William A. Gould, Corinna Gries, Gary D. Grossman, Julio R. Gutierréz, Stephen Hale, Mark E. Harmon, John Harte, Gary Haskins, Donald L. Henshaw, Luise Hermanutz, Pamela Hidalgo, Pedro Higuchi, Andrew Hoey, Gert Van Hoey, Annika Hofgaard, Kristen Holeck, Robert D. Hollister, Richard Holmes, Mia Hoogenboom, Chih-Hao Hsieh, Stephen P. Hubbell, Falk Huettmann, Christine L. Huffard, Allen H. Hurlbert, Natália Macedo Ivanauskas, David Janík, Ute Jandt, Anna Jażdżewska, Tore Johannessen, Jill Johnstone, Julia Jones, Faith A. M. Jones, Jungwon Kang, Tasrif Kartawijaya, Erin C. Keeley, Douglas A. Kelt, Rebecca Kinnear, Kari Klanderud, Halvor Knutsen, Christopher C. Koenig, Alessandra R. Kortz, Kamil Král, Linda A. Kuhnz, Chao-Yang Kuo, David J. Kushner, Claire Laguionie-Marchais, Lesley T. Lancaster, Cheol Min Lee, Jonathan S. Lefcheck, Esther Lévesque, David Lightfoot, Francisco Lloret, John D. Lloyd, Adrià López-Baucells, Maite Louzao, Joshua S. Madin, Borgþór Magnússon, Shahar Malamud, Iain Matthews, Kent P. Mcfarland, Brian Mcgill, Diane Mcknight, William O. Mclarney, Jason Meador, Peter L. Meserve, Daniel J. Metcalfe, Christoph F. J. Meyer, Anders Michelsen, Nataliya Milchakova, Tom Moens, Even Moland, Jon Moore, Carolina Mathias Moreira, Jörg Müller, Grace Murphy, Isla H. Myers-Smith, Randall W. Myster, Andrew Naumov, Francis Neat, James A. Nelson, Michael Paul Nelson, Stephen F. Newton, Natalia Norden, Jeffrey C. Oliver, Esben M. Olsen, Vladimir G. Onipchenko, Krzysztof Pabis, Robert J. Pabst, Alain Paquette, Sinta Pardede, David M. Paterson, Raphaël Pélissier, Josep Peñuelas, Alejandro Pérez-Matus, Oscar Pizarro, Francesco Pomati, Eric Post, Herbert H. T. Prins, John C. Priscu, Pieter Provoost, Kathleen L. Prudic, Erkki Pulliainen, B. R. Ramesh, Olivia Mendivil Ramos, Andrew Rassweiler, Jose Eduardo Rebelo, Daniel C. Reed, Peter B. Reich, Suzanne M. Remillard, Anthony J. Richardson, J. Paul Richardson, Itai Van Rijn, Ricardo Rocha, Victor H. Rivera-Monroy, Christian Rixen, Kevin P. Robinson, Ricardo Ribeiro Rodrigues, Denise De Cerqueira Rossa-Feres, Lars Rudstam, Henry Ruhl, Catalina S. Ruz, Erica M. Sampaio, Nancy Rybicki, Andrew Rypel, Sofia Sal, Beatriz Salgado, Flavio A. M. Santos, Ana Paula Savassi-Coutinho, Sara Scanga, Jochen Schmidt, Robert Schooley, Fakhrizal Setiawan, Kwang-Tsao Shao, Gaius R. Shaver, Sally Sherman, Thomas W. Sherry, Jacek Siciński, Caya Sievers, Ana Carolina Da Silva, Fernando Rodrigues Da Silva, Fabio L. Silveira, Jasper Slingsby, Tracey Smart, Sara J. Snell, Nadejda A. Soudzilovskaia, Gabriel B. G. Souza, Flaviana Maluf Souza, Vinícius Castro Souza, Christopher D. Stallings, Rowan Stanforth, Emily H. Stanley, José Mauro Sterza, Maarten Stevens, Rick Stuart-Smith, Yzel Rondon Suarez, Sarah Supp, Jorge Yoshio Tamashiro, Sukmaraharja Tarigan, Gary P. Thiede, Simon Thorn, Anne Tolvanen, Maria Teresa Zugliani Toniato, Ørjan Totland, Robert R. Twilley, Gediminas Vaitkus, Nelson Valdivia, Martha Isabel Vallejo, Thomas J. Valone, Carl Van Colen, Jan Vanaverbeke, Fabio Venturoli, Hans M. Verheye, Marcelo Vianna, Rui P. Vieira, Tomáš Vrška, Con Quang Vu, Lien Van Vu, Robert B. Waide, Conor Waldock, Dave Watts, Sara Webb, Tomasz Wesołowski, Ethan P. White, Claire E. Widdicombe, Dustin Wilgers, Richard Williams, Stefan B. Williams, Mark Williamson, Michael R. Willig, Trevor J. Willis, Sonja Wipf, Kerry D. Woods, Eric J. Woehler, Kyle Zawada, Michael L. Zettler

Research outputs 2014 to 2021

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.

Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains …

In Wound Repair Vimentin Mediates The Transition Of Mesenchymal Leader Cells To A Myofibroblast Phenotype., J. L. Walker, B. M. Bleaken, A. R. Romisher, A. A. Alnwibit, A. S. Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely understood. The ex vivo mock cataract surgery cultures are an attractive model with which to address this question. With this model we study, concurrently, the mechanisms that control mesenchymal leader cell function in injury repair within their native microenvironment and the signals that induce this same cell population to acquire a myofibroblast phenotype when these cells encounter the environment of …

Cyber War And Deterrence: Applying A General Theoretical Framework, Isaac Nacita, Mark Reith

Faculty Publications

There is a saying that politicians and generals are always fighting the last war, which is emphasized when the weapons and characteristics of warfare are changing rapidly. However, if this is true, it is often not due to an inability to learn lessons from previous conflicts, but to “overlearn” or overcompensate for the failures and experiences of the past. In reality, this is not a learning problem but one of forming poor implications from historical events, which leads to poor applications of doctrine the next time around. The DOD now acknowledges that warfare has extended into cyberspace, and it is …

Proteomic Study Of The Exponential-Stationary Growth Phase Transition In The Haloarchaea Natrialba Magadii And Haloferax Volcanii, M Cerletti, Mi Giménez, C Tröetschel, C D’Alessandro, Et Al

School of Biomedical Sciences

The dynamic changes that take place along the phases of microbial growth (lag, exponential, stationary, and death) have been widely studied in bacteria at the molecular and cellular levels, but little is known for archaea. In this study, a high-throughput approach was used to analyze and compare the proteomes of two haloarchaea during exponential and stationary growth: the neutrophilic Haloferax volcanii and the alkaliphilic Natrialba magadii. Almost 2000 proteins were identified in each species (˜50% of the predicted proteome). Among them, 532 and 432 were found to be differential between growth phases in H. volcanii and N. magadii, respectively. Changes …

Postoperative Remote Automated Monitoring: Need For And State Of The Science, Mh Mcgillion, Protect Network Investigators

Peninsula Medical School

Worldwide, more than 230 million adults have major noncardiac surgery each year. Although surgery can improve quality and duration of life, it can also precipitate major complications. Moreover, a substantial proportion of deaths occur after discharge. Current systems for monitoring patients postoperatively, on surgical wards and after transition to home, are inadequate. On the surgical ward, vital signs evaluation usually occurs only every 4-8 hours. Reduced in-hospital ward monitoring, followed by no vital signs monitoring at home, leads to thousands of cases of undetected/delayed detection of hemodynamic compromise. In this article we review work to date on postoperative remote automated …

Leafminers Of Vegetable Crops (Order: Diptera; Family: Agromyzidae), Diane G. Alston, Ann Mull

All Current Publications

Agromyzid leafminers are small black-and-yellow flies that are pests of vegetable and ornamental crops throughout the world. In Utah, three species of leafminer flies attack vegetable crops: American serpentine leafminer [Liriomyza trifolii (Burgess)], pea leafminer [Liriomyza huidobrensis (Blanchard)], and vegetable leafminer [Liriomyza sativae (Blanchard)]. All three species are native to the New World (Western Hemisphere) but have spread worldwide. In the U.S., leafminers are most problematic in the southern states from Florida to California, and in Hawaii. Allium leafminer, [Phytomyza gymnostoma (Loew)] is a recent invasive pest to the northeastern U.S. that targets both wild and …

Kbase: The United States Department Of Energy Systems Biology Knowledgebase, Adam P. Arkin, Robert W. Cottingham, Christopher S. Henry, Nomi L. Harris, Rick L. Stevens, Sergei Maslov, Doreen Ware, Fernando Perez, Shane Canon, Michael W. Sneddon, Matthew L. Henderson, William J. Riehl, Dan Murphy-Olson, Stephen Y. Chan, Roy T. Kamimura, Sunita Kumari, Meghan M. Drake, Thomas S. Brettin, Elizabeth M. Glass, Dylan Chivian, Dan Gunter, David J. Weston, Benjamin H. Allen, Jason Baumohl, Nathan L. Tintle

Faculty Work Comprehensive List

No abstract provided.

Light Chain Diversity Among The Botulinum Neurotoxins, Alexander Gardner, Joseph T. Barbieri

College of Nursing Faculty Research and Publications

Botulinum neurotoxins (BoNT) are produced by several species of clostridium. There are seven immunologically unique BoNT serotypes (A–G). The Centers for Disease Control classifies BoNTs as ‘Category A’ select agents and are the most lethal protein toxins for humans. Recently, BoNT-like proteins have also been identified in several non-clostridia. BoNTs are di-chain proteins comprised of an N-terminal zinc metalloprotease Light Chain (LC) and a C-terminal Heavy Chain (HC) which includes the translocation and receptor binding domains. The two chains are held together by a disulfide bond. The LC cleaves Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The cleavage of SNAREs …