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The Effects Of Fungicide And Genetics On Fungal Diseases On Wheat In Nebraska With Emphasis On Stem Rust, Javed Sidiqi

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Foliar fungal diseases of wheat (Triticum aestivum L.) pose a serious threat to wheat production. Despite the significant progress that has been made limiting major fungal diseases by developing resistant cultivars, these diseases challenge the economic sustainability of wheat production. The objectives of this research were (1) To determine the effect of fungal plant pathogens on grain yield in eastern Nebraska, released and pre-release winter wheat genotypes were studied in fungicide treated and untreated plots from 2015 to 2017. (2) To determine if Sr7b is present using allelism tests in ‘Gage’ wheat as previously hypothesized.

Sixty genotypes were planted …

Cchs: An R Package For Stratified Case-Cohort Studies, Edmund Jones

The R Journal

The cchs package contains a function, also called cchs, for analyzing data from a stratified case-cohort study, as used in epidemiology. For data from this type of study, cchs calculates Estimator III of Borgan et al. (2000), which is a score-unbiased estimator for the regression coefficients in the Cox proportional hazards model. From the user’s point of view, the function is similar to coxph (in the survival package) and other widely used model-fitting functions. Convenient software has not previously been available for Estimator III since it is complicated to calculate. SAS and S-Plus code-fragments for the calculation have been published, …

Lba: An R Package For Latent Budget Analysis, Enio G. Jelihovschi, Ivan Bezerra Allaman

The R Journal

The latent budget model is a mixture model for compositional data sets in which the entries, a contingency table, may be either realizations from a product multinomial distribution or distribution free. Based on this model, the latent budget analysis considers the interactions of two variables; the explanatory (row) and the response (column) variables. The package lba uses expectation-maximization and active constraints method (ACM) to carry out, respectively, the maximum likelihood and the least squares estimation of the model parameters. It contains three main functions, lba which performs the analysis, goodnessfit for model selection and goodness of fit and the plotting …

Tackling Uncertainties Of Species Distribution Model Projections With Package Mopa, M. Iturbide, J. Bedia, J.M. Gutiérrez

The R Journal

Species Distribution Models (SDMs) constitute an important tool to assist decision-making in environmental conservation and planning in the context of climate change. Nevertheless, SDM projections are affected by a wide range of uncertainty factors (related to training data, climate projections and SDM techniques), which limit their potential value and credibility. The new package mopa provides tools for designing comprehensive multi-factor SDM ensemble experiments, combining multiple sources of uncertainty (e.g. baseline climate, pseudo-absence realizations, SDM techniques, future projections) and allowing to assess their contribution to the overall spread of the ensemble projection. In addition, mopa is seamlessly integrated with the climate4R …

Preparation And Characterization Of Functionalized Heparin-Loaded Poly-Ɛ-Caprolactone Fibrous Mats To Prevent Infection With Human Papillomaviruses, Daniela Gonzalez, Jorge Ragusa, Peter C. Angeletti, Gustavo F. Larsen

Department of Chemical and Biomolecular Engineering: Faculty Publications

In this study, heparin-loaded poly-ε-caprolactone (PCL) fibrous mats were prepared and characterized based on their physical, cytotoxic, thermal, and biological properties. The main objective of the work described here was to test the hypothesis that incorporation of heparin into a PCL carrier could serve as bio-compatible material capable of inhibiting Human Papillomavirus (HPV) infection. The idea of firmly anchoring heparin to capture soluble virus, vs. a slow heparin release to inhibit a virus in solution was tested. Thus, one material was produced via conventional heparin matrix encapsulation and electrohydrodynamic fiber processing in one step. A second type of material was …

Type 2 Bovine Viral Diarrhea Virus NPro Suppresses Type I Interferon Pathway Signaling In Bovine Cells And Augments Bovine Respiratory Syncytial Virus Replication, Abdulrahman Abdulaziz A. Alkheraif

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Bovine viral diarrhea virus (BVDV) and bovine respiratory syncytial virus (BRSV) infections contribute to the bovine respiratory disease complex (BRDC), which is a multi-factorial disorder involving co-infections of viruses and bacteria including mycoplasma. BRDC causes great economic losses to the United States feedlot industry. BVDV infection induces immunosuppression in infected animals. BVDV N^pro binds and degrades the transcription factor interferon regulatory factor-3 (IRF-3) and effectively blocks type I interferon (type I IFN) expression in host cells. BRSV nonstructural proteins, NS1 and NS2, block activation of IRF-3. In calves, concurrent infection with BVDV and BRSV resulted in more severe clinical …

Pollen Evidence Of Medicine From An Embalming Jar Associated With Vittoria Della Rovere, Florence, Italy, Karl Reinhard, Kelsey B. Lynch, Annie Larsen, Braymond Adams, Leon Higley, Marina Milanello Do Amaral, Julia Russ, Donatella Lippi, Johnica J. Morrow, Dario Piombino-Mascali

Karl Reinhard Publications

Various samples of human viscera fragments, sponges, and cloth were collected from embalming jars belonging to members of the Medici family of Florence. One jar was labeled with the name Vittoria della Rovere, who died in March of 1694. This jar contained viscera fragments that were identified as a section of collapsed intestine. The intestine of the Vittoria della Rovere sample contained a large concentration of pollen belonging to the Myrtaceae family. The Myrtaceae pollen was sometimes observed in clusters during analysis, which is indicative of purposeful ingestion of flowers, buds, or a substance derived from floral structures. Thus, the …

Smart Bandage For Monitoring And Treatment Of Chronic Wounds, Pooria Mostafalu, Ali Tamayol, Rahim Rahimi, Manuel Ochoa, Akbar Khalilpour, Gita Kiaee, Iman K. Yazdi, Sara Bagherifard, Mehmet R. Dokmeci, Babak Ziaie, Sameer R. Sonkusale, Ali Khademhosseini

Department of Mechanical and Materials Engineering: Faculty Publications

Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to …

Justice In The Laws, A Restatement: Why Plato Endorses Public Reason, Samuel Director

Jepson School of Leadership Studies articles, book chapters and other publications

In the Laws, Plato argues that the legislator should attempt to persuade people to obey the laws voluntarily. This persuasion is accomplished through use of legislative preludes. In this essay, I argue that Plato's use of persuasive preludes shows that he endorses the core features of a public reason theory of political justification.

The Effectiveness Of Localized Ultrasound And Aptamer Surface Modification On Nanoemulsions For Drug Delivery To Spheroids., Daniel A. Hodge

Electronic Theses and Dissertations

Cancer is a group of diseases that affects 1.6 million and kills nearly 600,000 Americans each year. The National Cancer Institute defines it as “diseases in which abnormal cells divide without control and can invade nearby tissues” and it is often treated with one or more of the following: chemotherapy, radiation, surgery. The expense for these treatments is expected to rise to $156 billion by 2020. Localized delivery can improve effectiveness and cancer survival rates, decrease the cost of treatment, and decrease the side effects of chemotherapy. This paper addresses models for this localized delivery through nanoemulsions. Nanoemulsions are a …

Fisheries Bycatch Risk To Marine Megafauna Is Intensified In Lagrangian Coherent Structures, Kylie L. Scales, Elliot L. Hazen, Michael G. Jacox, Frederic Castruccio, Sara M. Maxwell, Rebecca L. Lewison, Steven J. Bograd

Biological Sciences Faculty Publications

Incidental catch of nontarget species (bycatch) is a major barrier to ecological and economic sustainability in marine capture fisheries. Key to mitigating bycatch is an understanding of the habitat requirements of target and nontarget species and the influence of heterogeneity and variability in the dynamic marine environment. While patterns of overlap among marine capture fisheries and habitats of a taxonomically diverse range of marine vertebrates have been reported, a mechanistic understanding of the real-time physical drivers of bycatch events is lacking. Moving from describing patterns toward understanding processes, we apply a Lagrangian analysis to a high-resolution ocean model output to …

Biotime: A Database Of Biodiversity Time Series For The Anthropocene, Maria Dornelas, Laura H. Antão, Faye Moyes, Amanda E. Bates, Anne E. Magurran, Dušan Adams, Asem A. Akhmetzhanova, Ward Appeltans, José Manuel Adam, Frank P. Day

Biological Sciences Faculty Publications

Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.

Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains …

Arthropod Transcriptional Activator Protein-1 (Ap-1) Aids Tick-Rickettsial Pathogen Survival In The Cold, Supreet Khanal, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Ixodes scapularis ticks transmit several pathogens to humans including rickettsial bacterium, Anaplasma phagocytophilum. Here, we report that A. phagocytophilum uses tick transcriptional activator protein-1 (AP-1) as a molecular switch in the regulation of arthropod antifreeze gene, iafgp. RNAi-mediated silencing of ap-1 expression significantly affected iafgp gene expression and A. phagocytophilum burden in ticks upon acquisition from the murine host. Gel shift assays provide evidence that both the bacterium and AP-1 influences iafgp promoter and expression. The luciferase assays revealed that a region of approximately 700 bp upstream of the antifreeze gene is sufficient for AP-1 binding to promote …

Evaluating Material Consumption At The Intersection Of Technological Innovation And Shifting Consumer Demand: A Case Study Of Consumer Electronics, Barbara V. Kasulaitis

Theses

Increasing availability of consumer electronics offers the potential to improve quality of life, extend educational access, and improve efficiency of industrial processes, yet introduce their own set of challenges including increasingly diverse material supply chains, the fastest growing waste stream, and high life cycle resource demands. A significant body of research has been developed to understand material and energy flows across the product life cycle, but to date, that research has neglected to understand aggregate material flows across a community of interrelated products that are consumed, used, and disposed of together.

This research explores that research gap, first evaluating the …

Oxidative Insults Disrupt Opa1-Mediated Mitochondrial Dynamics In Cultured Mammalian Cells, Iraselia Garcia, Wendy Innis-Whitehouse, Alma Lopez, Megan Keniry, Robert Gilkerson

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Objective: To explore the impact of oxidative insults on mitochondrial dynamics. In mammalian cells, oxidative insults activate stress response pathways including inflammation, cytokine secretion, and apoptosis. Intriguingly, mitochondria are emerging as a sensitive network that may function as an early indicator of subsequent cellular stress responses. Mitochondria form a dynamic network, balancing fusion, mediated by optic atrophy-1 (OPA1), and fission events, mediated by dynamin-related protein-1 (DRP1), to maintain homeostasis.

Methods: Here, we examine the impact of oxidative insults on mitochondrial dynamics in 143B osteosarcoma and H9c2 cardiomyoblast cell lines via confocal microscopy, flow cytometry, and protein-based analyses.

Results: When challenged …

Transcription Factor Gata4 Associates With Mesenchymal-Like Gene Expression In Human Hepatoblastoma Cells, Tea Soini, Katja Eloranta, Marjut Pihlajoki, Antti Kyrönlahti, Oyediran Akinrinade, Noora Andersson, Jouko Lohi, Mikko P Pakarinen, David B Wilson, Markku Heikinheimo

2010-2019 OA Pubs

GATA4, a transcription factor crucial for early liver development, has been implicated in the pathophysiology of hepatoblastoma, an embryonal tumor of childhood. However, the molecular and phenotypic consequences of GATA4 expression in hepatoblastoma are not fully understood. We surveyed GATA4 expression in 24 hepatoblastomas using RNA in situ hybridization and immunohistochemistry. RNA interference was used to inhibit GATA4 in human HUH6 hepatoblastoma cells, and changes in cell migration were measured with wound healing and transwell assays. RNA microarray hybridization was performed on control and GATA4 knockdown HUH6 cells, and differentially expressed genes were validated by quantitative polymerase chain reaction or …

Cellular Trafficking Of Sn-2 Phosphatidylcholine Prodrugs Studied With Fluorescence Lifetime Imaging And Super-Resolution Microscopy, Dolonchampa Maji, Jin Lu, Pinaki Sarder, Anne H Schmieder, Grace Cui, Xiaoxia Yang, Dipanjan Pan, Matthew D Lew, Samuel Achilefu, Gregory M Lanza

Open Access Publications

While the

Thermodynamic And Kinetic Study Of The Removal Of Cu2+ And Pb2+ Ions From Aqueous Solution Using Fe7s8 Nanomaterial, Jesus Cantu, Diego F. Gonzalez, Yvette Cantu, Thomas Eubanks, Jason Parsons

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

In the present study, pyrrhotite (Fe7S8) was investigated for the removal of Pb2+ and Cu2+ ions from aqueous solution. The Fe7S8 material was prepared through a solvothermal method and was characterized using XRD. The average particle size for the nanomaterial was determined to be 29.86 ± 0.87 nm using XRD analysis and Scherrer's equation. Batch studies were performed to investigate the effects of pH, time, temperature, interfering ions, and the binding capacity of Pb2+ and Cu2+ ions to the Fe7S8 nanomaterial. During the pH profile studies, the optimum pH for the binding of Pb2+ and Cu2+ was determined to be …

From Borderlands To Border Islands: Intersections Between Anzaldúa's Chicana Feminist Theory And U.S. Latina Literature From The Hispanic Caribbean, Cristina Gonzalez Martin

Theses and Dissertations

This thesis studies three texts by three U.S. Latina authors from the Hispanic Caribbean through the lens of Chicana feminist border theory. The works analyzed are How the García Girls Lost Their Accents (1991) by Dominican author Julia Alvarez, Dreaming in Cuban (1992) by Cuban-American novelist Cristina García, and the memoir Almost a Woman (1998) by Puerto Rican author Esmeralda Santiago. The theoretical framework used is Gloria Anzaldúa’s Borderlands/La Frontera: The New Mestiza. The objective is to show how these texts manifest the formation of a hybrid, diasporic, in-between identity that corresponds with Anzaldúa’s definition of mestiza consciousness or la …

Examining The Role Of Shame In Somatic Pain And Symptoms, Heather Fritch

Doctoral Dissertations and Projects

Shame has been linked to several types of psychopathology, however its role in health and wellness is less understood. This study sought to answer the following questions to bring further theoretical understanding to the unique features that shame plays in somatic pain and symptoms. First, does internalized shame predict somatic pain and symptoms? Second, does externalized shame predict somatic pain and symptoms? Third, does internalized shame predict a greater influence over somatic pain and symptoms than externalized shame? Lastly, does externalized shame moderate the relationship between internalized shame and somatic pain and symptoms? This study revealed that internalized and externalized …

The Relationship Between Teacher Pedagogy Skills, As Reported By The Network For Educator Effectiveness Teacher Evaluation System, And Eighth Grade Science Achievement Scores In Missouri, Grant Stock

Doctoral Dissertations and Projects

Every year in thousands of schools across the United States high stake decisions are made regarding the retention, promotion, professional development, and training of staff using teacher evaluation instruments. Therefore, it is vital to determine if these evaluation instruments as well as the teaching strategies they measure are effective in improving student achievement. The purpose of this study was to see if there is a correlation between the scores eighth grade science teachers receive on the Network for Educator Effectiveness observation instrument for the teaching practices of cognitive engagement, problem solving and critical thinking, and formative assessment and how well …

Designing For Online Computer-Based Clinical Simulations: Evaluation Of Instructional Approaches, Ilana Dubovi

Instructional Technology and Learning Sciences Faculty Publications

Background: Online computer-based simulations are becoming more widespread in nursing education. Therefore, an understanding of when and how to implement the variety of instructional strategies related to these simulations is fundamental.

Objectives: This study compares the effectiveness of online computer-based simulations designed using two alternative instructional approaches—Productive Failure and Simple-to-Complex sequencing—on learning of clinical reasoning skills.

Participants: Participants in this study were undergraduate nursing students (n = 103, mean age = 23.4 ± 2.1) enrolled at a university in Israel.

Methods: Participants completed two online simulations designed using Productive Failure approach (emergency medicine, mental health) and two online simulations using …

Software For Peak Finding And Elemental Composition Assignment For Glycosaminoglycan Tandem Mass Spectra, John D. Hogan, Joshua A. Klein, Jiandong Wu, Pradeep Chopra, Geert Jan Boons, Luis Carvalho, Cheng Lin, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

Glycosaminoglycans (GAGs) Covalently Linked to Proteoglycans (PGs) Are Characterized by Repeating Disaccharide Units and Variable Sulfation Patterns Along the Chain. GAG Length and Sulfation Patterns Impact Disease Etiology, Cellular Signaling, and Structural Support for Cells. We and Others Have Demonstrated the Usefulness of Tandem Mass Spectrometry (MS 2 ) for Assigning the Structures of GAG Saccharides; However, Manual Interpretation of Tandem Mass Spectra is Time-Consuming, So Computational Methods Must Be Employed. in the Proteomics Domain, the Identification of Monoisotopic Peaks and Charge States Relies on Algorithms that Use Averagine, or the Average Building Block of the Compound Class Being Analyzed. …

The Fault Is Not In Our Stars: Avoiding An Arms Race In Outer Space, David A. Koplow

Georgetown Law Faculty Publications and Other Works

The world is on the precipice of a new arms race in outer space, as China, Russia, the United States, and others undertake dramatic new initiatives in anti-satellite weaponry. These accelerated competitive efforts at space control are highly destabilizing because developed societies have come to depend so heavily upon satellite services to support the entire civilian economy and the modern military apparatus; any significant threat or disruption in the availability of space assets would be massively, and possibly permanently, disruptive.

International law regarding outer space developed with remarkable rapidity in the early years of the Space Age, but the process …

Floristic Survey Of Crawford And Cherokee Counties In Southeast Kansas: An Evaluation Of Change Over Five Decades, Samantha Pryer

Electronic Theses & Dissertations

This project had two main objectives. The first objective was to document comprehensively the vascular flora of Crawford and Cherokee counties in extreme southeast Kansas. Each county had seen limited collecting in recent decades, though a comprehensive survey had never been done for Cherokee County. PSU student E.S. Gibson summarized the flora for Crawford County in 1963. Fieldwork for the present study occurred mostly in 2014 and 2015. Based on 6500+ newly collected specimens, vouchers from Gibson’s study, and taxa documented by Biota of North America (BONAP) (Kartesz 2017), 1440 taxa are reported, which includes 33 state and 263 county …

Utilizing Molecular And Statistical Modeling Methods To Enhance White Nose Syndrome Detection In Bat Hibernacula, Samuel Miller

Electronic Theses & Dissertations

White Nose Syndrome (WNS) is a fungal infection in bats caused by Pseudogymnoascus destructans (Pd). Successfully identifying hibernacula infected with WNS is essential to help control and regulate the spread of WNS. Assessing the presence of WNS in bat hibernacula is usually done by visually confirming Pd on hibernating bats within infected hibernacula. This can be problematic because most visual confirmation occurs during the winter when bat populations are at their peak within hibernacula. When surveys are conducted in the winter, there is an increased chance of disturbing bats. One alternative method to visually confirming WNS on bats …

An Immodest Proposal For Birth Registration In Donor-Assisted Reproduction, In The Interest Of Science And Human Rights, Elizabeth Samuels

Articles

Increasingly, an individual or a couple raising a newborn child may not be biologically related to the child. The child may be conceived with donated gametes -- a donated egg or sperm or both. A surrogate may gestate the child. The couple may be same-sex. Although we are aware of these developments, we are failing to collect information about them that is vital for medical, public health, and social science research as well as for protecting human rights. Information drawn from birth records is crucial for research, but it is becoming less accurate and less useful as parents who are …

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Academic Catalog

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Academic Catalog

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