Digital Commons Network^™

Identifying Off-Target Effects Of Etomoxir Reveals That Carnitine Palmitoyltransferase I Is Essential For Cancer Cell Proliferation Independent Of Β-Oxidation, Cong-Hui Yao, Gao-Yuan Liu, Rencheng Wang, Sung Ho Moon, Richard W. Gross, Gary J. Patti

Open Access Publications

No abstract provided.

Dgidb 3.0: A Redesign And Expansion Of The Drug-Gene Interaction Database, Kelsy C. Cotto, Alex H. Wagner, Yang-Yang Feng, Susanna Kiwala, Adam C. Coffman, Gregory Spies, Alex Wollam, Nicholas C. Spies, Obi L. Griffith, Malachi Griffith

Open Access Publications

No abstract provided.

Associations Between Circulating Igg Antibodies To Apolipoprotein B100-Derived Peptide Antigens And Acute Coronary Syndrome In A Chinese Han Population, Weina Hu, Xueying Zhang, Yunan Han, Yong Wang, Mingming Lei, Ian L. Megson, Jun Wei, Yuanzhe Jin

Open Access Publications

No abstract provided.

Catsper Channels Are Regulated By Protein Kinase A, Gerardo Orta, José Luis De La Vega-Beltran, David Martin-Hidalgo, Celia M. Santi, Pablo E. Visconti, Alberto Darszon

Open Access Publications

No abstract provided.

Lysmd3 Is A Type Ii Membrane Protein Without An In Vivo Role In The Response To A Range Of Pathogens, Christine C. Yokoyama, Megan T. Baldridge, Daisy W. Leung, Guoyan Zhao, Chandni Desai, Ta-Chiang Liu, Jeremy P. Huynh, Jacqueline M. Kimmey, Camaron R. Hole, Rachel A. Idol, Sunmin Park, Caihong Wang, Ashley Viehmann Milam, Scott A. Handley, Indira U. Mysorekar, Paul M. Allen, Mary C. Dinauer, Tamara L. Doering, Christina L. Stallings, Gaya K. Amarasinghe, Craig A. Micchelli, Herbert W. Virgin, Et Al.

Open Access Publications

No abstract provided.

Structural And Functional Characterization Of A Modified Legionaminic Acid Involved In Glycosylation Of A Bacterial Lipopolysaccharide, Nathan D. Mcdonald, Kristen E. Demeester, Amanda L. Lewis, Catherine Leimkuhler Grimes, E. Fidelma Boyd

Open Access Publications

No abstract provided.

Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley

Open Access Publications

No abstract provided.

Targeting Of Nonlipidated, Aggregated Apoe With Antibodies Inhibits Amyloid Accumulation, Fan Liao, Aimin Li, Monica Xiong, Hong Jiang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, David M Holtzman, Et Al

Open Access Publications

The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. Herein, we tested whether anti-human apoE antibodies can decrease Aβ pathology in mice producing both human Aβ and apoE4, and investigated the mechanism underlying these effects. We utilized APPPS1-21 mice crossed to apoE4-knockin mice expressing human apoE4 (APPPS1-21/APOE4). We discovered an anti-human apoE antibody, anti-human apoE 4 (HAE-4), that specifically …

Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek

Open Access Publications

Nighttime restlessness and daytime drowsiness are common and early symptoms of Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet the role of the circadian system in AD pathogenesis is unknown. To evaluate the role of the circadian clock in amyloid-β (Aβ) dynamics and pathology, we used a mouse model of β-amyloidosis and disrupted circadian clock function either globally or locally in the brain via targeted deletion of the core clock gene

Cell Circuits Between B Cell Progenitors And Il-7+ Mesenchymal Progenitor Cells Control B Cell Development, Chris Fistonich, Sandra Zehentmeier, Jeffrey J. Bednarski, Runfeng Miao, Hilde Schjerven, Barry P Sleckman, João P Pereira

Open Access Publications

B cell progenitors require paracrine signals such as interleukin-7 (IL-7) provided by bone marrow stromal cells for proliferation and survival. Yet, how B cells regulate access to these signals in vivo remains unclear. Here we show that proB and IL-7

Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al

Open Access Publications

No abstract provided.

Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al

Open Access Publications

No abstract provided.

Data-Driven Models Of Dominantly-Inherited Alzheimer’S Disease Progression, Neil P. Oxtoby, Alexandra L. Young, David M. Cash, Tammie L.S. Benzinger, Anne M. Fagan, John C. Morris, Randall J. Bateman, Nick C. Fox, Jonathan M. Schott, Daniel C. Alexander

Open Access Publications

No abstract provided.

Longo: An R Package For Interactive Gene Length Dependent Analysis For Neuronal Identity, Matthew J. Mccoy, Alexander J. Paul, Matheus B. Victor, Michelle Richner, Harrison W. Gabel, Haijun Gong, Andrew S. Yoo, Tae-Hyuk Ahn

Open Access Publications

Motivation: Reprogramming somatic cells into neurons holds great promise to model neuronal development and disease. The efficiency and success rate of neuronal reprogramming, however, may vary between different conversion platforms and cell types, thereby necessitating an unbiased, systematic approach to estimate neuronal identity of converted cells. Recent studies have demonstrated that long genes (>100 kb from transcription start to end) are highly enriched in neurons, which provides an opportunity to identify neurons based on the expression of these long genes.

Results: We have developed a versatile R package, LONGO, to analyze gene expression based on gene length. We propose …

Multiethnic Meta-Analysis Identifies Ancestry-Specific And Cross-Ancestry Loci For Pulmonary Function, Mary F. Feitosa, Mary K. Wojczynski, Michael A. Province

Open Access Publications

No abstract provided.

Safety Of The Deferral Of Coronary Revascularization On The Basis Of Instantaneous Wave-Free Ratio And Fractional Flow Reserve Measurements In Stable Coronary Artery Disease And Acute Coronary Syndromes, Javier Escaned, Jasvindar Singh, Et Al

Open Access Publications

No abstract provided.

Version 3 Of The Alzheimer Disease Centers’ Neuropsychological Test Battery In The Uniform Data Set (Uds), Sandra Weintraub, John C. Morris, Et Al.

Open Access Publications

No abstract provided.

Evaluation Of Avoralstat, An Oral Kallikrein Inhibitor, In A Phase 3 Hereditary Angioedema Prophylaxis Trial: The Opus-2 Study, M. A. Riedl, H. J. Wedner, Et Al

Open Access Publications

No abstract provided.

Congenital Titinopathy: Comprehensive Characterization And Pathogenic Insights, Emily C. Oates, Alan Pestronk, Anne M. Connolly, Et Al

Open Access Publications

No abstract provided.

A Direct Test Of The Diathesis–Stress Model For Depression, L Colodro-Conde, B Couvy-Duchesne, G Zhu, Wl Coventry, Em Byrne, S Gordon, Mj Wright, Gw Montgomery, Paf Madden, Major Depressive Disorder Working Group Of The Psychiatric Genomics Consortium, S Ripke, Lj Eaves, Ac Heath, Nr Wray, Se Medland, Ng Martin

Open Access Publications

No abstract provided.

In Vivo Monitoring Of Intracellular Ca2+ Dynamics In The Pancreatic Β-Cells Of Zebrafish Embryos, Reka Lorincz, Christopher H. Emfinger, Andrea Walcher, Michael Giolai, Claudia Krautgasser, Maria S. Remedi, Colin G. Nichols, Dirk Meyer

Open Access Publications

No abstract provided.

Risk Of Subsequent Joint Arthroplasty In Contralateral Or Different Joint After Index Shoulder, Hip, Or Knee Arthroplasty: Association With Index Joint, Demographics, And Patient-Specific Factors, Joseph D. Lamplot, Anchal Bansal, Joseph T. Nguyen, Robert H. Brophy

Open Access Publications

No abstract provided.

Transvaginal Fast-Scanning Optical-Resolution Photoacoustic Endoscopy, Yuan Qu, Chiye Li, Junhui Shi, Ruimin Chen, Song Xu, Hasan Rafsanjani, Konstantin Maslov, Hannah Krigman, Laura Garvey, Peng Hu, Peinan Zhao, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald Mccarthy, Sarah K. England, George A. Macones, Qifa Zhou, K. Kirk Shung, Jun Zhou, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Open Access Publications

No abstract provided.

Capillaria Ova And Diagnosis Of Trichuris Trichiura Infection In Humans By Kato-Katz Smear, Liberia, Kerstin Fischer, Abakar Gankpala, Lincoln Gankpala, Fatorma K. Bolay, Kurt C. Curtis, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.

Safety Of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study, Christopher J. Dy, Daniel A. Osei, Travis G. Maak, Michael B. Gottschalk, Alan L. Zhang, Michael D. Maloney, Angela P. Presson, Regis J. O'Keefe

Open Access Publications

No abstract provided.

Systemic Anti-Cancer Therapy In Synovial Sarcoma: A Systematic Review, Richard F. Riedel, Robin L. Jones, Antoine Italiano, Chet Bohac, Juliette C. Thompson, Kerstin Mueller, Zaeem Khan, Seth M. Pollack, Brian A. Van Tine

Open Access Publications

No abstract provided.

Long‐Term Effects Of Crizotinib In Alk‐Positive Tumors (Excluding Nsclc): A Phase 1b Open‐Label Study, Carlo Gambacorti-Passerini, Brian A. Van Tine, Et Al

Open Access Publications

No abstract provided.

Electrocortical Responses To Emotional Stimuli In Psychotic Disorders: Comparing Schizophrenia Spectrum Disorders And Affective Psychosis, Adam J. Culbreth, Dan Foti, Deanna M. Barch, Greg Hajcak, Roman Kotov

Open Access Publications

No abstract provided.

Catheter Removal And Outcomes Of Multidrug-Resistant Central-Line-Associated Bloodstream Infection, Jason P. Burnham, Rebecca P. Rojek, Marin H. Kollef

Open Access Publications

No abstract provided.

Protein Network Analysis Reveals Selectively Vulnerable Regions And Biological Processes In Ftd, Celeste M. Karch, Natalie Wen, Aaron Ofori-Kuragu

Open Access Publications

No abstract provided.