Digital Commons Network^™

Harnessing The Anopheles Microbiome To Conditionally Express Anti-Plasmodial Effectors During The Blood Meal, Jackie Shane

Electronic Theses and Dissertations

The control of vector-borne diseases such as malaria has been an extremely important research subject for hundreds of years. Because of the complex lifecycles of the pathogens that cause these diseases, finding a comprehensive treatment or preventative strategy has proven extremely difficult. Malaria alone is responsible for almost half a million deaths annually, most of them children under 5 years old. This disease is caused by parasitic protists in the genus Plasmodium that are transmitted to humans from Anopheles sp. mosquitoes. Most preventative strategies that are in use today revolve around controlling the vectors, including bed nets, insecticides, and larval …

Navigating The Storm: How Proficient Organizational Culture Promotes Clinician Retention In The Shift To Evidence-Based Practice, Nathaniel J. Williams, Rinad S. Beidas

Social Work Faculty Publications and Presentations

Objective

Clinician turnover is a major concern as mental health systems and organizations invest substantial resources in the implementation of evidence-based practice (EBP). In this study, we identify malleable factors associated with reduced clinician turnover during a systemwide EBP implementation initiative. Specifically, we examine how proficient organizational culture (i.e., norms and behavioral expectations that clinicians prioritize improvement in client well-being and exhibit competence in up-to-date treatment practices), EBP implementation climate (i.e., perceptions that the organization’s policies, procedures, and practices support EBP use), and change in these organizational characteristics relate to clinician turnover during a system-wide EBP transformation.

Method

Data were …

Senior Day December 2018, University Of Michigan Law School

Commencement and Honors Materials

Program for the December 21, 2018 Senior Day ceremonies.

A Tree-Based Multiscale Regression Method, Haiyan Cai, Qingtang Jiang

Mathematics and Statistics Faculty Works

A tree-based method for regression is proposed. In a high dimensional feature space, the method has the ability to adapt to the lower intrinsic dimension of data if the data possess such a property so that reliable statistical estimates can be performed without being hindered by the “curse of dimensionality.” The method is also capable of producing a smoother estimate for a regression function than those from standard tree methods in the region where the function is smooth and also being more sensitive to discontinuities of the function than smoothing splines or other kernel methods. The estimation process in this …

Adapting To College Life: An Ethnographic Study Of The Linguistic Challenges Faced By Domestic Black Immigrant Students At Bridgewater State University, Johnson (Carter) Remy

Honors Program Theses and Projects

This linguistic qualitative ethnographic study sought to understand whether domestic and international, Black, English second language learning (ESL), immigrant students, who have completed their first year of college at BSU, perceive themselves as linguistically prepared for college life. Linguistic preparedness is critical for successful participation in the classroom and completion of required work. The research seeks to identify and analyze the programs BSU has established to assist this population in their adaptation to college life and in acquiring linguistic proficiency. The study employs a multi-tiered methodology beginning with semi-structured interviews with diversity administrators, ESL and Global Language faculty, informal interviews …

A Tree-Based Multiscale Regression Method, Haiyan Cai, Qingtang Jiang

Educator Preparation & Leadership Faculty Works

A tree-based method for regression is proposed. In a high dimensional feature space, the method has the ability to adapt to the lower intrinsic dimension of data if the data possess such a property so that reliable statistical estimates can be performed without being hindered by the “curse of dimensionality.” The method is also capable of producing a smoother estimate for a regression function than those from standard tree methods in the region where the function is smooth and also being more sensitive to discontinuities of the function than smoothing splines or other kernel methods. The estimation process in this …

Identification Of Genes Required For Eye Development By High-Throughput Screening Of Mouse Knockouts., Bret A Moore, Brian C Leonard, Lionel Sebbag, Sydney G Edwards, Ann Cooper, Denise M Imai, Ewan Straiton, Luis Santos, Christopher Reilly, Stephen M Griffey, Lynette Bower, David Clary, Jeremy Mason, Michel J Roux, Hamid Meziane, Yann Herault, Colin Mckerlie, Ann M Flenniken, Lauryl M J Nutter, Zorana Berberovic, Celeste Owen, Susan Newbigging, Hibret Adissu, Mohammed Eskandarian, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan J Gallegos, John R Seavitt, Jason D Heaney, Arthur L Beaudet, Mary E Dickinson, Monica J Justice, Vivek M. Philip, Vivek Kumar, Karen L. Svenson, Robert E Braun, Sara Wells, Heather Cater, Michelle Stewart, Sharon Clementson-Mobbs, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, J K Seong, Glauco Tocchini-Valentini, Mark Moore, Colin Fletcher, Natasha Karp, Ramiro Ramirez-Solis, Jacqueline K White, Martin Hrabe De Angelis, Wolfgang Wurst, Sara M Thomasy, Paul Flicek, Helen Parkinson, Steve D M Brown, Terrence F Meehan, Patsy M. Nishina, Stephen A Murray, Mark P. Krebs, Ann-Marie Mallon, K C Kent Lloyd, Christopher J Murphy, Ala Moshiri

Faculty Research 2018

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the …

Atypical Activation Of The G Protein Gα By The Oncogenic Mutation Q209p, Marcin Maziarz, Anthony Leyme, Arthur Marivin, Alex Luebbers, Prachi P. Patel, Zhe Chen, Stephen R. Sprang, Mikel Garcia-Marcos

Biological Sciences Faculty Publications

The causative role of G protein-coupled receptor (GPCR) pathway mutations in uveal melanoma (UM) has been well-established. Nearly all UMs bear an activating mutation in a GPCR pathway mediated by G proteins of the G family, driving tumor initiation and possibly metastatic progression. Thus, targeting this pathway holds therapeutic promise for managing UM. However, direct targeting of oncogenic Gα mutants, present in ∼90% of UMs, is complicated by the belief that these mutants structurally resemble active Gα WT. This notion is solidly founded on previous studies characterizing Gα mutants in which a conserved catalytic glutamine (Gln-209 in Gα) is replaced …

Probiotic Use In Trauma Patients: A Pathway To Determining The Standard Of Care To Improve Outcomes, Heather Vitko

Electronic Theses and Dissertations

The gut microbiome consists of normally non-pathogenic bacteria, viruses, and fungi. These friendly microbes serve to maintain GI barrier function and integrity, play a role in host nutrient and drug metabolism, immunomodulation, and prevent pathogenic bacteria from colonizing or causing disease. The importance of a healthy microbiome for the overall health of the host is just recently being appreciated within the medical and science communities. Disruption of the microbiome places one at greater risk for illness and infection. Patients who suffer a traumatic injury are among those at highest risk for complications associated with microbial imbalance, or dysbiosis. In addition …

1998 - 2030 Land Use And Water Needs Conditions

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

Documentation of the methodology and data used to estimate the land use, M&I water needs, and pumped agricultural water under the 2030 conditions. One of the primary goals of the Salinas River Basin Management Plan (BMP) is to meet the agricultural, and municipal and industrial water needs of the Valley under the existing conditions (1995 level of development) as well as, under the future conditions (2030 level of development), while stopping the seawater intrusion and balancing the hydrologic conditions in the basin. In order to meet the 2030 water needs, a reasonable estimate of land use and water use conditions …

New Ohio Review Has Record Year, Goes More ‘New,’ More ‘Ohio’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Rosen And Thankachan Present On Byod In Indian Classrooms, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Brief Amici Curiae, Rhode Island School Of Design

Advocacy | Amicus Briefs + Comments

No abstract provided.

Effects Of Cultural And Language Barriers On The Outcome Of Autism Spectrum Disorder Amongst Children From The Somali Immigrant Population Of Minnesota, Amal Farah

Theses and Graduate Projects

Autism Spectrum Disorder (ASD) is a devastating developmental disorder with a decline in both neurological and behavioral functions. ASK can present with delays in language development, social skills, and restricts behavioral patterns. The prevalence of ASD has been on the rise int he United States with a rate of one in 69 children. Moreover, the prevalence of ASD has been drastically increasing in the Somali community of Minnesota affecting one in 32 children. Many research studies associate the rise of ASD in the Somali community with the elements of culture, tradition, and language barriers. This research paper will explore how …

Regan V. Denney Respondent's Brief Dckt. 46545

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Arthur Bedrosian V. Usa

2018 Decisions

USDC for the Eastern District of Pennsylvania

A Potent Lassa Virus Antiviral Targets An Arenavirus Virulence Determinant, Ikenna G. Madu, Megan Files, Dima N. Gharaibeh, Amy L. Moore, Kieh-Hoon Jung, Brian B. Gowen, Dongcheng Dai, Kevin F. Jones, Shanthakumar R. Tyavanagimatt, James R. Burgeson, Marcus J. Korth, Kristin M. Bedard, Shawn P. Iadonato, Sean M. Amberg

Animal, Dairy, and Veterinary Science Faculty Publications

Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a recent outbreak in Nigeria was larger and more geographically diverse than usual. We are developing LHF-535, a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, as a therapeutic candidate for Lassa fever and other hemorrhagic fevers of arenavirus origin. Using a lentiviral pseudotype infectivity assay, we determined that LHF-535 had sub-nanomolar potency against the viral envelope glycoproteins from all Lassa …

Hypoxic Preconditioning Attenuates Reoxygenation-Induced Skeletal Muscle Dysfunction In Aged Pulmonary Tnf-Α Overexpressing Mice, China-Chen Chuang, Tingyang Zhou, Mark Olfert, Li Zuo

Faculty & Staff Scholarship

No abstract provided.

Non-Symbolic Exact Quantity Representation In A Language-Impaired Population, John Verbos

Electronic Theses and Dissertations

The linguistic relativity hypothesis argues that language influences non-linguistic cognition. One version of the hypothesis suggests that language is a set of tools or technologies that variously enhance or dampen an individual’s capacity to perceive and operate upon the world in certain ways. A domain in which this may be tested is number, where it is hypothesized that counting language allows us to bridge our innate capacities for recognizing small exact quantities (subitizing) and approximating quantities larger than three or four (analog magnitude estimation). To test this, previous studies have asked adult participants who have limited or no access to …

Using An In Vitro-In Vivo Correlation For The ‘Bioequivalence By Design’ Development Of An Immediate Release Carbamazepine Product, Douglas Steinbach

Electronic Theses and Dissertations

The quality of a drug product may be characterized by the consistency with which its indicated clinical effect, and safety profile, is experienced by the patient. The concept that such quality should be built into a product is at the core of the United States Food and Drug Administration’s (FDA) quality by design (QbD) initiative. This vision for pharmaceutical product development emphasizes the risk-based identification of critical quality attributes (CQA) which summarize a product’s performance, the efficient refinement of critical product/process parameters (CPP) that can affect such attributes, and the systematic development of CPP limits, which assure appropriate performance of …

The Association Between Depression, Anxiety And Clinical Outcomes For Type 2 Diabetes Mellitus, Elham Heidari

Electronic Theses and Dissertations

Objective: To evaluate the impact of depression and/or anxiety on clinical outcomes of diabetes, including glycosylated hemoglobin (HgA1c), blood glucose, blood pressure, total cholesterol, weight and LDL among patients with incident type 2 diabetes mellitus (T2DM).

Method: A retrospective cohort study utilizing electronic medical record (EMR) data from a primary care physician (PCP) group practice was conducted to identify patients newly diagnosed with T2DM with at least 6 months pre-diagnosis and 12 months post-diagnosis of EMR data using International Classification of Disease 9th edition Clinical Modification (ICD-9-CM) coding. The presence of comorbid depression and anxiety was identified to identify four …

Well-Trained Mentors: The Missing Component Of The Comprehensive New Teacher Induction Program In The Silver Oak Area School, Daniel Bosnic

Electronic Theses and Dissertations

“If well-trained, competent, caring teachers were present in every classroom, we would witness a staggering increase in student achievement, motivation, and character improvement along with a marked decrease in discipline problems” (Breaux & Wong, 2003, p.22). If school districts do not take the initiative to design and implement effective induction programs with embedded mentoring, they are essentially setting their teachers and students up for failure. Regardless of educator training programs, new teachers are unprepared to face the diverse and challenging needs of education today (Bartell, 2005). All individuals entering education need assistance in applying their prior knowledge and experience to …

Consciousness Against Commodifcation: The Potential For A Radical Housing Movement In The Cully Neighborhood, Cameron Hart Herrington

Dissertations and Theses

A right to housing is a central iteration of the broader demand for a democratic right to the city. The perpetual housing crisis for lower-income people results from a commodified system in which access to housing is based on the exchange value interests of property owners, rather than a universal right to a decent, affordable home. This system is a pillar of neoliberal urban governance and justified by a hegemonic ideology that equates speculative homeownership with the American Dream. Achieving a right to housing, even at the local scale, requires a radical movement that cultivates individual and collective consciousness, discredits …

An Investigation Of Civilian Implicit Attitudes Toward Police Officers, Rikki Hope Sargent

Theses - ALL

This research investigated implicit attitudes toward police among civilians. Two preliminary studies served as an empirical foundation for the current study, as both assessed the implicit construct activation of safety and fear when participants were primed with police using a modified version of the Word Fragment Completion Task (e.g., Johnson & Lord, 2010). The findings were counter-intuitive, such that in a college sample safety construct activation increased and fear decreased when primed with police, whereas in an online sample safety and fear construct activation increased. The current study sought to clarify these trends by utilizing four modified versions of the …

Runzhou Zhang Order On Defendant Scott Hosteler's Motion To Enforce Judgment, Melvin Westmoreland

Superior Court of Fulton County: Metro Atlanta Business Case Division Opinions

No abstract provided.

We Three Kings ... Of Cologne, Joan Milligan

University Libraries Blog Archive

Rare manuscripts reveal 15th-century interpretations of the Magi.

List Of Maker Competencies, Including Preamble And Acknowledgmentsmaker Competencies, Martin K. Wallace, Katie Musick Peery, Gretchen Trkay, Morgan Chivers, Tara Radniecki

UTA Libraries Staff Publications - Archive

Maker competencies are the skills, talents and dispositions that one acquires or improves upon while problem-solving and working on projects in makerspaces or similar learning environments. However, while learners can develop any number of technology-specific competencies while working in makerspaces, dependent on the types of technology made available within the specific makerspace, this list of competencies is better defined as the higher-level, technology-agnostic, transferable skills and talents that one may acquire or strengthen when working in makerspaces. A quick review of the list of competencies will reveal no mention of 3D printers, Arduinos, or any of the other popular technologies …

Dwivedi Named To National Suicide Prevention Organization Board, Staff

Browse All News

No abstract provided.

Mary In The News: Dec. 21, 2018, Michael Duricy

Marian Library Blog Archive

Read recent items about Mary in both Catholic and secular news. Also, see International Marian Research Institute news and updates.

Dynamics Of Prochlorococcus Diversity And Photoacclimation During Short-Term Shifts In Water Column Stratification At Station Aloha, Anne W. Thompson, Ger Van Den Engh, Nathan A. Ahlgren, Kathleen Kouba, Samantha Ward, Samuel T. Wilson, David M. Karl

Biology

The cyanobacterium Prochlorococcus is the dominant phototroph in surface waters of the vast oligotrophic oceans, the foundation of marine food webs, and an important component of global biogeochemical cycles. The prominence of Prochlorococcus across the environmental gradients of the open ocean is attributed to its extensive genetic diversity and flexible chlorophyll physiology, enabling light capture over a wide range of intensities. What remains unknown is the balance between temporal dynamics of genetic diversity and chlorophyll physiology in the ability of Prochlorococcus to respond to a variety of short (approximately 1 day) and longer (months to year) changes in the environment. …