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Fast Voltage-Gated Sodium Channel Currents And Action Potential Firing In R6/2 Skeletal Muscle, Eric Joshua Reed

Browse all Theses and Dissertations

Huntington’s disease (HD) is a degenerative disorder caused by expanded CAG repeats in the Huntingtin gene, which results in cognitive problems as well as muscle weakness, chorea, rigidity, and dystonia. Most research in HD has focused on neurodegeneration, but recent studies have found peripheral defects that may help explain the debilitating motor symptoms of HD. We have shown that skeletal muscle from the R6/2 transgenic mouse model of HD is hyperexcitable due to decreases in resting chloride and potassium currents. Other groups have speculated that the fast voltage-gated sodium channels may be affected in Huntington’s disease as well. To fully …

Using Natural Language Processing And Machine Learning For Analyzing Clinical Notes In Sickle Cell Disease Patients, Shufa Khizra

Browse all Theses and Dissertations

Sickle Cell Disease (SCD) is a hereditary disorder in red blood cells that can lead to excruciating pain episodes. SCD causes the normal red blood cells to distort its shape and turn into sickle shape. The distorted shape makes the hemoglobin inflexible and stick to the walls of the vessels thereby obstructing the free flow of blood and eventually making the tissues suffer from lack of oxygen. The lack of oxygen causes serious problems including Acute Chest Syndrome (ACS), stroke, infection, organ damage, and over the lifetime an SCD can harm a persons spleen, brain, kidneys, eyes, bones. Sickling of …

The Intersection Of Economic Disadvantage And Race And The Expanded Role Of Parent-Led School-Supporting Nonprofit Organizations In K-12 Public Schools In The Richmond, Virginia, Metropolitan Area: A Mixed Methods Approach, Rachel A. Levy

Theses and Dissertations

Nongovernmental actors have long been involved in the funding of U.S. K-12 public schools. With recent cuts to state funding to public education, however, groups called school-supporting nonprofits (Nelson & Gazley, 2014) have taken on a much larger role in school funding. Nonacademic, volunteer, parent-led groups such as parent teacher associations (PTAs), parent teacher organizations (PTOs), and booster clubs, especially, have grown in number and in amount of revenues raised, and are funding core school needs and functions. This situation confuses obligations of public institutions, undermines equity, and complicates the role of educational leaders. This mixed-methods study explores the influence …

Periodontal Therapy Improves Oral And Gut Microbiota And Reduces Systemic Inflammation And Endotoxemia In Patients With Cirrhosis, Payam Matin

Theses and Dissertations

Objectives: The aim of this pilot study was to compare the changes in oral and gut microbiota, endotoxemia, and systemic and local inflammatory markers following oral interventions in subjects with and without cirrhosis.

Methods: Study subjects displaying gingivitis or mild/moderate periodontitis were placed into two groups: with cirrhosis (n= 24) and without cirrhosis (n=21). Each subject received nonsurgical periodontal therapy. Serum, stool and saliva samples were collected prior to and 30 days post-therapy and analyzed for stool/saliva microbiome, MELD score, endotoxin and IL-6 levels.

Results: There was no difference in age, gender and the periodontal disease status between groups. At …

A World Without You, Brian C. Patterson

Theses and Dissertations

The following thesis is adapted from screenplay format. The

document from which it derives serves as a shooting script

for a film/video called A World Without You . The shooting

script contains explicit scene description, camera set-ups

that include angle and lens choices, dialog, and

transitions - all the relevant instruction needed for

anyone to reproduce the film with explicit similarity to

its original. The thesis reflects a series of short videos

I completed as research. In their finished state, the

series of videos coalesce to a single film/video with a

sixty-two-minute running time. That conglomeration emerged

as a “shadow” …

Effects Of Geography On Mental Health Disparities On Sexual Minorities In New York City, Jacob Felson, Amy Adamczyk

Publications and Research

Gay and lesbian individuals have higher rates of psychological distress than do heterosexual individuals. The minority stress hypothesis attributes this disparity to adversity related stress experienced by sexual minorities. In support of this idea, research in the U.S. has generally found that mental health disparities between sexual minorities and others are narrower in places where tolerance is relatively high. However, few studies have examined disparities between sexual minorities and others in neighborhoods where sexual minorities are most highly concentrated. Likewise, little research attention has been given to disparities for people who move to more tolerant places from less tolerant states …

Rodrigo And Ressentiment: I Don't Want It If You Are Going To Get It, Too - Why Classical Economic And Political Theory Fails To Explain The Obamacare Vote, But Legal Realism And Cls Can, Richard Delgado

Articles

No abstract provided.

Duty To Protect: Enhancing The Federal Framework To Prevent Childhood Lead Poisoning And Exposure To Environmental Harm, Allyson E. Gold, Emily A. Benfer, Emily Coffey, Mona Hanna-Attisha, Bruce Lanphear, Helen Y. Li, Norton, Ruth Ann;, David Rosner, Kate Walz

Articles

Scientific evidence indisputably demonstrates that lead poisoning causes permanent neurological damage and numerous co-morbidities for children and adults. Exposure to lead hazards irreversibly harms individuals and, left unchecked, can devastate communities into the future. In recognition of these threats, the President's Task Force on Environmental Health Risks and Safety Risks to Children (Task Force) was established by Executive Order in 1997. The original Task Force created the first coordinated federal response to eliminate childhood lead poisoning in the United States and set an ambitious ten-year timeline to achieve its goals of prevention, treatment, research, and progress management. However, the most …

End Of Life And Autonomy: The Case For Relational Nudges In End-Of-Life Decision-Making Law And Policy, Megan S. Wright

Faculty Scholarship

Autonomy is a central principle in many areas of health law. In the case of end-of-life decision-making law and policy, however, the principle of autonomy requires revision. On the whole, law conceptualizes autonomy at the end of life as an individual making private, personal decisions based solely on their interests and values, and independent of others. But ordinary people understand autonomous decisionmaking at the end of life differently, in a way that acknowledges the importance of their interpersonal relationships. Social science research has documented that strengthening relationships with others, sharing responsibility in the decision-making process with healthcare providers, and taking …

Community Economic Development And The Concept Of Justice Symposium: Community Economic Development Is Access To Justice, Steven H. Hobbs

Articles

No abstract provided.

Waste Not, Want Not: Using Source-Separated Urine To Cultivate Maize In The Southern Highlands, Tanzania, Lucy Hatfield

Dissertations, Master's Theses and Master's Reports

In Sub-Saharan African countries, soil fertility is low due to unsustainable agricultural practices and little to no access to chemical fertilizer. Poor yields have resulted in many of these countries struggling to produce enough food to feed their growing populations. Human urine has been used as an effective, low-cost alternative to chemical fertilizers in greenhouse and plot trials on a variety of vegetables, but its effects on elemental grain composition in cereal crops are largely unknown. Here we tested whether diluted human urine applied as a fertilizer can increase maize crop growth, yield and nutritional content on small family-owned plots. …

Ecological Implications Of Foraging And Life-History In Three Cold-Adapted Species, Andrew Von Duyke

Dissertations, Master's Theses and Master's Reports

This research investigates the ecology of: ringed seals (Pusa hispida), moose (Alces alces), and bowhead whales (Balaena mysticetus). Each of these species draws upon specialized strategies to meet the physical demands of life in their extreme environments. However, they are currently experiencing unprecedented changes in their habitats. This work adds to what is known about the behavior, physiology, and population dynamics of cold-adapted species—providing insights of value for an improved understanding of foraging and life-history theory, and informing conservation and ecosystem monitoring efforts. Chapter 1 provides a brief introduction to the scope of work …

Housing And Transition: Meeting The Needs Of Young Adults With Mental Health Conditions, Barbara J. Friesen, Nancy Koroloff

School of Social Work Faculty Publications and Presentations

This report addresses challenges faced by transition-age youth and young adults with mental health conditions as they try to find and maintain stable housing. This document was written specifically for program designers, administrators, and policy-makers, and others who are planning to develop or modify housing supports that are available to young adults. It may also be of interest to advocates and young people working to improve housing policy and program options for young people. The document is grounded in two critical considerations: 1) the current political and economic conditions that affect the availability of affordable housing also restrict the availability …

Environmental Risk, Resource And Production, Nancye Gannaway

Farm Systems and Economics published reports

Plan Prepare Prosper - workshop

Aims

• To identify and plan for projected changes in weather patterns and in the physical resources that underpin the productivity of the farm enterprise.
• To develop initiatives to manage observed and likely threats from the environment to farm enterprises.
• To support the achievement of long-term economic viability of land under production

Today's content will help develop risk management strategies for agricultural production systems.

The Role Of Sociality And Disturbance In Shaping Elk (Cervus Canadensis) Population Structure, Brittany L. Slabach

Theses and Dissertations--Biology

Investigating how and why individuals interact is an important component to understanding species ecology. The type and patterning of relationships (social structure) provides pertinent insight into how ecological factors such as spatial heterogeneity of resources and predation influence associations between individuals. Many taxa exhibit temporally fluid association patterns, where individuals associate with a variety of others at different rates. Ungulate species exhibit prime examples of highly fluid grouping patterns and individuals form both temporary and long-term associations. The effects of human disturbance on ungulate behavior are well documented and these changes are further exacerbated during the hunting season. Species such …

Biting The Hands That Feed “The Alligators”: A Case Study In Morbid Obesity Extremes, End-Of-Life Care, And Prohibitions On Harming And Accelerating The End Of Life, Michael J. Malinowski

Journal Articles

Obesity, recognized as a disease in the U.S. and at times as a terminal illness due to associated medical complications, is an American epidemic according to the Centers for Disease Control and Prevention (“CDC”), American Heart Association (“AHA”), and other authorities. More than one third of Americans (39.8% of adults and 18.5% of children) are medically obese. This article focuses on cases of “extreme morbid obesity” (“EMO”)—situations in which death is imminent without aggressive medical interventions, and bariatric surgery is the only treatment option with a realistic possibility of success. Bariatric surgeries themselves are very high risk for EMO patients. …

The Effects Of Temperature On Batrachochytrium Dendrobatidis Resistance And Heart Rate In The Polymorphic Eastern Red-Backed Salamanders, Plethodon Cinereus, Joseph Alan Demarchi

Masters Theses

No abstract provided.

Regulation Of Prostaglandin D2 And Angiogenesis-Related Factors From Human Skin Mast Cells By Interleukin-6 And Resveratrol, Cody Cody Mchale

Theses and Dissertations

Mast cells are classically recognized as the effector cells of Immunoglobulin E (IgE)-mediated hypersensitivity reactions (i.e. allergic reactions). Mast cells also play an important role in the innate immune response to parasitic helminth infection. Allergic disease including allergic rhinitis, asthma, atopic dermatitis, and anaphylaxis, is a major health concern in the United States with greater than 60 million Americans suffering from allergy and asthma. In addition, mast cells have more recently been implicated in non-allergic disease including various human cancers, which will affect approximately 39.6% of U.S. men and women. Therefore, understanding the immunological and molecular mechanisms that regulate mast …

Efficiency Of Ambulatory Blood Pressure Monitoring Vs. 5-Day Serial Monitoring In A Military Treatment Facility, Kadijatu Kakay

Theses and Dissertations

The purpose of this process improvement project is to determine efficiency of ambulatory blood pressure monitoring (ABPM) vs. 5-day blood pressure checks in a military treatment facility. The sample consists of male and female active duty soldiers ages 18 to 54 years without a previous diagnosis of hypertension (HTN). The soldiers were assigned to a unit that is physically and mentally challenging, has demanding training opportunities and duty requirements, and are rapidly deployable in support of peacekeeping, humanitarian and combat missions.

The data collection method included a retrospective chart review of 128 charts randomly selected between June 2016 and May …

New Insight For Activity Intensity Relativity: Metabolic Expenditure During Object Projection Skill Performance, Ryan S. Sacko

Theses and Dissertations

This dissertation consist of four studies that examine energy expenditure (EE) during object projection skill performance (OPSP). These four studies have the potential to inform physical education (PE) curricula and physical activity (PA) interventions by providing an understanding the acute EE associated with performing OPSP in developmentally appropriate activities. If OPSP is associated with high EE, then promoting their development during physical activity interventions and physical education (PE) will have both an acute and long-term health-enhancing benefit. Thus, the purposes of these four studies was to examine adult and children’s EE associated with the performance of object projection skills at …

Coscarelli V. Esquared, Southern District Of New York

Historical and Topical Legal Documents

No abstract provided.

Strafford County 2017 Annual Report Of The Commissioners, Treasurer, Other County Officers And The Strafford County Delegation Strafford County, New Hampshire For The Year Ending December 31, 2017., Stafford County Representatives

Strafford County, NH Annual Reports

This is an annual report containing vital statistics for a county in the state of New Hampshire.

Strauss V. Angie's List, District Of Kansas

Historical and Topical Legal Documents

No abstract provided.

Normative Data For Four Neuropsychological Tests In A Sample Of Adults Who Are Illiterate And From Latin America, Alejandra Morlett Paredes

Theses and Dissertations

Neuropsychological tests are standardized tasks used to measure psychological functioning that is associated with a particular brain structure. These tests often are used in diagnosing a cognitive deficiency resulting from brain injuries. Currently, there are a limited number of studies that have focused on standardization of neuropsychological tests in Latin America. Therefore, the vast majority of cognitive tests used in the evaluation of patients with brain damage have no normative parameters adjusted to the cultural characteristics of Latinos and Latinas. As a result, neuropsychological diagnoses among this population may be inadequate, and evaluation of rehabilitation program effectiveness limited. The importance …

Reading The Unreadable: Salò And Its Significance, Michael Ramsey

Comparative Literature M.A. Essays

No abstract provided.

Breast Milk Supply Establishment For Mothers Of Nicu Infants: A Retrospective Chart Review Examining Milk Volume, Maternal Factors And Pump Type, Cynthia C. Jackson

Books, Presentations, Posters, Etc.

No abstract provided.

The Interface Between Wheat And The Wheat Curl Mite, Aceria Tosichella, The Primary Vector Of Globally Important Viral Diseases, Anna Skoracka, Brian G. Rector, Gary L. Hein

Department of Entomology: Faculty Publications

Wheat production and sustainability are steadily threatened by pests and pathogens in both wealthy and developing countries. This review is focused on the wheat curl mite (WCM), Aceria tosichella, and its relationship with wheat. WCM is a major pest of wheat and other cereals and a vector of at least four damaging plant viruses (Wheat streak mosaic virus, High plains wheat mosaic virus, Brome streak mosaic virus, and Triticum mosaic virus). The WCM–virus pathosystem causes considerable yield losses worldwide and its severity increases significantly when mixed-virus infections occur. Chemical control strategies are largely ineffective because WCM occupies …

The Influence Of Spatiotemporally Decoupled Land Use On Honey Bee Colony Health And Pollination Service Delivery, Matthew D. Smart, Clint R. V. Otto, Benjamin L. Carlson, Cali L. Roth

Department of Entomology: Faculty Publications

Societal dependence on insects for pollination of agricultural crops has risen amidst concerns over pollinator declines. Habitat loss and lack of forage have been implicated in the decline of both managed and native pollinators. Land use changes in the Northern Great Plains of the US, a region supporting over 1 million honey bee colonies annually, have shifted away from historical grassland ecosystems bees rely on for forage toward landscapes dominated by corn, soybeans, and other row crops. We investigated how land use impacts honey bee colony population size during the growing season and subsequent colony population size for almond pollination …

Abscisic And Jasmonic Acids Contribute To Soybean Tolerance To The Soybean Aphid (Aphis Glycines Matsumura), Kaitlin M. Chapman, Lia Marchi-Werle, Thomas E. Hunt, Tiffany M. Heng-Moss, Joe Louis

Department of Entomology: Faculty Publications

Plant resistance can provide effective, economical, and sustainable pest control. Tolerance to the soybean aphid has been identified and confirmed in the soybean KS4202. Although its resistance mechanisms are not fully understood, evidence suggests that enhanced detoxification of reactive oxygen species (ROS) is an active system under high aphid infestation. We further explored tolerance by evaluating the differences in constitutive and aphid-induced defenses in KS4202 through the expression of selected defense-related transcripts and the levels of the phytohormones abscisic acid (ABA), jasmonic acid (JA), JA-isoleucine (JA-Ile), cis-(+)-12-oxo-phytodienoic acid (OPDA), and salicylic acid (SA) over several time points. Higher constitutive levels …

Parental Rnai Suppression Of Chromatin Remodeling Genes To Control Coleopteran Pests, Blair D. Siegfried, Kenneth E. Narva, Kanika Arora, Sarah E. Worden, Chitvan Khajuria, Elane Fishilevich, Nicholas P. Storer, Meghan Frey, Ronda L. Hamm, Ana Maria Velez

Department of Entomology: Faculty Publications

This disclosure concerns nucleic acid molecules and meth ods of use thereof for control of hemipteran pests through RNA interference - mediated inhibition of target coding and transcribed non - coding sequences in hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of hemipteran pests, and the plant cells and plants obtained thereby.