Digital Commons Network^™

Paclobutrazol Enhances Tall Fescue Salt Tolerance Via Physiological And Root System Architecture Modulation, Shugao Fan, Xindi Sun, Guohao Liang, Zhuanzhuan Ma, Jincheng Hao, Jiawei Wu, Ying Zhao

School of Mathematical & Statistical Sciences Faculty Publications

Background: Salinity represents a major global constraint on crop productivity. Promoting the cultivation of tall fescue in saline environments offers not only nutritional advantages for livestock but also enhances its potential for ornamental use. In this mesocosm study, we examined the effects of paclobutrazol (PBZ) on tall fescue performance under salt stress, focusing on key physiological traits to evaluate salt tolerance.

Results: Under high salt stress, paclobutrazol application increased the total number of lateral roots by 85%, from 18.39 to 34.04, and widened their growth angle by 24%, from 24.10° to 29.88°, fundamentally enhancing topsoil exploration. This reconfigured root system …

Harnessing The Power Of Amphoterically Modified Chitosan Coagulants For Enhanced Polyester Microplastic Fibre Removal From Water, Nimesha Thathsarani, Mohadeseh Najafi, Mehdi Khiadani, Muhammad Rizwan Azhar, Masoumeh Zargar

Research outputs 2022 to 2026

Microplastic fibre (MPF) is the dominant type of microplastic present in water treatment plants’ influent. Coagulation–flocculation followed by sedimentation effectively removes microplastics during pre-treatment; however, conventional inorganic coagulants produce high sludge volume, causing secondary pollution. Chitosan offers a greener alternative but is limited by poor solubility and low molecular weight. In this study, two amphoteric modifications were successfully incorporated into Chitosan, including CMC-CTA, synthesised by modifying carboxymethyl Chitosan (CMC) with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CTA); and CMC-g-PDMC, synthesised by grafting poly[(2-methacryloyloxyethyl) trimethyl ammonium chloride] (PDMC) onto CMC. Their coagulation performance for MPF removal was assessed by turbidity measurement. The effects …

Testing If Vitamin K1 Reduces The Progression Of Non-Severe Calcific Aortic Stenosis: Design And Rationale Of The Prevention Of Aortic Stenosis Progression Phylloquinone Ossification Reduction Trial (Passport), William A. Courtney, Jarryd Walker, Aindreas Dorai-Raj, Tom Gilbert, Adil Rajwani, Jamie W. Bellinge, Jonathan M. Hodgson, Graham S. Hillis, Carl J. Schultz

Research outputs 2022 to 2026

Aims Calcific aortic stenosis (CAS) is the most common heart valvulopathy in high-income countries. There is no known treatment for CAS other than replacement of the valve in severe, symptomatic disease. Observational studies and a small openlabel randomized trial have reported that vitamin K1 supplementation may reduce the progression rate of calcification and obstruction in CAS. Methods and results 3PASSPORT(ACTRN12622000447752) will be a prospective, randomized, double-blind, placebo-controlled clinical trial investigating if nutritional supplementation with 10 mg of vitamin K1 can reduce the rate of valvular calcification and haemodynamic progression in CAS. Patients identified to have mild or moderate CAS based …

Development And Characterization Of Sustainable Aluminum Metal Matrix Composites With Date Palm Agro-Residues As Reinforcement, Ansar Kareem

Dissertations

Aluminum Matrix Composites (AMCs) are extensively used in various industrial applications owing to their exceptional mechanical, material, and tribological properties. This led to the development of AMCs with every possible aluminum alloy as matrix, incorporated with various reinforcement materials to achieve desired material properties. There has been an increasing trend in the utilization of agricultural and industrial waste products as reinforcement material in AMCs. Date palm trees produce huge quantity of agricultural waste in different forms. Usually, these wastes are burned or disposed of in landfills which cause environmental pollution. Date palm agro-wastes can be incinerated to produce date palm …

Selective Sharing And Social Bonding: A Qualitative Study Of Online Health Information Behaviour Among Older Adults In Shanghai, Minzhi Ye, Yan Liu

School of Social Work Faculty Publications

The health information landscape has been revolutionised by the advent of social media, significantly affecting older adults’ access to and interaction with online health information. In this study, we examine how older adults interact with health information on social media. In total, 30 participants aged 60 years and older from Shanghai were interviewed, focusing on their health information-seeking behaviour, perceptions, and subsequent actions using a semi-structured, in-depth interview approach. Furthermore, in this study, we employed grounded theory to analyze the data, and the results revealed that older adults utilise a comprehensive cognitive process for evaluating health information. Information-sharing decisions among …

Structural-Level Stigma Within Emergency Food Assistance Programs: Perspectives From Delaware And Pennsylvania, Mckenna M Halverson, Evyn Y Appel, Valerie A Earnshaw, Raquelle Powell, Grace Sands, Nithila Chrisostam, Shreela V Sharma, Allison Karpyn

Faculty, Staff and Student Publications

To characterize the ways in which structural stigma manifests within emergency food program settings.

Methods : We conducted 30-minute semi-structured interviews with 18 emergency food program clients in Pennsylvania and Delaware between August and December of 2024. The discussion guide included open-ended questions regarding client experiences of structural stigma, with an emphasis on issues of access and quality. Demographic data and household food insecurity (Hunger Vital Sign) were also captured. A hybrid inductive and deductive coding approach was used to analyze the data.

Results : Structural stigma is a persistent issue within emergency food program environments, impacting both participant access …

Mitigating Food Insecurity-Related Stigma: A Review Of Intervention Strategies, Evyn Y Appel, Mckenna M Halverson, Valerie A Earnshaw, Tania Cruz Cordero, Maya Rozin, Raquelle Powell, Grace Sands, Nithila Chrisostam, Sarah E Katz, Shreela V Sharma, Allison Karpyn

Faculty, Staff and Student Publications

Objective: To characterize intervention strategies addressing food insecurity-related stigma implemented in federal nutrition programs (e.g. SNAP, WIC) and emergency food programs (e.g. food pantries, food cupboards) within high income countries.

Methods: Six databases (PubMed, PsychINFO, Web of Science, CINAHL, Sociological Abstracts, Dissertations and Theses Global) and the Internet were searched through September 2024. Data on study characteristics and stigma intervention characteristics were extracted with a structured template. Descriptive statistics and thematic analysis were used.

Results: The review found 46 intervention strategies across 18 articles. The majority of articles were based in the United States (89.9%) with the remaining portion from …

Ai Recipe Blog Is Evaluated Similarly To A Recipe Blog Created By Nutrition And Dietetic Students, Katie N. Kraus, Stacy L. Bevan, Sarah Moore Smith, Maeci H. Armstrong, Brooke Campbell Jeppesen, Catherine Fish, Heidi J. Wengreen

Nutrition, Dietetics, and Food Sciences Faculty Publications

With the growing use of AI, it is important to know target audiences’ perceptions of its use. A convenience sample of students were invited to take an online survey in which they were randomly assigned to Group 1 (evaluated a student-generated blog; n = 456) or Group 2 (evaluated an AI-generated blog; n = 492). The results of independent t-tests and chi-squared tests indicated no group differences in ratings of ease of recipe preparation, time to prepare the recipe, utilization of common ingredients, and frequency of intended use of the blog. The student-generated blog was rated higher on budget …

Evaluating Interactions Between National And Subnational Governments In The Czech Republic For Physical Activity Policy Development And Implementation, Michael Pratt, Juliana Mejía-Grueso, Eugen Resendiz, Aleš Jakubec, Zdeněk Hamřík, Deborah Salvo, Andrea Ramírez Varela, Josef Mitáš

Faculty, Staff and Student Publications

Background: Most countries now have physical activity (PA) policies but translating them into action at national and subnational levels remains poor. To better understand the disconnect, the "Interaction between National and Local Government Levels in Development and Implementation of Physical Activity Policies Tool" (INTEGRATE-PA-Pol) was developed by the Global Observatory for Physical Activity (GoPA!).

Methods: The Czech Republic was chosen as a European pilot site based on existing research capacity and relationships. The INTEGRATE-PA-Pol tool was translated and adapted for use in the country. This questionnaire-based tool has 8 components assessing government levels, political system, and sectors across the 5 …

N Y State Dent J November 2025

The New York State Dental Journal

In the November 2025 issue, the reader will find the following feature articles:

• "Attitudes of New York State Pediatric Dentists Toward Treating Hasidic Patients"
• "A Qualitative Assessment of the Role of Dental Specialists in U.S. Opioid Epidemic"
• "Revolutionizing Dental Operatories"
• "An Update on Non-Cigarette Nicotine-Containing Products and the Periodontal Patient"

This issue includes regular columns with regional news impacting the New York membership including: editorial and legal columns, association activities, component news, continuing education opportunities, and classifieds.

Buy Better: How Food Policy Councils Leverage Procurement To Improve Food Worker Conditions, Frank Sarfo, Laura-Anne Minkoff-Zern, Jonnell A. Robinson

The Lender Center for Social Justice

Food system workers; farm laborers, grocery clerks, restaurant staff, and food processors are the backbone of our everyday meals, yet their voices are largely missing from the councils that shape local food policy. Despite being essential to food security and community health, these workers face low wages, poorworking conditions, and limited protections. Food Policy Councils (FPCs), which aim to advance equity and sustainability in food systems, rarely prioritize labor issues. The study, drawing on national survey data and interviews with over 25 FPC leaders, finds that structural constraints, internal conflicts, limited capacity, and weak connections with labor organizations prevent meaningful …

Theory Of Mind Across Cultures: Psychological Implications, Lewis Hancock, Simon Dein

Online Readings in Psychology and Culture

Theory of Mind (ToM) refers to a set of social and cognitive abilities that we use to infer and understand other people’s mental states. This paper begins by outlining ToM, its component skills, and what research methods have been used to measure it. It then summarises research on how culture and other social factors such as language, parenting, and socio-economic status can impact its development, in particular differences in age of mastery of various aspects of ToM. Mental disorders characterised by deficits in ToM – in particular ASD – are also discussed and used to elucidate its nature and development. …

The Anchor: November 2025, Hope College

The Anchor: 2025

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Screening And Identification Of Antioxidant Peptides From Sea Cucumber Gonad Proteins And Their Activation Of Superoxide Dismutase, Zhiqin Zhang, Jingxuan Wang, Yongke Deng, Yugui Wang, Peipei Dou, Hongbing Fan, Xiangquan Zeng, Xinguang Fan, Lili Zhang, Haimei Liu, Qin Zhao

Animal and Food Sciences Faculty Publications

The gonad is one of the major byproducts of sea cucumber. Four novel antioxidant peptides (NPWGQ, PGHPF, VPYPR and ATGPQGPAGQRGPAGPTGPTGPAG) were isolated and identified from sea cucumber gonad proteins through enzymatic hydrolysis and antioxidant activity-guided fractionation, bioinformatics approaches and in silico screening. These peptides demonstrated great free radical (2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS))-scavenging activity and notable superoxide dismutase (SOD)-activation capacity. Molecular docking and molecular dynamics simulation data suggested that these peptides could form strong binding with SOD through hydrogen bonding, electrostatic interactions, and hydrophobic interactions. Among these peptides, NPWGQ displayed the most potent antioxidant and SOD-activating effects. Through searching …

The Performance, Energy And Nutrient Utilization, And Bone Mineralization Of Broiler Chickens Fed Corn-Soybean Meal-Based Diets With Reduced Metabolizable Energy, Calcium, And Available Phosphorus Supplemented With Exogenous Enzymes, Megan M. Bauer, Tuoying Ao, Jacqueline P. Jacob, Michael J. Ford, Anthony J. Pescatore, Ronan F. Power, Sunday A. Adedokun

Animal and Food Sciences Faculty Publications

This study evaluated the performance and energy and nutrient utilization of broiler chickens fed corn-soybean meal-based diets supplemented with a naturally fermented enzyme complex containing xylanase and phytase. This was evaluated using 300 one-day-old male Cobb broiler chicks in a randomized complete block design with five dietary treatments replicated 10 times with 6 chicks per replicate. The treatments consisted of a positive control (PC) group containing commercially recommended energy and nutrient levels, a negative control (NC) group with reduced metabolizable energy, calcium, and available phosphorus, and three levels of exogenous enzyme supplementation to the NC diet at 150, 200, 250 …

The 10-Year Status Of Pediatric Gastroenterologists' Perception Of Their Roles In The Management Of Childhood Obesity., Sara Karjoo, Senthilkumar Sankararaman, Fotini Tania Mitsinikos, Marwa Abu El Haija, Sheela Mahendra, Ayesha Baig, Ruba A. Abdelhadi, Ruben E. Quiros-Tejeira, Timothy Sentongo

Manuscripts, Articles, Book Chapters and Other Papers

In 2013, a survey of NASPGHAN members on their involvement in managing pediatric obesity revealed that most pediatric gastroenterologists viewed their roles as primarily supportive, focusing on the management of obesity-related gastrointestinal comorbidities. This 10-year follow-up survey, which targeted pediatric gastroenterology programs and practices, found similar perceptions, along with an increased interest in learning about obesity pharmacotherapy. Additionally, most programs and practices reported limited access to dedicated dietitians, a lack of funding, and a desire for greater institutional support for multidisciplinary programs addressing obesity. Notably, none of the funded programs cited philanthropy as a source of funding. These findings underscore …

Delayed Presentation Of A Retained Colonic Segment In A Child With Intestinal Failure On Teduglutide, Rachel C Bordelon, Sarah J Varalla, Varaha S Tammisetti, Mohamed M Shahin, Amanda Tchakarov, Essam Imseis, Allison L Speer

Faculty, Staff and Student Publications

Teduglutide is a glucagon-like peptide 2 (GLP-2) analogue that was approved by the United States Food and Drug Administration for the treatment of pediatric (>1 year) intestinal failure due to short bowel syndrome in 2019. GLP-2 analogues promote rapid intestinal adaptation, increasing the absorptive capacity of residual intestine after surgical resection to aid the achievement of enteral autonomy or reduce parenteral nutrition requirements. Despite relatively few reported side effects, there is a theoretical risk of proliferative complications. Here we present an intriguing case of a pediatric patient found to have a decade-long retained, discontinuous segment of colon from a …

Replication-Competent, Tumor-Specific Immuno-Gene Vectors Allow For Exchange Of Transgenes And Lead To Viral Persistence Following Iv Administration, Lee S Rosen, Christian Ottensmeier, Maria Hawkins, Aung Naing, Guru Sonpavde, Brian A Van Tine, Eileen E Parkes, Sean M O'Cathail, Rui-Ru Ji, Matthew Thomas, Andrea Stacey, Maria Stella Sasso, Oliver Rosen

Faculty, Staff and Student Publications

Introduction: Enadenotucirev (EnAd) and successor transgene-armed Tumor-Specific Immuno-Gene (T-SIGn) vectors are replication-competent, blood-stable viral vectors that traffic to tumor sites following intravenous (IV) administration. Following initial proof of mechanism for this immunotherapy modality, there is a need to identify a safe dosing approach, understand whether transgenes affect tolerability, and determine how to measure exposure and pharmacodynamic effects.

Methods: Safety data from multiple phase 1 trials were aggregated to assess various dosing regimens and toxicities, including those that may be associated with transgene arming. Viral delivery to tumors, peripheral viral persistence, transgene expression, and cytokine responses were also assessed and compared …

Prevalence Of Obesity With Confirmed Excess Adiposity In Us Children And Adolescents, Alexandra B Palmer, Kyung Hyun Lee, Rashedeh Roshani, Elizabeth Frankel, Miryoung Lee, Mohammad Y Anwar, Heather M Highland, Kristin L Young, Mariaelisa Graff, Joseph B Mccormick, Susan P Fisher-Hoch, Joyce P Samuel, Jennifer E Below, Kari E North, Penny Gordon-Larsen

Faculty, Staff and Student Publications

No abstract provided.

Missing The Target: A Scoping Review Of The Use Of Percent Weight Loss For Obesity Management, Diana Sherifali, Megan Racey, Donna Fitzpatrick-Lewis, Michelle Greenway, Sanjeev Sockalingam, Jun Wada, Soo Huat Teoh, Ian Patton, David Macklin, Elizabeth F C Van Rossum, Luca Busetto, Deborah Bade Horn, J D Patricia Nece, Morgan Emile Gabriel Salmon Leguede, Nicole Pearce, Carel Le Roux, Jamy Ard, Angela S Alberga, Lee Kaplan, Arya M Sharma, Sean Wharton

Faculty, Staff and Student Publications

Introduction: To co-create comprehensive targets for obesity management, we need to understand the genesis and current use of percent weight loss targets in research. The goals of our scoping review are to (1) synthesize the literature on percent weight loss targets for adults with obesity and (2) discuss the percent weight loss targets in context with their health benefits.

Methods: We searched Cochrane, MEDLINE, and EMBASE for English language, pharmaceutical, and/or behavioral intervention studies in adults with obesity where the explicit aim of the study was weight reduction defined as a percent of body weight. Reviewers screened citations and extracted …

Fontan Circulation And Transplantation: Considerations For The Complex Candidate., Drishti Tolani, Sharon Chen, Edo Bedzra, Kurt R. Schumacher, Shahnawaz Amdani

Manuscripts, Articles, Book Chapters and Other Papers

The Fontan operation has transformed survival for patients with single ventricle congenital heart disease, but the long-term durability of this physiology remains limited. Fontan circulatory failure (FCF) is a progressive, heterogeneous condition associated with multiorgan dysfunction, lymphatic failure, and elevated post-transplant risk when not recognized early. With increasing survival into adulthood, heart transplantation has emerged as the definitive "fourth stage" of palliation. However, referrals for advanced therapies are often delayed, with many patients presenting in advanced stages of decline. This review synthesizes current evidence on the pathophysiology of Fontan failure, outlines consensus indications for transplant evaluation, and highlights pre-transplant strategies …

Hypertension Prevention Program And Its Effects On Blood Pressure Levels Among Young Adults In A Christian Community In Southwest Michigan, Cindel Hollancid

Doctor of Nursing Practice Projects

Background

Although the majority of patients who present are adults over the age of 40 years old; with blood pressures ranging from 140/88 – 190/110 and many times higher readings, it was intriguing and important to assess whether a direct intervention, teaching young adults ages 18 – 39 years the benefits of lifestyle choices would be beneficial as a preventative measure to implement for hypertension reduction patterns as one ages. According to Hinton et al. (2019), hypertension affects 1 in 8 adults between the ages of 20 and 40 years old and is thus common among young people; with the …

Recycling Waste Via Insect Agriculture: Frass Impacts On Soil And Plant Health, Helen C.S. Amorim, Amanda J. Ashworth, Thomas F. Ducey, Valerie B. Brewer-Gunsaulis, Gerson L. Drescher, Philip R. Owens, Alana H. Patterson, Giovanna De Blais, Iris Van Straaten

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Frass-the main by-product of insect rearing for animal feed-is emerging as a promising soil amendment and plant growth promoter. However, basic agronomic information is lacking and prevents frass' widespread use as a biofertilizer. This study assessed impacts of black soldier fly (Hermetia illucens L. [Diptera: Stratiomyidae]) frass on soil fertility, crop growth, and quality compared to poultry litter (PL). Irrigated and non-irrigated soybean (Glycine max L. Merr.) and non-irrigated switchgrass (Panicum virgatum L.) plots received either PL (5.6 Mg ha(-1)), low frass rate (LF; 5.6 Mg ha(-1)), high frass rate (HF; 11.2 Mg ha(-1)), besides the unamended control (CT). In …

November 2025, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

• SWOSU Wellness Fall 5k!
• November is National Diabetes Month
• The Wellness Committee has one desktop adjustable computer stand to loan out.
• Spooktacular Step Challenge Results
• November Word Search

Data As Policy, Janet Freilich, W. Nicholson Price Ii

Faculty Scholarship

A large literature on regulation highlights the many different methods of policy-making: command-and-control rulemaking, informational disclosures, tort liability, taxes, and more. But the literature overlooks a powerful method to achieve policy objectives: data. The state can provide (or suppress) data as a regulatory tool to solve policy problems. For administrations with expansive views of government’s purpose, government-provided data can serve as infrastructure for innovation and push innovation in socially desirable directions; for administrations with deregulatory ambitions, suppressing or choosing not to collect data can reduce regulatory power or serve as a back-door mechanism to subvert statutory or common law rules. …

State Of Menstrual Health Education In 2024: Content Analysis Of Us K-12 Public School Education Standards, Emily Richardson, Sarah Bemis, Page Dobbs, Hope Ballentine, Shristi Bhochhibhoya, Victor Kwaku Akakpo, Kylie Lovett

The Eleanor Mann School of Nursing Faculty Publications and Presentations

Background: Exploratory study aiming to assess the prevalence and time of initiation of menstrual health curriculum in US public school education standards by state. Methods: US public school Kindergarten-12th grade education standards from each state's Department of Education website, including D.C. (n = 51), were searched for menstruation, menstrual, menses, menopause, period, menarche, reproduction, puberty, and growth and development. Results25.5% (n = 13) of US education standards include menstruation. Of these, constructs of comprehensive menstrual health were recorded including abnormal menstruation (n = 6), menstrual hygiene (n = 6), menopause (n = 1), and stigma (n = 7). Education is …

Carroll County Advisory Council 2025, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Determining The Accumulation Potential Of Nanoplastics In Crops: An Investigation Of 14C-Labelled Polystyrene Nanoplastic Into Radishes, Nathaniel J. Clark, Astrid C. Fischer, Demelza Carne, George R. Littlejohn, Lee J. Durndell, Anne Plessis, Richard C. Thompson

School of Biological and Marine Sciences

The capacity of crops to accumulate nanoplastics has remained relatively unexplored largely due to analytical constraints. To address this challenge, the present study employed a radiolabelling approach to demonstrate, for the first time, that polystyrene nanoplastics (¹⁴C-PS NPs) accumulate and move into the edible tissues of radishes (Raphanus sativus). Radishes were exposed hydroponically for five days, with only their non-fleshy roots in contact with the ¹⁴C-PS NPs, while accumulation in the fleshy (edible) roots and shoots was subsequently measured. The radish roots retained nearly 5 % of the ¹⁴C-PS NPs from the exposure, either through accumulation …

A Historical Cohort Comparison After Inpatient Admission For Adolescents With Anorexia Nervosa: Feasibility Of Virtual Group Therapy, Elizabeth V Franklin, Margaret Mathias, Rachel Wolfe, Duc T Nguyen, Drusilla M Rosales, Sofia Pedroza, Albert C Hergenroeder, Constance M Wiemann

Center for Medical Ethics and Health Policy Staff Publications

Objective: Access to follow-up care after a medical admission for adolescents with anorexia nervosa (AN) is important; yet access can be delayed or unavailable. This study assessed the feasibility and acceptability of a supplemental virtual 8-week outpatient group therapy program following inpatient care. A secondary aim explored the outpatient program's impact on self-reported anxiety, disordered eating, and depression symptoms, and readmission rates.

Method: A retrospective chart review study compared 68 adolescents (aged 11-18) with AN enrolled in an 8-week group therapy program (Recovery and Prevention Program [RAPP]) to 64 adolescents who were not enrolled in RAPP (historical cohort). "RAPP completers" …

Restricting Metabolic Plasticity Enhances Stress Adaptation Through The Modulation Of Pdh And Hif1a In Trap1-Depleted Colon Cancer, Hong-Yuan Tsai, Miao-Hsueh Chen, Jihye Yun, Lisa A Lai, John F Valentine, Mary P Bronner, Teresa A Brentnall, Sheng Pan, Ru Chen

Faculty, Staff and Student Publications

Metabolic plasticity allows cancer cells to survive under adverse conditions. To investigate the role of mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1) in this process, we used CRISPR/Cas9 mediated genetic deletion to knock out (KO) TRAP1 in colon cancer cells. Depletion of TRAP1 triggered a series of events: induced metabolic reprogramming, increased glycolytic flux, downregulation of mitochondrial complex I, and elevated ROS generation. TRAP1-deficient cells showed tolerance to Oxidative Phosphorylation (OXPHOS) inhibitors and exhibited a higher extracellular acidification rate (ECAR). Additionally, TRAP1 depletion activated hypoxia response elements (HREs) and upregulated HIF1A target genes such as GLUT1 and MCT1. …