Digital Commons Network^™

Phylogeny, Ancestral Genome, And Disease Diagnoses Models Constructions Using Biological Data, Bing Feng

Theses and Dissertations

Studies of bioinformatics develop methods and software tools to analyze the biological data and provide insight of the mechanisms of biological process. Machine learning techniques have been widely used by researchers for disease prediction, disease diagnosis, and bio-marker identification. Using machine-learning algorithms to diagnose diseases has a couple of advantages. Besides solely relying on the doctors’ experiences and stereotyped formulas, researchers could use learning algorithms to analyze sophisticated, high-dimensional and multimodal biomedical data, and construct prediction/classification models to make decisions even when some information was incomplete, unknown, or contradictory. In this study, first of all, we built an automated computational …

Blended Learning And Its Effect On Student Achievement: An Action Research Study, Christopher Michael Turpin

Theses and Dissertations

This action research study seeks to determine the effects of blended learning on student achievement in a social studies classroom. The research focus is centered on the idea that students are not reaching their full potential on assessments, and a question about how to most effectively assist them in realizing their potential through a new teaching method. This action research study follows Mertler’s (2014) action research framework to find an answer to the research question. The participants of this study were a group of 10th grade students enrolled in an Honors World History course. Students were taught using a blended …

Effective Leadership For The Implementation Of The Common Core State Standards: Principal Behaviors That Develop Professional Capital To Create Conditions For Positve Change, Eileen Beth Brett

Dissertations

Identifying specific leadership behaviors of elementary school principals that create conditions for positive change is critical to implementing educational reform. The purpose of this research is to identify specific leadership behaviors of principals that have positively impacted the implementation of the Common Core State Standards through the development of professional capital.

The Common Core Standards represent a recent movement to create national standards, founded on the belief that schools have an obligation to ensure that all students are college and career ready (McLaughlin & Overturf, 2012; Conley; 2014a). Implementing the Common Core has challenged principals to develop leadership skills to …

Structural And Chemical Consequences Of High Oxygen Coverages On Rh(111), Rachael Gabrielle Farber

Dissertations

Partial oxidations of small molecules over metal surfaces are central to many heterogeneously catalyzed reactions. However, the identity of the actual surface species that promote or hinder these reactions has remained elusive for a variety of reasons. Recently, the understanding of the role of surface oxides in catalytic activity has changed. Instead of being thought of as poisons, they are now believed to be effective promoters of selective catalysis.

Rhodium (Rh) effectively promotes oxidation reactions and is a benchmark system for models of heterogeneously catalyzed chemistry. For this reason, Rh(111) was chosen as the model system for this dissertation work. …

The Enzymatic Activity And Inhibition Of Dape Encoded N-Succinyl-L,L-Diaminopimelic Acid Dessucinylase, Tahirah Heath

Dissertations

The bacterial enzyme DapE is a hydrolase in the late stage of the mDAP/lysine biosynthetic pathway that catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (L,L-SDAP) to succinic acid and L,L-diaminopimelate (DAP). The product DAP is ultimately converted to m-DAP and then to lysine which is used in the construction of proteins, whereas for humans, lysine is an essential amino acid obtained through diet. DapE has been shown to be conserved across many strains of bacteria. The m-DAP produced through the succinylase pathway is used by both gram negative and gram-positive bacteria in the construction of the essential peptidoglycan cell wall. Because …

Universal Design For Learning: An Examination Of Leadership Promoting Student Learning For All, Martha Ryan-Toye

Dissertations

Martha Ryan-Toye

Loyola University Chicago

UNIVERSAL DESIGN FOR LEARNING: AN EXAMINATION OF LEADERSHIP PROMOTING STUDENT LEARNING FOR ALL

This study examines the intersection of leadership, Universal Design for Learning and a framework for continuous improvement. Universal Design for Learning is a tool that unites beliefs and actions to address the needs of all children in our educational systems. We fall short in our efforts to close the learning gaps for children with disabilities, children of lower income and children of differing racial and ethnic backgrounds. Universal Design for Learning demonstrates a commitment to proactively addressing the variability of learners so …

The Molecular Pathophysiology Of Sepsis-Associated Disseminated Intravascular Coagulation And Its Pharmacologic Modulation, Amanda Temple Walborn

Dissertations

Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection. Sepsis patients are at risk of disseminated intravascular coagulation (DIC), a severe blood coagulation disorder. In DIC, inappropriate coagulation leads to the deposition of fibrin in the microvasculature and subsequent organ failure. This consumes platelets and coagulation factors, leaving patients at risk of severe or fatal bleeding. No treatments are approved for DIC in the United States.

In order to test the hypothesis that DIC would be best described by a combination of biomarkers representative of multiple physiological processes, an array of biomarkers, representative of hemostasis, inflammation, …

Pbw Bases And Marginally Large Tableaux In Type D, Ben Salisbury, Adam Schultze, Peter Tingley

Mathematics and Statistics: Faculty Publications and Other Works

We give an explicit description of the unique crystal isomorphism between two realizations of B(∞) in type D: that using marginally large tableaux and that using PBW monomials with respect to one particularly nice reduced expression of the longest word

How Often Does The Best Team Win? A Unified Approach To Understanding Randomness In North American Sport, Michael J. Lopez, Gregory J. Matthews, Benjamin S. Baumer

Mathematics and Statistics: Faculty Publications and Other Works

Statistical applications in sports have long centered on how to best separate signal (e.g., team talent) from random noise. However, most of this work has concentrated on a single sport, and the development of meaningful cross-sport comparisons has been impeded by the difficulty of translating luck from one sport to another. In this manuscript we develop Bayesian state-space models using betting market data that can be uniformly applied across sporting organizations to better understand the role of randomness in game outcomes. These models can be used to extract estimates of team strength, the between-season, within-season and game-to-game variability of team …

How Often Does The Best Team Win? A Unified Approach To Understanding Randomness In North American Sport, Michael J. Lopez, Gregory J. Matthews, Benjamin S. Baumer

Mathematics and Statistics: Faculty Publications and Other Works

Statistical applications in sports have long centered on how to best separate signal (e.g. team talent) from random noise. However, most of this work has concentrated on a single sport, and the development of meaningful cross-sport comparisons has been impeded by the difficulty of translating luck from one sport to another. In this manuscript, we develop Bayesian state-space models using betting market data that can be uniformly applied across sporting organizations to better understand the role of randomness in game outcomes. These models can be used to extract estimates of team strength, the between-season, within-season, and game-to-game variability of team …

Crystal Structure Of (2-{[(8-Aminona­Phthalen-1-Yl)Imino]­Meth­Yl}-4,6-Di-Tert-Butyl­Phenolato-Κ3n,N′,O)Bromido­Nickel(Ii), Patrick O’Brien, Matthias Zeller, Wei-Tsung Less

Chemistry: Faculty Publications and Other Works

The title compound, [NiBr(C25H29N2O)], contains an NiII atom with a slightly distorted square-planar coordination environment defined by one O and two N atoms from the 2-{[(8-aminonaphthalen-1-yl)imino]methyl}-4,6-di-tert-butylphenolate ligand and a bromide anion. The Ni—O and Ni—N bond lengths are slightly longer than those observed in the phenyl backbone counterpart, which can be attributed to the larger steric hindrance of the naphthyl group in the structure of the title compound. The molecule as a whole is substantially distorted, with both the planar naphthalene-1,8-diamine and imino–methyl– phenolate substitutents rotated against the NiN2OBr plane by 38.92 (7) and 37.22 (8), respectively, giving the molecule …

Principles Of Surface Chemistry Central To The Reactivity Of Organic Semiconductor Materials, Gregory J. Deye

Dissertations

Organic thin-films are rapidly becoming implemented as semiconducting materials in electronic devices and as a result, surface reactivity plays an increasingly important role in the improvement of semiconducting properties. My dissertation addresses how organic thin-films react with gaseous molecules. Previous reports of chemical reactions on organic surfaces claim, “phase rebuilding reaction mechanisms,” whereby reactions only proceed if chemisorbed adsorbate molecules are able to traverse through voids in the molecular lattice. The over-assumptions of this model and lack of correlation to reaction temperature make understanding of organic substrate reactivity incomplete. In contrast, I argue applied heat causes deformation of the molecular …

A Mixed Methods Evaluation Of The Social Emotional Needs Of Middle School Students, Vicky Karahalios

Dissertations

Middle school is a critical transition for all school-aged youth. On a personal level they experience rapid changes across several areas of development. Their environment simultaneously adapts as schools’ expectations seem greater and social pressures arise. During this juncture, they are more vulnerable to academic and psychological difficulties. Research findings demonstrate how positive school climates have the ability to moderate the detrimental effects of middle school students’ self-criticism on internalizing and externalizing behaviors (Kuperminc, Leadbeater, & Blatt, 2001). Historically schools have responded to the social emotional challenges students face at an individual level, however these finding points to the importance …

Abstract Innovation, Virtual Ideas, And Artificial Legal Thought, Andrew C. Michaels

Journal of Business & Technology Law

No abstract provided.

The Financial Banking Institute Act And The Financial Choice Act: The Wrong Choice For The American Economy, Kirby Mcmahon

Journal of Business & Technology Law

No abstract provided.

Design Of Revising Proximity Between Space And Time Cues On Flight Deck Displays To Support Nextgen – The First Phase, Chang-Geun Oh, Jennie J. Gallimore, Pamela S. Tsang

International Journal of Aviation, Aeronautics, and Aerospace

The objective of this study is to develop and evaluate novel display formats to support RTA operations for near to midterm NextGen. Traditional cockpit displays separate space and time information in distant display sources in heterogeneous formats (graphics vs. text). This design composition may cause potential pilot errors when required time of arrival (RTA) obligations are imposed at every waypoint in NextGen. Pilots were randomly assigned to four different display conditions in a simulator – one traditional display with distant space and time cues, and three novel displays with close spatial proximity between the two cues. In the first phase …

Design Of Revising Proximity Between Space And Time Cues On Flight Deck Displays To Support Nextgen – The Second Phase, Chang-Geun Oh, Jennie J. Gallimore, Pamela S. Tsang

International Journal of Aviation, Aeronautics, and Aerospace

The prior first phase of this study investigated the effectiveness of new design of flight deck display for required time of arrival operation of NextGen by collecting objective query response data during autopilot flights and subjective data about the perception between display condition and situation awareness level. To evaluate pilots’ mental workload during the operations when they interacted with novel flight deck display design, this second phase provided pilots with simulation flight tasks arriving at four successive waypoints on time in the same display conditions as the first phase and asked them to rate their mental workload ratings. The workload …

Understanding The Impact On The Wellbeing Of Students With Specific Learning Difficulties Through Teaching Interventions, Dylan K Williams

Plymouth Institute of Education Theses

The study set out to explore whether teaching methods can improve the wellbeing of students with SpLDs. This study addresses a gap in the literature, identifying wellbeing differences between different types of educational environment and SEN provisions. It explores whether there are benefits from inclusive education to student wellbeing, considering constructs of wellbeing relevant to the impact of SpLDs, synthesising pedagogic, psychotherapeutic and developmental perspectives. 74 student participants were recruited through the SEN departments of 4 UK schools - each with differing approaches to SEN support. Student participants completed two psychometric wellbeing questionnaires. They also engaged in photographic exercise, capturing …

Autonomous Biogeochemical Floats Detect Significant Carbon Dioxide Outgassing In The High-Latitude Southern Ocean, Alison R. Gray, Kenneth S. Johnson, Seth M. Bushinsky, Stephen C. Riser, Joellen L. Russell, Lynne D. Talley, Rik Wanninkhof, Nancy L. Williams, Jorge L. Sarmiento

Marine Science Faculty Publications

Although the Southern Ocean is thought to account for a significant portion of the contemporary oceanic uptake of carbon dioxide (CO₂), flux estimates in this region are based on sparse observations that are strongly biased toward summer. Here we present new estimates of Southern Ocean air-sea CO₂ fluxes calculated with measurements from biogeochemical profiling floats deployed by the Southern Ocean Carbon and Climate Observations and Modeling project during 2014–2017. Compared to ship-based CO₂ flux estimates, the float-based fluxes find significantly stronger outgassing in the zone around Antarctica where carbon-rich deep waters upwell to the surface ocean. …

Teachers’ Knowledge, Perceptions And Practices Regarding Academic Literacy Development Of Long-Term English Learners, Daniel William Alamo

LMU Theses and Dissertations

Secondary educators must be knowledgeable in their content while increasing the academic literacy of their students, a process further complicated when working with students who are long-term English learners (LTELs). This mixed-methods study explored the knowledge, practices, and perceptions of six secondary teachers working to develop the academic literacy of LTEL students in content-specific classrooms. Set within a sociocultural framework, the study provides a greater understanding of the challenges and successes educators experience when working at the secondary level with students with diverse learning needs. The data were collected in two phases. Phase I included a quantitative survey of teachers, …

Global Education: Assets And Challenges For Global Competency In Catholic Schools, Beate Winkler Nguyen

LMU Theses and Dissertations

Global education for global competency in Catholic schools of the Archdiocese of Los Angeles is neither defined nor aligned as a priority for its 21st-century learners. Various schools within the Department of Catholic Schools address global competency through world languages, dual-language immersion, activities, or programs, but no specific global education focus permeates the entire district. The relevance of global competency for nearly 80,000 students from Early Childhood (EC) programs/PreK–12th grade (high school) Catholic schools in Los Angeles is not just a curricular necessity or spiritual aspiration, it is, at its core, a question of social justice, particularly for students of …

Transformative Urban Education Leaders In Los Angeles, Sarah Figueroa

LMU Theses and Dissertations

The job of an education system-level leader in urban environments is becoming more demanding, and the environment in which they operate more complex. Filling these very critical roles with individuals who possess the right characteristics could mean the difference between success and failure at improving the educational outcomes of students who are more often than not students of color and economically disadvantaged students.

Through seven interviews, this qualitative study focused on understanding the leadership dispositions that contributed to the success of transformative urban education system-level leaders in Los Angeles. The new transformative urban education leadership framework was developed using elements …

Computational Modelling Of Human Aesthetic Preferences In The Visual Domain: A Brain-Inspired Approach, François Lemarchand

Other Faculty of Science and Engineering Theses

Following the rise of neuroaesthetics as a research domain, computational aesthetics has also known a regain in popularity over the past decade with many works using novel computer vision and machine learning techniques to evaluate the aesthetic value of visual information. This thesis presents a new approach where low-level features inspired from the human visual system are extracted from images to train a machine learning-based system to classify visual information depending on its aesthetics, regardless of the type of visual media. Extensive tests are developed to highlight strengths and weaknesses of such low-level features while establishing good practices in the …

A Continued Musical And Personal Dialogue With The Waves Of Epilepsy., Alan Douglas Miles

Other Faculty of Arts, Humanities and Business Theses

A Continued Musical and Personal Dialogue with the Waves of Epilepsy. In the early hours of the morning several years ago I awoke with paramedics leaning over me. In a state of confusion, my first conscious decision was to enter my music production studio while they attempted to lead me to the ambulance. Music was important to me even in a disorientated post-ictal state (an altered state of consciousness following a seizure). Two weeks later I awoke with paramedics standing over me again. I had started to experience multiple seizures. During the previous weeks, I also experienced numerous incidents of …

Algorithmic Sovereignty, Denis Roio

Other Faculty of Arts, Humanities and Business Theses

This thesis describes a practice based research journey across various projects dealing with the design of algorithms, to highlight the governance implications in design choices made on them. The research provides answers and documents methodologies to address the urgent need for more awareness of decisions made by algorithms about the social and economical context in which we live. Algorithms consitute a foundational basis across different fields of studies: policy making, governance, art and technology. The ability to understand what is inscribed in such algorithms, what are the consequences of their execution and what is the agency left for the living …

Post African Futures: Decoloniality And Actional Methodologies In Art And Cultural Practices In African Cultures Of Technology, Tegan Mary Bristow

Other Faculty of Arts, Humanities and Business Theses

This thesis addresses the presence and role of critical aesthetic practices by cultural practitioners and creative technologists in addressing cultures of technology in contemporary African societies. Nairobi and Johannesburg are used as primary case studies through which a closer understanding of these unique cultures of technology are unpacked. The learning established from the findings of the cases is applied to understanding the concerns of cultures of technology within these and other African contexts. In this, attention is placed on latent neo-colonialism found in the relationship between African cultures and the networked global information economy being led by technology practices. This …

Analyzing Metabolomics Data For Association With Genotypes Using Two-Component Gaussian Mixture Distributions, Jason Westra, Nicholas Hartman, Bethany Lake, Gregory Shearer, Nathan L. Tintle

Faculty Work Comprehensive List

Standard approaches to evaluate the impact of single nucleotide polymorphisms (SNP) on quantitative phenotypes use linear models. However, these normal-based approaches may not optimally model phenotypes which are better represented by Gaussian mixture distributions (e.g., some metabolomics data). We develop a likelihood ratio test on the mixing proportions of two-component Gaussian mixture distributions and consider more restrictive models to increase power in light of a priori biological knowledge. Data were simulated to validate the improved power of the likelihood ratio test and the restricted likelihood ratio test over a linear model and a log transformed linear model. Then, using real …

Analysis Of Embodied And Situated Systems From An Antireductionist Perspective, Federico Da Rold

Other Faculty of Science and Engineering Theses

The analysis of embodied and situated agents form a dynamical system perspective is often limited to a geometrical and qualitative description. However, a quantitative analysis is necessary to achieve a deep understanding of cognitive facts. The field of embodied cognition is multifaceted, and the first part of this thesis is devoted to exploring the diverse meanings proposed in the existing literature. This is a preliminary fundamental step as the creation of synthetic models requires well-founded theoretical and foundational boundaries for operationalising the concept of embodied and situated cognition in a concrete neuro-robotic model. By accepting the dynamical system view the …

Developing An Artificial Colour-Sound Association For Musical Composition, Richard Abbott

Other Faculty of Arts, Humanities and Business Theses

Some great composers - Messiaen, Scriabin, Liszt in exemplum - have been found to have an internal colour world that responds to music and characterises the way they experience and express music. Many of these artists, it could be strongly argued, had the neurological trait synaesthesia. The author, a non-synaesthete, creates a logical correspondence between colour and sound and uses it to explore the tonality of aesthetic colour combinations in nature and modern life. He argues that if the colour-sound practitioner is consistent in their colour-sound association, they can benefit in harmonic discoveries as the synaesthete does. It was found …

Economic Resilience In Great Britain: An Examination Of The Determinants Of The 2008 Crisis Impact On Gb's Local Authority Districts, Anastasios Kitsos

Other Faculty of Arts, Humanities and Business Theses

In 2008, a severe economic crisis hit economies around the world. Its effects included a significant loss of GDP and employment which led to several social ills associated with recessions. However, the crisis did not impact all places with the same severity. This thesis investigates the crisis impact across GB Local Authority Districts during 2008-2014 within a framework that utilises the concept of economic resilience. However, this concept does not have a universally accepted definition or methodology of investigation. Hence, the study adopts an operational definition, comparing the conditions in local labour markets before and after the start of the …