Digital Commons Network^™

Partners@Um, Issue 2, 2018, Centre Of Innovation & Commercialization University Of Malaya

Archival Material (2010s)

No abstract provided.

University Of Malaya Research Bulletin, Volume 18, Number 2, 2018, Institute Of Research Management & Monitoring University Of Malaya

Archival Material (2010s)

Previously known as IPPP UM Research Bulletin

The Clinical Features Of Patients Concurrent With Guillain-Barré Syndrome And Myasthenia Gravis, Junliang Yuan, Juan Zhang, Bingwei Zhang, Wenli Hu

Neurosciences

Objectives: To evaluate all the coincidence cases of Guillain-Barré syndrome (GBS) and myasthenia gravis (MG). Methods: We performed web-based research of the overlapping incidence of GBS and MG in studies occurring from 1982 to 2016 and restricted to the English language. Results: Among 15 cases, an elevated CSF protein level without pleocytosis was found in 10 cases (66.7%); reduced nerve conduction was found in 13 cases (86.6%); a positive repetitive nerve stimulation test occurred in 11 cases (73.3%); anti-AChR antibodies were found in 13 cases (86.6%); anti-GQ1b antibodies were found in 6 cases (40%); a positive edrophonium chloride test was …

The Effect Of Race On Parents' Intent To Vaccinate Their Children Against Human Papillomavirus, Ariana L. Ruiz Aguilar

Honors Undergraduate Theses

Human papillomavirus (HPV) is a sexually transmitted disease that often presents as genital warts, but may also lead to cancers, including those of the vagina, penis, mouth and tonsils. Despite three vaccines being currently available to prevent HPV, the HPV vaccine retains a low national average vaccination rate when compared to the Tetanus-Diptheria- Pertussis (Tdap) vaccine. Considering the need for improvement it is important to identify factors that may be contributing to this low national immunization rate, one of them being parental race. The purpose of this literature review is to identify whether race affects parents' intent to vaccinate their …

Reducing The Rate Of Misdiagnosis Of Postural Orthostatic Tachycardia Syndrome, Isabelle C. Gill

Honors Undergraduate Theses

Postural orthostatic tachycardia syndrome (POTS) is a common yet frequently misdiagnosed dysautonomia characterized by a significant increase in heart rate upon standing. POTS patients experience severe fatigue, dizziness, pre-syncope, and a diminished quality of life. The intent of this thesis is to investigate factors contributing to POTS misdiagnosis and develop a proposal for improving diagnostic procedures. The first part of this thesis presents an overview of other frequently misdiagnosed conditions, providing an understanding of the basis for the diagnostic problems in POTS and methods to combat such difficulties. The second part of this thesis details a meta-analysis performed on POTS …

Prevalence Of Helicobacter Pylori And Health Related Risk Factors At The University Of Central Florida, Evan Holsonback

Honors Undergraduate Theses

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that infects and resides in the gastric mucosa of humans. Without treatment, H. pylori infection may cause chronic inflammation of the gastric mucosa. This inflammation creates progressive damage to the lining of the stomach and can lead to multiple diseases located in the upper gastrointestinal region. Worldwide prevalence of H. pylori infection is estimated to be close to 50%. H. pylori has been identified as the primary cause of peptic ulcer disease, gastric cancer, and mucosa-associated lymphoid tissue lymphoma.

The purpose of this study was to identify the prevalence and risk factors …

Investigation Of Aminoglycoside Induced Nanoparticle Self-Assemblies, Michael Leong

Honors Undergraduate Theses

Aminoglycosides are a group of broad-spectrum antibiotics that, under neutral pH conditions, carry a positive charge. The net cationic charge arises from the high number of amino groups in the core structure of aminoglycosides. Previous studies performed have shown that negatively charged citrate ligand-capped gold nanoparticles (AuNPs) can interact with various biomolecules such as aminoglycosides. AuNPs bound to biomolecules have been used in conjugation with various assaying techniques to detect and study compounds in vitro and in vivo. AuNPs also have strong light scattering properties that can be used with a wide variety of imaging and assaying techniques. Our laboratory …

The Effects Of Sepsis Management Protocols On Time To Antibiotic Administration In The Emergency Department, Margaret K. Lorch

Honors Undergraduate Theses

Sepsis is one of the leading causes of death in U.S. hospitals, resulting from organ dysfunction caused by an inappropriate inflammatory reaction to an infection. Timely treatment with empiric antibiotics in the emergency department is crucial to facilitate positive patient outcomes. The Surviving Sepsis Campaign (SSC) recommends initiating empiric antibiotic therapy within one hour of presentation to the emergency department. Some emergency departments have implemented sepsis management protocols to guide care and ensure timely treatment. The purpose of this study is to determine the effect of a formal sepsis protocol in the emergency department on the time to antibiotic administration. …

Researching The History Of Hiv/Aids: An Interview With Christopher Ewing, Emily Furlich

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

No abstract provided.

Investigation Into The Role Of Manganese In The Growth Of The Opportunistic Pathogen Streptococcus Sanguinis, Brittany Spivey

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

While Streptococcus sanguinis plays a beneficial role in the oral cavity as a competitor of Streptococcus mutans and Streptococcus sobrinus, the bacteria that produce dental caries, it can cause deadly infective endocarditis if given the opportunity to colonize the vegetations that form over damaged endocardial tissue. Pre-existing heart conditions, surgery, and intravenous drug use predispose individuals to endocarditis. S. sanguinis growth and consequential virulence is significantly impeded by restriction to manganese. This is due to the resulting overwhelming oxidative stress and formation of reactive oxygen species which damage DNA and other cellular components. Manganese is essential for S. sanguinis proteins …

Experimental Infection Of Tadarida Brasiliensis With Pseudogymnoascus Destructans, The Fungus That Causes White-Nose Syndrome, Michelle L. Verant, Carol U. Meteyer, Benjamin Stading

KIP Articles

White-nose syndrome (WNS) is causing significant declines in populations of North American hibernating bats, and recent western and southern expansions of the disease have placed additional species at risk. Understanding differences in species susceptibility and identifying management actions to reduce mortality of bats from WNS are top research priorities. However, the use of wild-caught susceptible bats, such as Myotis lucifugus, as model species for WNS research is problematic and places additional pressure on remnant populations. We investigated the feasibility of using Tadarida brasiliensis, a highly abundant species of bat that tolerates captivity, as the basis for an experimental animal model …

Prenatal Lactation-Focused Motivational Interviewing For Enhancing Breastfeeding Initiation, Exclusivity, And Duration: Feasibility And Preliminary Outcomes, Sarah H. Addicks

Graduate Theses, Dissertations, and Problem Reports (ETD)

Breastfeeding promotes health and well-being for both mother and infant. A variety of environmental and individual factors, including psychological ones, affect infant feeding practices. The purpose of this study was to determine the feasibility and effectiveness of a single-session Motivational Interviewing (MI) intervention delivered during the third trimester of pregnancy for enhancing breastfeeding outcomes. The Theory of Planned Behavior provided a theoretical framework for the intervention and outcome measures. The sample consisted of predominantly rural participants living in the North Central Appalachian region. Women were recruited through social media, local clinics, and word of mouth. Participants (N = 81) completed …

Cluster-Based Network Proximities For Arbitrary Nodal Subsets, Kenneth S. Berenhaut, Peter S. Barr, Alyssa M. Kogel, Ryan L. Melvin

Faculty & Staff Scholarship

The concept of a cluster or community in a network context has been of considerable interest in a variety of settings in recent years. In this paper, employing random walks and geodesic distance, we introduce a unified measure of cluster-based proximity between nodes, relative to a given subset of interest. The inherent simplicity and informativeness of the approach could make it of value to researchers in a variety of scientific fields. Applicability is demonstrated via application to clustering for a number of existent data sets (including multipartite networks). We view community detection (i.e. when the full set of network nodes …

Eastern Oyster Larval Transcriptomes In Response To Probiotic And Pathogenic Bacteria, Tejashree Modak

Open Access Dissertations

Oysters are described as keystone species serving an important ecological role. As filter-feeders they help in maintaining water quality. Oyster reefs provide refuge and support to different organisms. The eastern oyster, Crassostrea virginica, native to the East Coast of United States and Gulf of Mexico is a part of the rapidly growing aquaculture industry. Aquaculture production depends on a healthy and constant supply of oyster larvae that are provided by hatcheries. Several hatcheries on the east coast that provide C. virginica seed to oyster farms face significant losses owing to Vibrio infections causing massive larval mortalities. Use of antibiotics …

Dispositional Optimism And Autonomic Reactivity During Difficult And Easy Stress Tasks, Daniel Stephenson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Studies examining the association between dispositional optimism and autonomic reactivity to stress have yielded mixed results, with some studies finding associations between optimism and less reactivity, some studies finding no association between optimism and reactivity, and some finding that optimism was associated with greater reactivity. One factor not considered previously in this literature is difficulty of the stressful task employed to elicit autonomic reactivity. The current study was based on Carver and Scheier's Behavioral Self-Regulation Model (Carver & Scheier, 2000), that states that optimists are more likely to persist in overcoming challenging obstacles than pessimists. The current study investigated whether …

Benchmark Assessment Of Orphaned And Vulnerable Children In Areas Of The Zambia Family (Zamfam) Project—Brief, Michael Mbizvo, Paul C. Hewett

HIV and AIDS

The US Agency for International Development and US President’s Emergency Plan for AIDS Relief (PEPFAR) are supporting the Zambia Family (ZAMFAM) project to strengthen comprehensive, integrated service delivery and support to children living with, affected by, or vulnerable to HIV/AIDS (OVC) in the Lusaka, Copperbelt, Southern, and Central Provinces of Zambia. To inform that effort, Project SOAR conducted a benchmark survey among beneficiaries in the four provinces of the ZAMFAM program. The benchmark survey measured the status and conditions of OVC and their families. This brief provides a summary of the findings outlined in the final report on the needs …

Benchmark Assessment Of Orphaned And Vulnerable Children In Areas Of The Zambia Family (Zamfam) Project, Michael Mbizvo, Paul C. Hewett, Nkomba Kayeyi, Lyson Phiri, Saziso N. Mulenga, Bwalya Mushiki, Mwelwa Chibuye

HIV and AIDS

The US Agency for International Development and US President’s Emergency Plan for AIDS Relief (PEPFAR) are supporting the Zambia Family (ZAMFAM) project to strengthen comprehensive, integrated service delivery and support to children living with, affected by, or vulnerable to HIV/AIDS (OVC) in the Lusaka, Copperbelt, Southern, and Central Provinces of Zambia. To inform that effort, Project SOAR conducted a benchmark survey among beneficiaries in the four provinces of the ZAMFAM program. The benchmark survey measured the status and conditions of OVC and their families. The findings provide a deeper understanding of the needs of OVC families and the gaps in …

The Ada And The Fight Against Employment Discrimination, 52 Uic J. Marshall L. Rev. 51 (2018), Brianne Perkins

UIC Law Review

No abstract provided.

A Statutory Patent Reversion Period May End The Debate On Employee Inventions, 51 J. Marshall L. Rev. 675 (2018), Yucheng Wang

UIC Law Review

No abstract provided.

Modification Of 4,5- Aminoglycosides To Overcome Drug Resistance Bacteria And Toxic Side Effect, Guanyu Yang

Wayne State University Dissertations

ABSTRACT

MODIFICATION OF 4,5- AMINOGLYCOSIDES TO OVERCOME DRUG RESISTANCE BACTERIA AND TOXIC SIDE EFFECT

by

Guanyu Yang

September 2018

Advisor: Professor David Crich

Major: Chemistry

Degree: Doctor of Philosophy

Infectious diseases causing by antibiotic resistant pathogen are one of the major threat to human health and society today. Many researchers tried to develop next generation of antibiotics by reinvesting the existing antibacterial drugs. Aminoglycosides have long been used as highly potent and broad-spectrum antibiotics for treating bacterial infections. But their side effect, especially the irreversible ototoxicity, and the fast-growing resistant problem limit their application. The goal of this research was …

Comparison Of Standard Agglutination Tests, Enzyme Immunoassay, And Coombs Gel Test Used In Laboratory Diagnosis Of Human Brucellosis, Emi̇ne Emel Koçman, Memnune Selda Erensoy, Meltem Taşbakan, Meltem Çi̇çekli̇oğlu

Turkish Journal of Medical Sciences

Background/aim: It was aimed to evaluate the results of Rose Bengal (RB), ELISA total tests (IgM and IgG), and the Brucella Coombs gel test (BCGT), which are used as screening tests, with the combined results of a tube agglutination test (standard Wright test: SWT) and a tube agglutination test with antihuman globulin (AHG TAT). Materials and methods: Samples from 97 patients prediagnosed with brucellosis (age ≥18 years) were screened with RB, ELISA, and BCGT. SWT < 160 samples and RB-negative but ELISA- or BCGT-positive samples were tested by AHG TAT. SWT ≥ 160 or AHG TAT ≥ 160 was taken as reference. Results: Thirty-two of 56 RB-positive samples and one RB-negative but ELISA- and BCGT-positive sample were found to be ≥160 with SWT or AHG TAT. Sensitivity, specificity, accuracy, and agreement (kappa) values according to SWT ≥ 160 or AHG TAT ≥ 160 positivity were as follows, respectively: RB 96.9%, 62.5%, 74.2%, and 0.509; ELISA total 100%, 60.9%, 74.2%, and 0.515; BCGT test 97%, 70.3%, 79.4%, and 0.594. Conclusion: Sensitivities of the screening tests are similar, but positivities should be confirmed by more specific tests. Positive samples from screening tests should be tested with AHG if the SWT value is

Biosynthetic Mechanism Of The Antibiotic Capuramycin, Erfu Yan

Theses and Dissertations--Pharmacy

A-102395 is a member of the capuramycin family of antibiotics which was isolated from the culture broth of Amycolatopsis sp. SANK 60206. A-102339 is structurally classified as a nucleoside antibiotic, which like all members of the capuramycin family, inhibits bacterial MraY (translocase I) with IC₅₀ of 11 nM which is the lowest among the capuramycin family. A semisynthetic derivative of capuramycin is currently in clinical trials as an antituberculosis antibiotic, suggesting high potential for using A-102395 as a starting point for new antibiotic discovery. In contrast to other capuramycins, A-102395 has a unique arylamine-containing polyamide side chain. The biosynthetic …

A Closer Examination Of The Patient Experience In The Ambulatory Space: A Retrospective Qualitative Comparison Of Specialty Care To Primary Care Experiences, Zahi R. Jurdi

MUSC Theses and Dissertations

With the advent of consumerism in one of the most complex and fragmented industries in the United States, the healthcare space now has a collective interest to further understand its consumers and help to shape their experiences. In this qualitative research study, we explore the key patient experience impressions responsible for driving quality. Differences between primary care patient perspectives and specialty care patient perspectives were analyzed using a mixed methods design in high, median and low quality performing practices. We found that primary care patients highly value (a) provider listening, (b) time spent with provider, and (c) consistent and effective …

The Body Disordered: Diagnosing The Philippine Nation In José Rizal’S Noli Me Tángere (1887), Azariah Alfante

Decimonónica

José Rizal (1861-1896) was a Philippine nationalist, writer, and physician, whose status as national hero is manifest in the mandatory study of his works in educational institutions across the Philippine archipelago since the enactment of the nationalist Rizal Law (Republic Act No. 1425) on 12 June 1956 (Francia, “José Rizal” 44-45). Joan Torres Pou describes Rizal as a “médico oftalmólogo, licenciado en Filosofía y Letras, políglota, filólogo, antropólogo, escritor, agricultor, liberal, asimilacionista, independentista y masón” (7). In his profile of the Filipino polymath, however, Torres Pou omits a salient dimension of Rizal’s identity: his Catholic religion. Although during his life …

Persistence Of Long-Lived Memory B Cells Specific To Duffy Binding Protein In Individuals Exposed To Plasmodium Vivax, Siriruk Changrob, Amy M. Mchenry, Myat Htut Nyunt, Jetsumon Sattabongkot, Eun-Taek Han, John H. Adams, Patchanee Chootong

Epidemiology and Biostatistics Faculty Publications

The major challenge in designing a protective Duffy binding protein region II (DBPII)-based vaccine against blood-stage vivax malaria is the high number of polymorphisms in critical residues targeted by binding-inhibitory antibodies. Here, longevity of antibody and memory B cell response (MBCs) to DBL-TH variants, DBL-TH2, -TH4, -TH5, -TH6 and -TH9 were analyzed in P. vivax-exposed individuals living in a low malaria transmission area of southern Thailand. Antibody to DBL-TH variants were significantly detected during P. vivax infection and it was persisted for up to 9 months post-infection. However, DBL-TH-specific MBC responses were stably maintained longer than antibody response, at …

Medicine@Yale February/March 2018 Volume 14, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Project Help: A Study Protocol To Pilot Test A Shared Decision-Making Tool About Treatment Options For Patients With Hepatitis C And Chronic Kidney Disease, M C. Politi, N George, T Li, K M. Korenblat, K J. Fowler, C Ho, A Liapakis, D Roth, Jerry Yee

Nephrology Articles

Background: Recent advances in treatment have given patients with chronic kidney disease (CKD) access to safer and more effective medications to treat comorbid hepatitis C virus (HCV) infection. Given the variety and complexity of treatment options that depend on patients' clinical characteristics and personal preferences, education and decision support are needed to prepare patients better to discuss treatment options with their clinicians.

Methods: Drawing on International Patient Decision Aids Standards guidelines, literature reviews, and guidance from a diverse expert advisory group of nephrologists, hepatologists, and patients, we will develop and test a HCV and CKD decision support tool. Named

Discussion: …

Hidden Hunger: Solutions For America’S Aging Populations, Manfred Eggersdorfer, Ucheoma Akobundu, Regan L. Bailey, Julie Shlisky, Amy R. Beaudreault, Gilles Bergeron, Robert B. Blancato, Jeffrey B. Blumberg, Megan W. Bourassa, Filomena Gomes, Gordon Jensen, Mary Ann Johnson, Douglas Mackay, Keri Marshall, Simin Nikbin Meydani, Katherine L. Tucker

Department of Nutrition and Health Sciences: Faculty Publications

The global population, including the United States, is experiencing a demographic shift with the proportion of older adults (aged ≥ 65 years) growing faster than any other age group. This demographic group is at higher risk for developing nutrition-related chronic conditions such as heart disease and diabetes as well as infections such as influenza and pneumonia. As a result, an emphasis on nutrition is instrumental for disease risk reduction. Unfortunately, inadequate nutrient status or deficiency, often termed hidden hunger, disproportionately affects older adults because of systematic healthcare, environmental, and biological challenges. This report summarizes the unique nutrition challenges facing the …

Single Cell Analysis Of The Hiv-1 Latent Reservoir, Lillian Brumer Cohn

Student Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immune deficiency syndrome (AIDS), is one of the world's most serious health and development challenges. Worldwide there are approximately 36.7 million people living with HIV, and tens of millions have died of AIDS-related causes since the beginning of the epidemic. Treatment of HIV-1 infection with combinations of antiretroviral drugs has significantly reduced the death rate and improved the quality of life of HIV-1 infected individuals. Despite over thirty years of HIV-1 research, however, both a cure and a vaccine remain elusive. Complete eradication of HIV-1 by antiretroviral drugs is …

Surface Coat Replacement Dynamics And Antigen Glycosylation In T. Brucei Influence Evasion Of The Host Antibody Response, Jason M. Pinger

Student Theses and Dissertations

The protozoan parasite Trypanosoma brucei, a causative agent of human and animal trypanosomiasis, evades host immunity through antigenic variation of its variant surface glycoprotein (VSG) coat. During infection, the VSG coat elicits a robust antibody response, but the parasite escapes antibody-mediated clearance by repeatedly accessing its large genomic VSG repertoire and switching expression to antigenically distinct VSGs. Much of our knowledge of the process of VSG switching and the extent of VSG diversity has come from genetic analyses, but deep understanding of the T. brucei host-pathogen interface also requires examination of these topics at the protein level. In this thesis, …