Digital Commons Network^™

Nursing Compliance With Vap Bundle, Taylor Meadows

Scholars Week

It has been proposed that by initiating the highest percentages of nursing compliance, overall patient outcomes will improve along with a decrease in the number of ventilator-associated events (VAEs). The aim of the study is to appraise the association between nursing compliance with a ventilator bundle and a successful decline in the number of events of ventilator-associated pneumonia (VAP) in the intensive care unit (ICU). The study also provides evidence-based direction on the best nursing practices essential to reducing the rates of VAP. Objectives include expanding the awareness of critical care staff on prevention and compliance and to improve teamwork …

Cyberbiosecurity: An Emerging New Discipline To Help Safeguard The Bioeconomy, Randall S. Murch, William K. So, Wallace G. Buchholz, Sanjay Raman, Jean Peccoud

Department of Chemical and Biomolecular Engineering: Faculty Publications

Cyberbiosecurity is being proposed as a formal new enterprise which encompasses cybersecurity, cyber-physical security and biosecurity as applied to biological and biomedical-based systems. In recent years, an array of important meetings and public discussions, commentaries and publications have occurred that highlight numerous vulnerabilities. While necessary first steps, they do not provide a systematized structure for effectively promoting communication, education and training, elucidation and prioritization for analysis, research, development, test and evaluation and implementation of scientific, technological, standards of practice, policy, or even regulatory or legal considerations for protecting the bioeconomy. Further, experts in biosecurity and cybersecurity are generally not aware …

Debunking The Myth About Gut Worms By Unlocking The Secrets Of Gut Microbiota/ Yvonne Lim Ai Lian, Ai Lian Yvonne Lim

Archival Material (2010s)

No abstract provided.

Ohio Pride Society Rallies Bobcats For Aids Walk Ohio (April 5, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Comparison Of Microbiological Examination By Test Tube And Congo Red Agar Methods To Detect Biofilm Production On Clinical Isolates, Dewi Klarita Furtuna, Kartuti Debora, Eddy Bagus Warsito

Folia Medica Indonesiana

Biofilm on medical devices can cause significant diseases and deaths and give a large effecton disease transmission among patients and health providers and potentially increasethe cost of patient treatment. By knowing the presence of biofilm on a patient, one can differentiate the treatment management for that particular patient from the patients without biofilm on their medical device. The purpose of this study was to obtain diagnostic method to detect biofilm formation on isolates from the medical devices by simple method that is easy to do and can be applied in resource-limited microbiology laboratory. 36 specimens obtained from IV Line, CVC, …

Vaccines: History And Science, Khyllian Lowry

Honors Projects

This document aims to provide some information about vaccination including their history and the basic science behind their design.

Insights Into Early Stage Of Antibiotic Development In Small And Medium-Sized Enterprises: A Survey Of Targets, Costs, And Durations, Christine Årdal, Enrico Baraldi, Ursula Theuretzbacher, Kevin Outterson, Jens Plahte, Francesco Ciabuschi, John-Arne Røttingen

Faculty Scholarship

Antibiotic innovation has dwindled to dangerously low levels in the past 30 years. Since resistance continues to evolve, this innovation deficit can have perilous consequences on patients. A number of new incentives have been suggested to stimulate greater antibacterial drug innovation. To design effective solutions, a greater understanding is needed of actual antibiotic discovery and development costs and timelines. Small and medium-sized enterprises (SMEs) undertake most discovery and early phase development for antibiotics and other drugs. This paper attempts to gather a better understanding of SMEs’ targets, costs, and durations related to discovery and early phase development of antibacterial therapies.

Syringomyelia In An Adult American Paint Horse, Jacqueline P. Kurz, Kate E. Schoenhals, Gordon A. Hullinger, Arnaud J. Van Wettere

Animal, Dairy, and Veterinary Science Faculty Publications

Syringomyelia is a form of myelodysplasia defined by the formation of one or more fluid-filled cavities within the spinal cord that do not communicate with the central canal. The defect may be congenital or acquired. Clinical signs correlate to the segment of spinal cord affected and include pain, paresis, proprioceptive deficits, alterations in sensation, scoliosis, and autonomic dysfunction. This report describes the clinical and pathologic changes in a case of acquired syringomyelia in a 10-year-old American Paint Horse mare. The horse had a six-week history of progressive proprioceptive deficits in all four limbs, bilateral pelvic limb ataxia, and muscle fasciculations …

Nutrition Misconceptions And Awareness Among College Students In A University Community, Shervia Singleton Taylor

LSU Doctoral Dissertations

Identification of misconceptions of macronutrients (carbohydrate, protein, and fat ) and awareness of ailments linked to micronutrients (potassium, fiber, Vitamin D. and food label use) based on certain demographics are vital to improving and developing long term health benefits, increasing consumption of fruits and vegetables, and decreasing healthcare cost associated with poor dietary lifestyles among non-major general biology college students at a historically black college and university located in the southern part of the United States. Misconception Identification (all groups) was determined using the pretest and posttest Nutrition Knowledge Test via Qualtrics that included two and three tiered question format …

Characterization Of The Interaction Between R. Conorii And Human Host Vitronectin In Rickettsial Pathogenesis, Abigail Inez Fish

LSU Doctoral Dissertations

Spotted Fever Group Rickettsia are inoculated into the mammalian host during hematophagous arthropod feeding. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon their ability to evade innate host defenses until a proper cellular target is reached. The establishment of a successful infection also relies on the ability of the bacteria to attach and invade target cells, as failure to do so results in destruction of the bacterium. Rickettsia conorii expresses an outer membrane protein, Adr1, which binds the multifunctional human glycoprotein, vitronectin, to promote resistance to complement mediated killing. Homologs of Adr1 are …

Analysis Of Downstream Signaling Of Tlrs After U0126 Inhibition, Brandy Frazier

Student Scholar Showcase

Francisella tularensis (F. tularensis) is a pathogenic bacterium which causes the disease tularemia. F. tularensis is thought to be able to enter and multiply inside of liver cells because it interacts with toll-like receptors (TLRs). Examining the signaling pathway downstream of the TLRs will allow for better understanding of how this disease works and possible treatment strategies. In this study I propose to examine how molecular inhibitors affect signaling downstream of TLRs in HepG2 cells treated with lipopolysaccharides (LPS) from E. coli. Mitogen-activated protein kinase is a cellular molecule in signaling cascades that directs cellular response mechanisms. MAPK can be …

Chris Juday V. Merck & Co Inc

2018 Decisions

USDC for the Eastern District of Pennsylvania

A Multivariate Approach For An Improved Assessment Of Pre-Erythrocytic Stage Therapies Targeting Plasmodium Vivax And Plasmodium Falciparum, Alison E. Roth

USF Tampa Graduate Theses and Dissertations

The malaria pre-erythrocytic stages have been identified as an ideal therapeutic target, but complex in vitro models for Plasmodium vivax and Plasmodium falciparum lack the efficiency needed for rapid screening and evaluation of new vaccines and drugs, especially targeting the P. vivax hypnozoite. To address this challenge, we employed a multi-parameter approach using “omics’” to identify pre-erythrocytic targets and biomarkers, guide phenotypic therapeutic screening, and study parasite functionality with innovative bioassays using highcontent screening. Herein, we discuss three novel bioassays formatted in 384-well plate systems with utilization of commercially-available materials and application of high-content imaging for rapid bio-image analysis. To …

Determination Of An Aspergillus Fumigatus-Specific Immunoglobulin G Reference Range In An Adult Omani Population, Munira Al-Rahman, Mahmood Al Kindi, Ibrahim Al-Kalbani, Ibrahim, Jalila Alshekaili

Sultan Qaboos University Medical Journal

Objectives: The presence of abnormally high levels of Aspergillus fumigatus-specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic pulmonary aspergillosis. This study aimed to determine a reference range of A. fumigatus-specific IgG levels within a healthy adult Omani population. Methods: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. The sera of 125 healthy Omani blood donors were tested for A. fumigatus-specific IgG levels using an automated fluorescence enzyme immunoassay. Results: Initially, the data were not normally distributed; however, log transformation and the exclusion …

Evaluation Of A Clinical Pharmacist Intervention On Clinical And Drug-Related Problems Among Coronary Heart Disease Inpatients: A Pre-Experimental Prospective Study At A General Hospital In Indonesia, Vina A. Sagita, Anton Bahtiar, Retnosari

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate the role of a clinical pharmacist intervention in decreasing subsequent clinical and drug-related problems (DRPs) among coronary heart disease (CHD) inpatients with at least one previous DRP. Methods: This pre-experimental study with a pre-post design was carried out from January to April 2017 among inpatients with at least one previous DRP at a general hospital in Tangerang District, Banten, Indonesia. Clinical and DRPs were documented prospectively by a clinical pharmacist, with DRPs classified using Version 6.2 of the DRP classification scheme of the Pharmaceutical Care Network Europe Foundation. The intervention consisted of a discussion …

The Potential Impact Of Using Vaccination And Insect Repellent To Control The Spread Of Yellow Fever, Erin N. Bodine, Erin Deery, Casey E. Middleton

Spora: A Journal of Biomathematics

Yellow fever is a viral hemorrhagic fever transmitted by the Aedes aegypti mosquito. It has historically caused thousands of deaths throughout Africa, the Americas, Europe, and the Caribbean and continues to pose threats in Africa and Central and South America. The disease is most detrimental in densely populated areas with warmer climates where individuals have limited access to health care facilities. These conditions are exemplified by the yellow fever epidemic of 1878 in Memphis, Tennessee. The limited medical knowledge, warm climate, and densely populated urban areas greatly contributed to the magnitude of the epidemic that killed thousands. We developed an …

Global Health Navigators: A New Component In A Refugee-Centered Medical Home Model Of Care, Ruth M. Carrico

Journal of Refugee & Global Health

In this video, Dr. Ruth Carrico, Director of the Global Health Center Travel Clinic and Refugee Health Programs:

• Describes the University of Louisville refugee-centered medical home care model
• Introduces a novel element, the Global Health Navigator, and their roles and responsibilities in the care of the refugee population
• Reviews the competencies and training components important for this new role
• Uses case scenarios to demonstrate the value of Global Health Navigators in refugee care

A Rare Co-Infection Of Ehrlichiosis And Rocky Mountain Spotted Fever In South Florida, Fiu Herbert Wertheim College Of Medicine Affiliates, Seema Chandra, Nicole Ross

All Publications

Abstract Category: Research

Purpose: Tick-borne rickettsial diseases (TBRD) are a group of geographically distinct infectious diseases that share a common molecular structure and clinical presentation. TBRDs include Rocky Mountain spotted fever, human monocytic ehrlichiosis, and human granulocytic anaplasmosis. These rickettsial diseases are caused by a group of gram-negative obligate intracellular coccobacilli that present with acute-onset fever, headache, generalized muscle pain, and a characteristic rash. As these symptoms mimic viral illness, they are often misdiagnosed early on in the disease course, delaying the onset of proper antimicrobial treatment. A high index of suspicion is necessary for clinical diagnosis; thus, it is …

The Mosquito Can Be More Dangerous Than The Mortar Round, Arthur M. Smith, Craig Hooper

Naval War College Review

These words, penned in 1943 by the commander in chief of British forces in Burma during World War II, underline the reality that losses to malaria and other preventable diseases among Allied forces operating in the China-Burma- India theater far exceeded the number of casualties inflicted by enemy action.1 Today, as the global war on terrorism evolves, a similar failure to appreciate noncombat environmental threats—including mosquitoes and other disease- carrying insect vectors—will once again degrade combat effectiveness of deployed forces.

Prevention Of Central Line-Associated Bloodstream Infection (Clabsi) In Adult Oncology Patients, Christina Winkelman

Doctoral Projects

Central Line-Associated Bloodstream Infection (CLABSI) is a preventable issue in healthcare. CLABSI contributes to negative patient outcomes and increased healthcare cost. Research demonstrates that many interventions are effective in reducing the rate of CLABSI. The implementation of CLABSI bundles can significantly reduce the occurrence of CLABSI. This quality improvement project implemented a CLABSI bundle that specifically targeted identified areas of weakness in CLABSI prevention at an organization with a focus on adult oncology care. The three part CLABSI prevention bundle focused on: (a) registered nurses (RN) changing and documenting endcaps in the electronic health record after blood administration, (b) RNs …

Involuntary Sterilization Among Hiv-Positive Garifuna Women From Honduras Seeking Asylum In The United States: Two Case Reports, Holly G. Atkinson, Deborah Ottenheimer

Publications and Research

Voluntary sterilization is one of the most widely used forms of contraception by women worldwide; however, involuntary sterilization is considered a violation of multiple human rights and grounds for asylum in the United States. Women have been disproportionately affected by this practice. We report two cases of involuntary sterilization in HIV-positive Garifuna women from Honduras who sought asylum in America and were medically evaluated at the request of their attorneys. Key lessons can be drawn from these cases with regard to the importance of medical evaluations in establishing persecution. These include the need for a detailed account of the events …

Synthesis Of Novel Agents For The Treatment Of Infectious And Neurodegenerative Diseases, Benjamin Joe Eduful

USF Tampa Graduate Theses and Dissertations

Infectious and neurodegenerative diseases continue to be a major concern worldwide. In spite of the great advances in drug therapy for treating various infectious and neurodegenerative diseases, there is still an urgent need for new and improved drugs due to increasing drug resistance among pathogens, emergence of new pathogens, ease of transmission of infections, ineffective available treatments, toxicity associated with current standard of care, aging populations and the lack of better alternative treatment options.

The first part of this manuscript (chapters 1 - 5) describes the synthesis of novel agents active against Leishmania donovani. According to the World Health Organization …

President's Annual Report 2018, University Of Alabama In Huntsville

Annual Reports

No abstract provided.

Medicine + Health Magazine, Spring 2018, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

Marshall Magazine Spring 2018, Marshall University

Marshall Magazine

No abstract provided.

The Impact Of Syrian Refugees On Jordan: A Framework For Analysis, Wa’Ed Alshoubaki, Michael Harris

Public Administration Faculty Research

The civil war in Syria has caused a mass influx of Syrian refugees into other countries throughout the region and beyond. Jordan has received a large share of Syrian refugees, currently totaling to the alarming number of 1.2 mln people. Addressing the need of Syrian refugees has drained the resources of Jordanian government and has had its substantial impact on Jordanian society overall. In an effort to better understand the humanitarian, political, economic, sociocultural and environmental challenges to Jordan and its government, this study has developed a comprehensive analytical framework. The comprehensive analytical framework has been developed based on the …

Vaccine Epidemiology And Decision-Making: A Bryant Student Focus, Hannah Coburn

Honors Projects in Science and Technology

The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1). Annual influenza vaccination remains to be the most effective way in controlling the spread and symptom severity of influenza infections (1). Influenza infections are especially virulent on college campuses as a dense population of students interact in close quarters such as shared housing, bathrooms, dining halls, classrooms, and social activities (2). Despite influenza vaccinations being safe, effective, easily accessible to Bryant University students, and free of cost, many students choose not …

Profile: A Model For Living And Learning: The Campaign For The University Of Minnesota, Morris, Communications And Marketing

Profile (1996-)

In this issue: A new chapter begins: the inauguration of Chancellor Michelle Behr; Model citizens: find out how donors are making Morris a stronger model than ever before; Giving news; Coming home: Homecoming celebrations remembered in photos; Campus news briefs; Spotlight: special edition: Get to know the men and women behind our biggest fundraising effort to date; A model for living and learning: See what the campaign for Morris is all about (and what you can do to help); The big picture; Alumni news; Class notes; Cougar Sports news

Career Corner: Quidel Rep On Campus To Talk About Open Science Positions, April 6, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Interactions Between Aerobic Exercise Volume, Academic Stress, And Immune Function, Teresa Wiczynski

Masters Theses & Specialist Projects

Many college students exercise individually or participate in collegiate and intramural sports in addition to fulfilling their stressful academic requirements. The combination of accumulated stress and vigorous exercise could result in an impaired immune system, prompting the onset of disease and absences in class and sports practice.

Twenty-six male and female participants aged 18 to 23 were recruited for this study. Over the course of an academic semester, participants completed weekly electronic surveys documenting stress levels, aerobic exercise, and symptoms related to upper respiratory tract infections. Participants were evaluated at four different time points (Baseline, Post-Midterm Exam, Baseline Reassessment, and …