Digital Commons Network^™

Testing Methods To Mitigate Caribbean Yellow-Band Disease On Orbicella Faveolata, Carly J. Randall, Elizabeth M. Whitcher, Tessa Code, Clayton Pollock, Ian Lundgren, Zandy Hillis-Starr, Erinn M. Muller

United States National Park Service: Publications

Outbreaks of coral diseases continue to reduce global coral populations. In the Caribbean, yellow band is a severe and wide-spread disease that commonly affects corals of the Orbicella spp. complex, significantly impeding coral reproduction, and hindering the natural recovery of Orbicella spp. populations. Caribbean yellow-band disease (CYBD) lesions may be severe, and often result in the complete loss of coral tissue. The slow spread of CYBD, however, provides an opportunity to test methods to mitigate the disease. Here we report the results of in situ experiments, conducted within Buck Island Reef National Monument in St. Croix, USVI, to test the …

Successful Patient Participation In Acute Hospital Physical Therapy, Jesse Kim, Joseph Fertitta, Patrick Williams

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Research has demonstrated that physical therapy plays a crucial role in patient recovery in the acute hospital setting. Despite known benefits, scheduled sessions do not always occur and are called nontreatment (NT) events. Reported NT ranges from 15% to 26% of scheduled sessions. Previous studies have found an association between NT and patient diagnosis as well as between NT and day of the week on which treatment was scheduled. Identifying additional factors that affect NT is important if therapists and administrators are to make improvements. The purpose of this study is to determine if an association exists between physical …

A Passion For Public Health, Jody Record

UNH Today Archive

No abstract provided.

Physical And Social Systems Resilience Assessment And Optimization, Daniel Romero Rodriguez

USF Tampa Graduate Theses and Dissertations

Resilience has been measured using qualitative and quantitative metrics in engineering,economics, psychology, business, ecology, among others. This dissertation proposes a resilience metric that explicitly incorporates the intensity of the disruptive event to provide a more accurate estimation of system resilience. A comparative analysis between the proposed metric and average performance resilience metrics for linear and nonlinear loss and recovery functions suggests that the new metric enables a more objective assessment of resilience for disruptions with different intensities. Moreover, the proposed metric is independent of a control time parameter. This provides a more consistent resilience estimation for a given system and …

Cardiovascular Risk Among Patients With Drug-Resistant Tuberculosis And Hiv In South Africa, Erin Rachel Whitehouse

Dissertations

South Africa has the highest incidence of drug resistant-tuberculosis (DR-TB) in sub-Saharan Africa and outcomes are poor. Only 54% of patients successfully complete treatment. The prevalence of HIV co-infection and cardiovascular (CVD) risk factors is also increasing. The purpose of this study was to describe cardiovascular risk in DR-TB patients with and without HIV co-infection and the impact of this risk on 6-month DR-TB negative treatment outcomes among patients co-infected with HIV.

America's State Of Readiness Against Bioterrorism, Cameron Funk

Pepperdine Policy Review

No abstract provided.

Comprehensive User Engagement Sites (Cues): Is This A Viable Option For The Opioid Epidemic In Philadelphia?, Siddardth Umapathy, Samuel Schadt, John Dubensky, Matthew Dimeglio, Sonul Gulati, Kevin Cooney, Olivia Nguyen, Priscilla Rodriguez, Marvin Lee, Peter Clark

Research Day

INTRODUCTION: Opioid drug abuse has become an increasing concern throughout the United States, especially within the Philadelphia region. In 2017, the number of deaths by drug overdose were four times that of deaths by homicide. In addition, a total of 935 cases of secondary conditions due to needle sharing such as HIV and HCV occurred during the past year. The opioid epidemic has caused a public health emergency and any measures that could decrease the morbidity and mortality associated with opioid abuse are vital. A current proposal to combat this issue in Philadelphia is the implementation of a Comprehensive User …

Revealing Biotic Diversity: How Do Complex Environments Influence Human Schistosomiasis In A Hyperendemic Area, Martina Rose Laidemitt

Biology ETDs

Human schistosomiasis is one of the great neglected tropical diseases (NTDs) of our time with more than 206 million individuals infected and more than 90% of those infected reside in Sub-Saharan Africa (WHO 2017). Chemotherapy based control programs play an essential role in contributing to the elimination of human schistosomiasis; however, there is an increasing consensus that chemotherapy needs to be supplemented by other means if interruption of transmission and elimination are to be achieved. Given this situation, the focus of this dissertation was to better understand transmission dynamics in a hyperendemic setting in western Kenya and to find alternative …

Protocol For A Randomised Trial Of Higher Versus Lower Intensity Patient-Provider Communication Interventions To Reduce Antibiotic Misuse In Two Paediatric Ambulatory Clinics In The Usa., Kathy Goggin, Andrea Bradley-Ewing, Angela Myers, Brian R. Lee, Emily A. Hurley, Kirsten B. Delay, Sarah Schlachter, Areli Ramphal, Kimberly Pina, David Yu, Kirsten Weltmer, Sebastian Linnemayr, Christopher C. Butler, Jason G. Newland

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Children with acute respiratory tract infections (ARTIs) are prescribed up to 11.4 million unnecessary antibiotic prescriptions annually. Inadequate parent-provider communication is a chief contributor, yet efforts to reduce overprescribing have only indirectly targeted communication or been impractical. This paper describes our multisite, parallel group, cluster randomised trial comparing two feasible interventions for enhancing parent-provider communication on the rate of inappropriate antibiotic prescribing (primary outcome) and revisits, adverse drug reactions and parent-rated quality of shared decision-making, parent-provider communication and visit satisfaction (secondary outcomes).

METHODS/ANALYSIS: We will attempt to recruit all eligible paediatricians and nurse practitioners (currently 47) at an academic …

Serum Lipidomics Of Bovine Paratuberculosis: Disruption Of Choline-Containing Glycerophospholipids And Sphingolipids, Paul L. Wood, Erdal Erol, Glen F. Hoffsis, Margaret Steinman, Jeroen Debuck

Veterinary Science Faculty Publications

Objectives: Bovine paratuberculosis is a devastating infection with Mycobacterium avium subspecies paratuberculosis that ultimately results in death from malnutrition. While the infection is characterized by a long (2–4 years) subclinical phase with immune activation, ultimately host defense mechanisms fail and the bacteria spread from the small intestine to other organs. Since both the gastrointestinal tract and liver are essential for the biosynthesis of structural glycerophospholipids, we investigated the circulating levels of these lipids in field infections and experimentally infected cattle.

Methods: Serum lipidomics of control and M. avium subspecies paratuberculosis–infected cattle were performed utilizing high-resolution mass spectrometry.

Results: In …

Armed Conflict-Related Detention Of Particularly Vulnerable Persons: Challenges And Possibilities, Sandesh Sivakumaran

International Law Studies

Persons detained for reasons related to an armed conflict are in a vulnerable position. Deprived of their liberty, they are at the mercy of their captors. Certain groups of detainees are particularly vulnerable. Additionally, the way in which non-international armed conflicts are fought can make it difficult for some parties to the conflict to comply with the rules benefiting particularly vulnerable detainees. This Article identifies groups of particularly vulnerable detainees and analyzes the general and special protections that are afforded to them under the conventional and customary international law of armed conflict. It then considers the realities of detention in …

Students To Examine Past, Current And Future Public Health Issues On Trip Around The Southeast, Alicia Rohan

Browse All News

No abstract provided.

Factors Associated With Immunization Opinion Leadership Among Men Who Have Sex With Men In Los Angeles, California, Ian W. Holloway, Robert Bednarczyk, Vincent L. Fenimore, Cameron Goldbeck, Elizabeth Wu, Rebecca Himmelstein, Diane Tan, Laura Randall, Chelsea S. Lutz, Paula M. Frew

Environmental & Global Health Faculty Research

We sought to identify the characteristics of men who have sex with men (MSM) who are opinion leaders on immunization issues and to identify potential opportunities to leverage their influence for vaccine promotion within MSM communities. Using venue-based sampling, we recruited and enrolled MSM living in Los Angeles (N = 520) from December 2016 to February 2017 and evaluated characteristic differences in sociodemographic characteristics, health behaviors, and technology use among those classified as opinion leaders versus those who were not. We also asked respondents about their past receipt of meningococcal serogroups A, C, W, and Y (MenACWY) and meningococcal B …

A New Age In Aquamedicine: Unconventional Approach In Studying Aquatic Diseases, Michael Gotesman, Simon Menanteau-Ledouble, Mona Saleh, Sven M. Bergmann, Mansour El-Matbouli

Publications and Research

Background

Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and marine fish communities are rapidly incorporating novel and most up to date techniques for detection, characterization and treatment strategies. Rapid detection of infectious diseases is important in preventing large disease outbreaks.

Main text

One hundred forty-six articles including reviews papers were analyzed and their conclusions evaluated in the present paper. This allowed us to describe the most recent development research regarding the control of diseases in the aquatic environment …

Fat Shaming The Delta: How Social Issues Are Individualized Via 'Delta Obesity Talk', Amy Ulmer

Student Theses and Dissertations

Discussions of obesity in the Delta often highlight the region’s unhealthy food culture and lifestyle as explanations for what is considered an epidemic especially severe in the region. I call this discourse “Delta obesity talk” and examine it in the media and clinical literature of obesity prevention and health campaigns targeting the Lower Mississippi River Delta. I argue that by focusing on individual behavior thought to contribute to obesity and poor health, the narratives of these media outlets and public health programs direct our attention away from broader social issues contributing to ill health and onto individual fat bodies. Focusing …

Increasing Awareness Of International Adoption Through Literature, Romy Newberry

Honors Theses

No abstract provided.

Trpv1 And The Mcp-1/Ccr2 Axis Modulate Post-Uti Chronic Pain., John Rosen, Ryan E. Yaggie, Patrick J. Woida, Richard J. Miller, Anthony J. Schaeffer, David J. Klumpp

Manuscripts, Articles, Book Chapters and Other Papers

The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and its receptor TLR4 are required for post-UTI chronic pain development. However, downstream mechanisms of post-UTI chronic pelvic pain remain unclear. Because the TRPV1 and MCP-1/CCR2 pathways are implicated in chronic neuropathic pain, we explored their role in post-UTI chronic pain. Mice were infected with the E. coli strain SΦ874, known to produce chronic allodynia, and treated with the TRPV1 antagonist capsazepine. Mice treated with capsazepine at the time of SΦ874 infection failed to develop chronic allodynia, whereas …

Catpanion: A Ui/Ux Ios-Based App Design To Support Cat Adoptions, Chenchen Ji

Theses

Homeless and abandoned cats are becoming an issue in urban areas around the world: a majority of them may carry illnesses that may lead to infectious diseases. Once back in the wild, cats may also harm the ecological equilibrium of urban areas as they are known to be hunters of birds and smaller mammals.

The popularity of online cat-related material has ballooned over the past decade. Within the confines of social media, cat-related matters have gained an enormous amount of attention. Due to the increase in cat enthusiasts, celebrities occasionally help post information about cats and have even helped ask …

Toward Understanding Posttraumatic Stress And Depression Among Trauma-Affected Widows In Sri Lanka, Jessica E. Lambert, Alyssa Banford Witting, Spencer James, Lakmal Ponnamperuma, Thulitha Wickrama

Faculty Publications

Objective: In this study, we applied conservation of resources theory (Hobfoll, 1989) to explain high rates of depression and posttraumatic stress symptoms (PTSS) among war- and disaster-affected Tamil widows in the Eastern Province of Sri Lanka. We hypothesized exposure to potentially traumatic events and severity of current contextual problems would influence PTSS and depressive symptoms directly and indirectly through loss of psychological (view of self), environmental (sense of community), and energy (physical health) resources. Method: Trained research assistants interviewed a convenience sample (N = 381) of women, using established measures of the constructs of interest. Data were analyzed using …

Conference Program, Anne Skaja Robinson, Raghavan Venkat, Gene Schaefer

Cell Culture Engineering XVI

No abstract provided.

Characterization Of An N-Terminal Non-Core Domain Of Rag1 Gene Disrupted Syrian Hamster Model Generated By Crispr Cas9, Jinxin Miao, Baoling Ying, Rong Li, Ann E. Tollefson, Jacqueline F. Spencer, William S.M. Wold, Seok-Hwan Song, Il-Keun Kong, Karoly Toth, Yaohe Wang, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

The accumulating evidence demonstrates that Syrian hamsters have advantages as models for various diseases. To develop a Syrian hamster (Mesocricetus auratus) model of human immunodeficiency caused by RAG1 gene mutations, we employed the CRISPR/Cas9 system and introduced an 86-nucleotide frameshift deletion in the hamster RAG1 gene encoding part of the N-terminal non-core domain of RAG1. Histological and immunohistochemical analyses demonstrated that these hamsters (referred herein as RAG1-86nt hamsters) had atrophic spleen and thymus, and developed significantly less white pulp and were almost completely devoid of splenic lymphoid follicles. The RAG1-nt86 hamsters had barely detectable CD3+ and CD4+ T cells. The …

Mobile Hiv Units In South Africa: A Systematic Review, Meaghan Doherty

Senior Honors Projects, 2010-2019

Abstract

Objective: To examine existing literature on mobile HIV testing units to determine if they have the potential to increase access to testing, treatment, and HIV education to decrease rates of HIV in South Africa.

Participants: Ten research articles evaluating the HIV intervention method of mobile HIV units in South Africa, including outcome measures.

Analysis: Systematic search of 87 articles from 2000 to 2018 and review of the 10 articles that met inclusion criteria.

Results: Several studies (n=5) showed that mobile testing units are effective at attracting hard to reach populations, such as men and young adults. Studies (n=3) also …

Antimicrobial Activity Of Novel Cationic Amphiphiles, Melanie Kusakavitch

Senior Honors Projects, 2010-2019

This project focused on the development of amphiphiles in order to prevent hospital-acquired infections before they have a chance to enter the host, thereby reducing the need for antibiotics. The antibiotic resistance crisis of the 21st century is a dangerous epidemic with global consequences. Therefore, there is a desperate need for novel approaches in antimicrobial research. This would decrease the overall length of stay in hospitals and costs associated with such a stay. In this study, tetracationic amphiphiles with two 12-carbon chains and an aliphatic linker were studied. The MIC value of each amphiphile and strain pair was determined and …

Characterization Of Isolates And Whole Samples From Turkeys Infected With Bordetellosis, Alexandra Lovrinic

Senior Honors Projects, 2010-2019

Bordetellosis is a disease in turkeys attributed to the Gram-negative bacterium, Bordetella avium. The closely related species, B. hinzii, is known to colonize in turkeys as well but was not thought to cause disease. However, over the past few years, B. hinzii has been isolated from turkeys diagnosed with bordetellosis. The presumed identification of isolates obtained from Butterball farms in different locations was conducted through standard identification tests, including hemagglutination, PCR of B. avium specific genes, 16s rDNA PCR, carbohydrate utilization tests, and complete genome sequencing of a few strains. Out of ~100 isolates tested, 14 yielded contradictory …

Health & Wellness On The Voyages Of James Cook, Dave Smith

Honors Capstone Projects

18^th century English Navy captain James Cook was able to achieve a level of health amongst his crew that was strikingly superior to other voyages before or (to a point) since. Cook’s efforts in dealing with scurvy, infectious disease, and putrid general living conditions resulted in an oeuvre that would be the envy of any health-minded seaman for the better part of the next two-hundred years. While the discrete factors leading to Cook’s success were many, I argue that these factors were but extensions of one key characteristic: Cook’s meticulous nature in dealing with health on his vessels. Whether …

Evolution Of Bordetella Pertussis Genome May Play A Role In The Increased Rate Of Whooping Cough Cases In The United States, Kevin Loftus

Senior Honors Projects, 2010-2019

Bordetella pertussis is the bacterium responsible for pertussis, a disease commonly referred to as whooping cough. Recently, pertussis has made a resurgence in the U.S. despite high-vaccination coverage. Possible causes of the increased number of pertussis cases include genetic evolution of B. pertussis, increased awareness of the disease, better laboratory diagnostics, and the switch from a whole-cellular (wP) vaccine to an acellular vaccine (aP) in the 1990s. Fortunately, just as B. pertussis is evolving, so is the arsenal of technologies used to understand and combat this pathogenic bacterium. Whole genome sequencing is one technology that helps researchers better understand …

Elucidation Of The Functions Of Neuropilin 2 In Osteoclasts In Promoting Prostate Cancer Bone Metastasis., Navatha S. Polavaram

Theses & Dissertations

Bone metastasis is one of the major clinical concerns that causes skeletal related malignancies and increased mortality. Bone is one of the preferred sites for metastatic prostate cancer. The metastatic prostate cancer cells interact with bone cells (osteoblasts and osteoclasts) resulting in an imbalance in the bone homeostasis leading to increased activation of osteoblasts over osteoclasts. Our preliminary data indicated a non-tyrosine kinase receptor Neuropilin 2 (NRP2) is expressed in osteoclasts induced by metastatic prostate cancer cells and acts as a negative regulator of osteoclast differentiation and function. We hypothesize that prostate cancer -induced NRP2 expression in osteoclasts is necessary …

Pandemic Planning: Estimating Disease Burden Of Pandemic Influenza To Guide Preparedness Planning Decisions For Nebraska Medicine, Angelia Wimberly

Theses & Dissertations

This year marks the 100^th anniversary of the 1918 “Spanish Flu” outbreak that killed 50-100 million people worldwide. If a pandemic of this proportion happened today, the federal pandemic influenza plan predicts that 30 percent of the population could become infected with up to 50 percent seeking outpatient care. With Nebraska Medicine currently operating at nearly full capacity (95-97%), surge capacity for hospital space, staff, and supplies would be in severe demand and would quickly overwhelm the organization. To assess the impact of pandemic influenza in Douglas County Nebraska and Nebraska Medicine, pandemic modeling tool FluAid and FluSurge 2.0 …

Performing Authentic Savagery: National Myth-Making And Indigenous Survival At American World's Fairs, 1893-1904, Hannah Facknitz

Senior Honors Projects, 2010-2019

The late nineteenth century in America was a period of intense change, where society took on the project of describing what exactly made America what it was. An important vehicle for this exploration of identity was the world’s fair. This paper analyzes the Chicago World Columbian Exposition of 1893, the Omaha Trans-Mississippi and International Exposition of 1898, and the St. Louis Louisiana Purchase Exposition of 1904 and their depictions of Indigenous North Americans which were closely tied up in the current project of national myth making. A three-way conflict emerges in this study between contemporary anthropologists, entertainment professionals, and so-called …

Health Care Priorities In Developing Countries: A Systematic Review, Heather Mckay

Senior Honors Projects, 2010-2019

Countries around the globe are struggling to find an affordable health care system. Developing countries have it particularly challenging with a lack of health care professionals and funding to spend on health care. This systematic review analyzes five developing countries’ (China, Dominican Republic, Ghana, Peru and Turkey) health care systems to find what is working well and what needs improvement. The main findings that these countries could adopt are requiring medical student graduates to do their residency in rural areas, giving more power of health care to local governments rather than the federal government, making insurance companies non-profit, and providing …