Digital Commons Network^™

Cwu Faculty Senate Minutes - 05/30/18, Janet Shields

Faculty Senate Minutes

These are the official Central Washington University Faculty Senate minutes for the June 1, 2016 regular meeting.

Novel Antifolates To Target Antibiotic Resistant Gram-Negative Pathogens, Michael Lombardo

Doctoral Dissertations

Antibiotic resistance has limited our ability to treat life-threatening infections putting pressure on the scientific community to discover new effective therapeutics. There have been significant research efforts to develop drugs for the treatment of infections caused by Gram-negative pathogens as they are the leading cause of healthcare-associated infections and have a high propensity to accumulate antibiotic resistance genes. The two major challenges to Gram-negative antibiotic development are finding drug chemotypes that are able to penetrate the cell envelope and accounting for plasmid-associated resistance genes. We have developed a novel class of antifolates, designated as propargyl-linked antifolates, as effective antimicrobials against …

Feasibility And Effect Of Life Skills Building Education And Multiple Micronutrient Supplements Versus The Standard Of Care On Anemia Among Non-Pregnant Adolescent And Young Pakistani Women (15-24 Years): A Prospective, Population-Based Cluster-Randomized Trial, Jo-Anna B. Baxter, Yaqub Wasan, Sajid Bashir Soofi, Zamir Suhag, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Adolescence is a critical period for physical and psychological growth and development, and vitamin and mineral requirements are correspondingly increased. Health and health behaviours correspond strongly from adolescence to adulthood. Developing a preconception care package for adolescent and young women in resource-limited settings could serve to empower them to make informed decisions about their nutrition, health, and well-being, as well as function as a platform for the delivery of basic nutrition-related interventions to address undernutrition.
Methods: In this population-based two-arm, cluster-randomized, controlled trial of life skills building education (provided bi-monthly) and multiple micronutrient supplementation (provided twice-weekly; UNIMMAP composition), we …

Firefighters: The Emotional Processing Of Physiological Risks, Beth Larson, John Thoburn

School of Psychology, Family, and Community Research Conference

This presentation acknowledges the deficiency and necessity for research regarding emotional processing of firefighters at risk of developing cancer due to occupational risk. The developing research project will use qualitative methodology to gather and investigate subjective detailed descriptions of firefighters' psychological experiences regarding occupational risk. Because the goal of this project is to identify explanatory concepts of emotional processing, we will follow a grounded theory approach. Participants, a minimum of six firefighters, will undergo in-person interviews based on three open-ended questions. All interviews will be audio recorded, transcribed, coded, and analyzed for similar themes and patterns.

Comparison Of Xpert Mtb/Rif With Histology For The Detection Of Mycobacterium Tuberculosis In Formalin Fixed Paraffin Embedded Tissues At Aga Khan University Hospital, Nairobi, Njau Allan Njoroge

Master of Medicine in Anatomic Pathology

Background: Diagnosis of extrapulmonary tuberculosis (EPTB) continues to be a challenge due to the complexity of the causative organism and the wide array of pathologic features seen in this infection. A number of studies have shown polymerase chain reaction (PCR) for EPTB to be a feasible, sensitive and specific test for diagnosis of tuberculosis (TB) of which, the World Health Organisation (WHO) has given recommendations. As pertains EPTB, Xpert MTB/RIF may be used in place of conventional tests such as microscopy, histopathology and culture in lymph nodes and other tissues from patients suspected to have EPTB. It has been demonstrated …

Evidence-Based Guidelines For Prevention, Screening, And Management Of Multiple Organ Dysfunction Syndrome, Manju N. Daniel, Gagandeep Singh

International Nursing Research Congress (INRC)

Sepsis is life-threatening organ dysfunction. Half of the mortality observed in the hospital settings is attributable to multiple organ dysfunction syndrome. Evidence based guidelines recommend early detection and quick interventions to prevent progression of sepsis to Multi-organ Dysfunction Syndrome. Early interventions to focus on antibiotics, hemodynamic stabilization and pulmonary stabilization.

First Results On Survival From A Large Phase 3 Clinical Trial Of An Autologous Dendritic Cell Vaccine In Newly Diagnosed Glioblastoma, Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D'Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A. Goldlust, Daniela A Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A. Toms, Kevin O. Lillehei, Tom Mikkelsen, Tobias Walbert, Steven R. Abram, Andrew J. Brenner, Steven Brem, Matthew G. Ewend, John L. Villano

Internal Medicine Faculty Publications

Background: Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax^®-L) to standard therapy for newly diagnosed glioblastoma.

Methods: After surgery and chemoradiotherapy, patients were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or temozolomide and placebo (n = 99). Following recurrence, all patients were allowed to receive DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); the secondary endpoint was overall survival (OS).

Results: For the intent-to-treat (ITT) population (n = 331), median OS (mOS) was 23.1 months …

Increasing Follow-Up In College Students With Latent Tuberculosis Infection, Emily Middleton, Dnp, Aprn, Ccrn, Kathy James, Dnsc, Aprn, Faan, Kimberly Woodruff, Md, Mph

Doctor of Nursing Practice Final Manuscripts

Around 13 million people in the United States have latent tuberculosis infection (LTBI) with a 5-10% chance of developing active tuberculosis (TB) in their lifetime if not treated (Center for Disease Control, 2015). At a University Student Health Center (SHC), there is a matriculation requirement for TB testing for students that screen as high risk. Many students have these testing requirements performed at outside clinics, including foreign clinics, and follow-up regarding education about LTBI and treatment recommendations was often missing. The purpose of this evidence-based practice (EBP) project was to increase follow-up, education, and treatment options after diagnosis of LTBI. …

Provider Insight On Surmounting Specialty Practice Challenges To Improve Tdap Immunization Rates Among Pregnant Women, Arpita Mehrotra, Allison Kennedy Fisher, Jennifer Mullen, Leslie Rodriguez, Angela J. Jiles, Alison P. Albert, Laura A. Randall, Paula M. Frew

Environmental & Global Health Faculty Research

Background Pertussis, or “whooping cough,” is an acute, contagious pulmonary disease that, despite being vaccine-preventable, has become an increasingly widespread problem in the United States. As a result, the Advisory Committee on Immunization Practices and American College of Obstetricians and Gynecologists updated recommendations stating clinicians should give a Tdap dose during every pregnancy, preferably at 27–36 weeks. Despite this recommendation, reported Tdap vaccine receipt rates during pregnancy vary from 16–61%, and previous studies have shown that clinician recommendation and vaccine administration are strongly associated with vaccine uptake among pregnant women. Methods Our aim was to inform new strategies to increase …

Mirnas Reshape Immunity And Inflammatory Responses In Bacterial Infection, Xikun Zhou, Xuefeng Li, Min Wu

Biomedical Sciences Faculty Publications

Pathogenic bacteria cause various infections worldwide, especially in immunocompromised and other susceptible individuals, and are also associated with high infant mortality rates in developing countries. MicroRNAs (miRNAs), small non-coding RNAs with evolutionarily conserved sequences, are expressed in various tissues and cells that play key part in various physiological and pathologic processes. Increasing evidence implies roles for miRNAs in bacterial infectious diseases by modulating inflammatory responses, cell penetration, tissue remodeling, and innate and adaptive immunity. This review highlights some recent intriguing findings, ranging from the correlation between aberrant expression of miRNAs with bacterial infection progression to their profound impact on host …

Researcher Awarded K23 Grant To Study Malaria Prevention In Pregnant Women In Cameroon, Staff

Browse All News

No abstract provided.

A Study On Transcriptomic Profiling Of Differentially Expressed Genes Relevant To Innate And Adaptive Immune Pathways In Transgenic Rainbow Trout (Oncorhynchus Mykiss) Harboring Cecropin P1 Transgene, Yueh-Chiang Han

Doctoral Dissertations

Introduction of antimicrobial peptide (AMP) genes into fish genome by the transgenic technology provided a promising solution to control fish disease. Cecropin P1, a known porcine originated AMP, had been introduced into the rainbow trout genome for production of transgenic fish by Chiou et al. (2014) in Chen’s laboratory. Repeated, in vivo, challenge studies demonstrated that these transgenic fish exhibited resistant characteristic to infection by microbial pathogens. Here, we hypothesized that cecropin P1 transgene product may not only directly eliminate microbial pathogens, but also indirectly exert immunomodulatory activity in the transgenic hosts to elevate their disease resistance. To address this …

Isolation Of Cryptococcus-Like Yeast From Natural Environments, Sarah L. Ward, Brian Hoeynck, Dennis Baumgardner

Aurora Family Medicine Residents - Milwaukee

No abstract provided.

The Impact Of Infectious Disease On Costly Social Signals, Nicole Potts

Creative Collaborations: Annual Showcase of Undergraduate Research

Male house mice (mus musculus) excrete large quantities of proteins, known as major urinary proteins (MUPs), in their urine. Few studies have directly addressed to what extent MUPs are an honest signal of an individual?s health. We assessed this relationship by measuring the effects infection (a high energy cost) had on urinary MUPs concentration. BALB/c and wild-derived male mice were infected with either a low or high virulence strain of Friend Virus Complex (FVC). Their MUPs concentration were analyzed before infection, during infection and post infection. Virulence was measured using spleen mass as FVC causes splenomegaly. Initial results showed no …

Admission Eeg Findings In Diverse Paediatric Cerebral Malaria Populations Predict Outcomes., Douglas G Postels, Xiaoting Wu, Chenxi Li, Peter W Kaplan, Karl B Seydel, Terrie E Taylor, Youssef A Kousa, Richard Idro, Robert Opoka, Chandy C John, Gretchen L Birbeck

Pediatrics Faculty Publications

BACKGROUND: Electroencephalography at hospital presentation may offer important insights regarding prognosis that can inform understanding of cerebral malaria (CM) pathophysiology and potentially guide patient selection and risk stratification for future clinical trials. Electroencephalogram (EEG) findings in children with CM in Uganda and Malawi were compared and associations between admission EEG findings and outcome across this diverse population were assessed. Demographic, clinical and admission EEG data from Ugandan and Malawian children admitted from 2009 to 2012 with CM were gathered, and survivors assessed for neurological abnormalities at discharge.

RESULTS: 281 children were enrolled (Uganda n = 122, Malawi n = 159). …

The Conduits And Barriers To Reentry For Formerly Incarcerated Individuals In San Bernardino, Annika Anderson, Noe J. Nava, Patricia Cortez

Journal of Prison Education and Reentry (2014-2023)

Numerous scholars have noted that the majority of prisoners will be reincarcerated within three years of their release. However, while there has been extensive research on recidivism, much less attention has been paid to the reentry process in the sociological and criminological literature. Given the high rates of former prisoners reentering society with struggles that may affect their friends, family members, and communities, policymakers and practitioners should understand the successful methods for their reintegration. In this paper, we explore the conduits and barriers to reentry for a sample of San Bernardino county callers using United Way’s 211 Reentry Call Center …

Protozoal Coinfection In Horses With Equine Protozoal Myeloencephalitis In The Eastern United States, Sarah Schale, Daniel Howe, Michelle Yeargan, Jennifer K. Morrow, Amy Graves, Amy L. Johnson

Maxwell H. Gluck Equine Research Center Faculty Publications

Background: Infection by 2 or more protozoa is linked with increased severity of disease in marine mammals with protozoan encephalitis.

Hypothesis/Objectives: To assess whether horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona also have evidence of infection with Neospora hughesi or Toxoplasma gondii. We hypothesized that horses with EPM would be more likely than horses with cervical vertebral stenotic myelopathy (CVSM) to be positive for antibodies to multiple protozoan parasites.

Animals: One hundred one horses with neurologic disease: 49 with EPM and 52 with CVSM.

Methods: Case review. Archived serum and cerebrospinal fluid (CSF) from 101 horses …

Week Of May 22, 2018, New York Medical College

InTouch

• Students Delve into an Array of Public Health Issues at SHSP Research Day
• Department of Family and Community Medicine Hosts Sixth Annual Research Day
• Eighth Annual Paul K. Woolf, M.D., Pediatric Trainee Research Symposium Highlights New and Innovative Biomedical Research
• Would You Like to Interview Applicants to the School of Medicine?
• SOM P2P Committee Recognizes Role Models at NYMC

Placentophagy: A Women's Right To Her Placenta, Amber Goeden

Concordia Law Review

Placentophagy is the consumption of the placenta after childbirth. While not every woman participates in placentophagy, there has been a notable increase of the practice. Many reasons exist in why woman partake in placentophagy. The most notable reasons for the growth, is the claimed increased breast milk production and the potential for reducing the effects of post-partum depression. Even though a woman might choose to partake in placentophagy, she might be met with law, or the lack thereof, that restricts her access to her placenta. Due to the increased requests for the placenta it has highlighted that a woman’s right …

2018-May-21-Nih Funding, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

The Economic Case For A Pandemic Fund, Kevin Berry

ISER Articles

The rapid urban spread of Ebola virus in West Africa in 2014 and consequent breakdown of control measures led to a significant economic impact as well as the burden on public health and wellbeing. The US government appropriated $5.4 Billion for FY2015 and WHO proposed a $100 Million emergency fund largely to curtail the threat of future outbreaks. Using epidemiological analyses and economic modeling, we propose that the best use of these and similar funds would be to serve as global insurance against the continued threat of emerging infectious diseases. An effective strategy would involve the initial investment in strengthening …

Antimicrobial Peptide Ll-37 And Recombinant Human Mannose-Binding Lectin Express Distinct Age- And Pathogen-Specific Antimicrobial Activity In Human Newborn Cord Blood In Vitro, Annette Scheid, Ning Li, Carleen Jeffers, Francesco Borriello, Sweta Joshi, Al Ozonoff, Matthew Pettengill, Ofer Levy

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: There is a need to prevent and treat infection in newborns. One approach is administration of antimicrobial proteins and peptides (APPs) such as LL-37, a membrane-active cathelicidin antimicrobial peptide, and mannose-binding lectin (MBL), a pattern-recognition protein that binds to microbial surface polysaccharides resulting in opsonization and complement activation. Low plasma/serum levels of LL-37 and of MBL have been correlated with infection and exogenous administration of these agents may enhance host defense. Methods: The antimicrobial activity of LL-37 (15 µg/ml) or rMBL (0.5, 2 and 10 µg/ml) was tested in hirudin-anticoagulated preterm and term human cord blood (N = 12-14) …

Decreasing Recurrent Bowel Obstructions, Improving Quality Of Life With Physiotherapy: Controlled Study, Amanda D Rice, Kimberley Patterson, Evette D Reed, Belinda F Wurn, Kristen Robles, Bernhard Klingenberg, Leonard B Weinstock, Janey S. A. Pratt, C. Richard King Iii, Lawrence J Wurn

Open Access Publications

AIM: To compare (1) quality of life and (2) rate of recurrent small bowel obstructions (SBO) for patients treated with novel manual physiotherapy

METHODS: One hundred and three subjects (age 19-89) with a history of recurrent adhesive SBO were treated with a manual physiotherapy called the Clear Passage Approach (CPA) which focused on decreasing adhesive crosslinking in abdominopelvic viscera. Pre- and post-therapy data measured recurring obstructions and quality of life, using a validated test sent 90 d after therapy. Results were compared to 136 untreated control subjects who underwent the same measurements for subjects who did not receive any therapy, …

How Expressive Arts Therapy Benefits Children Living With Acquired Brain Injuries, Stacia Boynton

Expressive Therapies Capstone Theses

This literature review explores the positive effects of using an intermodal expressive arts therapy approach when working with children living with an acquired brain injury (ABI). This review outlines symptoms and difficulties children living with ABI experience, it introduces general brain structure, and provides evidence for the potential use of intermodal expressive arts therapy with this population. This review is intended as a tool kit for therapists who are not experienced in working with this client population. It will share research on surrounding expressive therapy modalities such as art, music, dance, drama, and expressive arts therapy; also referred to as …

Miles Apart: A Comparative Case Study Analysis Of The Acculturation And Socioeconomic Status Of Former Colonized Populations In Post-Imperialist States, Mariea Melanie Sekijima

Senior Theses

This undergraduate thesis assesses the impact of government policies and acculturation strategies on the current socioeconomic status of former colonized populations living in their respective post-imperialist states. Despite a shared colonial history, the current positioning of Zainichi Koreans in Japan and British Hindu Indians in the UK is vastly different. I argue that this can be linked to two factors—the government strategy in response to these populations and the existence of other minorities within the same state. Using a case study approach to analyze these contrasting experiences, this thesis contributes to a wider conversation on the continual legacies of imperialism …

Subsidizing Climate Change: How The Agricultural Business Is Harming Our Planet, Caroline Berejka

Student Theses 2015-Present

In exploring the concept of environmental sustainability in the modern age, it is important to look at the practices of the agriculture industry and the role of agricultural production in the multifaceted issue of climate change. The agriculture industry's overwhelming power in the US government and its resistance to moving toward more sustainable practices is an issue that the average American has little awareness of. In order to push the movement of environmental sustainability forward, it is necessary to examine the economic reasons for the slow shift towards sustainable agriculture and possible incentives for industrial farmers to modify their practices. …

Parasite Rearing And Infection Temperatures Jointly Influence Disease Transmission And Shape Seasonality Of Epidemics, Marta S. Shocket, Daniela Vergara, Andrew J. Sickbert, Jason M. Walsman, Alexander T. Strauss, Jessica L. Hite, Meghan A. Duffy, Carla E. Caceres, Spencer R. Hall

School of Biological Sciences: Faculty Publications

Seasonal epidemics erupt commonly in nature and are driven by numerous mechanisms. Here, we suggest a new mechanism that could determine the size and timing of seasonal epidemics: rearing environment changes the performance of parasites. This mechanism arises when the environmental conditions in which a parasite is produced impact its performance—independently from the current environment. To illustrate the potential for “rearing effects”, we show how temperature influences infection risk (transmission rate) in a Daphnia-fungus disease system through both parasite rearing temperature and infection temperature. During autumnal epidemics, zooplankton hosts contact (eat) fungal parasites (spores) reared in a gradually cooling environment. …

Art Therapy And The Recovery Process: A Literature Review, Michelle Sharp

Expressive Therapies Capstone Theses

Addiction to drugs and alcohol is a multi-faceted disease that has physical, mental, and financial consequences for the individual and for society at large. The global burden of disease related to substance use disorder is 5.4 percent worldwide according to World Health Organization (2014). There is a need to expand knowledge of the illness as well as create a more effective treatment method. The demand for addiction-based treatment is rising. There is a need to explore and strengthen research on therapeutic approaches to help individuals to combat substance use disorder and aide in the recovery process. Art therapy, according to …

In Vivo And In Vitro Studies Of Cry5b And Nicotinic Acetylcholine Receptor Agonist Anthelmintics Reveal A Powerful And Unique Combination Therapy Against Intestinal Nematode Parasites, Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K. Nielsen, Raffi V. Aroian

Veterinary Science Faculty Publications

Background

The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate. Drug combinations, when properly made, are ideal for treating infectious diseases. Although there are some clinical trials using drug combinations against STNs, little quantitative and systemic work has been performed to define the …

Seeing Red: Analyzing Iucn Red List Data Of South And Southeast Asian Amphibians, Alexandra Gonzalez

Master's Theses

In the midst of the sixth mass extinction event which is currently underway, it appears that amphibians are one of the most impacted vertebrates. Over 6,500 amphibian species are listed on the IUCN Red List (an assessment tool which provides species’ conservation status, perceived threats, and distribution range). While it is well-known that populations under multiple stressors are more likely to undergo significant declines, there are little to no resources available for visualizing how these threats may work synergistically and interact within a species’ range. This is especially the case for Southeast Asian amphibians, which much less attention has been …