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2018

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Seroprevalence And Molecular Detection Of Middle East Respiratory Syndrome Caused By Corona Virus In Some Cameles In Egypt, Adel El-Gohary, Amro Mohamed, Osama Selim, Nader Nassar Jun 2018

Seroprevalence And Molecular Detection Of Middle East Respiratory Syndrome Caused By Corona Virus In Some Cameles In Egypt, Adel El-Gohary, Amro Mohamed, Osama Selim, Nader Nassar

Mansoura Veterinary Medical Journal

This study was carried out to investigate seroprevalence and molecular detection of Middle East Respiratory Syndrome – Corona virus (MERS-CoV) in some camels in Egypt. For this purpose, a total of 177 blood samples were collected from camels at different abattoirs and localities in Egypt ( Nahya, 20,Alwarraque, 27,Belbais, 12, Kerdasa, 20, Kerdasa camel houe hold, 6, Banha, 7, camel studies and developing center farm in Marsa Matrouh sahara, 5) and examined serologically by microneutralization test . The results revealed that the overall prevalence was 59.3% (105 out of 177). The respective percentages of mentioned abattoirs and localities were 30, …


The Hospital Antimicrobial Use Process: From Beginning To End., William R Truong, Jason Yamaki Jun 2018

The Hospital Antimicrobial Use Process: From Beginning To End., William R Truong, Jason Yamaki

Articles, Abstracts, and Reports

Hospital antimicrobial stewardship (AMS) programs are responsible for ensuring that all antimicrobials are utilized in the most appropriate and safe manner to improve patient outcomes, prevent adverse drug reactions, and prevent the development of antimicrobial resistance. This Perspectives article outlines the hospital antimicrobial use process (AUP), the foundational system that ensures that all antimicrobials are utilized in the most appropriate and safe manner. The AUP consists of the following steps: antimicrobial ordering, order verification, preparation and delivery, administration, monitoring, and discharge prescribing. AMS programs should determine how each step contributes to how an antimicrobial is used appropriately or inappropriately at …


Prevalence And Factors Associated With Female Sexual Dysfunction Amongst Women Using Hormonal And Non-Hormonal Contraception At The Aga Khan University Hospital Nairobi Clinics, Momin Butt Jun 2018

Prevalence And Factors Associated With Female Sexual Dysfunction Amongst Women Using Hormonal And Non-Hormonal Contraception At The Aga Khan University Hospital Nairobi Clinics, Momin Butt

Master of Medicine in Family Medicine

Background: Female sexual function is a complex phenomenon. It integrates all the body systems and is influenced by a variety of factors. Contraceptives have been shown to have variable effects on female sexual function, but there have not been adequately powered studies on this in our setting. Justification: The prevalence of female sexual dysfunction (FSD) has been shown to vary among different population subsets globally. The associations of different factors with FSD have also shown variable conclusions that are not generalizable to our setting. In Kenya there is a high discontinuation rate of contraception and this is mainly attributed to …


The Prairie Naturalist: The Journal Of The Great Plains Natural Science Society Volume 50 No. 1 Jun 2018

The Prairie Naturalist: The Journal Of The Great Plains Natural Science Society Volume 50 No. 1

The Prairie Naturalist

TABLE OF CONTENTS

1 EDITOR’S NOTE

RESEARCH ARTICLES

3 Spatiotemporal Distribution of Waterfowl Disease Outbreaks in Kansas, USA Thomas A. Becker, Adam A. Ahlers, Shane Hesting, and David A. Haukos

14 Wild Turkey Occupancy in a Prairie Landscape Joshua C. Courlas and R. Scott Lutz

24 Age and Growth of Cottonwood Trees along the Missouri River, North Dakota Jonathan M. Friedman, Fisher R. Ankeny, and Marshall Wolf

NOTES

34 Hoary Bat Impaled on Barbed Wire Fence

37 Lekking Behavior of a Sharp-Tailed Grouse in South-Central Nebraska

BOOK REVIEWS

40 Force of Nature: George Fell, Founder of The Natural Areas Movement. …


Choosing Medical Malpractice, Nadia N. Sawicki Jun 2018

Choosing Medical Malpractice, Nadia N. Sawicki

Washington Law Review

Modern principles of patient autonomy and health care consumerism are at odds with medical malpractice law’s traditional skepticism towards the defenses of contractual waiver and assumption of risk. Many American courts follow a patient-protective view, exemplified by the reasoning in the seminal Tunkl case, rejecting any attempts by physicians to relieve themselves of liability on the grounds of a patient’s agreement to assume the risk of malpractice. However, where patients pursue unconventional treatments that satisfy their personal preferences but that arguably fall outside the standard of care, courts have good reason to be more receptive to such defenses. This Article …


Mechanism Of Virus Inactivation By Cold Atmospheric-Pressure Plasma And Plasma-Activated Water, Li Guo, Ruobing Xu, Lu Gou, Zhichao Liu, Yiming Zhao, Dingxin Liu, Lei Zhang, Hailan Chen, Michael G. Kong Jun 2018

Mechanism Of Virus Inactivation By Cold Atmospheric-Pressure Plasma And Plasma-Activated Water, Li Guo, Ruobing Xu, Lu Gou, Zhichao Liu, Yiming Zhao, Dingxin Liu, Lei Zhang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

ABSTRACT Viruses cause serious pathogenic contamination that severely affects the environment and human health. Cold atmospheric-pressure plasma efficiently inactivates pathogenic bacteria; however, the mechanism of virus inactivation by plasma is not fully understood. In this study, surface plasma in argon mixed with 1% air and plasma-activated water was used to treat water containing bacteriophages. Both agents efficiently inactivated bacteriophages T4, ϕ174, and MS2 in a time-dependent manner. Prolonged storage had marginal effects on the antiviral activity of plasma-activated water. DNA and protein analysis revealed that the reactive species generated by plasma damaged both nucleic acids and proteins, consistent with the …


Evaluation The Efficacy Of Diluted Chloroxylenol Against Biofilm Producing Pseudomonas Aeruginosa In Clinical Isolates, Safaa Toma Aka, Aryan R. Ganjo, Sayran H. Haji Jun 2018

Evaluation The Efficacy Of Diluted Chloroxylenol Against Biofilm Producing Pseudomonas Aeruginosa In Clinical Isolates, Safaa Toma Aka, Aryan R. Ganjo, Sayran H. Haji

Polytechnic Journal

The extensive use of disinfectant and their causing in dissemination at the hospitals can contribute to alterations in bacteria leading to the expansion of highly resistant microorganisms to antibacterial agents. The mechanisms of resistance in bacteria are similar for both antibacterial agents and disinfectant. The main objective of this study was to assess the activity of the various dilution of the chloroxylenol as an ordinarily used disinfectant against P. aeruginosa at hospitals and their association to biofilm production. This study was carried out on 91 P. aeruginosa obtained from different clinical specimens at hospitals in Erbil city. All clinical isolates …


Inspire : Vol 1, Issue 3, Department Of Medicine Jun 2018

Inspire : Vol 1, Issue 3, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

  • Tribute to Dr. Saeed Hamid
  • Global Congestive Heart Failure (G-CHF)Study
  • HIBA; New addition to Dr. Bilal's Family
  • Dr. Muhammad Irfan elected National Delegate of European Respiratory Society (ERS) for Pakistan for next 3 years (2018-2021) and presented 3 papers
  • Celebrating Dept. of Medicine at National and International Forums
  • Dr. Zainab Samad,Dr. Javid Khan, Dr.Yawer Saeed and Dr.Saulat Fatima celebrating Heart Health Event IN Partnership with the Karachi Press Club
  • Dr. Om Prakash Invited speaker to 1stNepal association of liver disease meeting and 6th South Asia association for liver disease


How Dehumanization Influences Attitudes Towards Immigrants, Stephen M. Utych Jun 2018

How Dehumanization Influences Attitudes Towards Immigrants, Stephen M. Utych

Political Science Faculty Publications and Presentations

Immigrants, as a group, are frequently described in ways, such as vermin or disease, that portray them as less than human. This type of dehumanizing language leads to negative emotional responses and negative attitudes towards the dehumanized group. This paper examines how the dehumanization of immigrants influences immigration policy attitudes I use original experimental data to show that dehumanization leads to more negative immigration attitudes. I further find that these negative attitudes are mediated by the role of emotion. Dehumanization increases anger and disgust towards immigrants, which causes anti-immigrant sentiment.


Examining Multimorbidities Using Association Rule Learning, Kaylee Dudley Jun 2018

Examining Multimorbidities Using Association Rule Learning, Kaylee Dudley

Undergraduate Honors Theses

All insurance companies, regardless of the kind of insurance they offer, do their best to predict the future by comparing current to historical information. Any statistically significant correlation, regardless of expectations and hidden factors, can help to actuarially model future behavior. Using deidentified data from over 6 million health insurance policies over one year, we looked for any significant groupings of medical issues. The medical issues are defined based on the commercial “Episode Treatment Groups” (ETGs) classification, and our claims contain 347 different ETGs. We performed different kinds of analysis, including Bayesian posterior cluster analysis, k-means cluster analysis, and association …


Assessing Natural Infection With Zika Virus In The Southern House Mosquito, Culex Quinquefasciatus, During 2016 In Puerto Rico, Donald A. Yee, Rebeca De Jesus Crespo, Fiona F. Hunter, Fengwei Bai Jun 2018

Assessing Natural Infection With Zika Virus In The Southern House Mosquito, Culex Quinquefasciatus, During 2016 In Puerto Rico, Donald A. Yee, Rebeca De Jesus Crespo, Fiona F. Hunter, Fengwei Bai

Faculty Publications

The epidemic of Zika in the Western hemisphere has led to intense investigations of all species important in the transmission of Zika virus (ZikV), including putative mosquito vectors. Although evidence points to Stegomyia (= Aedes) (Diptera: Culicidae) mosquitoes as the primary vectors in nature among humans, there remains the possibility that other common mosquito species may be implicated in the rapid spread of the virus. Herein, field-caught Culex quinquefasciatus (Diptera: Culicidae) collected during June 2016 in different neighbourhoods in San Juan, Puerto Rico were examined for the presence of natural infection with ZikV. Stegomyia aegypti (= Aedes aegypti) …


Book Review On “Handbook Of Recent Trends In Homoeopathy For Infectious Diseases In India And Abroad”, Chaturbhuja Nayak Jun 2018

Book Review On “Handbook Of Recent Trends In Homoeopathy For Infectious Diseases In India And Abroad”, Chaturbhuja Nayak

Indian Journal of Research in Homoeopathy

No abstract provided.


Assessing Vancomycin Dosing Per Pharmacy In Elderly Patients Over The Age Of 74 Years, Lee H. Nguyen, Martin Breen, Jason Yamaki, Geraldine Cadalin, Nilomi Shah, Linda Lumintaintang Jun 2018

Assessing Vancomycin Dosing Per Pharmacy In Elderly Patients Over The Age Of 74 Years, Lee H. Nguyen, Martin Breen, Jason Yamaki, Geraldine Cadalin, Nilomi Shah, Linda Lumintaintang

Pharmacy Faculty Articles and Research

Vancomycin has a complex pharmacokinetic profile and carries potential risks for nephrotoxicity and ototoxicity. The pharmacokinetic profile in elderly patients significantly differs from that of younger patients. It is common practice in many institutions for pharmacists to intentionally round serum creatinine levels to 1 mg/dl in elderly patients with levels <1 mg/ dl to avoid overestimating clearance and toxicities. This can potentially lead to underestimation of creatinine clearance, and subsequently lead to vancomycin under dosing. The aim of this study was to evaluate vancomycin target trough attainment and the time to trough attainment with vancomycin dosing per pharmacy in elderly patients.


Borrelia Burgdorferi Spovg Dna- And Rna-Binding Protein Modulates The Physiology Of The Lyme Disease Spirochete, Christina R. Savage, Brandon L. Jutras, Aaron Bestor, Kit Tilly, Patricia A. Rosa, Yvonne Tourand, Philip E. Stewart, Catherine A. Brissette, Brian Stevenson Jun 2018

Borrelia Burgdorferi Spovg Dna- And Rna-Binding Protein Modulates The Physiology Of The Lyme Disease Spirochete, Christina R. Savage, Brandon L. Jutras, Aaron Bestor, Kit Tilly, Patricia A. Rosa, Yvonne Tourand, Philip E. Stewart, Catherine A. Brissette, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The SpoVG protein of Borrelia burgdorferi, the Lyme disease spirochete, binds to specific sites of DNA and RNA. The bacterium regulates transcription of spoVG during the natural tick-mammal infectious cycle and in response to some changes in culture conditions. Bacterial levels of spoVG mRNA and SpoVG protein did not necessarily correlate, suggesting that posttranscriptional mechanisms also control protein levels. Consistent with this, SpoVG binds to its own mRNA, adjacent to the ribosome-binding site. SpoVG also binds to two DNA sites in the glpFKD operon and to two RNA sites in glpFKD mRNA; that operon encodes genes necessary for glycerol catabolism …


Deconvoluting The Effects Of Surface Chemistry And Nanoscale Topography: Pseudomonas Aeruginosa Biofilm Nucleation On Si-Based Substrates, Jing Zhang, Jingling Huang, Carmen Say, Robert L. Dorit, Kate Queeney Jun 2018

Deconvoluting The Effects Of Surface Chemistry And Nanoscale Topography: Pseudomonas Aeruginosa Biofilm Nucleation On Si-Based Substrates, Jing Zhang, Jingling Huang, Carmen Say, Robert L. Dorit, Kate Queeney

Chemistry: Faculty Publications

Hypothesis

The nucleation of biofilms is known to be affected by both the chemistry and topography of the underlying substrate, particularly when topography includes nanoscale (nm) features. However, determining the role of topography vs. chemistry is complicated by concomitant variation in both as a result of typical surface modification techniques. Analyzing the behavior of biofilm-forming bacteria exposed to surfaces with systematic, independent variation of both topography and surface chemistry should allow differentiation of the two effects.

Experiments

Silicon surfaces with reproducible nanotopography were created by anisotropic etching in deoxygenated water. Surface chemistry was varied independently to create hydrophilic (OH- terminated) …


Shifts In Assemblage Of Foraging Bats At Mammoth Cave National Park Following Arrival Of White-Nose Syndrome, Marissa M. Thalken, Michael J. Lacki, Joseph S. Johnson Jun 2018

Shifts In Assemblage Of Foraging Bats At Mammoth Cave National Park Following Arrival Of White-Nose Syndrome, Marissa M. Thalken, Michael J. Lacki, Joseph S. Johnson

Forestry and Natural Resources Faculty Publications

The arrival of white-nose syndrome (WNS) to North America in 2006, and the subsequent decline in populations of cave-hibernating bats have potential long-term implications for communities of forest-dwelling bats in affected regions. Severe declines in wintering populations of bats should lead to concomitant shifts in the composition and relative abundance of species during the staging, maternity, and swarming seasons in nearby forested habitats. We examined capture rates of bats collected in mist nets from 2009 to 2016 to evaluate summer patterns in abundance of species pre- and post-arrival of WNS to Mammoth Cave National Park, KY. The data demonstrated a …


Silk Route To The Acceptance And Re-Implementation Of Bacteriophage Therapy—Part Ii, Wilbert Sybesma, Christine Rohde, Pavol Bardy, Jean Paul Pirnay, Ian Cooper, Jonathan Caplin, Nina Chanishvili, Aidan Coffey, Daniel De Vos, Amber Hartman Scholz, Shawna Mccallin, Hilke Marie Püschner, Roman Pantucek, Rustam Aminov, Jiří Doškař, D. İpek Kurtböke Jun 2018

Silk Route To The Acceptance And Re-Implementation Of Bacteriophage Therapy—Part Ii, Wilbert Sybesma, Christine Rohde, Pavol Bardy, Jean Paul Pirnay, Ian Cooper, Jonathan Caplin, Nina Chanishvili, Aidan Coffey, Daniel De Vos, Amber Hartman Scholz, Shawna Mccallin, Hilke Marie Püschner, Roman Pantucek, Rustam Aminov, Jiří Doškař, D. İpek Kurtböke

Department of Biological Sciences Publications

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This perspective paper follows up on earlier communications on bacteriophage therapy that we wrote as a multidisciplinary and intercontinental expert-panel when we first met at a bacteriophage conference hosted by the Eliava Institute in Tbilisi, Georgia in 2015. In the context of a society that is confronted with an ever-increasing number of antibiotic-resistant bacteria, we build on the previously made recommendations and specifically address how the Nagoya Protocol might impact the further development of bacteriophage therapy. By reviewing a number of recently conducted case studies with bacteriophages involving patients with bacterial …


Prevalence And Determinants Of Self-Medication With Antibiotics In High And Low-Income Areas Within Cairo, Shaymaa Mohamed Hassan Jun 2018

Prevalence And Determinants Of Self-Medication With Antibiotics In High And Low-Income Areas Within Cairo, Shaymaa Mohamed Hassan

Theses and Dissertations

Antimicrobial Resistance (AMR) is currently a global threat, and one of the reasons for increasing AMR rates is antibiotics overuse. Antibiotics overuse is not only due to physician prescriptions -although that is also high- but also because of self-medication with antibiotics (SMA). SMA varies across countries and populations depending on multiple factors and among them is the socioeconomic status. Socioeconomic disparities have been linked to SMA rates. In Egypt, namely Cairo, little data is available regarding SMA or surveillance of antibiotic consumption. The aims of this study were to a) estimate and compare the prevalence of SMA in two socioeconomically …


Pharmacokinetics Of A Single Intravenous Injection Of Cefquinome In Rabbits, M.G. El-Sayed,, M.S Amer, S.M El-Nabtity, Sara T. El-Azab Jun 2018

Pharmacokinetics Of A Single Intravenous Injection Of Cefquinome In Rabbits, M.G. El-Sayed,, M.S Amer, S.M El-Nabtity, Sara T. El-Azab

Mansoura Veterinary Medical Journal

The current study was carried out to investigate the pharmacokinetic profile of cefquinome following a single IV injection in ten New Zealand white rabbits (2-2.5 kg body weight). Cefquinome was injected intravenously (2mg/kg body weight) and blood samples were collected before drug administration and up to 24h after injection. Cefquinome plasma concentrations were measured using HPLC (high- performance liquid chromatography). The result showed that the plasma concentration of cefquinome was 9.13 ± 0.43 µg/mL at 5min post injection then declined gradually to 0.73 ± 0.18µg/mL after 2 hours. No cefquinome concentration could be detected at 4h post injection. The major …


Effect Of Cefquinome In Treatment Of Diarrhea In Calves, Mohamed El-Sayed, Mohamed El-Diasty, Doaa Waheed Jun 2018

Effect Of Cefquinome In Treatment Of Diarrhea In Calves, Mohamed El-Sayed, Mohamed El-Diasty, Doaa Waheed

Mansoura Veterinary Medical Journal

This study was conducted by using cefquinome for the treatment of diarrheic calves. 20 diarrheic Holstein calves (3- 15 day old) were used and divided into 2 groups (10 animal / group). The first group was injected intramuscularly by cefquinome (2mg/kg body weight). The second group was served as control . Results revealed a significant increase on total leucocytic count, globulin, aspartate transaminase (AST), Alkaline phosphatase (ALP), urea and creatinine. On the other hand there were a significant decrease in total erythrocytic count, hemoglobin content, packed cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, neutrophil count, thrombocyte count, total …


Perception Of Food Safety Risk From Animal Contact Questionnaire For Extension Audiences, Melissa Cater, Wenqing Xu Jun 2018

Perception Of Food Safety Risk From Animal Contact Questionnaire For Extension Audiences, Melissa Cater, Wenqing Xu

Journal of Extension

Animal contact in public settings for both leisure and work increases the odds of infectious diseases. This circumstance is exacerbated by inadequate understanding of the connection between exposure to animals and food safety risks. The purpose of our research was to develop a survey for assessing adults' perceptions of food safety risk from exposure to animals. Results of our study suggest that the survey has acceptable internal structure and reliability. It may prove useful to Extension professionals who are assessing the need for associated programming or seeking to track progress toward relevant outcomes.


Cold Genocide: Falun Gong In China, Maria Cheung, Torsten Trey, David Matas, Richard An Jun 2018

Cold Genocide: Falun Gong In China, Maria Cheung, Torsten Trey, David Matas, Richard An

Genocide Studies and Prevention: An International Journal

The article explores patterns of a cold genocide in the eradication campaign against Falun Gong. Falun Gong is a spiritual practice that has been targeted for eradication by the Chinese regime since 1999. In comparison to the documented cases of genocide, the genocide of Falun Gong stands out as anomalous because it is virtually ignored. The article seeks to elucidate the multi-faceted nature of this concealed genocide from an interdisciplinary perspective encompassing social work, medicine and law, In particular, the article demonstrates that the eradication campaign against Falun Gong is distinguishable as a cold genocide as it is: (1) multi-dimensional …


Stuff Happens: Understanding Causation In Policy And Strategy, Andrew A. Hill, Stephen J. Gerras Jun 2018

Stuff Happens: Understanding Causation In Policy And Strategy, Andrew A. Hill, Stephen J. Gerras

The US Army War College Quarterly: Parameters

No abstract provided.


Effect Of Imidocarb Dipropionate On Foetal Development In Rats, Magdy S. Amer, Gehan N. Gad, Reham A. El-Shafei, Rasha A. Eltaysh, Fayza M. Abdel-Moaty Jun 2018

Effect Of Imidocarb Dipropionate On Foetal Development In Rats, Magdy S. Amer, Gehan N. Gad, Reham A. El-Shafei, Rasha A. Eltaysh, Fayza M. Abdel-Moaty

Mansoura Veterinary Medical Journal

Imidocarb is widely used in veterinary field as an antiprotozoal agent for the treatment of Babesiosis and Anaplasmosis. from this view, The toxicity of imidocarb was tested in female rat and their foeti. The study was applied on fourty female mature rats which divided into four groups, 1st and 2nd groups were kept as control (injected normal saline intramuscularly on 6th and 10th day of pregnancy respectively), while the third group was injected by imidocarb (0.4 mg/kg b.wt.) on the 6th day of pregnancy , while the fourth group was injected with the therapeutic dose of imidocarb (.4 mg/kg b.wt) …


Significance Of Selected Clinicopathologic Variables In Calves With Bronchopneumonia, Missing Missing Jun 2018

Significance Of Selected Clinicopathologic Variables In Calves With Bronchopneumonia, Missing Missing

Mansoura Veterinary Medical Journal

The present study was delineated to evaluate the significance of using a qualitative cardiac troponin I (cTnI) kits for the diagnosis of cardial injury in calves suffering from bronchopneumonia. A total number of 120 calves were enrolled in this study. Out of these calves, 100 animals exhibited various clinical symptoms of acute (n = 50) and (n= 50) bronchopneumonia, while other 20 apparently healthy calves were selected and served as a control. The concentration of cTnI was quantitatively and qualitatively determined in blood sera using either ELISA kits or a rapid assay with a commercial kit, respectively. Also, blood samples …


Spatiotemporal Distribution Of Waterfowl Disease Outbreaks In Kansas, Usa, Thomas A. Becker, Adam A. Ahlers, Shane Hesting, David A. Haukos Jun 2018

Spatiotemporal Distribution Of Waterfowl Disease Outbreaks In Kansas, Usa, Thomas A. Becker, Adam A. Ahlers, Shane Hesting, David A. Haukos

The Prairie Naturalist

Causes and impacts of disease outbreaks in wild bird populations are rarely studied beyond documentation of large epizootic events. In Kansas, USA, a central disease surveillance and reporting protocol currently does not exist within the Kansas Department of Wildlife, Parks and Tourism, which has led to a lack of available knowledge of disease occurrences that could be used to predict and manage future outbreaks. We compiled historic records of documented waterbird disease outbreaks in Kansas from 1967–2014 and related the frequency of outbreaks with light geese (Ross’s goose [Anser rossii]; Snow goose [A. caerulescens]) populations from 1970–2014. We found 32 …


Absence Of Evidence Or Evidence Of Absence? A Discussion On Paleoepidemiology Of Neoplasms With Contributions From Two Portuguese Human Skeletal Reference Collections (19th–20th Century), Carina Marques, Vítor Matos, Tiago Costa, Albert Zink, Eugénia Cunha Jun 2018

Absence Of Evidence Or Evidence Of Absence? A Discussion On Paleoepidemiology Of Neoplasms With Contributions From Two Portuguese Human Skeletal Reference Collections (19th–20th Century), Carina Marques, Vítor Matos, Tiago Costa, Albert Zink, Eugénia Cunha

Anthropology Faculty Publications

Biological, sociocultural, demographic and environmental factors are major contributors to the contemporary burden of oncological diseases. Although cancer’s current epidemiological landscape is fairly well known, its past occurrence and history seem more obscure. In order to test the hypothesis that paleopathological diagnosis is an adequate measure of the prevalence of malignant neoplasms in human remains, 131 skeletons (78 females, 53 males, age-at-death range: 15–93 years) from Coimbra and Lisbon Identified Skeletal Collections, 19th/20th century (Portugal), were examined. The cause of death for all of the selected skeletons was a malignant neoplasm, as recorded in the collection’s documental files. Through the …


Absence Of Evidence Or Evidence Of Absence? A Discussion On Paleoepidemiology Of Neoplasms With Contributions From Two Portuguese Human Skeletal Reference Collections (19th–20th Century), Carina Marques, Vítor Matos, Tiago Costa, Albert Zink, Eugénia Cunha Jun 2018

Absence Of Evidence Or Evidence Of Absence? A Discussion On Paleoepidemiology Of Neoplasms With Contributions From Two Portuguese Human Skeletal Reference Collections (19th–20th Century), Carina Marques, Vítor Matos, Tiago Costa, Albert Zink, Eugénia Cunha

Anthropology Faculty Publications

Biological, sociocultural, demographic and environmental factors are major contributors to the contemporary burden of oncological diseases. Although cancer’s current epidemiological landscape is fairly well known, its past occurrence and history seem more obscure. In order to test the hypothesis that paleopathological diagnosis is an adequate measure of the prevalence of malignant neoplasms in human remains, 131 skeletons (78 females, 53 males, age-at-death range: 15–93 years) from Coimbra and Lisbon Identified Skeletal Collections, 19th/20th century (Portugal), were examined. The cause of death for all of the selected skeletons was a malignant neoplasm, as recorded in the collection’s documental files. Through the …


Development Of Affinity Monoliths In 3d Printed Microfluidic Devices For Extraction Of Preterm Birth Biomarkers, Ellen Kelsey Parker Jun 2018

Development Of Affinity Monoliths In 3d Printed Microfluidic Devices For Extraction Of Preterm Birth Biomarkers, Ellen Kelsey Parker

Theses and Dissertations

Preterm birth (PTB) is defined as birth before the 37th week of pregnancy and affects 15 million infants per year. Presently, there is no clinical test to determine PTB risk. A 3D printed microfluidic device is being developed as a clinical test for PTB risk via detection of a panel of biomarkers. A significant step is extraction of the PTB biomarkers from blood serum. In this work, I developed 3D printed microfluidic devices in which monoliths can be polymerized. Using the monolith as a solid support to attach antibody, I show that ferritin, one of the PTB biomarkers, can be …


Inflammation And Immune Evasion Coexist In Treponema Pallidum-Infected Skin, Rodolfo Trujillo, Jorge Cervantes, Kelly L. Hawley, Adriana R. Cruz, Sankhiros Babapoor, Michael Murphy, Soheil S. Dadras, Juan C. Salazar Jun 2018

Inflammation And Immune Evasion Coexist In Treponema Pallidum-Infected Skin, Rodolfo Trujillo, Jorge Cervantes, Kelly L. Hawley, Adriana R. Cruz, Sankhiros Babapoor, Michael Murphy, Soheil S. Dadras, Juan C. Salazar

Biology Faculty Publications

Syphilis is a systemic, multistage, sexually transmitted infection caused by the highly invasive spirochetal bacterium, Treponema pallidum, subspecies pallidum. In the United States, the annual rate of primary and secondary syphilis (SS) between 2002 and 2016 has increased from 2.1 to 8.7 cases per 100,000.1 Gestational and congenital syphilis cases have also increased in the last few years. There is no evidence of a change in T pallidum susceptibility to penicillin as an explanation for the significant increase in the number of syphilis cases in the United States. It is more likely that changes in risk-taking behavior in …