Digital Commons Network^™

Application Of Quality Of Experience In Networked Services: Review, Trend & Perspectives, Asif Ali Laghari, Hui He, Muhammad Shafiq, Asiya Khan

School of Engineering, Computing and Mathematics

No abstract provided.

Living Inside The Box: Environmental Effects On Mouse Models Of Human Disease., John P Sundberg, Paul N Schofield

Faculty Research 2018

The impact of the laboratory environment on animal models of human disease, particularly the mouse, has recently come under intense scrutiny regarding both the reproducibility of such environments and their ability to accurately recapitulate elements of human environmental conditions. One common objection to the use of mice in highly controlled facilities is that humans live in much more diverse and stressful environments, which affects the expression and characteristics of disease phenotypes. In this Special Article, we review some of the known effects of the laboratory environment on mouse phenotypes and compare them with environmental effects on humans that modify phenotypes …

Niccolo Leo Caldararo, Big Brains And The Human Superorganism: Why Special Brains Appear In Hominids And Other Social Animals. Rowman & Littlefield, 2017, Andrew Targowski

Comparative Civilizations Review

No abstract provided.

Paper Promises For Drug Innovation, Erika Lietzan

Faculty Publications

Innovation does not stop when a new medicine is launched. Development of new uses for already approved drugs, in particular, can make profound contributions to the public health. Whether a new use is suspected during the initial premarket trials, identified through focused research after approval, or discovered serendipitously by physicians treating patients, however, it requires extensive clinical testing before it can be approved by FDA. This testing takes time and money — three to five years on average, and as much as $300 million. This Article considers the incentives that federal law offers to companies to make this investment: patent …

Harald Von Beckh, Pioneer Of Microgravity Medical Research, Pablo De Leon

Space Studies Faculty Publications

Harald Von Beckh was born in Vienna, Austria, on November 17, 1917. He graduated as a Doctor of Medicine from the Vienna University Faculty of Medicine in 1940. He began working at the Academy of Aviation Medicine in Berlin where he helped in the development of the concept of the Keplerian trajectory to obtain periods of microgravity while collaborating with Dr. Heinz von Diringshofen. In 1941 he was appointed as a faculty member at the Academy of Medicine of the Luftwaffe.

At the end of the war, without any possibility to continue his research in Germany, Von Beckh made contacts …

Introduction, Shari S. Diamond, Richard O. Lempert

Articles

Experts bedeviled the legal system long before seventeenth-century Salem, when the town's good citizens relied on youthful accusers and witchcraft experts to identify the devil's servants in their midst. As in Salem, claims of expertise have often been questioned and objections raised about the bases of expert knowledge. Expertise, then and now, did not have to be based on science; but the importance of science and the testimony of scientific experts has since medieval times been woven into the fabric of the English jurisprudence that Americans inherited. In cases as long ago as 1299 we find examples of courts seeking …

Learning Opportunities 2018/2019, Illinois Mathematics And Science Academy

Course Catalogs

The graduation requirements of the Illinois Mathematics and Science Academy are established by the IMSA Board of Trustees. Each semester students must take a minimum of five academic courses (2.5 credits) for a letter grade (not Pass/Fail) not including Fine Arts, Wellness, and Independent Study courses. Students may enroll in a maximum of nine courses each semester including academic courses, Fine Arts, Wellness, SIR, and Independent Study. Only courses taken for a letter grade will count towards graduation credit.

Semi-Permeable Membrane Experiment For Unsaturated Liquid Permeability Of Building Materials: Potential And Practice, Chi Feng, Hans Janssen

International Building Physics Conference 2018

The unsaturated liquid permeability is a crucial hygric property of porous building materials. Its direct measurement is very challenging however, because currently available experimental protocols are either demanding in test facilities, complicated in data processing, or limited in moisture content range. Inspired by the osmosis phenomenon, we study the possibility to apply semi-permeable membranes for directly measuring the liquid permeability of porous building materials. The key principle is studied profoundly and a simple experimental set-up is constructed. Trial tests on calcium silicate insulation and autoclaved aerated concrete are performed. Results show that the experimental set-up can be used to measure …

Passive Survivability In Residential Buildings During Heat Waves Under Dynamic Exterior Conditions, Timothy Aduralere, Jacqueline Isaacs, David Fannon

International Building Physics Conference 2018

The increased frequency of heat waves around the world has prompted numerous studies to improve building resilience and maintain thermal comfort in the face of extreme conditions. However, previous studies rely on the assumption of steady-state conditions, including external temperature, which limits real-world applicability, demanding a more practical perspective. This paper presents the use of recorded heat wave temperatures for a specified location to simulate the effect of extreme temperatures on the interior temperature of buildings when air conditioning is not used. The objective of this study is to determine how a building becomes uninhabitable during extreme heat and to …

Comparison Of Thermally Actuated Retro-Diels-Alder Release Groups For Nanoparticle Based Nucleic Acid Delivery, Mohammad Abu-Laban, Raju R. Kumal, Jonathan Casey, Jeff Becca, Daniel Lamaster, Carlos N. Pacheco, Dan G. Sykes, Lasse Jensen, Louis H. Haber, Daniel J. Hayes

Faculty Publications

© 2018 Elsevier Inc. The present study explores alternate pericyclic chemistries for tethering amine-terminal biomolecules onto silver nanoparticles. Employing the versatile tool of the retro-Diels-Alder (rDA) reaction, three thermally-labile cycloadducts are constructed that cleave at variable temperature ranges. While the reaction between furan and maleimide has widely been reported, the current study also evaluates the reverse reaction kinetics between thiophene-maleimide, and pyrrole-maleimide cycloadducts. Density Functional Theorem (DFT) calculations used to model and plan the experiments, predict energy barriers for the thiophene-maleimide reverse reaction to be greatest, and the pyrrole-maleimide barriers the lowest. Based on the computational analyses, it is projected …

Graduate Athletic Training Education Program Newsletter, Fall 2018, University Of Arkansas, Fayetteville. Athletic Training Education Program

Athletic Training Education Newsletter

No abstract provided.

Bioh 463.01: Tutoring Human Anatomy And Physiology For Health Professions I (Honors), Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Parental Hormones Are Associated With Crop Loss And Family Sickness Following Catastrophic Flooding In Lowland Bolivia, Benjamin C. Trumble, Jonathan Stieglitz, Adrian Jaeggi, Bret Beheim, Matthew Schwartz, Edmond Seabright, Daniel Cummings, Hillard Kaplan, Michael Gurven

ESI Publications

The physiology of fatherhood is a growing field of study, and variability in hormonal mediators of reproductive effort (e.g. testosterone, cortisol) can predict variability in paternal investment. Studies often find that lower testosterone levels are associated with increased paternal investment, though most studies are conducted under relatively stable ecological conditions. In this paper, we examine parental physiological correlates of crop loss and family health problems among Tsimane forager-horticulturalists following a catastrophic flood in lowland Bolivia. Immediately after a devastating 2014 flood that impacted >75% of Tsimane communities, we conducted structured interviews examining crop losses and morbidity, and collected saliva specimens …

Comparison Of Laws And Regulations Concerning Human Factors In Maritime Accident, Yifang Xu

World Maritime University Dissertations

No abstract provided.

Quality Of Experience Framework For Cloud Computing (Qoc), A Laghari, H He, Ai Khan, N Kumar, R Kharel

School of Engineering, Computing and Mathematics

No abstract provided.

Controlling The Oxygen Microenvironment: The Role Of Hif-1Α In Early Tumor Progression, Sandra Lam

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cancer drug efficacy has remained a critical obstacle for researchers as it has one of the lowest probabilities of success compared to other diseases. One method to help improve this success rate is to create better tumor models on which to perform the drug testing. With growing interesting in microphysiological systems, scientists can create more advanced in vitro models of human organ systems as well as diseased states. These “organ-on-a-chip” platforms aim to improve drug response prediction for both efficacy and toxicity. One underappreciated characteristic of many disease states is that they are often at a lower oxygen tension that …

Louisiana Urban And Suburban Homeowners’ Fertilizer Management Behavioral Beliefs, Intentions, And Past Behaviors, Natalie Levy

LSU Doctoral Dissertations

Nutrient runoff of nitrogen and phosphorus from improper lawn and landscape fertilization practices contributes to water quality issues within the Mississippi River drainage basin and the Northern Gulf of Mexico (NRC, 2009a; Robbins & Birkenholtz, 2003). The implementation of fertilizer best management practices has become a critical strategy for reducing nutrient runoff (Carey et al., 2012a; Carey et al., 2013; U.S. EPA, 2005). The purpose of this study was to determine if relationships exist among selected perceptual measures regarding home lawn and landscape fertilizer management practices among Louisiana urban and suburban homeowners. Ajzen’s (1991) Theory of Planned Behavior (TPB) was …

Aboloshing 21st Century Enslavement: Capitalism's Pattern Of Labor Abuse During Economic Shifts And Restructuring (1840-Present), A Thematic Paper For The “Politics Of Getting Labor To Support The Abolition Of Capitalism” Session, R. K. Piper, Minshuai Ding

Past Publications

This paper re-examines and updates a controversial historical economic analysis, presented almost 45 years ago by Robert William Fogel1 and Stanley L. Engerman in their “Time on the Cross: The Economics of American Negro Slavery (1974).” The authors purported their work has two main objectives: 1) to revise an erroneous, “traditional” characterization of the slave economy and myths about black slaves themselves and 2) to apply rapid advances in economics, quantitative statistics, applied mathematics and the availability of high-speed computers to analyze large data sets, to re-examine and better understand the institution of slavery.

Design And Synthesis Of Circadian Clock Modulators And The Study Of Lov Domain Protein Lkp2 In Arabidosis Thaliana And Brassica Rapa, Aditi Nagar

Chemistry Theses and Dissertations

Circadian rhythms are self-autonomous endogenous clocks synchronized with the rotation of the Earth. With the Earth’s rotation and revolution on its axis, the internal clock undergoes oscillation in the period of ~24 hour and governs day to day activities in most organisms. In humans, it regulates the day to day physiological activities. Today’s modern lifestyle has an impact on health: shift work, jet lag, and irregular eating habits contribute to the misalignment of the endogenous circadian oscillator, thereby, increasing the risk of many metabolic disorders including diabetes, irregular blood pressure, sleep disorders, obesity, depression, and cancer. The primary goal of …

Relational Identities And Other-Than-Human Agency In Archaeology, Eleanor Harrison-Buck, Julia A. Hendon

Gettysburg College Faculty Books

Relational Identities and Other-than-Human Agency in Archaeology explores the benefits and consequences of archaeological theorizing on and interpretation of the social agency of nonhumans as relational beings capable of producing change in the world. The volume cross-examines traditional understanding of agency and personhood, presenting a globally diverse set of case studies that cover a range of cultural, geographical, and historical contexts.

Agency (the ability to act) and personhood (the reciprocal qualities of relational beings) have traditionally been strictly assigned to humans. In case studies from Ghana to Australia to the British Isles and Mesoamerica, contributors to this volume demonstrate that …

The Effect Of Midsole Cushioning On The Kinetics, Kinematics, And Control Of Running, Brian Joseph Prejean

Kinesiology Dissertations - Archive

The incidence of musculoskeletal injuries associated with the stress of running, known as running-related injuries (RRIs), has risen in conjunction with the resurgence of running as a health-related physical activity approximately half a century ago, with some reports giving an annual prevalence as high as 79% of practitioners surveyed. Running shoes with increased amounts of midsole cushioning have been promoted to reduce the risk of sustaining RRIs by absorbing some of the high magnitude and frequency ground reaction forces (GRFs) imposed on the leg with every stride. However, individual variability, as well as the ability of the motor system to …

Early Turn-Taking Prediction For Human Robot Collaboration, Tian Zhou

Open Access Dissertations

To enable natural and fluent human robot collaboration, it is critical for a robot to comprehend their human partners’ on-going actions, predict their behaviors in the near future, and plan its actions accordingly. Specifically, the capability of making early predictions can allow robots to determine the precise timing of turn-taking events and start planning and executing preparative tasks to take the turn. Such proactive behavior would save waiting time and increase efficiency and naturalness in collaborative tasks.

To that end, this dissertation presents the design and implementation of an early turn-taking prediction framework, centered around physical human robot collaboration tasks. …

Stretching Vascular Smooth Muscle Cells On Micropatterned Surfaces, Suzanne Nicole Bradley

All Theses

Vascular smooth muscle cells regulate blood flow by contracting and relaxing blood vessels. Vascular smooth muscle cells display one of two distinct phenotypes: contractile or synthetic. The contractile phenotype enables cells to contract, and the majority of cells in healthy blood vessels exhibit this phenotype. Transition to the synthetic phenotype is associated with abnormal mechanical forces and the development of vascular diseases, including hypertension and atherosclerosis. Cell-extracellular matrix interactions and mechanical stimulation are factors that affect phenotypic modulation. Micropatterning techniques create a microenvironment used to control cell morphology, adhesion, migration, proliferation, and differentiation. Vascular smooth muscle cells are circumferentially arranged …

Advancing Risk Assessment: Mechanistic Dose-Response Modelling Of Listeria Monocytogenes Infection In Human Populations, Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu

Mathematics and Statistics Faculty Publications

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. The utility of characterizing the effects of strain variation and individual/subgroup susceptibility on dose-response outcomes has motivated the search for new approaches beyond the popular use of the exponential dose-response model for listeriosis. While descriptive models can account for such variation, they have limited power to extrapolate beyond the details of particular outbreaks. By contrast, this study exhibits dose-response relationships from a mechanistic basis, quantifying key biological factors involved in pathogen-host dynamics. An …

Comparison Of Muscle Physiology And Performance Outcomes From Either Relative Intensity Or Repetition Maximum Training, Kevin Carroll

Electronic Theses and Dissertations

The main purpose of this dissertation was to compare performance and physiological outcomes of between a repetition maximum (RM) and a relative intensity using sets-and-repetitions (RI_SR) resistance training (RT) program in well-trained lifters. Fifteen subjects underwent RT 3 d·wk^-1 for 10-weeks in either a RM group (n=8) or RI_SR group (n=7). The RM group achieved a relative maximum each day while the RI_SR group trained based on percentages. Testing included percutaneous needle biopsies of the vastus lateralis, ultrasonography, unweighted (g to assess within and between-group alterations. RI_SR from pre-to-post yielded statistically significant increases in …

Evidence For A Perceptual Recalibration Of Self-Control During Thermal Stress, Drew Michael Morris

All Dissertations

Introduction: Stress can negatively affect conscientiousness, decision making, behavior inhibition, and other examples of self-control. Environmental cold stress has been shown to curtail various aspects of cognitive performance, however the extent to which thermal stress may impact general measures of self-control is unknown. The purpose of the current dissertation is to understand how cold stress impacts executive functioning based self-control, the delay of gratification, state self-report self-control, and performance persistency; and whether variability in self-control failure can be predicted. Method: The current research explores the relationship between thermal stress and self-control across two studies. Cold stress was manipulated using cooling …

Effects Of Serving Temperature On Sensory Perception And Acceptance Of Brewed Coffee, Matthew James Chapko

Graduate Theses and Dissertations

Coffee continues to be one of the most widely consumed beverages worldwide. How an individual perceives a cup of coffee is impacted by a plethora of factors including origin, growing climate, roasting level, and consumption habits. This thesis utilized both trained descriptive panelists and untrained consumer panelists to analyze how serving/consumption temperature modulates sensory perception of brewed coffee in regards to appearance, aroma, flavor, taste, and mouthfeel. Three varieties of coffee (Colombia, Ethiopia, and Kenya) were brewed and served to panelists at four temperatures: 70, 55, 40, and 25 °C. In one study (Study 1, Chapter 3), results from descriptive …

Chelation Therapy To Prevent Diabetes-Associated Cardiovascular Events, Denisse Diaz, Vivian Fonseca, Y. Wady Aude, Gervasio A. Lamas

School of Medicine Publications

Purpose of review

For over 60 years, chelation therapy with disodium ethylene diamine tetraacetic acid (EDTA, edetate) had been used for the treatment of cardiovascular disease (CVD) despite lack of scientific evidence for efficacy and safety. The Trial to Assess Chelation Therapy (TACT) was developed and received funding from the National Institutes of Health (NIH) to ascertain the safety and efficacy of chelation therapy in patients with CVD.

Recent findings

This pivotal trial demonstrated an improvement in outcomes in postmyocardial infarction (MI) patients. Interestingly, it also showed a particularly large reduction in CVD events and all-cause mortality in the prespecified …

Investigation Of Spinal Cord Injury-Induced Gastrointestinal Dysfunction And Related Microbiota, Fungal, And Intestinal Alterations In A Rat Model And Humans With Spinal Cord Injury, Elisabeth Sarah Jeffrey

Open Access Theses

Spinal cord injury (SCI) is a serious medical condition that can result in a spectrum of neurological impairments and physical disabilities. There is an average of 11-12,000 new injuries per year in the US alone, and no cure for either the paralysis, or other secondary effects. Although there have been significant strides made in the research of the pathophysiology of Spinal Cord Injury (SCI), there is still limited knowledge on the consequences of SCI in remote organs. SCI produces significant effects on the entire body including the gastrointestinal tract. Individuals with SCI often experience severe, debilitating bowel dysfunction in addition …

The Iceman's Last Meal Consisted Of Fat, Wild Meat, And Cereals., Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, Albert Zink

Articles, Abstracts, and Reports

The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter-gatherer lifestyle to agriculture in Neolithic Europe [1], very little information exists on the daily dietary habits of our ancestors. By undertaking a complementary -omics approach combined with microscopy, we analyzed the stomach content of the Iceman, a 5,300-year-old European glacier mummy [2, 3]. He seems to have had a remarkably high proportion of fat in his diet, supplemented with fresh or dried wild meat, cereals, and …