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Articles 6781 - 6810 of 62346
Full-Text Articles in Entire DC Network
Due Process, Free Expression, And The Administrative State, Martin H. Redish, Kristin Mccall
Due Process, Free Expression, And The Administrative State, Martin H. Redish, Kristin Mccall
Notre Dame Law Review
The first Part of this Article will explore the theoretical foundations of procedural due process, focusing particularly on the essential due process requirement of a neutral adjudicator. We will follow that discussion with an analysis of the extent to which administrative adjudication of constitutional challenges to its regulatory authority or decisions satisfies the demands of procedural due process. After concluding that administrative regulators categorically fail to satisfy the requirements of due process, at least in the context of constitutional challenges to their regulatory authority, we will explain why the availability of post–administrative judicial review cannot cure the constitutional defect in …
Cell Specific Control Of The Pallidostriatal Pathway, Shubha Verma '19
Cell Specific Control Of The Pallidostriatal Pathway, Shubha Verma '19
Student Publications & Research
Parkinson’s Disease is a neurodegenerative disorder of the basal ganglia. The main cause for Parkinson’s Disease is the depletion of dopamine, a neurotransmitter. The basal ganglia contains four major nuclei: the substantia nigra, the subthalamic nucleus, the external globus pallidus, and the striatum. These nuclei communicate with each other by the use of neurons.
Classification Of Intensity-Modulated Proton Therapy Plans, Louise Gabrielle Lima '19, Alice Liu '19
Classification Of Intensity-Modulated Proton Therapy Plans, Louise Gabrielle Lima '19, Alice Liu '19
Student Publications & Research
Proton Radiotherapy
Proton radiotherapy is a form of radiation treatment that uses energized protons to break DNA, leading to cell death and killing cancers.
How American Protest Music Has Changed: A Study On The Lives And Music Of Billie Holiday, Nina Simone And Janelle Monae: An Annotated Bibliography, Amy Feeney
Musicology and Ethnomusicology: Student Scholarship
American protest music has been a prominent and acknowledged art form since the 1930’s and has affected many artists both positively and negatively. I aim to examine what about protest music and society’s consumption of it has changed, for better or worse, over the course of its existence. To do so, I will be looking at the lives and works of 3 women who were actively involved in music of protest spanning the existence of the genre, Billie Holiday, Nina Simone and Janelle Monae.
The Effects Of Incorporating Music Into Daily Life On Cognitive Decline, Devlin Deveney
The Effects Of Incorporating Music Into Daily Life On Cognitive Decline, Devlin Deveney
Musicology and Ethnomusicology: Student Scholarship
Dementia currently affects over 35 million people worldwide – a number that is expected to triple by the year 2050 according to the report, “Dementia: a public health priority” by World Health Organization and Alzheimer’s Disease International. Despite the high population of people with dementia, there are currently no cures for the diseases within this category. The aim of this article is to explore the cognitive effects of incorporating music into daily life prior to the onset of dementia and determining whether or not these effects have an impact on age-related cognitive decline. It is hoped that this paper will …
From Gig Economy To Gig Education, Olga Kosheleva, Julian Viera Jr., Vladik Kreinovich
From Gig Economy To Gig Education, Olga Kosheleva, Julian Viera Jr., Vladik Kreinovich
Departmental Technical Reports (CS)
Modern economy has benefited from gig economy idea, where, instead of hiring permanent employees, a company assigns each task to the person who is the most efficient in performing this task. This way, each task is performed in the best possible way -- by a person who is the most suited for this job. Why not extend this idea to education? Every student deserves the best possible teacher in every topic. So why not have a teacher who is the best in town in explaining quadratic equations teach quadratic equations to all the students from the town? In this paper, …
Persistent Social-Emotional Symptoms Following A Concussion: Recommendations For School Psychology Practice, Susan C. Davies, Elana R. Bernstein
Persistent Social-Emotional Symptoms Following A Concussion: Recommendations For School Psychology Practice, Susan C. Davies, Elana R. Bernstein
Counselor Education and Human Services Faculty Publications
Concussions can result in a constellation of physical, cognitive, and social– emotional symptoms, most of which resolve within 1 to 2 weeks following the injury. In some instances, social–emotional difficulties following concussion persist, causing ongoing distress and psychosocial impairments. It is important that school psychologists understand the nature of these symptoms, as well as ways in which they can support students who are recovering from concussions. As part of a collaborative concussion team, school psychologists can provide valuable insight into the complex interaction of symptoms that may present following a concussion. This article summarizes the existing literature on persistent social–emotional …
Surgical Management Of Metastatic Lesions Of Proximal Femur And The Hip, Mujahid Jamil Khattak, Umair Ashraf, Zohaib Nawaz, Shahryar Noordin, Masood Umer
Surgical Management Of Metastatic Lesions Of Proximal Femur And The Hip, Mujahid Jamil Khattak, Umair Ashraf, Zohaib Nawaz, Shahryar Noordin, Masood Umer
Section of Orthopaedic Surgery
Metastatic bony lesions involving proximal femur and hip joint pose a challenge to orthopedic surgeons. Lesions in this important weight-bearing zone of the femur weaken its ability to sustain load causing pain and impending pathologic fracture. These Patients warrant multidisciplinary approach including orthopedic surgeons, oncologist and medical specialties. Management of these lesions has evolved over the last 60 years from benign neglect to internal fixation and recently to prosthetic reconstruction for optimum function. Decision for surgical approach requires consideration for location of the lesion, presence of a fracture, tumor type, cortical destruction, patient's life expectancy, patient preferences and the expected …
Ankle Arthrodesis Using Ilizarov Ring Fixator: A Primary Or Salvage Procedure?: An Analysis Of Twenty Cases, Obada Hasan, Shah Fahad, S. Sattar, Masood Umer, Haroon Rashid
Ankle Arthrodesis Using Ilizarov Ring Fixator: A Primary Or Salvage Procedure?: An Analysis Of Twenty Cases, Obada Hasan, Shah Fahad, S. Sattar, Masood Umer, Haroon Rashid
Section of Orthopaedic Surgery
Introduction: Ankle arthrodesis using the Ilizarov technique provides high union rate with the added benefits of early weight-bearing, and the unique advantage of its ability to promote regeneration of soft tissue around the bone, including skin, muscle and neuro-vascular structures, and its versatility to allow correction of the position of the foot by adjusting the frame post-operatively as needed. We describe our experience with this technique and the functional outcomes in our patients.
Materials and Methods: This retrospective study was conducted in 20 ankle fusion cases using the Ilizarov method between the years 2007 and 2017. We defined success in …
Radiological And Clinical Outcomes In Patients Undergoing Anterior Cervical Discectomy And Fusion: Comparing Titanium And Peek (Polyetheretherketone) Cages, Muhammad Junaid, Mamoon Ur Rashid, Syed Sarmad Bukhari, Mamoon Ahmed
Radiological And Clinical Outcomes In Patients Undergoing Anterior Cervical Discectomy And Fusion: Comparing Titanium And Peek (Polyetheretherketone) Cages, Muhammad Junaid, Mamoon Ur Rashid, Syed Sarmad Bukhari, Mamoon Ahmed
Section of Neurosurgery
Objectives: To study clinical and radiological outcomes in patients who had undergone the procedure of anterior cervical discectomy and fusion with titanium or PEEK (polyetheretherketone) cages for cervical disc prolapse.
Methods: This is a retrospective/non-randomized study which was conducted at the Combined Military Hospital Peshawar. Study interval was four years from 1st October, 2010 to 31st September, 2014. Total number of included patients were 149. All of the patients had undergone the procedure of anterior cervical discectomy and fusion with titanium or PEEK (polyetheretherketone) cages. All of the patients had plain MRI cervical spine done for diagnosis of anterior cervical …
Tumour Treating Fields (Ttfs) For Paediatric Brain Tumours, Brain Metastases And Other Novel Applications, Farhan Arshad Mirza, Muhammad Shahzad Shamim
Tumour Treating Fields (Ttfs) For Paediatric Brain Tumours, Brain Metastases And Other Novel Applications, Farhan Arshad Mirza, Muhammad Shahzad Shamim
Section of Neurosurgery
Tumour treating fields (TTFs) are now FDA approved for high grade glioma treatment. Novel application of this treatment modality is being assessed for paediatric brain tumours and intracranial metastatic disease. Clinical trials are being conducted to test the efficacy of this treatment modality as adjuvant therapy to current standard of care. Here we will discuss the existing literature on TTF its role in pathologies other than GBM. In addition, aspects of safety, compliance and cost are also discussed.
Competence In Endoscopic Ultrasound And Endoscopic Retrograde Cholangiopancreatography, From Training Through Independent Practice, Sachin Wani, Rajesh N. Keswani, Samuel Han, Eva M. Aagaard, Matthew Hall, Violette Simon, Wasif M. Abidi, Subhas Banerjee, Todd H. Baron, Michael Bartel, Erik Bowman, Brian C. Brauer, Jonathan M. Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A. Coté, Koushik K. Das, Christopher J. Dimaio, Andrew M. Dries, Steven A. Edmundowicz, Abdul H. El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S. Gan, Lisa M. Gangarosa, Bhargava Gannavarapu, Stuart R. Gordon, Nalini M. Guda, Hazem T. Hammad, Cynthia Harris, Sujai Jalaj, Paul S. Jowell, Sana Kenshil, Jason Klapman, Michael L. Kochman, Srinadh Komanduri, Gabriel Lang, Linda S. Lee, David E. Loren, Frank J. Lukens, Daniel Mullady, V. Raman Muthusamy, Andrew S. Nett, Mojtaba S. Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M. Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M. Scheiman, Isaiah Schuster, Raj J. Shah, Rishi Sharma, Joshua P. Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H. Tabibian, Demetrios Tzimas, Dushant S. Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y. Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Dayna Early
Competence In Endoscopic Ultrasound And Endoscopic Retrograde Cholangiopancreatography, From Training Through Independent Practice, Sachin Wani, Rajesh N. Keswani, Samuel Han, Eva M. Aagaard, Matthew Hall, Violette Simon, Wasif M. Abidi, Subhas Banerjee, Todd H. Baron, Michael Bartel, Erik Bowman, Brian C. Brauer, Jonathan M. Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A. Coté, Koushik K. Das, Christopher J. Dimaio, Andrew M. Dries, Steven A. Edmundowicz, Abdul H. El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S. Gan, Lisa M. Gangarosa, Bhargava Gannavarapu, Stuart R. Gordon, Nalini M. Guda, Hazem T. Hammad, Cynthia Harris, Sujai Jalaj, Paul S. Jowell, Sana Kenshil, Jason Klapman, Michael L. Kochman, Srinadh Komanduri, Gabriel Lang, Linda S. Lee, David E. Loren, Frank J. Lukens, Daniel Mullady, V. Raman Muthusamy, Andrew S. Nett, Mojtaba S. Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M. Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M. Scheiman, Isaiah Schuster, Raj J. Shah, Rishi Sharma, Joshua P. Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H. Tabibian, Demetrios Tzimas, Dushant S. Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y. Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Dayna Early
Gastroenterology Articles
BACKGROUND & AIMS: It is unclear whether participation in competency-based fellowship programs for endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) results in high-quality care in independent practice. We measured quality indicator (QI) adherence during the first year of independent practice among physicians who completed endoscopic training with a systematic assessment of competence.
METHODS: We performed a prospective multicenter cohort study of invited participants from 62 training programs. In phase 1, 24 advanced endoscopy trainees (AETs), from 20 programs, were assessed using a validated competence assessment tool. We used a comprehensive data collection and reporting system to create learning curves …
Neuroscientist Featured Speaker In Cibbr Seminar Series, Unh Communications And Public Affairs
Neuroscientist Featured Speaker In Cibbr Seminar Series, Unh Communications And Public Affairs
UNH Today Archive
No abstract provided.
Fluctuating Fishing Intensities And Climate Dynamics Reorganize The Gulf Of Mexico's Fisheries Resources, Joshua P. Kilborn, Michael Drexler, David L. Jones
Fluctuating Fishing Intensities And Climate Dynamics Reorganize The Gulf Of Mexico's Fisheries Resources, Joshua P. Kilborn, Michael Drexler, David L. Jones
Marine Science Faculty Publications
Integrated ecosystem assessment provides a practical framework for implementing ecosystem‐based fisheries management (EBFM) while also balancing socioeconomic and ecological objectives. However, significant challenges remain, including (1) the identification of relevant ecosystem‐level fisheries management indicators; (2) quantitatively describing the historical qualitative changes to fisheries ecosystem resource organization; (3) elucidating dynamic system regimes and their trade‐offs related to variability in both natural and anthropogenic drivers; and (4) distilling and communicating the results to stakeholders and managers. Here, we describe the Ecosystem‐Level, Management‐Indicator Selection Tool (EL‐MIST), which was developed to address these EBFM challenges. We also present a case study from the Gulf …
Meridians 17:2 Cartographies For The Twenty-First Century, Ginetta Candelario
Meridians 17:2 Cartographies For The Twenty-First Century, Ginetta Candelario
Meridians: Feminism, Race, Transnationalism
The first African feminist I ever met was Wambui Mwangi, my 1990 classmate at Smith College. It was the spring of 1988, at the Mwangi Cultural Center, where all the heads of student of color organizations on campus had gathered together to discuss and strategize our response to yet another instance of institutional racism at Smith....
The Banner - V. 153, No. 10 - (November 2018), Christian Reformed Church In North America
The Banner - V. 153, No. 10 - (November 2018), Christian Reformed Church In North America
The Banner
No abstract provided.
The Effect Of Spice Powder On Blood Glucose, Lipid Profile And Body Composition In Adults At Risk Of Cardiovascular Disease: A Controlled, Randomized, Single-Blind, Parallel-Design Study, Dana Hasan Mustafa Alkhatib
The Effect Of Spice Powder On Blood Glucose, Lipid Profile And Body Composition In Adults At Risk Of Cardiovascular Disease: A Controlled, Randomized, Single-Blind, Parallel-Design Study, Dana Hasan Mustafa Alkhatib
Philosophy Dissertations
A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus have become known as the Metabolic Syndrome (MetS). In the United Arab Emirates, 42% of the population was diagnosed with MetS. Previous researchers observed the anti-diabetic, hypolipidemic anti-oxidative, anti-inflammatory and antiantitumorigenic properties of spices on body composition, blood parameters and blood pressure. The aim of the study was to assess the macronutrient, micronutrient, sugar and caffeine content for seven commonly consumed spices. Moreover, the aim of the study was to measure the effect of ginger (Zingiber officinale), cinnamon (Cinnamomum) and black seed (Nigella sativa) consumption on …
Not Just An Ache: Examining The Rate Of Musculoskeletal Pain In City Bus Drivers, Jeremy Steele
Not Just An Ache: Examining The Rate Of Musculoskeletal Pain In City Bus Drivers, Jeremy Steele
Mineta Transportation Institute
This paper examines the rates of musculoskeletal discomfort in a sample of 957 city bus drivers at King County Metro, a public transportation agency serving the greater Seattle area. It also examines how often such pain prevented drivers from doing their normal work, needed treatment from a medical professional, or incited one or more worker’s compensation claims. To assess the level of musculoskeletal discomfort in city bus drivers, an anonymous survey was distributed to drivers at King County Metro, a public transportation agency serving the greater Seattle area. This survey consisted of a Nordic Questionnaire asking drivers whether or not …
Health & Kinesiology News, Georgia Southern University
Health & Kinesiology News, Georgia Southern University
Health Sciences & Kinesiology: News & Publications (2015-2023)
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Wilson Serves as Guest Speaker for USA Basketball
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Georgia Southern Named One of the Most Affordable Sport Management Master’s Degrees
Mentorship In Medicine And Nephrology: More Important Than Ever, Belinda Jim, Jerry Yee
Mentorship In Medicine And Nephrology: More Important Than Ever, Belinda Jim, Jerry Yee
Nephrology Articles
Mentorship has always been important in medicine. In fact, one can argue that that is how doctors are trained. Moreover, mentorship has been proven to preserve and elevate those who wish to pursue academic medicine. In nephrology, mentorship has become paramount, as interest in the field has declined during this decade. In this article, we will delineate how mentorship impacts physician careers, describe different types of mentors and their characteristics, and summarize responsibilities of mentors and mentees. We will discuss specific challenges in nephrology and the steps that have been taken to address them via mentorship. We conclude that mentorship …
Leadership As Tribal Leader, Jerry Yee
Population And Fertility By Age And Sex For 195 Countries And Territories, 1950–2017: A Systematic Analysis For The Global Burden Of Disease Study 2017, Christopher J.L. Murray, Charlton S.K.H. Callender, Xie Rachel Kulikoff, Vinay Srinivasan, Degu Abate, Kalkidan Hassen Abate, Solomon M. Abay, Nooshin Abbasi, Hedayat Abbastabar, Jemal Abdela, Ahmed Abdelalim, Omar Abdel-Rahman, Alireza Abdi, Nasrin Abdoli, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Haftom Temesgen Abebe, Molla Abebe, Zegeye Abebe, Teshome Abuka Abebo, Ayenew Negesse Abejie, Victor Aboyans, Haftom Niguse Abraha, Daisy Maria Xavier Abreu, Aklilu Roba Abrham, Laith Jamal Abu-Raddad, Niveen M.E. Abu-Rmeileh, Manfred Mario Kokou Accrombessi, Pawan Acharya, Abdu A. Adamu
Population And Fertility By Age And Sex For 195 Countries And Territories, 1950–2017: A Systematic Analysis For The Global Burden Of Disease Study 2017, Christopher J.L. Murray, Charlton S.K.H. Callender, Xie Rachel Kulikoff, Vinay Srinivasan, Degu Abate, Kalkidan Hassen Abate, Solomon M. Abay, Nooshin Abbasi, Hedayat Abbastabar, Jemal Abdela, Ahmed Abdelalim, Omar Abdel-Rahman, Alireza Abdi, Nasrin Abdoli, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Haftom Temesgen Abebe, Molla Abebe, Zegeye Abebe, Teshome Abuka Abebo, Ayenew Negesse Abejie, Victor Aboyans, Haftom Niguse Abraha, Daisy Maria Xavier Abreu, Aklilu Roba Abrham, Laith Jamal Abu-Raddad, Niveen M.E. Abu-Rmeileh, Manfred Mario Kokou Accrombessi, Pawan Acharya, Abdu A. Adamu
Civil & Environmental Engineering Faculty Publications
Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods: We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on …
Hilltopics: Volume 16, Issue 2, Hilltopics Staff
Plight Of The Public Defender: Excessive Caseload As A Non-Mitigating Factor In Sanctions For Ethical Violations, Taylor Payne
Plight Of The Public Defender: Excessive Caseload As A Non-Mitigating Factor In Sanctions For Ethical Violations, Taylor Payne
Missouri Law Review
This Note discusses the thought-provoking ruling in In re Karl William Hinkebein and its implications for public defenders in Missouri. Part II of this Note details the facts and holding of the case. Part III of this Note gives a brief history of the Missouri State Public Defender System (“MSPD”), highlighting its current shortcomings and challenges. Part III then discusses the influential ethics opinion issued by the American Bar Association (“ABA”) and the ABA Standards for Imposing Lawyer Sanctions (“ABA Standards”). Part IV of this Note analyzes the decision of the Supreme Court of Missouri to sanction Karl Hinkebein. Part …
Book Review - The One True Universal. Barbara Ehrenreich, Natural Causes: An Epidemic Of Wellness, The Certainty Of Dying, And Killing Ourselves To Live Longer (New York: Twelve, 2018), Norma Anderson
Bridgewater Review
No abstract provided.
Large Mediastinal Mass In A 15-Year-Old Boy, Mariyam Gohar Ali, Ali Bin Sarwar Zubairi, Farah Naz Qamar
Large Mediastinal Mass In A 15-Year-Old Boy, Mariyam Gohar Ali, Ali Bin Sarwar Zubairi, Farah Naz Qamar
Section of Pulmonary & Critical Care
Hyperimmunoglobulin E syndrome is a rare multisystem inherited disorder characterised by high serum IgE levels, skin disorder causing eczema, dermatitis, recurrent staphylococcal infections and pulmonary infections and various skeletal and connective tissue abnormalities. Common presentation is with recurrent skin and sinopulmonary infections. Several features unrelated to immune system such as characteristic facial features, hyperextensibility of joints, multiple bone fractures and craniosynostosis have been described in the literature. We describe a rare presentation of this disease with invasive aspergillosis presenting as mediastinal mass with extension to mediastinalstructures and pulmonary vasculature.
Combining Mass Spectrometry And Nmr Improves Metabolite Detection And Annotation, Fatema Bhinderwala, Nishikant Wase, Concetta Dirusso, Robert Powers
Combining Mass Spectrometry And Nmr Improves Metabolite Detection And Annotation, Fatema Bhinderwala, Nishikant Wase, Concetta Dirusso, Robert Powers
Department of Biochemistry: Faculty Publications
Despite inherent complementarity, nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) are routinely separately employed to characterize metabolomics samples. More troubling is the erroneous view that metabolomics is better served by exclusively utilizing MS. Instead, we demonstrate the importance of combining NMR and MS for metabolomics by using small chemical compound-treatments of Chlamydomonas reinhardtii as an illustrative example. A total of 102 metabolites were detected (82 by GC-MS, 20 by NMR and 22 by both techniques). Out of these 47 metabolites of interest were identified, where 14 metabolites were uniquely identified by NMR and 16 metabolites were uniquely identified …
Pavela Elected To Lead Ethics Section For National Public Health Organization, Alicia Rohan
Pavela Elected To Lead Ethics Section For National Public Health Organization, Alicia Rohan
Browse All News
No abstract provided.
Applied Neuromarketing Research: Examining Delta Brain Waves Activity As Predictor Of Consumer Choice, Matteo Peroni
Applied Neuromarketing Research: Examining Delta Brain Waves Activity As Predictor Of Consumer Choice, Matteo Peroni
Faculty and Staff Publications & Presentations
No abstract provided.
Vwa Proteins Of Leptospira Interrogans Induce Hemorrhage In Leptospirosis By Competitive Inhibition Of Vwf/Gpib-Mediated Platelet Aggregation., Jia-Qi Fang, Muhammad Imran, Wei-Lin Hu, David M. Ojcius, Yang Li, Yu-Mei Ge, Kai-Xuan Li, Xu'ai Lin, Jie Yan
Vwa Proteins Of Leptospira Interrogans Induce Hemorrhage In Leptospirosis By Competitive Inhibition Of Vwf/Gpib-Mediated Platelet Aggregation., Jia-Qi Fang, Muhammad Imran, Wei-Lin Hu, David M. Ojcius, Yang Li, Yu-Mei Ge, Kai-Xuan Li, Xu'ai Lin, Jie Yan
All Dugoni School of Dentistry Faculty Articles
BACKGROUD: Leptospira interrogans is the major causative agent of leptospirosis, a worldwide zoonotic disease. Hemorrhage is a typical pathological feature of leptospirosis. Binding of von Willebrand factor (vWF) to platelet glycoprotein-Ibα (GPIbα) is a crucial step in initiation of platelet aggregation. The products of L. interrogans vwa-I and vwa-II genes contain vWF-A domains, but their ability to induce hemorrhage has not been determined.
METHODS: Human (Hu)-platelet- and Hu-GPIbα-binding abilities of the recombinant proteins expressed by L. interrogans strain Lai vwa-I and vwa-II genes (rLep-vWA-I and rLep-vWA-II) were detected by flowcytometry, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). Hu-platelet …