Digital Commons Network^™

Evidence From A Quasi-Experimental Study For The Effectiveness Of The Influenza Vaccination Against Myocardial Infarction In Uk Adults Aged At Least 65 Y, Aj Streeter, We Henley

Peninsula Medical School

No abstract provided.

Clinical Chronobiology: A Timely Consideration In Critical Care Medicine, Helen Mckenna, Der Horst Gtj Van, Irwin Reiss, Daniel Martin

Peninsula Medical School

No abstract provided.

Po-511 High Mir-9 Levels Represent A Novel Prognostic Biomarker To Predict Development Of Malignant Meningioma, D Baiz, C Negroni, S Ferluga, E Ercolano, C Adams, Oc Hanemann

Peninsula Medical School

Introduction Meningioma is the most common primary tumour affecting the central nervous system; it is classified as benign (WHO I,~80%), atypical (WHO II,~15%–20%) and anaplastic/malignant (WHO III,~1%–3%). The 3 year recurrence rate in WHO I meningioma is estimated in about 50% and it is much greater in WHO II and III tumours. MicroRNAs (miRNAs) represent a large class of small RNAs driving regulation of gene expression at post-transcriptional level and playing a role in cell proliferation, differentiation, apoptosis and carcinogenesis. Several studies showed that miRNAs are involved in tumour progression and therefore proposed as diagnostic tools. Here, we evaluated miRNAs …

Insulin Resistance Is Higher In Prepubertal Girls But Switches To Become Higher In Boys At Age 16: A Cohort Study (Earlybird 57), Sc Jeffery, Joanne Hosking, An Jeffery, Michael J. Murphy, Linda D. Voss, Terence J. Wilkin, Jonathan Pinkney

Peninsula Medical School

No abstract provided.

The Evolving Purposes Of Medical Revalidation In The United Kingdom: A Qualitative Study Of Professional And Regulatory Narratives, Abigail Tazzyman, Jane Ferguson, Kieran Walshe, Alan Boyd, John Tredinnick-Rowe, Charlotte Hillier, De Bere S Regan, Julian Archer

Peninsula Medical School

Purpose Previous research found professionalism and regulation to be competing discourses when plans for medical revalidation in the United Kingdom were being developed in 2011. The purpose of this study was to explore how these competing discourses developed and how the perceived purposes of revalidation evolved as the policy was implemented. Method Seventy-one interviews with 60 UK policy makers and senior health care leaders were conducted during the development and implementation of revalidation: 31 in 2011, 26 in 2013, and 14 in 2015. Interviewees were selected using purposeful sampling. Across all interviews, questions focused around three areas: individual roles in …

Empowering Students With The Hidden Curriculum, Hilary Neve, Tracey Collett

Peninsula Medical School

No abstract provided.

Differential Phosphorylation And N-Terminal Configuration Of Capsid Subunits In Parvovirus Assembly And Viral Trafficking, J Gil-Ranedo, E Hernando, N Valle, L Riolobos, B Maroto, Jm Almendral

Peninsula Medical School

No abstract provided.

Can Practitioners Use Patient Reported Measures To Enhance Person Centred Coordinated Care In Practice? A Qualitative Study, Hannah Wheat, Jane Horrell, Jose M. Valderas, James Close, Ben Fosh, Helen Lloyd

Peninsula Medical School

No abstract provided.

Engaging Multiple Stakeholder Groups In The Development Of Standards For Multiple Sclerosis Care: A Modified Delphi Process, J Hobart, A Bowen, L Eberhard, G Pepper, G Giovannoni

Peninsula Medical School

No abstract provided.

The Pursuit Of Innovation: An Analysis Of International Competitive Advantage In A Globalized Knowledge Economy, Tanay Gupte

CMC Senior Theses

With the advent of the internet age, the way in which global society interacts with technology has changed dramatically. The instantaneous availability of information and connectivity, signal the rise of a knowledge economy. This is a system in which the most valuable resource, to nations and private enterprise, is knowledge. This thesis argues that value is created through knowledge flows, which result in innovation and technological advancement. This technological advancement is the primary determinant of a nation’s global competitive advantage in a globalized knowledge economy. This thesis then posits that these innovations are fostered by institutional, social, cultural, economic, and …

Evaluating The Effects Of Nutritional Intake During Adolescence On Educational Attainment And Labor Market Earnings As An Adult, Mikaela Connell

CMC Senior Theses

In this thesis, I analyze whether nutritional intake at the time of adolescence can impact academic attainment and earnings later on in life. Millions of children in the United States are living in food insecure households and do not have access to an adequate nutritious diet. Since adolescence is a time period of intense growth and development, it is essential to meet nutritional needs at this time. Using data from the Longitudinal Study of Adolescent to Adult Health (Add Health), I measure the nutrition of a nationally representative sample of youth in the United States through their daily food intake, …

Examining The Cross-Cultural Differences In Affect Valuation: Whites, East Asians, And Third Culture Kids, Joey Yamada

CMC Senior Theses

This paper explores the cross-cultural differences in affect valuation, emotion regulation, and the relationship between affect valuation, emotion regulation and subjective well-being across White Americans, Asians, and Third Culture Kids (TCKs). Emotional experiences shape every facet of our lives, yet understanding the extent to which emotional experiences are universal is still poorly understood. This is particularly the case among individuals with diverse cultural experiences. In the current study, we look at TCK individuals, a group composed of White-identifying individuals who spent a significant time of their childhood in East Asian countries. Through a questionnaire that was distributed via email and …

The Effects Of Recreational Marijuana Legislation On The Opioid Epidemic In Washington State, Steven Dickerson

CMC Senior Theses

This paper analyzes the impact of the 2012 legalization of recreational marijuana in Washington State on opioid abuse. Using synthetic control methodology, this paper finds that the legislation prevented 638 overdose deaths and lead to over 3,600 individuals seeking treatment for opioid abuse disorders. Due to the large health, social, and economic impacts of the opioid epidemic, further research should be conducted into ways to reduce the number of opioid prescriptions, the number of opioid overdoses, and opioid abuse generally.

Is Avocado Toast The Reason I'M Still Living With My Parents?, Brendan Macdonald

CMC Senior Theses

Is avocado toast the reason that I am still living with my parents? In other words, does the consumption of avocado toast, or more specifically eating out in general, have any impact on one’s ability to be a homeowner. In May of 2017, an Australian real estate developer by the name of Tim Gurner was asked to provide advice to young people who could not afford to purchase a home. He responded by saying, “when I was trying to buy my first home, I wasn’t buying smashed avocado for $19 and four coffees at $4 each,” (Victor, 2017). While the …

Model Specification For Bank Failure: A Retrospective Look At Banks In Missouri During The Great Depression, Peter Welch

CMC Senior Theses

This paper examines banks in Missouri during the Great Depression in order to find the correct model specification for bank failure during economic downturns. The data set controls for a bank’s balance sheet, correspondent network, charters and memberships, county characteristics, and market share, and includes both Federal Reserve member and non-member banks. Using a probit model, it is concluded that the contractionary monetary policy employed by the St. Louis Federal Reserve did not help bank survival, as being a member of the Federal Reserve had no significant effect on a bank’s probability of survival. Additionally, while an increased network led …

The Psychological Impact Of Architectural Design, Natalie Ricci

CMC Senior Theses

The interplay between architectural design and human psychology is significant, yet it remains largely unnoticed or even ignored both in and outside the design industry. Moreover, the relationship between design and psychology is not only consequential, it is bidirectional. On the one hand, successful design has been shown to have clear psychological and physiological impacts; on the other, psychology, human experience, and the function of our neurological systems all play a significant role in what we perceive to be successful design. This thesis endeavors to create an understanding of how that complex relationship evolved and how it works in today's …

The Effects Of The Correspondent Banking Network On The Real Economy, Jack Brown

CMC Senior Theses

There is a longstanding academic debate regarding the role of financial networks. There is a tradeoff between improving the flow of funds and acting as a channel for contagion. This paper investigates the impact of banking networks on the real economy during the Great Depression. Building permit values are used as a proxy for real economic activity as implemented in previous research. A simple linear regression model estimated by ordinary least squares is used such that locational networks are differentiated from networks links to money centers and non-money centers. The results demonstrate that financial networks have both positive and negative …

Truth And Reconciliation Commissions And The Search For Justice: A Comparative Study Of Chile, Argentina And Guatemala, Pastor Jose Arroyo

CMC Senior Theses

During the mid to late 1900s many Latin American countries found themselves under the rule of violent military regimes and in civil war. The purpose of this paper is to discuss the atrocities committed in the late 20th century throughout Latin America and to discuss the ways in which these societies, affected by state violence, were able to overcome the past. In this paper, I will look at the purpose of truth and reconciliation commissions and their outcomes in Chile, Argentina, and Guatemala in order to find some similarities and compare and contrast the successes and failures of the different …

Mental Health In U.S. Prisons: How Our System Is Set Up For Failure, Katherine Daifotis

CMC Senior Theses

During the past 60 years, United States prisons have become one of the primary institutions caring for mentally ill individuals. Factors such as privatization of mental health care with a focus on profit-maximization, ineffective jail diversion programs, and unsuccessful mental health courts have contributed to prisons having an increased population of mentally ill inmates. In fact, about 20% of people who are currently incarcerated suffer from a major mental illness (Mason, 2007). Other elements outside of the justice system such as a lack of mental health awareness and a lack of resources have led to damaging interactions between the mentally …

Strength Through Diplomacy: A Fundamental Review Of The Relationship Between North Korea And The United States, Benjamin D. Blackstone

CMC Senior Theses

At the time that this thesis is printed, we are reminded of the tumultuous relationship between North Korea and the United States every day. If we follow the mainstream news regularly, it seems like we are on a steady path to war. Ultimately, this paper is centered around the question: what is the best foreign policy strategy for both countries to achieve respective goals, without descending into armed conflict? Specifically, I evaluated the failures of the last three U.S. Presidents and used their shortcomings to explain limitations in current foreign policy strategy. I also attempted to show North Korean concerns …

A Link Between Gut Microbes & Depression: Microbial Activation Of The Human Kynurenine Pathway, Christina Cobb

CMC Senior Theses

Our gut microbiota is involved in human development, nutrition, and the pathogenesis of gut disorders, but has more recently been implicated as a possible mechanism in the pathophysiology of several brain disorders, including disorders of mood and affect, such as depression. Researchers have referred to this dynamic, bidirectional signaling pathway between the gut and the brain as the “gut-brain axis.” However, most research on this axis has been limited to rodent studies, and there has been little insight into the mechanism behind it. I propose that the kynurenine pathway, where tryptophan is converted to kynurenine, is a compelling mechanism mediating …

The Mall Ain’T Dead Yet! An Aristotelian Argument For The Continuation Of Physical Retail Space With The Rise Of Modern Technology, Tarah Gilbreth

CMC Senior Theses

According to Aristotle, for a human being to live their best life, that is a life that flourishes, is to live a political life. A political life is lived best in a polis , or a self - sufficient community, so therefore, the most flourishing human life is one lived in a polis . Also, for a polis to be self - sufficient, its citizens must be flourishing, so there exists a special sort of constitutive relationship between the polis and its citizens. There are certain capacities available to human beings in the polis that promote their flourishing (namely loyalty …

The Effect Of Fast Food Restaurants On Type 2 Diabetes Rates, Grace Bailey

CMC Senior Theses

This paper conducts an analysis of county level data to determine the effect of fast food restaurants on type 2 diabetes rates. Due to endogeneity concerns with respect to the location of fast food restaurants, this paper follows the work of Dunn (2010) and uses the number of interstate exits in a given county to serve as an instrument for fast food restaurants. The strength of the instrument, which is theoretically and empirically tested in this paper, imposes some restraints on the interpretation of the findings. Using the Two-Stage Least Squares estimation method, I find that the presence of fast …

The Glass Ceiling’S Missing Pieces: Female Migrant Domestic Workers Navigating Neoliberal Globalization In Latin America, Roselyn Cantu

CMC Senior Theses

This thesis explores globalization’s effects on female migrant domestic workers in Latin America by examining the socioeconomic and political status of Paraguayan and Peruvian domestic workers in Argentina. Through this research, I answer several key questions. First, how does globalization shape neoliberal markets that enforce the exploitative structures of domestic labor? Second, how is gender inequality present in governmental and social discrimination? Third, do the costs of transnational care labor outweigh the benefits? The former two questions are answered by the rising demand for care labor and resulting global care chains that fuel greater cross-border migration and statelessness of female …

Ccl11 As A Biomarker For The In Vivo Diagnosis Of Chronic Traumatic Encephalopathy, Robert Weissenfels

CMC Senior Theses

Chronic traumatic encephalopathy is the neurodegenerative disease that is ascribed to the long term development of cognitive, behavioral, emotional, and motor deficits as a result of the exposure to high amounts of sub concussive traumatic brain injuries. The disease has gained recent popularity in the media for its prevalence in American football as a response to recent research that has suggested the prominence of the disease in nearly every NFL player that is examined post mortem. This has produced a growing concern for the consequences of head impact and participation in contact sports. Despite media attention, little is currently known …

Hyperthermia As A Cancer Treatment- From Theory To Practice, Graham Fullerton

CMC Senior Theses

Using iron super-paramagnetic and ferromagnetic nanoparticles composed of Fe₃O₄ molecules, scientists analyze the effectiveness and practicality of this new treatment theory, hyperthermia. The problems of magnetic particle density, isothermal barriers/cellular cooling thresholds, and nanoparticle specific targeting are addressed in this review.

Iron magnetic nanoparticles were chosen due to their relatively low biological reactivates and lack of subsequent cellular toxicity. However, there are significant heating problems associated with these magnetic nanoparticles due to their relative size and short thermal time constants or thermal half-lives. Effectively, these aforementioned issues create a phenomenon where cancerous cells, surrounded by unheated healthy …

Crispr-Cas9 Mediated Hmgcl Ko In 3xtg Ad Mice Reduces The Cognitive Deficit Improvement Seen In An Intermittent Metabolic Switching Regimen, Eric Joon Bum Kil

CMC Senior Theses

Individuals in modern Western societies are experiencing increasing sedentary lifestyles, overindulgence of high fat, high-sugar diets, and extremely sterilized conditions, putting immense pressure on researchers and clinicians alike to come up with viable treatments for conditions implicated with an aging society. Emerging research have published the benefits of IMS and metabolic switching in a variety of neuroprotective, cellular stress resistance, and neuroplasticity pathways in animal models and clinical results from randomized trials of IMS regimens with susceptible human populations are soon to be published. The application of genome editing and next-generation sequencing (NGS) strategies to clinical and neurodegenerative research continues …

Human Development And Subnationalism: A Disaggregated Analysis Of Indian States: Kerala And Uttar Pradesh, Manika Garg

CMC Senior Theses

This thesis investigates achievements in human development outcomes on health, education, and poverty indicators across Indian states, in order to discern what factors might influence a state’s better orientation toward social policies. After conducting data analysis, the study explains differences in outcomes, as achieved by Kerala and Uttar Pradesh, by building an argument of subnational solidarity and its impact on determining the state’s policy agendas.

Making Money And Making Change: Understanding And Overcoming Tension Between Profits And Purpose Within Social Entrepreneurship, Elijah H. Etzioni

CMC Senior Theses

Using a combination of interviews of social entrepreneurs and secondary research, this paper investigates the strategies that social entrepreneurs use to overcome tension and conflict between the two distinct goals of financial sustainability and mission fulfillment. The results suggest that although some social entrepreneurs can simultaneously achieve revenue generation and mission fulfillment, thus almost entirely eliminating any tension or misalignment, it is the creative responses of social entrepreneurs who have achieved one of these objectives and are attempting to achieve the other that prove the unique value of the practice. Additionally, the results gesture towards the conclusion that different kinds …

The Effect Of International Ngos On Influencing Domestic Policy And Law, Ashley Macarchuk

CMC Senior Theses

This thesis attempts to understand the impact of international human rights and environmental NGOs on affecting domestic policy and law. In particular, it looks at how State-NGO relations, civil society, and accountability affect the success of international NGOs in enacting change in domestic policy. The focus is on four countries with some of the largest human rights and environmental abuses: Argentina, China, India, and Russia. Through these countries, this thesis shows that NGOs have the most influence when State-NGO relations are strong, civil society is active, and NGOs are accountable to both the State and citizens. A key component to …