Digital Commons Network^™

Helping A State In Need, Callie Carr

UNH Today Archive

No abstract provided.

Platelet Cd36 Signaling Through Erk5 Promotes Caspase-Dependent Procoagulant Activity And Fibrin Deposition In Vivo, Moua Yang, Andaleb Kholmukhamedov, Marie L. Schulte, Brian C. Cooley, Na'il O. Scoggins, Jeremy P. Wood, Scott J. Cameron, Craig N. Morrell, Shawn M. Jobe, Roy L. Silverstein

Saha Cardiovascular Research Center Faculty Publications

Dyslipidemia is a risk factor for clinically significant thrombotic events. In this condition, scavenger receptor CD36 potentiates platelet reactivity through recognition of circulating oxidized lipids. CD36 promotes thrombosis by activating redox-sensitive signaling molecules, such as the MAPK extracellular signal-regulated kinase 5 (ERK5). However, the events downstream of platelet ERK5 are not clear. In this study, we report that oxidized low-density lipoprotein (oxLDL) promotes exposure of procoagulant phosphatidylserine (PSer) on platelet surfaces. Studies using pharmacologic inhibitors indicate that oxLDL-CD36 interaction–induced PSer exposure requires apoptotic caspases in addition to the downstream CD36-signaling molecules Src kinases, hydrogen peroxide, and ERK5. Caspases promote PSer …

Analysis Of Printed Electronic Adhesion, Electrical, Mechanical, And Thermal Performance For Resilient Hybrid Electronics, Clayton Neff

USF Tampa Graduate Theses and Dissertations

Today’s state of the art additive manufacturing (AM) systems have the ability to fabricate multi-material devices with novel capabilities that were previously constrained by traditional manufacturing. AM machines fuse or deposit material in an additive fashion only where necessary, thus unlocking advantages of mass customization, no part-specific tooling, near arbitrary geometric complexity, and reduced lead times and cost. The combination of conductive ink micro-dispensing AM process with hybrid manufacturing processes including: laser machining, CNC machining, and pick & place enables the fabrication of printed electronics. Printed electronics exploit the integration of AM with hybrid processes and allow embedded and/or conformal …

An Exploration Of The Quality Of Relationship Between Step-Children And Step-Parents Based On Address Term Usage, Sierra R. Payton

Theses and Dissertations

This study aimed to examine address term usage as a communicative component of blended/step-families by examining the address terms that step-children use to address their step-parent and whether address term usage can allude to the quality of relationship reported by step-children within the step-child step-parent relationship. Rowan University undergraduate students (n=67) were recruited to complete questionnaires on address term usage and quality of relationship using the Quality of Relationships Inventory (QRI). Address term usage was the independent variable and was measured using three levels: formal, familiar, and familial. Quality of relationship was the dependent variable and was measured using the …

When Doing What’S Right Is Wrong: The Psychology Of Personnel Security, Ibpp Editor

International Bulletin of Political Psychology

This article describes the psychology behind failed attempts to improve security, regardless of whether the service and product of industry and organization is one of education, health, commodity, process, or security itself.

The United States And Canadian System Of Healthcare: A Comparative Study, Mopelola O. Mopelola

University Honors College

here is a lot to be said about the world of healthcare. The significance of the role our health plays in our lives cannot be overemphasized. The idea of this paper is to explore two of the largest and functional healthcare systems in the world. The purpose of this is because of some key differences between the systems of healthcare that are very important as they relate to the accessibility and availability of healthcare and also the quality of care that is received. The two countries being compared in this paper are the United States and Canada. These countries utilize …

The Interaction Between The Minimum Wage And The Federal Eitc, Andrew Schaefer, Jess Carson, Marybeth Mattingly, Andrew Wink

Carsey Publications

In this fact sheet, authors Andrew Schaefer, Jessica Carson, Marybeth Mattingly, and Andrew Wink examine the interaction between the minimum wage and the federal Earned Income Tax Credit (EITC) to determine whether a minimum wage increase would produce gains in the sum of earnings plus EITC dollars for low-income workers. They report that for workers earning the minimum wage, an increase would result in higher income; none would experience a lower net income due to changes in the federal EITC credit (though this may be offset by loss of other safety net program benefits). For some family types, increased income …

Investigating The Role Of The Rna Binding Protein Lin28 In The Human Placenta: Implications For Preeclampsia, John Canfield

USF Tampa Graduate Theses and Dissertations

An essential event during early pregnancy is the invasion of trophoblasts into the maternal decidua, which is necessary for proper implantation and establishment of maternal-fetal interface and ultimately allows for proper nutrient exchange and immunological tolerance of the growing fetus. For this invasion to occur, cells originating from the trophectoderm undergo an epithelial to mesenchymal transition to become invasive extravillous trophoblasts and begin invading the uterine decidual tissue. Through the secretion of matrix metalloproteinases and through interactions with many cytokines and cell-adhesion molecules, this well-orchestrated process of trophoblast invasion results in extensive remodeling of the maternal spiral vasculature by the …

Investigation Of Anemarrhena Asphodeloides And Its Constituent Timosaponin-Aiii As Novel, Naturally Derived Adjunctive Therapeutics For The Treatment Of Advanced Pancreatic Cancer, Catherine B. Marelia

USF Tampa Graduate Theses and Dissertations

Pancreatic adenocarcinoma (PDAC) remains one of the most lethal cancer types, with 92% of patients succumbing to the disease within five years. One of the hallmarks of this intractable disease is its nearly universal resistance to chemotherapeutic intervention. The deoxycytidine analog gemcitabine persists as the primary chemotherapy for advanced PDAC patients despite little improvement to its toxicity and tenuous efficacy over the past two decades. Plant-based drug discovery has a longstanding history and has led to some of the most significant drugs of the modern era, including some chemotherapeutic agents like paclitaxel and camptothecin. Our study analyzed the potential inhibitory …

Teaching Differential Equations Without Computer Graphics Solutions Is A Crime, Beverly H. West

CODEE Journal

In the early 1980s computer graphics revolutionized the teaching of ordinary differential equations (ODEs). Yet the movement to teach and learn the qualitative methods that interactive graphics affords seems to have lost momentum. There still exist college courses, even at big universities, being taught without the immense power that computer graphics has brought to differential equations. The vast majority of ODEs that arise in mathematical models are nonlinear, and linearization only approximates solutions sufficiently near an equilibrium. Introductory courses need to include nonlinear DEs. Graphs of phase plane trajectories and time series solutions allow one to see and analyze the …

The Art Of Research: A Divergent/Convergent Framework And Opportunities For Science-Based Approaches, Glory E. Aviña, Christian D. Schunn, Austin R. Silva, Travis L. Bauer, George W. Crabtree, Curtis M. Johnson, Toluwalogo Odumosu, S. Thomas Picraux, R. Keith Sawyer, Richard P. Schneider, Rickson Sun, Gregory J. Feist, Venkatesh Narayanamurti, Jeffrey Y. Tsao

Faculty Research, Scholarly, and Creative Activity

Applying science to the current art of producing engineering and research knowledge has proven difficult, in large part because of its seeming complexity. We posit that the microscopic processes underlying research are not so complex, but instead are iterative and interacting cycles of divergent (generation of ideas) and convergent (testing and selecting of ideas) thinking processes. This reductionist framework coherently organizes a wide range of previously disparate microscopic mechanisms which inhibit these processes. We give examples of such inhibitory mechanisms and discuss how deeper scientific understanding of these mechanisms might lead to dis-inhibitory interventions for individuals, networks and institutional levels.

An Introduction To Psychological Statistics, Garett C. Foster, David Lane, David Scott, Mikki Hebl, Rudy Guerra, Dan Osherson, Heidi Zimmer

Open Educational Resources Collection

This work has been superseded by Introduction to Statistics in the Psychological Sciences available from https://irl.umsl.edu/oer/25/.

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We are constantly bombarded by information, and finding a way to filter that information in an objective way is crucial to surviving this onslaught with your sanity intact. This is what statistics, and logic we use in it, enables us to do. Through the lens of statistics, we learn to find the signal hidden in the noise when it is there and to know when an apparent trend or pattern is really just randomness. The study of statistics involves math and relies …

Myeloablative Vs Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation For Chronic Myeloid Leukemia, Saurabh Chhabra, Kwang Woo Ahn, Zhen-Huan Hu, Sandeep Jain, Amer Assal, Jan Cerny, Edward A. Copelan, Andrew Daly, Zachariah Defilipp, Shahinaz M Gadalla, Robert Peter Gale, Siddhartha Ganguly, Betty K. Hamilton, Gerhard C. Hildebrandt, Jack W. Hsu, Yoshihiro Inamoto, Abraham S. Kanate, H. Jean Khoury, Hillard M. Lazarus, Mark R. Litzow, Sunita Nathan, Richard F. Olsson, Attaphol Pawarode, Olle Ringden, Jacob M. Rowe, Ayman Saad, Bipin N. Savani, Harry C. Schouten, Sachiko Seo, Nirav N. Shah

Markey Cancer Center Faculty Publications

Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment of chronic myeloid leukemia (CML). Optimal conditioning intensity for allo-HCT for CML in the era of tyrosine kinase inhibitors (TKIs) is unknown. Using the Center for International Blood and Marrow Transplant Research database, we sought to determine whether reduced-intensity/nonmyeloablative conditioning (RIC) allo-HCT and myeloablative conditioning (MAC) result in similar outcomes in CML patients. We evaluated 1395 CML allo-HCT recipients between the ages of 18 and 60 years. The disease status at transplant was divided into the following categories: chronic phase 1, chronic phase 2 or greater, and accelerated phase. Patients …

System And Methods For Ventilation Through A Body Cavity, Mark A. Borden, Benjamin S. Terry

Department of Mechanical and Materials Engineering: Faculty Publications

A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles . Through circulation of oxygen microbubbles through the body cavity , oxygen and carbon dioxide exchange may occur . Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen - intake restricting injury and / or failure may be achieved through use of the invented system and methods .

State V. Plummer Respondent's Brief Dckt. 45513

Not Reported

No abstract provided.

Volume 116, Number 8 - Tuesday, November 13, 2018, Saint Mary's College Of California

The Collegian

No abstract provided.

When Friends Share About Brands: A Study Of Ewom On Social Networking Sites, Christina Devoss

Doctoral Dissertations

Word-of-mouth marketing has been recognized as a significant factor influencing consumer behavior. Research has indicated that certain peer consumers – often known as opinion leaders or market mavens – can influence purchase intentions and product attitudes. Likewise, bandwagon cues, which signal to consumers that a product or brand is popular among others, have also been found to influence consumer decisions. To date, most eWOM studies, and particularly those examining bandwagon cues, have assessed messages from anonymous individuals in digital environments such as online review sites.

To address this gap in the literature, this study explored how an individual’s judgment of …

Student Affairs Minutes 11/13/2018, Student Affairs Committee

Student Affairs Committee

No abstract provided.

I, Copyright, Huson, Garrett

Santa Clara High Technology Law Journal

I, Copyright

Computationally-Enhanced Ecologies, Organisms, And Parasites. Speculative Explorations Of Symbiotic Oscillations, S Didakis

School of Art, Design and Architecture

This paper presents theoretical and practical research related to computationally-enhanced environments, analysing speculative explorations of media technologies that extend our understanding on alternative modes of architectural realities. An analysis is made concerning this transformation of interior spaces that realise immaterial dimensions and hidden layers of information, demonstrating strategies for computationally-enhanced ecologies that become an essential organism of the functions and aesthetics of space. The case studies presented in this work attempt to focus on how technological development and cutting-edge media practices are utilized to create objects and systems within the physical space for augmenting and amplifying creative processes, and exploring …

The Social Side Of "Borderline:" Edgework In The Narrative Accounts Of Self-Injurers, Victoria Lynn Gaines

Electronic Theses and Dissertations Archive

Eleven in-depth life history interviews with respondents who identified as former self-injurers and a thematic analysis of the existing qualitative literature on self-injury constitute the data for this research. Self-injury, a growing public health concern, has typically been framed by researchers as an individual level, psychological, phenomenon with largely negative connotations. Edgework, a theoretical orientation which has been used to explain voluntary risk-taking such as skydiving and mountain climbing, has been applied to the activity of self-injury. The interviews and qualitative research on self-injury were coded for the presence of edgework as a vocabulary of motive. Framed as edgework, this …

Lindenwood Digest, November 13, 2018, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Alumnus receives fellowship position with Johns Hopkins Medicine

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern’s online master’s in sport management named one of the most affordable

• Savannah Wind Symphony opens season with concert on Armstrong Campus

• Georgia Southern alumnus, Perot Museum of Nature and Science unveil virtual reality app

• Georgia Southern University announces outstanding $5 million gift to the College of Business

Evaluation Of Proton Therapy Accuracy Using A Pmma Phantom And Pet Prediction Module, Wen Hsi

All Publications

Purpose: Positron emission tomography (PET) scanning is a widely used method of proton therapy verification. In this study, a proton radiotherapy accuracy verification process was developed by comparing predicted and measured PET data to verify the correctness of PET prediction and was tested at the Shanghai Proton and Heavy Ion Center.

Method: Irradiation was performed on a polymethyl methacrylate (PMMA) phantom. There were two dose groups, to which 2 and 4 Gy doses were delivered, and each dose group had different designed dose depths ranging from 5 to 20 cm. The predicted PET results were obtained using a PET prediction …

Childhood Obesity And Academic Outcomes In Young Adulthood, Igor Ryabov

Sociology Faculty Publications

The present study used nationally representative data from the National Longitudinal Study of Adolescent Health (a.k.a., Add Health) to examine the impact of childhood obesity on young adult educational attainment. In addition to weight status, independent variables included race–ethnicity, immigrant generational status, family socio-economic status (SES), preference for overweight and obese friends in school, school socio-economic and race–ethnic composition, and other important predictors. Educational attainment was measured as a categorical variable with the categories reflecting key educational benchmarks: (1) being a high school graduate; (2) having some college education; and (3) having completed a bachelor’s or higher degree. The results …

Distinct Role Of Il-27 In Immature And Lps-Induced Mature Dendritic Cell-Mediated Development Of Cd4, Fang Zhou, Guang-Xian Zhang, A. M. Rostami

Department of Neurology Faculty Papers

Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory responses and autoimmunity; however, the molecular mechanisms of IL-27 in modulation of immune tolerance and autoimmunity have not been fully elucidated. Dendritic cells (DCs) play a central role in regulating immune responses mediated by innate and adaptive immune systems, but regulatory mechanisms of DCs in CD4⁺ T cell-mediated immune responses have not yet been elucidated. Here we show that IL-27 treated mature DCs induced by LPS inhibit immune tolerance mediated by LPS-stimulated DCs. IL-27 treatment facilitates development of the CD4⁺ CD127⁺3G11⁺ regulatory T cell subset …

Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction-Induced Injury, Andrew N Billin, Samuel E Honeycutt, Alan V Mcdougal, Jaclyn P Kerr, Zhe Chen, Johannes M Freudenberg, Deepak K Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S Geske, Frank Fang, Bert Yao, Richard V Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C Hinken, Alan J Russell

Research outputs 2014 to 2021

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF.

METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects …

The Impact Of Race And Identity On College Student’S Mental Health And Academic Self-Concept: Understanding The Interrelationship Between Ethnic Identity And Perceived Racial Discrimination, Thiffany Rambana

Journal of Interdisciplinary Graduate Research

Despite the detailed history of racism in the United States and the centuries that have passed since slavery and the genocide of native communities, many ethnic populations continue to suffer the impact of racism. As racism persists in the modern era of American life, one must wonder how emerging adults are dealing with racism; especially college students. Therefore, it is important to describe the role played by racial discrimination, especially in the way individuals interact with those who are similar or different from them. The purpose of this study was to compare the perceptions of racial discrimination among all ethnic …

Sex Trafficking: A Toolbox For Apn's, Nissa Berbawy

Journal of Interdisciplinary Graduate Research

As the fastest growing crime in the world (Walker-Rodriguez, & Hill, 2011) and with sex slaves found in all 50 states (Grace et al, 2014), finding a solution to the problem of sex slavery is critical. One study showed 63.3% of sex slave survivors were treated in the emergency department while enslaved, revealing an opportunity for healthcare providers to intervene (The Emergency Nurses Association, 2015). This review of literature focused on the human trafficking subcategory of sexual exploitation (sex slaves). The purpose of this review of literature is to provide evidence based resources to better equip APN’s to identify, intervene, …