Digital Commons Network^™

Structure Of Native Lens Connexin 46/50 Intercellular Channels By Cryo-Em, Janette B. Myers, Bassam G. Haddad, Susan E. O'Neill, Dror S. Chorev, Craig C. Yashioka, Carol V. Robinson, Daniel M. Zuckerman, Steve L. Reichow

Chemistry Faculty Publications and Presentations

Gap junctions establish direct pathways for cell-to-cell communication through the assembly of twelve connexin subunits that form intercellular channels connecting neighbouring cells. Co-assembly of different connexin isoforms produces channels with unique properties and enables communication across cell types. Here we used single-particle cryo-electron microscopy to investigate the structural basis of connexin co-assembly in native lens gap junction channels composed of connexin 46 and connexin 50 (Cx46/50). We provide the first comparative analysis to connexin 26 (Cx26), which—together with computational studies—elucidates key energetic features governing gap junction permselectivity. Cx46/50 adopts an open-state conformation that is distinct from the Cx26 crystal structure, …

Loss-Of-Function Mutations In Atp6ap1 And Atp6ap2 In Granular Cell Tumors., Fresia Pareja, Alissa H. Brandes, Thais Basili, Pier Selenica, Felipe C. Geyer, Dan Fan, Arnaud Da Cruz Paula, Rahul Kumar, David N. Brown, Rodrigo Gularte-Mérida, Barbara Alemar, Rui Bi, Raymond S. Lim, Ino De Bruijn, Sho Fujisawa, Rui Gardner, Elvin Feng, Anqi Li, Edaise M. Da Silva, John R. Lozada, Pedro Blecua, Leona Cohen-Gould, Achim A. Jungbluth, Emad A. Rakha, Ian O. Ellis, Maria I.A. Edelweiss, Juan P. Palazzo, Larry Norton, Travis Hollmann, Marcia Edelweiss, Brian P. Rubin, Britta Weigelt, Jorge S. Reis-Filho

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs are currently unknown. Here, we apply whole-exome sequencing and targeted sequencing analysis to reveal mutually exclusive, clonal, inactivating somatic mutations in the endosomal pH regulators ATP6AP1 or ATP6AP2 in 72% of GCTs. Silencing of these genes in vitro results in impaired vesicle acidification, redistribution of endosomal compartments, and accumulation of intracytoplasmic granules, recapitulating the cardinal phenotypic characteristics of GCTs and providing a novel genotypic-phenotypic correlation. In addition, depletion of ATP6AP1 or ATP6AP2 results in …

The Effects Of Common Core State-Mandated, High-Stakes Testing On Teacher Stress In School Districts In Ohio, Gary P. Wegley

Doctoral Dissertations and Projects

The purpose of this quantitative, causal-comparative study was to explore the relationship between Common Core state-mandated, high-stakes testing and the stress levels, as measured by the Teacher Stress Inventory (TSI), of a convenience sampling of 204 secondary teachers in southwest Ohio who were assigned to teach Common Core high-stakes testing subjects and teachers not assigned to teach Common Core high-stakes testing subjects. This study sought to determine whether the Common Core state-mandated, high-stakes testing in the state of Ohio impacted teacher stress. The primary instrument used was the Teacher Stress Inventory (TSI), which was available through an online survey platform. …

A Strategic Evangelism Project For The Youth Of The Newly Formed South Brooklyn Academy Sparklers: The Indiscriminate Distribution Of God's Four Everlasting Covenant Provisions, Courtney W. Wickham

Doctoral Dissertations and Projects

God’s prophetic word to Jeremiah (31:31-34) echoes God’s plan of redemption which was there, even before the foundation of the earth. In this prophecy, God declares that “He will write His law on the hearts of men”. God’s law is His Word, and this Word “became flesh and dwelt among men” (John 1:14). This Thesis Project focuses on the first stage of Evangelism, sowing. The membership of the South Brooklyn Academy Sparklers Pathfinder Club, represent the youth arm of the Seventh-day Adventist Church. They are passionate about the Great Commission (Matt. 28:18-20) and the Three Angels Messages (Rev. 14:6-12). However, …

A Phenomenological Study Of School Counselors' Experiences Following Student Suicide, Suzanne Lea Nichols

Doctoral Dissertations and Projects

The purpose of this qualitative, hermeneutic, phenomenological study was to describe the lived experiences of school counselors who have been impacted by the death of a student by suicide in the United States. The central question of the study was: How do school counselors describe their experiences following the death of a student by suicide? The three subquestions were: (a) How do school counselors describe their reactions when a student dies by suicide? (b) How do school counselors perceive their professional involvements in postvention activities following a student suicide? (c) How do school counselors cope after the death of a …

School Suspension And Academic Achievement For Tenth And Eleventh Grade Male Students: A Correlational Study, Dante' L. Ferguson Sr

Doctoral Dissertations and Projects

The purpose of this correlational study was to examine the relationship between absenteeism due to suspensions and math and reading scores from the 2016 – 2017 Georgia Milestones Test for tenth and eleventh grade regular education, male students. The focus of this study was on determining if math and reading scores on standardized tests could be predicted by the number of days missed from school due to suspensions using a bivariate regression. A total of 93 male high school students in grades ten and eleven who have received one or more out of school suspensions during the previous school term …

Marching Into The Future: The Relationship Between Instrumental Music Class Participation And Advanced Placement English Language And Composition Test Results, Robert Alston Pettigrew

Doctoral Dissertations and Projects

Over the decades, there have been countless claims that participation in a music class will influence the cognitive abilities of students. Yet many districts elect to eliminate these programs in times of budgetary crisis. During a period when our national education system is focused on test scores, educational reformists should focus on the implementation of courses that yield academic success. This study was designed to determine if there is a significant relationship between instrumental music class participation and Advanced Placement English Language and Composition exam scores. Data for the group comparison consisted of 529 samples from a large county school …

The Relationship Of The Well-Being Of Adults With And Without Dyslexia: A Causal-Comparative Study, Ashleigh L. Anderson

Doctoral Dissertations and Projects

This study examined the effects of dyslexia on well-being as an adult. The researcher compared adults given a diagnosis of dyslexia with adults not given a diagnosis of dyslexia for well-being using a quantitative causal-comparative method. Participants for this study were a convenience sample, consisting of 219 adults with and without a self-identified diagnosis of dyslexia per the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV). The researcher used the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) and measured the well-being of adults who are diagnosed as dyslexic and adults that are not dyslexic. The researcher utilized a 14-item questionnaire …

Christ-Centered Worship: Five New Testament Principles For The Korean Church, Hallellu Choi

Doctoral Dissertations and Projects

The Protestant church of South Korea witnessed remarkable growth since the Gospel was first preached in Korea in the nineteenth century; growth in the second half of the twentieth century was particularly strong. The Presbyterian church in South Korea, however, experienced decline since 1995: this was mainly due to Christians’ lack of good influence toward the non-Christians in their lives. Their good influence on non-Christians in the world can be restored first by re-educating them with biblical principles of worship and by encouraging them to live out those principles. The purpose of this thesis is to suggest five principles of …

Using Tablet Technology To Teach Secondary Content Vocabulary: A Collective Case Study, Annie R. Raney

Doctoral Dissertations and Projects

The purpose of this collective case study was to provide an understanding of the instructional methods of teachers who use tablet technology in middle school classrooms to teach complex content vocabulary. Dewey’s theory of constructivism guided this study, as it explains that students learn by building upon what they know. Middle school students add new terms to their existing vocabulary banks so that they can learn the related concepts in their content-area classes. The study took place in a southern state with technology standards that require students to use technology for reading and learning purposes. There is extensive research about …

The Relationship Between Epistemological Beliefs And Attitudes Towards Science Of Undergraduate Elementary Education Majors, Renae Reimer Bullock

Doctoral Dissertations and Projects

Much of the educational research that has investigated the attitudes of pre-service elementary educators towards science has seemed to show that their attitudes are negative towards science. Research also indicates that factors of gender, perceived competence, anxiety, perceived relation to their lives, and epistemological beliefs are related to pre-service elementary educators’ attitudes towards science. The purpose of this study is to investigate the relationship between epistemological beliefs of undergraduate elementary education majors at a large, private, faith-based university in the southeastern United States and their attitudes towards science. Schraw et al.’s Epistemological Beliefs Inventory (EBI) (Schraw, Bendixen, & Dunkle, 2002) …

Health And Wellness Factors Affecting The Wholistic Lifestyle Of National And International Christian Missionaries, Angela C. Williams

Doctoral Dissertations and Projects

This thesis will focus on the health and wellness of missionaries and will develop a wholistic framework for healthier living. This framework will be used as a guide to help sustain missionaries living in various cultural contexts by connecting and integrating the mind, body, and spirit in harmony for wholistic lifestyle. God intended for His people to live a healthy lifestyle and to take care of their temples. Missionaries are the backbone of cross-cultural evangelism, but they often find themselves living unhealthy lifestyles. These unhealthy lifestyles can have a negative impact on missionaries’ overall health, wellness, and fruitfulness in serving …

Intraoperative Blood Loss During Induced Abortion: A Comparison Of Anesthetics, Camille A. Clare, Gabrielle E. Hatton, Neela Shrestha, Michael Girshin, Andre Broumas, Danielle Carmel, Mario A. Inchiosa Jr.

NYMC Faculty Publications

Objective: To determine whether there is a difference in intraoperative bleeding with inhalational versus noninhalational anesthetic agents for patients undergoing suction dilatation and curettage for first-trimester induced abortion. Methods: This is an IRB-approved retrospective chart review of the electronic medical records of patients undergoing induced abortion at gestational ages between 5 0/7 and 14 0/7 weeks of pregnancy at the New York City Health + Hospitals/Metropolitan. The records of 138 patients who underwent suction dilatation and curettage for induced abortion between June 2012 and June 2014 were reviewed for an association between anesthetic technique and intraoperative hemorrhage. Twenty patients received …

Recent Updates In Cancer Immunotherapy: A Comprehensive Review And Perspective Of The 2018 China Cancer Immunotherapy Workshop In Beijing, Zihai Li, Wenru Song, Mark Rubinstein, Delong Liu

NYMC Faculty Publications

The immune system is the hard-wired host defense mechanism against pathogens as well as cancer. Five years ago, we pondered the question if the era of cancer immunotherapy was upon us (Li et al., Exp Hem Oncol 2013). Exciting progresses have been made at all fronts since then, including (1) sweeping approval of six agents by the US Food and Drug Administration (FDA) to block the PD-1/PD-L1 pathway for treatment of 13 cancer types; (2) a paradigm shifting indication of PD-1 and CTLA4 blockers for the management of a broad class of cancers with DNA mismatch repair defect, the first-ever …

Physician-Assisted Suicide (Pas)/Physician-Assisted Death (Pad): The Rise Of Lifeboat Ethics, Jeffrey H. Dobken

NYMC Faculty Publications

No abstract provided.

From Public Ideology To Socio-Material Reproduction Of Agile Principles: The Case Of Pivotal Labs, Erica L. Wagner, Sue Newell, Neil Ramiller, Jeanne Enders

Business Faculty Publications and Presentations

This paper focuses on how regular invocation of a public ideology helps sustain local work practices. Existing research acknowledges that there is a recursive relationship between the local practices and the public ideas, with local practices leading to the adaption of public ideas over time. There is little study of how public ideology sustains local practices over the longer term – seeing translation of the ideology as an ongoing process. Through a case study and web-based analysis of Pivotal Labs, an agile software development company, we contribute to socio-material translation studies demonstrating the manifestation of the public ideology in socio-material …

Analyzing Policies Through A Dohad Lens: What Can We Learn?, Julia M. Goodman, Janne Boone-Heinonen, Dawn M. Richardson, Sarah B. Andrea, Lynne C. Messer

OHSU-PSU School of Public Health Faculty Publications and Presentations

Social, health, and environmental policies are critical tools for providing the conditions needed for healthy populations. However, current policy analyses fall short of capturing their full potential impacts across the life course and from generation to generation. We argue that the field of Developmental Origins of Health and Disease (DOHaD), a conceptual and research framework positing that early life experiences significantly affect health trajectories across the lifespan and into future generations, provides an important lens through which to analyze social policies. To illustrate this point, we synthesized evidence related to policies from three domains—family leave, nutrition, and housing—to examine the …

Mechanisms Of S1p-Induced Endothelial Barrier Enhancement, Natascha Guimarães Alves

USF Tampa Graduate Theses and Dissertations

Excessive microvascular permeability is a serious complication involved in traumatic injury and inflammatory diseases. Alcohol intoxication can exacerbate the physiological derangements produced by microvascular endothelial barrier dysfunction in such disease conditions. Sphingosine-1-phosphate (S1P) has known endothelial barrier-protective properties, and has been shown to ameliorate microvascular leakage in a model of combined alcohol intoxication and hemorrhagic shock and resuscitation (HSR). However, whether the barrier-protective properties of S1P extend to endothelial cells of the blood-brain barrier (BBB) is unclear. The mechanisms of S1P-induced barrier protection during alcohol intoxication or HSR are also unknown. In the current study, we tested the hypothesis that …

Using The Engagedmd Multimedia Platform To Improve Informed Consent For Ovulation Induction, Intrauterine Insemination, And In Vitro Fertilization, Jody L. Madeira, Jennifer Rehbein, Mindy S. Christianson, Miryoung Lee, J. Preston Parry, Guido Pennings, Steven R. Lindheim Md

Articles by Maurer Faculty

Objective: To study patient and provider feedback on how a multimedia platform (EngagedMD) helps patients to understand the risks and consequences of in vitro fertilization (IVF), ovulation induction (OI), and intrauterine insemination (IUI) treatments and the impact of the informed consent process.

Design: Prospective survey study.

Setting: IVF units in the United States.

Patient(s): Six-thousand three-hundred and thirty-three patients who viewed the multimedia platform before IVF or OI-IUI treatment at 13 U.S. IVF centers and 128 providers.

Intervention(s): Quantitative survey with 17 questions.

Main Outcome Measure(s): Assessment of the impact of a multimedia platform on patient anxiety, comprehension, and satisfaction …

Noise Induced Hearing Loss Accountability On Jobsites Within The Construction Industry, Joseph O. Lamphere

Construction Management

Noise induced hearing loss is a major issue on jobsites within the construction industry. Every day workers are exposed to hazardous levels of noise, but they are not being properly managed to mitigate this issue. Workers have misconceptions about the topic, but more surprisingly are sometimes indifferent to the effects; believing hearing loss is inevitable, or it can be cured with a hearing aide. Construction has inherent dangers that workers have to deal with every day. Hearing loss might not be on the top of their lists, but the effects are permanent, and they cannot be cured with a hearing …

Growing Grounds Nursery - Outdoor Plaza And Education Space, Keenan Brekke

Construction Management

This paper describes the planning, both design and financing, as well as the construction of an 800 square foot outdoor plaza area and education space. After six months of Planning and Fundraising, the scope of work included clearing and grubbing, relocation of irrigation lines, site grading and footing excavation, forming and pouring four architectural board form concrete benches and a planter, installing a perimeter French drain for site drainage, and installation of serpentine rock retaining walls, steel planters, a sail shade structure, outdoor string lights, a koi pond, and all significant landscaping. The author, over 100 volunteers, and various industry …

Hard Hat Safety By California Contractors, Jonathan G. Hernandez

Construction Management

The hard hat is the quintessential item of PPE, and yet it often gets overlooked when ensuring safety standards are being met. We all expect our hard hat to protect us, but many never inspect it to ensure that it is properly fulfilling its purpose. This disregard to inspection and maintenance can lead to serious injury or death in the event of an accident. While organizations such as OSHA and the hard hat manufacturers themselves post information on this topic, it is unclear if this information is actually being received by the people involved in a construction project. This research …

Improving Ductility Of Slender Reinforced Concrete, Luke M. Ostrom

Construction Management

The Sylmar earthquake of 1971 caused significant damage to slender, non-ductile reinforced concrete (RC) shear wall buildings in California. A later survey by the Concrete Coalition in 2011, under the guidance of members of the Earthquake Engineering Research Institute (EERI), indicated that there are over 3000 vulnerable concrete buildings in California [8]. This led to City of Los Angeles (LA) Ordinance 193893 enacted in 2015, which requires mandatory upgrades to these concrete buildings by 2035. Current practice to meet the requirements of this ordinance, with respect to RC wall buildings, involves adding new shear walls to the building plan or …

Raps Sheet, December 2018, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

Wet Markets And Avian Influenza: Public Policy Decisions In Hong Kong, Shawn Smallman

International & Global Studies Faculty Publications and Presentations

After the emergence of H5N1 avian influenza in 1997 Hong Kong implemented a sophisticated system to regulate live poultry markets. While this system is well implemented and thorough, it also has limitations. The rise of H7N9 avian influenza (which is typically acquired through contact with poultry, including in live markets) makes this an appropriate time to revisit the ethical and practical issues related to this trade. Based on data from field observations of live markets in Hong Kong, and interviews with experts in the field, this paper recommends that the government of Hong Kong create a committee to examine the …

Environmental And Equity Scenarios For Alternative Fuel Vehicle Ownership And Use In The Portland Region, John Macarthur, Kelly Clifton, Joseph Broach, Baxter Shandobil

TREC Final Reports

The City of Portland has been looking to understand the mobility profiles and the associated carbon impacts of different communities in the region. In addition, the City is evaluating its electric vehicle strategy, including placement of charging infrastructure based on locations that will have the greatest impact on reducing carbon emissions and encouraging use of electric vehicles (EVs). To help in this effort, the project is looking to answer the following questions: 1) How are carbon impacts from the use of personal vehicles distributed among different neighborhoods in Portland and the Metro region? 2) Do low-income and minority communities have …

Teen Driver System Modeling: A Tool For Policy Analysis, Celestin Missikpode, Corrine Peek-Asa, Daniel V. Mcgehee, James Torner, Wayne Wakeland, Robert Wallace

Complex Systems Faculty Publications and Presentations

Background: Motor vehicle crashes remain the leading cause of teen deaths in spite of preventive efforts. Prevention strategies could be advanced through new analytic approaches that allow us to better conceptualize the complex processes underlying teen crash risk. This may help policymakers design appropriate interventions and evaluate their impacts.

Methods: System Dynamics methodology was used as a new way of representing factors involved in the underlying process of teen crash risk. Systems dynamics modeling is relatively new to public health analytics and is a promising tool to examine relative influence of multiple interacting factors in predicting a health …

You Live Where? Maximizing O&M Services In Rural And Remote Areas Through Distance Consultation, Amy T. Parker, Mary J. Tellefson

Special Education Faculty Publications and Presentations

The region served by Portland State University’s Orientation and Mobility (O&M) and Visually Impaired Learner (VIL) hybrid preparation program is geographically vast. The states of OR, WA, ID, MT, AK, and HI comprise 28% of the US's geography, covering more than 1,061,000 square miles. Because of regional personnel shortages, faculty must prepare candidates to serve geographically dispersed children and adults with visual impairment or deaf-blindness using technologies that support distance-based consultation.

As a part of a federally funded grant from the US Department of Education, faculty in the O&M program developed an online learning module for candidates to use as …

Pedagogy Of The Edges: Anarchism And The Implicate Order, Jenka Soderberg

Leadership for Sustainability Education Comprehensive Papers

The ecological, structural and epistemological crisis that the planet is facing right now cannot be resolved within the modern educational model. Education can be a means for the transformation of society to a more just, sustainable future – but only if education itself is transformed and re-envisioned by looking to the perspectives that have been most marginalized. This new kind of pedagogy will develop outside the realm of an academic discourse, and will be found in transformative social justice movements and the relationships that are formed in these movements.

Seven Decades Of Vitamin D Research In Pakistan : Too Little, Too Much Or Just Right!, Aysha Habib Khan

Department of Pathology and Laboratory Medicine

No abstract provided.