Digital Commons Network^™

Ectopic High Endothelial Venules In Pancreatic Ductal Adenocarcinoma: A Unique Site For Targeted Delivery., Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang, Naima Banouni, Takaharu Ichimura, Vivek Kasinath, Siawosh K Eskandari, Nasim Annabi, Jonathan S Bromberg, Leonard D. Shultz, Dale L Greiner, Reza Abdi

Faculty Research 2018

BACKGROUND: Nanomedicine offers an excellent opportunity to tackle treatment-refractory malignancies by enhancing the delivery of therapeutics to the tumor site. High endothelial venules (HEVs) are found primarily in lymph nodes or formed de novo in peripheral tissues during inflammatory responses. They express peripheral node addressin (PNAd), which is recognized by the monoclonal antibody MECA79.

METHODS: Here, we demonstrated that HEVs form de novo in human pancreatic ductal adenocarcinoma (PDAC). We engineered MECA79 coated nanoparticles (MECA79-NPs) that recognize these ectopic HEVs in PDAC.

FINDINGS: The trafficking of MECA79-NPs following intravenous delivery to human PDAC implanted in a humanized mouse model was …

Prosecuting Poverty, Criminalizing Care, Wendy A. Bach

Scholarly Works

In 2013, state legislators sitting at the heart of America’s opiate epidemic created the crime of fetal assault. Although they offered a fairly standard series of criminologic rationales to justify the legislation, they also posited that the creation of this crime was a precondition to secure treatment (or care) resources for women addicted to opiates. This extraordinary supposition—that criminalizing conduct creates a road to care—is an outgrowth of three interlinked socio-legal trends: the building of the carceral state, the criminalization of poverty, and the rapid growth, since the late 1980s, of a new generation of problem-solving courts. Framed in this …

Negotiating Legacies: The 'Traffic In Women' And The Politics Of Filipina/O American Feminist Solidarity, Gina Velasco

Women, Gender, and Sexuality Studies Faculty Publications

I wait in the audience as National Heroes, a dramatic vignette presented at the 2006 Pilipino Cultural Night (PCN) performance, [Re]creation, at the University of California at Berkeley, begins with a completely silent, dark stage. I am surrounded by hundreds of expectant Filipina/o American students and their families, eager to witness this annual performance of Filipina/o American culture, which is repeated on college and high school campuses across the West Coast.1 As I wait in the dark, the figures on stage are lit sequentially. One by one, the characters’ tear-streaked faces become visible. The main character, a Filipina migrant domestic …

The Interprofessional Exploration Of Occupational Deprivation (Od) In Intimate Partner Violence (Ipv) To Inform The Health Professional, Chane' Wray, Cheryl Mae Granada

OCCUPATION: A Medium of Inquiry about Health through Occupation

One of the most common forms of violence against women is intimate partner violence (IPV), a public health issue affecting one in three women globally and one in four in the nation (World Health Organization [WHO], 2016). IPV produces long-term impressions as it is defined as any behavior within an intimate relationship that causes physical, psychological or sexual harm (WHO, 2016). Women affected by IPV are inclined to isolate themselves socially decreasing their participation in daily routines (Gorde et al., 2004). The prolonged preclusion of women from necessary/meaningful occupations such as child rearing and social interaction is a conflict outside …

The Use Of Occupation-Based Interventions In Hand Therapy, Rajesh Malikayil, Justin Jameson

OCCUPATION: A Medium of Inquiry about Health through Occupation

Certified hand therapists (CHTs) provide therapeutic rehabilitative services after injury or illness of the upper extremity (Colaianni, & Provident, 2010). The approaches to interventions that CHTs utilize differ from those more typically used by occupational therapists (OTs) because the approaches to interventions are often primarily based in the medical model of physical disabilities (Robinson, Brown, & O’Brien, 2016). There is growing concern that OTs in hand rehabilitation are not using occupations as a method to intervention, leading the occupational therapy profession away from its foundational tenets (Grice, 2015). Furthermore, according to Colaianni, Provident, Lessa, and Wheeler (2015), there is a …

Reading Recovery In South Carolina: 2017-2018 State Report, C. C. Bates, Maryann Mcbride, Mike Moss, Michelle Cater

Publications

Developed by New Zealand educator Dr. Marie M. Clay, Reading Recovery® is a short-term early intervention for first grade students who have the lowest achievement on measures of literacy outcomes. Students meet individually with a specially trained teacher for 30 minutes each day for a period of 12-20 weeks. The goal during this period is for children to develop a network of reading and writing strategies so they may independently perform within the average range of their class.

An Empirical Study Of Workers' Demands Through Industrial Actions: A Comparative Analysis Of The United States, Germany And The People's Republic Of China Under The Bargaining Model, Xiaohan Sun

Maurer Theses and Dissertations

The Chinese traditional manufacturing industry used to rely on raw materials and low labor costs to achieve a competitive advantage, however, the Chinese lowest–cost labor market is no longer competitive and the Chinese manufacturing industry is not the strongest player in the high-tech area. The transition of manufacturing industry is confronted with difficulties and challenges.

From the prior research, one of the reasons over labor conflicts is the awareness of rights consciousness. Employment dispute cases have had a significant increase since 2008, and labor disputes gradually increased since the year 2014. Industrial actions, such as strikes and protests, became the …

Risky Business: Pilot Of The Social Norms Program For Secondary Schools, Katherine Dix, Toby Carslake

Wellbeing

Intent on contributing to drug and alcohol education in secondary schools, Life Education set out in 2017 to explore the viability of using a social norms approach that confronted young people's misconceptions about risk-taking behaviours amongst their peers. A literature review (Ahmed, Mitchell & Trevitt, 2018) provided strong foundations for developing and piloting Australia's first social norms-based drug and alcohol program for secondary school students. Norms are considered to have a behavioural dimension – how the majority of people in a group behave – as well as an attitudinal dimension – how this majority believes they and others should behave. …

Survival Of Patients With Subglottic Squamous Cell Carcinoma, S D. Macneil, K Patel, K Liu, S Shariff, J Yoo, A Nichols, K Fung, A X Garg

Anatomy and Cell Biology Publications

Objective: Subglottic squamous cell carcinoma is a rare subsite of laryngeal cancer that behaves more aggressively and portends a worse prognosis. Using a population-based cancer registry, our objective was to report overall survival (OS) and laryngectomy-free survival (LFS) in patients diagnosed with subglottic squamous cell carcinoma, and to determine whether primary laryngectomy results in improved survival.

Methods: This retrospective population-based study considered patients with a new diagnosis of squamous cell carcinoma in the province of Ontario over a 15-year period (1995-2009). The Ontario Cancer Registry was examined for patients with the diagnosis of interest during the period …

Consensus-Based Care Recommendations For Adults With Myotonic Dystrophy Type 1., Tetsuo Ashizawa, Cynthia Gagnon, William J Groh, Laurie Gutmann, Nicholas E Johnson, Giovanni Meola, Richard Moxley, Shree Pandya, Mark T Rogers, Ericka Simpson, Nathalie Angeard, Guillaume Bassez, Kiera N Berggren, Deepak Bhakta, Marco Bozzali, Ann Broderick, Janice L B Byrne, Craig Campbell, Edith Cup, John W Day, Elisa De Mattia, Denis Duboc, Tina Duong, Katy Eichinger, Anne-Berit Ekstrom, Baziel Van Engelen, Belen Esparis, Bruno Eymard, Marla Ferschl, Shahinaz M Gadalla, Benjamin Gallais, Todd Goodglick, Chad Heatwole, James Hilbert, Venessa Holland, Marie Kierkegaard, Wilma J Koopman, Kari Lane, Daphne Maas, Ami Mankodi, Katherine D Mathews, Darren G Monckton, David Moser, Saman Nazarian, Linda Nguyen, Peg Nopoulos, Richard Petty, Janel Phetteplace, Jack Puymirat, Subha Raman, Louis Richer, Elisabetta Roma, Jacinda Sampson, Valeria Sansone, Benedikt Schoser, Laurie Sterling, Jeffrey Statland, S H Subramony, Cuixia Tian, Careniña Trujillo, Gordon Tomaselli, Chris Turner, Shannon Venance, Aparajitha Verma, Molly White, Stefan Winblad

Paediatrics Publications

Purpose of review: Myotonic dystrophy type 1 (DM1) is a severe, progressive genetic disease that affects between 1 in 3,000 and 8,000 individuals globally. No evidence-based guideline exists to inform the care of these patients, and most do not have access to multidisciplinary care centers staffed by experienced professionals, creating a clinical care deficit.

Recent findings: The Myotonic Dystrophy Foundation (MDF) recruited 66 international clinicians experienced in DM1 patient care to develop consensus-based care recommendations. MDF created a 2-step methodology for the project using elements of the Single Text Procedure and the Nominal Group Technique. The process generated a 4-page …

Phenytoin Activates Smad3 Phosphorylation And Periostin Expression In Drug-Induced Gingival Enlargement., Shawna S Kim, Georgia Nikoloudaki, Mark Darling, Michael J Rieder, Douglas W Hamilton

Paediatrics Publications

Drug-induced gingival enlargement (DIGE) is a fibrotic condition associated with systemic administration of the anti-epileptic drug, phenytoin. We have previously demonstrated that periostin, which is transforming growth factor-beta (TGF-β) inducible gene, is upregulated in various fibrotic conditions including gingival enlargement associated with nifedipine. The objective of this study was to assess periostin expression in phenytoin-induced gingival enlargement (PIGE) tissues and to investigate the mechanisms underlying periostin expression. Human PIGE tissues were assessed using Masson's trichrome, with cell infiltration and changes in extracellular matrix composition characterized through labeling with antibodies to periostin, phospho-SMAD 3, TGF-β, as well as the macrophage markers …

Bone Marrow-Derived Epithelial Cells And Hair Follicle Stem Cells Contribute To Development Of Chronic Cutaneous Neoplasms, Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel Asfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londono, Anupama Singh, Carol Trempus, Derek Gordon, Timothy C. Wang, Rebecca J. Morris

Paediatrics Publications

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Lineage-depleted BMCs migrated towards High Mobility Group Box 1 (HMGB1) protein and epidermal KCs in ex vivo invasion assays. Naive female mice receiving BMTs from DMBA-treated donors developed …

The Implementation And Feasibility Of The Supporting Physical Activity In The Childcare Environment (Space) Intervention: A Process Evaluation, Molly Driediger, Leigh M. Vanderloo, Shauna M. Burke, Jennifer D. Irwin, Anca Gaston, Brian W. Timmons, Andrew M. Johnson, Patricia Tucker

Paediatrics Publications

This study describes the process evaluation of the Supporting Physical Activity in the Childcare Environment (SPACE) intervention, consisting of educator physical activity training, provision of portable play equipment, and a modified outdoor schedule (i.e., 4 × 30-minute periods). Educators (N = 49) from 11 childcare centers in London, Ontario, Canada, delivered the 8-week intervention to 200 preschoolers (Mage = 3.38 years). Workshop attendance was documented while adherence to the outdoor schedule and number and timing of outdoor sessions offered (i.e., dose) were recorded in a daily log. Questionnaire-based program evaluation (n = 41) and in-person group interviews (n = 7) …

Assessment Of Interprofessional Team Collaboration Scale (Aitcs): Further Testing And Instrument Revision., Carole Orchard, Linda L Pederson, Emily Read, Cornelia Mahler, Heather Laschinger

Nursing Publications

INTRODUCTION: The need to be able to assess collaborative practice in health care teams has been recognized in response to the direction for team-based care in a number of policy documents. The purpose of this study is to report on further refinement of such a measurement instrument, the Assessment of Interprofessional Team Collaboration Scale (AITCS) first published in 2012. To support this refinement, two objectives were set: Objective 1: to determine whether the items from the data collected in 2016 load on the same factors as found for the 2012 version of the 37-item AITCS. Objective 2: to determine whether …

How Equity-Oriented Health Care Affects Health: Key Mechanisms And Implications For Primary Health Care Practice And Policy, Marilyn Ford-Gilboe, C. Nadine Wathen, Colleen Varcoe, Carol Herbert, Beth E. Jackson, Josée G. Lavoie, Bernadette (Bernie) Pauly, Nancy A. Perrin, Victoria Smye, Bruce Wallace, Sabrina T. Wong, Annette J. Browne

Nursing Publications

Policy Points A consensus regarding the need to orient health systems to address inequities is emerging, with much of this discussion targeting population health interventions and indicators. We know less about applying these approaches to primary health care. This study empirically demonstrates that providing more equity-oriented health care (EOHC) in primary health care, including trauma- and violence-informed, culturally safe, and contextually tailored care, predicts improved health outcomes across time for people living in marginalizing conditions. This is achieved by enhancing patients’ comfort and confidence in their care and their own confidence in preventing and managing health problems. This promising new …

Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method As A Simple Alternative For Benznidazole Pharmacokinetic Assessment, Danilo César Galindo Bedor, Noely Camila Tavares Cavalcanti Bedor, José Wellithom Viturino Da Silva, Giovana Damasceno Sousa, Davi Pereira De Santana, Facundo Garcia-Bournissen, Jaime Altcheh, Bethania Blum, Fabiana Alves, Isabela Ribeiro

Paediatrics Publications

Chagas disease (CD) is recognized as one of the major neglected global tropical diseases. Benznidazole (BNZ) is the drug of choice for the treatment of adults, young infants, and newborns with CD. However, the pharmacokinetics (PK) of BNZ have been poorly evaluated in all age groups, with consequent gaps in knowledge about PK-pharmacodynamic relationships in CD. The purpose of this study was to develop and validate a bioanalytical method to quantify BNZ levels in small-volume whole-blood samples collected as dried blood spots (DBS). The analysis was performed using high-performance liquid chromatography-positive electrospray tandem mass spectrometry. PK evaluation in healthy male …

Creation Of An Enhanced Recovery After Surgery (Eras) Guideline For Neonatal Intestinal Surgery Patients: A Knowledge Synthesis And Consensus Generation Approach And Protocol Study, Ashleigh C.N. Gibb, Megan A. Crosby, Caraline Mcdiarmid, Denisa Urban, Jennifer Y.K. Lam, Paul W. Wales, Megan Brockel, Mehul Raval, Martin Kautzky-Willer, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Frank J. Snoek, Mireille N.M. Van Poppel

Paediatrics Publications

Introduction: Enhanced Recovery After Surgery (ERAS) guidelines integrate evidence-based practices into multimodal care pathways designed to optimise patient recovery following surgery. The objective of this project is to create an ERAS protocol for neonatal abdominal surgery. The protocol will identify and attempt to bridge the gaps between current practices and best evidence. Our study is the first paediatric ERAS protocol endorsed by the International ERAS Society. Methods: A research team consisting of international clinical and family stakeholders as well as methodological experts have iteratively defined the scope of the protocol in addition to individual topic areas. A modified Delphi method …

Guinea Pig Models For Translation Of The Developmental Origins Of Health And Disease Hypothesis Into The Clinic, Janna L. Morrison, Kimberley J. Botting, Jack R.T. Darby, Anna L. David, Rebecca M. Dyson, Kathryn L. Gatford, Clint Gray, Emilio A. Herrera, Jonathan J. Hirst, Bona Kim, Karen L. Kind, Bernardo J. Krause, Stephen G. Matthews, Hannah K. Palliser, Timothy R.H. Regnault, Bryan S. Richardson, Aya Sasaki, Loren P. Thompson, Mary J. Berry

Paediatrics Publications

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have …

Improving Pregnancy Outcomes In Humans Through Studies In Sheep, Janna L. Morrison, Mary J. Berry, Kimberley J. Botting, Jack R.T. Darby, Martin G. Frasch, Kathryn L. Gatford, Dino A. Giussani, Clint L. Gray, Richard Harding, Emilio A. Herrera, Matthew W. Kemp, Mitchell C. Lock, I. Caroline Mcmillen, Timothy J. Moss, Gabrielle C. Musk, Mark H. Oliver, Timothy R.H. Regnault, Claire T. Roberts, Jia Yin Soo, Ross L. Tellam

Paediatrics Publications

Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base …

Revising Diagnostic And Statistical Manual Of Mental Disorders, Fifth Edition, Criteria For The Bipolar Disorders: Phase I Of The Aredoc Project, Gordon Parker, Gabriela Tavella, Glenda Macqueen, Michael Berk, Heinz Grunze, Thilo Deckersbach, David L. Dunner, Martha Sajatovic, Jay D. Amsterdam, Terence A. Ketter, Lakshmi N. Yatham, Lars Vedel Kessing, Darryl Bassett, Mark Zimmerman, Kostas N. Fountoulakis, Anne Duffy, Martin Alda, Cynthia Calkin, Verinder Sharma, Amit Anand, Manpreet K. Singh, Tomas Hajek, Philip Boyce, Benicio N. Frey, David J. Castle, Allan H. Young

Paediatrics Publications

Objective: To derive new criteria sets for defining manic and hypomanic episodes (and thus for defining the bipolar I and II disorders), an international Task Force was assembled and termed AREDOC reflecting its role of Assessment, Revision and Evaluation of DSM and other Operational Criteria. This paper reports on the first phase of its deliberations and interim criteria recommendations. Method: The first stage of the process consisted of reviewing Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and recent International Classification of Diseases criteria, identifying their limitations and generating modified criteria sets for further in-depth consideration. Task Force members …

Working Towards The Promise Of Participatory Action Research: Learning From Ageing Research Exemplars, Colleen E. Mcgrath

Occupational Therapy Publications

Within research addressing issues of social justice, there is a growing uptake of participatory action research (PAR) approaches that are ideally committed to equitable participation of community members in all phases of the research process in order to collaboratively enact social transformation. However, the utilization of such approaches has not always matched the ideal, with inconsistencies in how participation and action are incorporated. “Participation” within various research processes is displayed differently, with the involvement of community members varying from full participation to their involvement as simply participants for data collection. Similarly, “action” is varyingly enacted from researchers proposing research implications …

Algorithms For Left Atrial Wall Segmentation And Thickness – Evaluation On An Open-Source Ct And Mri Image Database, Rashed Karim, Lauren Emma Blake, Jiro Inoue, Qian Tao, Shuman Jia, R. James Housden, Pranav Bhagirath, Jean Luc Duval, Marta Varela, Jonathan Behar, Loic Cadour, Rob J. Van Der Geest, Hubert Cochet, Maria Drangova, Maxime Sermesant, Reza Razavi, Oleg Aslanidi, Ronak Rajani, Kawal Rhode

Bone and Joint Institute

© 2018 The Authors Structural changes to the wall of the left atrium are known to occur with conditions that predispose to Atrial fibrillation. Imaging studies have demonstrated that these changes may be detected non-invasively. An important indicator of this structural change is the wall's thickness. Present studies have commonly measured the wall thickness at few discrete locations. Dense measurements with computer algorithms may be possible on cardiac scans of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The task is challenging as the atrial wall is a thin tissue and the imaging resolution is a limiting factor. It is …

Ciliary Parathyroid Hormone Signaling Activates Transforming Growth Factor-Β To Maintain Intervertebral Disc Homeostasis During Aging, Liwei Zheng, Yong Cao, Shuangfei Ni, Huabin Qi, Zemin Ling, Xin Xu, Xuenong Zou, Tianding Wu, Ruoxian Deng, Bo Hu, Bo Gao, Hao Chen, Yusheng Li, Jianxi Zhu, Francis Tintani, Shadpour Demehri, Amit Jain, Khaled M. Kebaish, Shenghui Liao, Cheryle A. Séguin, Janet L. Crane, Mei Wan, Hongbin Lu, Paul D. Sponseller, Lee H. Riley, Xuedong Zhou, Jianzhong Hu, Xu Cao

Bone and Joint Institute

© 2018 The Author(s). Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor (PTH1R) to the cilia and enhances parathyroid hormone (PTH) signaling in NP cells. PTH induces transcription of integrin αvβ6 to activate the transforming growth factor (TGF)-β-connective tissue growth factor (CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH (iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, …

Impaired Object-Location Learning And Recognition Memory But Enhanced Sustained Attention In M2 Muscarinic Receptor-Deficient Mice, Carola Romberg, Susan Bartko, Jürgen Wess, Lisa M. Saksida, Timothy J. Bussey

Brain and Mind Institute Researchers' Publications

© 2018, The Author(s). Rationale: Muscarinic acetylcholine receptors are known to play key roles in mediating cognitive processes, and impaired muscarinic cholinergic neurotransmission is associated with normal ageing processes and Alzheimer’s disease. However, the specific contributions of the individual muscarinic receptor subtypes (M1–M5) to cognition are presently not well understood. Objectives: The aim of this study was to investigate the contribution of M2-type muscarinic receptor signalling to sustained attention, executive control and learning and memory. Methods: M2 receptor-deficient (M2−/−) mice were tested on a touchscreen-operated task battery testing visual discrimination, behavioural flexibility, object-location associative learning, attention and response control. Spontaneous …

The Psychological Science Accelerator: Advancing Psychology Through A Distributed Collaborative Network, Hannah Moshontz, Lorne Campbell, Charles R. Ebersole, Hans Ijzerman, Heather L. Urry, Patrick S. Forscher, Jon E. Grahe, Randy J. Mccarthy, Erica D. Musser, Jan Antfolk, Christopher M. Castille, Thomas Rhys Evans, Susann Fiedler, Jessica Kay Flake, Diego A. Forero, Steve M. Janssen, Justin Robert Keene, John Protzko, Balazs Aczel, Sara Álvarez Solas, Daniel Ansari, Dana Awlia, Ernest Baskin, Carlota Batres, Martha Lucia Borras-Guevara, Cameron Brick, Priyanka Chandel, Armand Chatard, William J. Chopik, David Clarance, Nicholas A. Coles, Katherine S. Corker

Brain and Mind Institute Researchers' Publications

Concerns have been growing about the veracity of psychological research. Many findings in psychological science are based on studies with insufficient statistical power and nonrepresentative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Crowdsourced research, a type of large-scale collaboration in which one or more research projects are conducted across multiple lab sites, offers a pragmatic solution to these and other current methodological challenges. The Psychological Science Accelerator (PSA) is a distributed network of laboratories designed to enable and support crowdsourced research projects. These projects can focus on novel research questions, or attempt to replicate prior …

Effects Of Tumor Necrosis Factor-Α Polymorphism On The Brain Structural Changes Of The Patients With Major Depressive Disorder, Rubai Zhou, Fan Wang, Guoqing Zhao, Weiping Xia, Daihui Peng, Ruizhi Mao, Jingjing Xu, Zuowei Wang, Wu Hong, Chen Zhang, Yong Wang, Yousong Su, Jia Huang, Tao Yang, Jijun Wang, Jun Chen, Lena Palaniyappan, Yiru Fang

Brain and Mind Institute Researchers' Publications

Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if proinflammatory genetic burden adversely affects the regional gray matter volume in patients with MDD. The aim of this study was to test whether rs1799724, an SNP of TNF-α, contributes to the neuroanatomical changes in MDD. In this cross-sectional study, a total of 144 MDD patients and 111 healthy controls (HC) well matched for age, sex and education were recruited from Shanghai Mental Health Center. Voxel-based morphometry (VBM) followed …

Rivaroxaban Or Aspirin For Patent Foramen Ovale And Embolic Stroke Of Undetermined Source: A Prespecified Subgroup Analysis From The Navigate Esus Trial, Scott E. Kasner, Balakumar Swaminathan, Pablo Lavados, Mukul Sharma, Keith Muir, Roland Veltkamp, Sebastian F. Ameriso, Sebastian F. Ameriso, Matthias Endres, Helmi Lutsep, Steven R. Messé, J. David Spence, Krassen Nedeltechev, Kanjana Perera, Gustavo Santo, Veronica Olavarria, Arne Lindgren, Shrikant Bangdiwala, Ashkan Shoamanesh, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly, Robert G. Hart, N. Abdelhamid, D. Abdul Rahman, M. Abdul-Saheb, P. Abreu, M. Abroskina, F. Abu Ahmad

Department of Medicine Publications

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For …

Impact Of Traumatic Upper-Extremity Amputation On The Outcome Of Injury Caused By An Antipersonnel Improvised Explosive Device, Shane A. Smith, Mark P. Dacambra, Vivian C. Mcalister

Office of Military Academic Medicine

Background: We have previously reported a higher than expected rate of upper-extremity amputation (UEA) in victims of an antipersonnel improvised explosive device (AP-IED) compared with a similar cohort injured by antipersonnel mines (APM). The goal of this study was to describe the rate, severity and impact of UAE caused by an AP-IED. Methods: We analyzed a prospective database of 100 consecutive dismounted AP-IED victims with pattern 1 injuries to compare the outcomes of the cohort with UEA to that without. Results: We found that UEA (8 above elbow, 19 below elbow, 1 through elbow, 3 hand, 15 digit(s)) was much …

Utilization Profile Of The Canadian-Led Coalition Role 2 Medical Treatment Facility In Iraq: The Growing Requirement For Multinational Interoperability., Mark P. Dacambra Lcol, Raymond L. Kao Capt (Navy), Christopher Berger Lcol, Vivian C. Mcalister Lcol

Office of Military Academic Medicine

Background: The Canadian Armed Forces deployed a Role 2 Medical Treatment Facility (R2MTF) to Iraq in November 2016 as part of Operation IMPACT. We compared the multinational interoperability required of this R2MTF with that of similar facilities previously deployed by Canada or other nations.

Methods: We reviewed data (Nov. 4, 2016, to Oct. 3, 2017) from the electronic Disease and Injury Surveillance Report and the Daily Medical Situation Report. Clinical activity was stratified by Global Burden of Diseases category, ICD-10 code, mechanism of injury, services used, encounter type, nationality and blood product usage. We reviewed the literature to identify utilization …

Father–Daughter Bonds: A Comparison Of Adolescent Daughters’ Relationships With Resident Biological Fathers And Stepfathers, Cynthia G. Campbell, Elizabeth J. Winn

Psychological Sciences Faculty Publications and Presentations

Objective: To investigate whether the interpersonal dynamics of closeness are different in stepfather–stepdaughter versus father–daughter relationships during adolescence.

Background: Establishing a general process model of the relational factors contributing to greater closeness between fathers and daughters is a preliminary step toward examining variations in such processes.

Method: The data were from the National Longitudinal Study of Adolescent to Adult Health (ADD Health), a nationally representative sample of adolescents. Respondents were female adolescents who were living with either a biological father (n = 1,881) or stepfather (n = 273) and reported on the availability and involvement of their (step)fathers, …