Digital Commons Network^™

Progress On Identifying And Characterizing The Human Proteome: 2018 Metrics From The Hupo Human Proteome Project., Gilbert S Omenn, Lydie Lane, Christopher M Overall, Fernando J Corrales, Jochen M Schwenk, Young-Ki Paik, Jennifer E Van Eyk, Siqi Liu, Michael Snyder, Mark S Baker, Eric W Deutsch

Articles, Abstracts, and Reports

The Human Proteome Project (HPP) annually reports on progress throughout the field in credibly identifying and characterizing the human protein parts list and making proteomics an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2018-01-17, the baseline for this sixth annual HPP special issue of the Journal of Proteome Research, contains 17 470 PE1 proteins, 89% of all neXtProt predicted PE1-4 proteins, up from 17 008 in release 2017-01-23 and 13 975 in release 2012-02-24. Conversely, the number of neXtProt PE2,3,4 missing proteins has been reduced from 2949 to 2579 to 2186 over the past …

Expanding The Use Of Spectral Libraries In Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, Hannes Röst

Articles, Abstracts, and Reports

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none captures a satisfactory level …

Flexible And Fast Mapping Of Peptides To A Proteome With Proteomapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, Robert L Moritz

Articles, Abstracts, and Reports

Bottom-up proteomics relies on the proteolytic or chemical cleavage of proteins into peptides, the identification of those peptides via mass spectrometry, and the mapping of the identified peptides back to the reference proteome to infer which possible proteins are identified. Reliable mapping of peptides to proteins still poses substantial challenges when considering similar proteins, protein families, splice isoforms, sequence variation, and possible residue mass modifications, combined with an imperfect and incomplete understanding of the proteome. The ProteoMapper tool enables a comprehensive and rapid mapping of peptides to a reference proteome. The indexer component creates a segmented index for an input …

Identification Of Experimental And Control Areas For Cctv Effectiveness Assessment—The Issue Of Spatially Aggregated Data, Adam Dabrowski, Piotr Matczak, Andrzej Wójtowicz, Michael Leitner

Faculty Publications

Progress in surveillance technology has led to the development of Closed-Circuit Television (CCTV) systems in cities around the world. Cameras are considered instrumental in crime reduction, yet existing research does not unambiguously answer the question whether installing them affects the number of crimes committed. The quasi-experimental method usually applied to evaluate CCTV systems’ effectiveness faces difficulties with data quantity and quality. Data quantity has a bearing on the number of crimes that can be conclusively inferred using the experimental procedure. Data quality affects the level of crime data aggregation. The lack of the exact location of a crime incident in …

Four Umn Morris Faculty Members Earn Research Awards, Communications And Marketing

Campus News Archive

Four University of Minnesota Morris faculty members received Grant-in-Aid of Research, Artistry, and Scholarship program (GIA) awards in the fall round.

Investigation Of Dengue Virus (Denv) Ns2b/3 Protease For Antiviral Development, Thimoro Cheng

Honors Capstones

Numerous studies have shown that Hepatitis C virus (HCV) and Dengue virus (DENV) are from the same family and have many characteristics in common. Despite the similarities, no adequate vaccines or antivirals have been developed for DENV yet although many are commercially available for HCV. In this research, we investigated the relationship between HCV and DENV, especially their NS3/4A and NS2B/3 proteases, to aid in the development of antiviral against DENV. To achieve this, in-depth structural analyses of the complexes were conducted; and molecular modeling stimulation software were utilized to visualize the interactions of the enzymes with different potential inhibitors …

Kenyon Collegiate - December 7, 2018

Kenyon Collegiate

No abstract provided.

Facilities Website User Survey Deadline Is Dec. 21 (December 7, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Adaptation Mechanism And Tolerance Of Rhodopseudomonas Palustris Psb-S Under Pyrazosulfuron-Ethyl Stress, Xiang-Wen Luo, De-Yang Zhang, Teng-Hui Zhu, Xuguo Zhou, Jing Peng, Song-Bai Zhang, Yong Liu

Entomology Faculty Publications

Background: Pyrazosulfuron-ethyl is a long lasting herbicide in the agro-ecosystem and its residue is toxic to crops and other non-target organisms. A better understanding of molecular basis in pyrazosulfuron-ethyl tolerant organisms will shed light on the adaptive mechanisms to this herbicide.

Results: Pyrazosulfuron-ethyl inhibited biomass production in Rhodopseudomonas palustris PSB-S, altered cell morphology, suppressed flagella formation, and reduced pigment biosynthesis through significant suppression of carotenoids biosynthesis. A total of 1127 protein spots were detected in the two-dimensional gel electrophoresis. Among them, 72 spots representing 56 different proteins were found to be differently expressed using MALDI-TOF/TOF-MS, including 26 up- and 30 …

The Daily Gamecock, Semester In Review, Fall 2018, University Of South Carolina, Office Of Student Media

December

No abstract provided.

Examining The Learning Of Students Participating In An Interactive Simulated Patient Experience, Mary Smyers

Theses and Dissertations

Simulated patients are becoming increasingly used in the educational program of future speech-language pathologists. The use of standardized patients provides the opportunity to teach students clinical skills in a controlled environment (Bradley, 2006; Zraick, 2012). Simucase, a speech-language pathology software program, allows clinicians to practice their assessment and treatment skills on virtual patients and is a valid method when teaching clinical skills. Thus, this project examined five undergraduate senior clinicians’ performance and reflection about the Simucase program and their own clinical knowledge. The undergraduate student clinicians engaged in controlled simulation experiences that shared similar characteristics to their current clients, and …

Experiences And Needs Of Parents After Their Child's Suicide Attempt, Maryna V. Haponava

Honors Capstones

The purpose of this literature review is to examine parents’ needs and experiences after their child committed a suicide attempt. According to the National Institute of Mental Health (2017), a suicide attempt is when a person injures herself or himself in order to kill herself or himself, but the actions do not result in death. The American Foundation of Suicide Prevention (2018) has analyzed the data and concluded that in 2015, 8.6 % of adolescents in grades 9-12 reported having made at least one suicide attempt in the past 12 months. Most of the time in the situation of a …

Whalesong 2018-12-07, Erin Laughlin, Kortney Stevens, Jordan Lewis, Sierra Lissick, Caitlin Burnham, Khrystl Brouillette, Melissa Scriven, Alyssa Madrid

Whalesong

No abstract provided.

Disparity Does Not Mean Bias: Making Sense Of Observed Racial Disparities In Fatal Officer-Involved Shootings With Multiple Benchmarks, Brandon Tregle, Justin Nix, Geoffrey P. Alpert

Criminology and Criminal Justice Faculty Publications

Racial disparities in officer-involved shootings have dominated the national discourse recently. Unfortunately, we have yet to identify an appropriate benchmark, or at-risk population, to put these observed racial disparities into context. In this article, we use seven benchmarks—based on population data from the US Census, police-citizen interaction data from the Police-Public Contact Survey, and arrest data from the Uniform Crime Report—to compare OIS fatality rates for black and white citizens from 2015 to 2017. Using population, police-citizen interactions, or total arrests as a benchmark, we observe that black citizens appear more likely than white citizens to be fatally shot by …

Tools To Increase Compliance And Decrease Mortality Due To Sepsis, Cody F. Carr

Doctoral Projects

Severe sepsis is a leading cause of death in the United States and is the most common cause of death among critically ill patients in non-coronary intensive care units (Mayr, Yende, & Angus, 2014). The incidence of severe sepsis is estimated to be 300 cases per 100,000 population and cost an estimated $14 billion in the United States (Mayr et al., 2014). This Doctor of Nursing Practice (DNP) project focused on identifying an early-assessment tool to identify sepsis and increase compliance when using the tool. Identifying sepsis early is important in starting a treatment plan to prevent morbidity and mortality. …

Postoperative Pain In Instrumented Spinal Surgery: A Policy For Intraoperative Dexmedetomidine Use, Clinton Whitley

Doctoral Projects

Instrumented multilevel spine surgery is associated with a large amount of opioid consumption, difficult mobilization, and significant pain in a population of patients who are predominantly already chronic pain sufferers (Mathiesen et al., 2013). The Health Resources and Services Administration (2018) recently claimed that our nation is in the midst of an opioid epidemic, with more than 115 opioid-related deaths occurring every year. As a result of this epidemic, many anesthesia providers have become aware and are attempting to do something about it. Organizations such as the Society for Opioid Free Anesthesia are at the forefront of the battle against …

Higher Education Reform: A Time For Action, The Lincy Institute

Brookings Scholar Lecture Series

The Lincy Institute has been at the forefront of research and analysis on higher education governance reform in Nevada. Following numerous statewide studies, The Lincy Institute has produced reports and policy briefs recommending significant structural changes to the State’s higher education landscape. To provide future generations of students with quality education and training in our 21st-century economy, researchers summarized findings and presented model legislation to improve the quality of education offered by Nevada’s eight institutions of higher learning. All Nevadans should demand an honest and transparent discussion of higher education reform. The 2019 legislative session will be a time for …

Rehabilitation Services News, Georgia Southern University

Clinical Sciences: News & Publications (2018-2023)

• Physical Therapy Students Attend National Student Conclave

Diagnostic & Therapeutic Sciences News, Georgia Southern University

Clinical Sciences: News & Publications (2018-2023)

• Medical Laboratory Science Program Awarded NAACLS Accreditation

Commencement Ceremonies, University Of North Florida

Commencement Printed Materials

Program for the Fall Commencement ceremonies.

Desecration With A Wonderful Meaning, Alexa Bills

USU Student Folklore Fieldwork

The Semi Colon tattoo is a part of a movement for mental health awareness. The punctuation mark is used when you can choose to end a sentence but decide not to. The tattoo has a similar meaning. It’s meant to indicate that you have power over yourself and can decide what happens. You can choose to continue your story. It’s also a symbol of comradery amongst those who have suffered from depression. A lot of people have this tattoo, a lot of people have struggled with their mental health. And seeing that, seeing people with similar struggles, people that have …

A Logitudinal Feature Selection Method Identifies Relevant Genes To Distinguish Complicated Injury And Uncomplicated Injury Over Time, Suyan Tian, Chi Wang, Howard H. Chang

Biostatistics Faculty Publications

Background: Feature selection and gene set analysis are of increasing interest in the field of bioinformatics. While these two approaches have been developed for different purposes, we describe how some gene set analysis methods can be utilized to conduct feature selection.

Methods: We adopted a gene set analysis method, the significance analysis of microarray gene set reduction (SAMGSR) algorithm, to carry out feature selection for longitudinal gene expression data.

Results: Using a real-world application and simulated data, it is demonstrated that the proposed SAMGSR extension outperforms other relevant methods. In this study, we illustrate that a gene’s expression profiles over …

Analysis Of Self, Nathan Wood

Dissertations, Theses, and Projects

Abstract

The following analysis of self is narrative and reflection of the life and beliefs of the author. Information used within this reflection include the authors background information in domains related to relationships, academics, career, work, mental health, chemical health, culture, coping skills, strengths, resilience, and hobbies. Interviews with significant others are used to evaluate others perception of the author. This reflection also analyzes the impact this research has on the author in terms of their professional identity and future plans for development are discussed.

United States Navy Fire Control Women Of The 1980s: Integrated Tribulations, Jo Nell Wildman

Browse all Theses and Dissertations

The Women’s Armed Service Act of 1948 limited women primarily to socially acceptable ratings in the clerical, medical and training fields. With the repeal of the Combat Exclusion Rule for women in 2013 and the opening of all ratings to any qualified person in 2016, today’s military women have opportunities unequal to those of the past. Between 1948 and 2016, policies regarding women fluctuated, opening and closing various nontraditional ratings and leaving women caught in the crossfire. The Navy’s Fire Controlman was one of those ratings, opening to women in 1972 and closing again in 1983. Approximately thirty women enlisted …

Proposed Interpretation Of The Aicpa Code Of Professional Conduct Staff Augmentation Arrangements Interpretation (Et Sec. 1.295.157), December 7, 2018, Comments Are Requested By March 7, 2019; Exposure Draft (American Institute Of Certified Public Accountants), 2018, December 7, American Institute Of Certified Public Accountants. Professional Ethics Executive Committee

Exposure Drafts, Comment Letters, and Statements of Position

No abstract provided.

The Future Of Freedom Of Expression Online, Evelyn Mary Aswad

Duke Law & Technology Review

Should social media companies ban Holocaust denial from their platforms? What about conspiracy theorists that spew hate? Does good corporate citizenship mean platforms should remove offensive speech or tolerate it? The content moderation rules that companies develop to govern speech on their platforms will have significant implications for the future of freedom of expression. Given that the prospects for compelling platforms to respect users’ free speech rights are bleak within the U.S. system, what can be done to protect this important right? In June 2018, the United Nations’ top expert for freedom of expression called on companies to align their …

Macromolecular-Clustered Facial Amphiphilic Antimicrobials, Md Anisur Rahman, Marpe Bam, Edgar Luat, Moumita Sharmin Jui, Mitra S. Ganewatta, Tinom Shokfai, Mitzi Nagarkatti, Alan W. Decho

Faculty Publications

Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requiring a globally conformational arrangement associated with highly unfavorable entropic loss. This concept of macromolecular architectures is demonstrated with a series of multicyclic natural product-based cationic polymers. We have shown that cholic acid derivatives with three charged head groups are more potent and selective than lithocholic and deoxycholic counterparts, particularly against Gram-negative bacteria. This is ascribed to the formation …

Unh Veterinary Clinic Makes Pet Ownership Possible, Sarah Schaier

UNH Today Archive

No abstract provided.

State V. Ihm Appellant's Brief Dckt. 46220

Not Reported

No abstract provided.

State V. Gambino Appellant's Reply Brief Dckt. 45885

Not Reported

No abstract provided.