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2018

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Effective Measures Of Weight Gain Five Years Post-Kidney Transplantation, Tara Calico Cherry Dec 2018

Effective Measures Of Weight Gain Five Years Post-Kidney Transplantation, Tara Calico Cherry

Theses and Dissertations (ETD)

BACKGROUND: Weight gain is commonly observed post-kidney transplantation and is associated with unfavorable health outcomes, such as graft loss, new onset diabetes, and cardiovascular disease. The purpose of this study was to determine the most effective measure for assessing body composition after kidney transplantation.

DESIGN: The study was a descriptive correlational follow-up study from a single kidney transplant site.

SUBJECTS: A total of 45 eligible patients from a 2007-2011 parent study were selected, ages of 37 to 78.

MEASUREMENTS: Body composition was obtained 5–8 years posttransplant via anthropometric measures (waist circumference, body mass index, and dual energy X-ray …


Implementing Evidence-Based Dietary Instruction Strategies In A Specialty Care Clinic, Jacobie Landers Dec 2018

Implementing Evidence-Based Dietary Instruction Strategies In A Specialty Care Clinic, Jacobie Landers

Doctor of Nursing Practice

Cardiovascular disease is a significant health concern that increases risks for stroke, escalates the development of renal disease, and significantly increases morbidity and mortality risk. Dietary changes can significantly reduce complications in patients with heart and vascular disease. This project was designed to effectively implement and sustain provider and cardiovascular staff instructions on dietary modifications to improve hypertension control and lower cholesterol in patients with cardiac disease using staff support. The project facilitated provider evaluation of patients’ dietary habits to promote wellness in a patient population which was not receiving dietary education. Project interventions included establishing structured methods of providing …


Establishing A Coumadin Clinic In A Rural Family Medicine Practice, Kathleen E. Zeledon Dec 2018

Establishing A Coumadin Clinic In A Rural Family Medicine Practice, Kathleen E. Zeledon

Doctor of Nursing Practice

Background. Coumadin is the most commonly prescribed oral anticoagulant worldwide and is safe and effective in the prevention and treatment of stroke and venous thromboembolism (Stoudenmire, DeRemer, & Elewa, 2014). Coumadin is dangerous when poorly managed due to high risk for bleeding and mortality. It is best managed using evidenced-based models of care such as point-of-care (POC) International Normalized Ratio (INR) testing (Garcia et al., 2008; Harrison, Shaw, & Harrison, 2015; Rossiter, Soor, Telner, Aliarzadeh, & Lake, 2013). Purpose. Establish a Coumadin Clinic in a rural family medicine practice with POC INR testing to improve anticoagulant management. Methods …


Practicing Justice : Justice In A Millennial, Wesleyan-Holiness Context, M. Andrew Gale Dec 2018

Practicing Justice : Justice In A Millennial, Wesleyan-Holiness Context, M. Andrew Gale

ATS Dissertations

No abstract provided.


Knowledge And Attitude Toward Hemoglobinopathies Premarital Screening Program Among Unmarried Population In Western Saudi Arabia, Safia M. Binshihon, Manal O. Alsulami, Wed M. Alogaibi, Asmaa H. Mohammedsaleh, Hayfa N. Mandourah, Bushra S. Albaity, Mohamad H. Qari Dec 2018

Knowledge And Attitude Toward Hemoglobinopathies Premarital Screening Program Among Unmarried Population In Western Saudi Arabia, Safia M. Binshihon, Manal O. Alsulami, Wed M. Alogaibi, Asmaa H. Mohammedsaleh, Hayfa N. Mandourah, Bushra S. Albaity, Mohamad H. Qari

Saudi Medical Journal

Objectives: To assess the knowledge and attitude toward hemoglobinopathies premarital screening (PMS) program among unmarried population in Jeddah, Kingdom of Saudi Arabia. Methods: A cross-sectional study was conducted among 1039 unmarried males and females from the general population who fulfilled the eligibility criteria. Data was collected from July-December 2017, using an electronic questionnaire to assess the socio-demographic data, knowledge and attitudes of the participants regarding PMS. Results: Approximately half of the participants had poor knowledge scores (51.1%), while 28.4% of them had fair and 20.5% had good scores. Individuals with an educational level of “university degree and above” had significantly …


Early-Childhood Computer-Based Testing: Effects Of A Digital Literacy Intervention On Student Confidence And Performance, Benjamin-David Christopher Legrand Dec 2018

Early-Childhood Computer-Based Testing: Effects Of A Digital Literacy Intervention On Student Confidence And Performance, Benjamin-David Christopher Legrand

Electronic Theses and Dissertations

Early-childhood digital students grow up in a fast-evolving age of technology requiring them to use and create with technologies and demonstrate core content knowledge. Although third grade students are mandated to master a new language of standardized testing, a large percentage must also learn a language of technology to complete new computer-based tests to measure content mastery. Krashen (1982) defines high affective filter as negative emotional/motivational factors interfering with understanding and cognition. This high affective filter reduces confidence and negatively impacts measuring content mastery on new computerbased tests. Two third grade classrooms at a high-poverty metropolitan school participated in a …


‘Where Have You Vanished?’: Aelred Of Rievaulx’S Lamentation On Simon, Anna Harrison Dec 2018

‘Where Have You Vanished?’: Aelred Of Rievaulx’S Lamentation On Simon, Anna Harrison

Theological Studies Faculty Works

In his lamentation on the death of his friend, Simon, Aelred responds to a centuries-long suspicion about grief by mounting an apology for mourning that is in keeping with a larger Cistercian trend. Aelred’s chief preoccupation in the lamentation is, however, to emphasize the productivity of grief, both for the living and for the dead. Aelred associates the desire to reunite with the beloved dead with stimulating the mourner’s desire for heaven as location for the longed-for reunion, and he conceives of the pain associated with bereavement as payment for the sins of the deceased.


Sentinel-2 As A Tool For Quantifying Suspended Particulate Matter In The Tamar Estuary, Uk, Duncan Wright Dec 2018

Sentinel-2 As A Tool For Quantifying Suspended Particulate Matter In The Tamar Estuary, Uk, Duncan Wright

The Plymouth Student Scientist

This project explores the potential use of Sentinel-2 as a tool for quantifying suspended particulate matter (SPM) in the Tamar estuary. In the first section of this project, the radiometric performance of Sentinel-2B is quantified using in situ above-surface reflectance data acquired autonomously off the waters of Lanai, Hawaii. Three band ratio algorithms were tested/developed for atmospheric correction over this location. No band ratio performed best, but greater inaccuracies were found using the red/green bands (RD -27 – -87 % at 560nm, RD 312 – 440 % at 665nm) in contrast to the blue bands (443nm (RD 4 – 11 …


The Reduction Of Wave Overtopping By Means Of Rubble Mound Revetment (At The Dawlish Coastline), Steffan Henson Dec 2018

The Reduction Of Wave Overtopping By Means Of Rubble Mound Revetment (At The Dawlish Coastline), Steffan Henson

The Plymouth Student Scientist

To evaluate the performance of an additional rubble mound breakwater to the Dawlish Coastline sea wall defence, a number of 2-dimensional physical model tests were undertaken at the Plymouth University Coast Laboratory. The subsequent results of the tests are presented and analysed in this paper. The research found that the most significant influencing factors on overtopping were the significant wave height and the crest freeboard.


Solar Domestic Hot Water Design And Optimisation In The United Kingdom, Edward Hunt Dec 2018

Solar Domestic Hot Water Design And Optimisation In The United Kingdom, Edward Hunt

The Plymouth Student Scientist

Solar energy is being increasingly implemented for domestic uses, such as hot water systems. However, the poor economic gains, particularly in cold climates and winter months, make this environmentally beneficial technology a less attractive investment. So far, research into optimising these designs have focussed on warmer climates and optimising the gains made during the summer months. Furthermore, most high budget research is geared towards industrial implementation which has limited use at the domestic, home-owner scale. To investigate an economically and energetically optimal domestic hot water system design for cold climates, mathematical methods and TRNSYS simulations were used to experiment with …


Scour From Bidirectional Current Flows Around Offshore Monopoles, Thomas Mackinnon Dec 2018

Scour From Bidirectional Current Flows Around Offshore Monopoles, Thomas Mackinnon

The Plymouth Student Scientist

Two tests for a unidirectional and bidirectional current were applied to a 100mm, cylindrical Perspex monopile and the surrounding bathymetries were measured using an industry standard laser profiler traverse system. It was observed the maximum scour depths for a bidirectional current were 47% larger the unidirectional current. The equilibrium scour depth was also predicted by four previously derived equations by other researchers. This found all four significantly over predicted the unidirectional maximum scour depth; however, the bidirectional current was more accurately predicted, with only a 1.5% error against a modern unidirectional prediction. Results identify bidirectional temporal scour development requires further …


Investigation And Identification Of Dye Structure As A Function Of Solvent And Temperature, Caroline Fiona Uncles Dec 2018

Investigation And Identification Of Dye Structure As A Function Of Solvent And Temperature, Caroline Fiona Uncles

The Plymouth Student Scientist

Triarylmethane dyes have absorption spectra that contain two peaks which overlap in polar solvents. The second peak being described as a shoulder peak. The body of work recorded in this dissertation aims to discover which of the theories behind the shoulder present on these absorbance spectra holds most precedence. Stock solutions of 5 different dyes with a range of steric factors and symmetries were prepared to a concentration of 10-3 M in 5 different solvents. These were primary, unbranched alcohols with chain lengths of C1 to C4 and water. The stock solutions were diluted to a concentration of 10-5 M, …


Welfare Implications Of An Enrichment Program For Two Species Of Common Aquaria Fish, Matthew Burgess Dec 2018

Welfare Implications Of An Enrichment Program For Two Species Of Common Aquaria Fish, Matthew Burgess

The Plymouth Student Scientist

Public and academic interest into the welfare of captive animals is strong, and ever growing (Barrows, 2017). In accordance with this, standards of zoo and aquarium welfare science has thrived within recent years, with considerable resource spent assuring the lives of those in captivity are to an acceptable standard (Damasceno et al, 2017). Despite this, an understanding into the mechanisms which impact welfare, and the theoretical tools to assess it, require further specification (Barrows, 2017). This research assessed the welfare of two common aquaria fish, a population of regal tangs (Paracanthurus hepatus), and a population of yellow tangs (Zebrasoma flavescens). …


Using Learning Express-Ways In Special Education Teacher Preparation: Developing Student-Faculty Relationships As A Path To Partnership, Heather H. Smith Ph.D., Anthony Sanchez M.A.T., Maria Peterson-Ahmad Ph.D., Christine Woodbury Ph.D., Belinda B. Mitchell Ph.D. Dec 2018

Using Learning Express-Ways In Special Education Teacher Preparation: Developing Student-Faculty Relationships As A Path To Partnership, Heather H. Smith Ph.D., Anthony Sanchez M.A.T., Maria Peterson-Ahmad Ph.D., Christine Woodbury Ph.D., Belinda B. Mitchell Ph.D.

The Journal of Special Education Apprenticeship

This paper explores the effects of implementing Learning Express-Ways as an instructional communication tool between students and faculty in courses that are part of a special education teacher preparation program and apprenticeship. Findings suggest that using Learning Express-Ways contributed to the development of learning relationships with faculty and this instructional communication tool may be helpful in creating a partnership-focused approach in special education teacher preparation program.


The Effect Of Digital Storytelling On Academic Performance, Interest And Motivation Of Police Cadets In A Law Enforcement Academy, Damon Ing Dec 2018

The Effect Of Digital Storytelling On Academic Performance, Interest And Motivation Of Police Cadets In A Law Enforcement Academy, Damon Ing

Theses and Dissertations

The Effect of Digital Storytelling on Academic Performance, Interest and Motivation of Police Cadets in a Law Enforcement Academy. Doctor of Education (Ed.D.), December 2018, 93pp., 6 tables, 83 references, 5 appendices. With increasing criticism concerning police interactions with the public and the use-of-force decisions, the importance of preservice law enforcement instruction is an ongoing concern for both police practitioners and the public. Law enforcement education can benefit from the integration of new instructional strategies that can increase comprehension and long-term knowledge retention transferable into the field. Digital storytelling has been proffered as an effective cross-cultural communication tool and has …


Cost Of Caring: The Effects Of Euthanasia On Animal Shelter Workers, Kim L. Nguyen-Finn Dec 2018

Cost Of Caring: The Effects Of Euthanasia On Animal Shelter Workers, Kim L. Nguyen-Finn

Theses and Dissertations

This mixed-methods study focuses on animal shelter workers, a population that has often been overlooked in research and clinical practice, and the emotional strains of the task of euthanasia. The effects of employment in a kill or no-kill shelter, participation in euthanasia, and number of years employed on mental health issues of substance abuse, anxiety, depression, secondary traumatic stress, and burnout were examined. A three-way MANOVA was run to test the hypothesis that there is a cell effect among the type of shelter employed in, participation in euthanasia, and years of experience on mental health, which was not supported by …


Longitudinal And Temporal Comparison Of Beach Sand On The Rio Grande Delta System, Samantha B. Moore Dec 2018

Longitudinal And Temporal Comparison Of Beach Sand On The Rio Grande Delta System, Samantha B. Moore

Theses and Dissertations

The Rio Grande is the 5th longest river in North America and defines a significant extent of the United States-Mexico border. It extends for 2830 km from its headwaters in the Rocky Mountains of Colorado to the Gulf of Mexico. The Rio Grande is fed by streams from the Sangre de Cristo Mountains, the Rio Conchos, the Pecos River, runoff from the Sacramento Mountains area, Devils River, the Rio Salado, and the Rio San Juan. This study addresses how the composition of sand forming the Rio Grande river delta into the Gulf of Mexico at Boca Chica Beach is changed …


Radiative Heat Transfer Analysis Of Railroad Bearings For Wayside Thermal Detector Optimization, James Alexandro Aranda Dec 2018

Radiative Heat Transfer Analysis Of Railroad Bearings For Wayside Thermal Detector Optimization, James Alexandro Aranda

Theses and Dissertations

Wayside hot-box detectors (HBDs) are devices that are currently used to evaluate the health of railcar components including bearings, axles, and brakes by monitoring their temperatures. While HBDs have been instrumental in reducing some train derailments in the past few decades, the number of non-verified bearing removals has increased significantly. In general, HBDs tend to underestimate bearing temperatures in both field service and in laboratory testing, which is not surprising considering the simple two-point calibration method that is used to calibrate these devices. Because of this, different calibrations were compared and analyzed including two-point, three-point, and multi-point calibrations. Analysis of …


Redefining The Mfa: Artistic Pragmatism For The Twenty-First Century, Cristina Ann Correa Dec 2018

Redefining The Mfa: Artistic Pragmatism For The Twenty-First Century, Cristina Ann Correa

Theses and Dissertations

The twenty-first century economy demands a culturally-adaptable and technologically-innovative workforce. Despite the expansion of creative industry, at least half of academically-trained artists will work in fields unrelated to their studies. Statistics reflecting employment changes every three years parallel twenty-first century, pragmatic realities. Job seekers must consistently adapt and add to acquired skill sets to remain marketable.

Visual artists constantly engage in research and experimentation to move their practice beyond comfort zones. While many artistic processes can be learned through the internet, books, and observational study, the road to a career in academia must begin with a Master of Fine Art …


Green Synthesis/Biosynthesis Of Silver Nanoparticles By Using Orange Peel Extract, Leela Joshi Dec 2018

Green Synthesis/Biosynthesis Of Silver Nanoparticles By Using Orange Peel Extract, Leela Joshi

Theses and Dissertations

Joshi, Leela, Green Synthesis/Biosynthesis of Silver Nanoparticles by Using Orange Peel Extract. Master of Science (MS), December, 2018, 40 pages, 23 figures, references, 36 titles. In this work, we report synthesis of silver nanoparticles (AgNPs) with an average size of ~6 nm. The aqueous solution of Ag+ ions is reduced using an aqueous extract from orange peel (Citrus Sinensis) at varying pHs. Reduction of Ag+ ions in solution was monitored using UV-visible absorption spectroscopy, and the corresponding surface plasmon resonance of AgNPs at 435 nm. The solution changed color from yellow to reddish-brown upon bioreduction of silver nitrate in orange …


Epistemic Violence In Beowulf, Joseph W. Krippel Dec 2018

Epistemic Violence In Beowulf, Joseph W. Krippel

Theses and Dissertations

Throughout the more than two centuries of scholarship on Beowulf scholars have engaged in a consistent controversy in interpretation revolving around the issue of Christian versus pre-Christian content in the poem. While scholars largely agree that the understanding of the poem depends on understanding this content, scholars still widely disagree on what that understanding should be. The history of this problem is summarized, moving from viewing the poem as primarily pre-Christian, to general agreement that it is primarily Christian, to the current climate of viewing the text as hybridization. The thesis then proposes that, following the theories of Michel Foucault …


Assessing The Grey Short-Tailed Opossum (Monodelphis Domestica) As A Potential Animal Model Of Autism Spectrum Disorder: Creation Of An Ethogram And Description Of Developmental Changes In Social Behavior, Angela M. Mar Dec 2018

Assessing The Grey Short-Tailed Opossum (Monodelphis Domestica) As A Potential Animal Model Of Autism Spectrum Disorder: Creation Of An Ethogram And Description Of Developmental Changes In Social Behavior, Angela M. Mar

Theses and Dissertations

Research using animal models is done when human subjects cannot participate due to ethical concerns. The majority of translational research is done using rat models. However, other animals are good candidates for translational research, such as Monodelphis domestica. Presently, little is known about Monodelphis domesticas’ behavior and how the animal can be used in research settings. The aim of the study is to fill the gap in the research by conducting behavioral observations of M. domestica pups using a longitudinal approach starting with post-weaned age and ending at the age of sexual maturity and creating an behavioral ethogram. …


Associative And Non-Associative Learning In The Monodelphis Domestica, Ana C. Ramirez Dec 2018

Associative And Non-Associative Learning In The Monodelphis Domestica, Ana C. Ramirez

Theses and Dissertations

Learning encompasses multiple important processes that vary within organisms and that are affected by different factors. Two of the most important types of learning are associative and non-associative learning. Even though past research has studied animal learning in multiple species, there is limited research on learning in the Monodelphis domestica. It is imperative to further the knowledge on this species since multiple fields use it as an animal model for research. The current study examined both non-associative and associative learning in the Monodelphis. Non-associative learning was explored by using a habituation-dishabituation paradigm, while associative learning was examined using the …


Arabidopsis Thaliana Transformed With Streptanthus Farnsworthianus Metal Tolerance Protein 1 (Sfmtp1) Or The Native A. Thaliana Metal Tolerance Protein 1 ( Atmtp1) Cdna And The Effects On Sod Enzyme Activity Upon Nickel Treatment, Selina Urbina Fernandez Dec 2018

Arabidopsis Thaliana Transformed With Streptanthus Farnsworthianus Metal Tolerance Protein 1 (Sfmtp1) Or The Native A. Thaliana Metal Tolerance Protein 1 ( Atmtp1) Cdna And The Effects On Sod Enzyme Activity Upon Nickel Treatment, Selina Urbina Fernandez

Theses and Dissertations

Superoxide Dismutase enzyme activity was analyzed in transgenic Arabidopsis thaliana, a non-accumulator weed plant species of the Brassicaceae family, that was transformed with Streptanthus farnsworthianus Metal Tolerance Protein1 (SfMTP1) or A. thaliana Metal Tolerance Protein 1 (AtMTP1 ). The transgenic A. thaliana was exposed to a 12 day treatment of 100 ?M Nickel Acetate in 1/10 X Hoaglands solution in hydroponics. Analysis of Super Oxide Dismutase activity determined that transgenic A. thaliana transformed with the AtMTP1 cDNA and treated with 100 µM Nickel showed a significant increase in Super Oxide Dismutase activity compared to A. thaliana …


A Stormwater Management Model For California Polytechnic State University Campus, Hsuan-Wen Chu Dec 2018

A Stormwater Management Model For California Polytechnic State University Campus, Hsuan-Wen Chu

Master's Theses

Developments that have been taking place on Cal Poly campus over the years have altered the natural hydrology of the area. Stormwater management practices could help reduce the impacts of these developments. Computer models can help to design effective and economical stormwater management solutions at a watershed scale. As such, the objective of this study was to develop a stormwater management model for Cal Poly campus. The model was developed based on the utility data obtained from the university and other watershed data available from open sources. Field surveys were conducted to address some anomalies in the utility data, and …


Planning The Reintroduction Of The Clouded Leopard (Neofelis Nebulosa) To Taiwan: An Assessment Of Attitudes And Potential Support, Evan Greenspan Dec 2018

Planning The Reintroduction Of The Clouded Leopard (Neofelis Nebulosa) To Taiwan: An Assessment Of Attitudes And Potential Support, Evan Greenspan

Theses

Large felid populations are in decline globally and wildlife managers have increasingly used reintroductions as a conservation tool, yet few studies have assessed public attitudes towards potential large felid reintroduction candidates prior to release. The clouded leopard was recently declared extinct in Taiwan; however, a reintroduction effort is ecologically feasible and success largely depends on resident attitudes towards clouded leopards and support for its reintroduction. In 2017, 263 semi-structured interviews with indigenous locals were conducted in southern Taiwan and an internet questionnaire was distributed to 500 urban residents for comparison. Rural and urban attitudes were 67% and 76% positive toward …


Prosthetic Rehabilitation Of Edentulous Mandible With Two-Implant Retained Fixed Hybrid Prosthesis: A Case Report, Meisha Gul, Muhammad Rizwan Nazeer, Rabia Ghafoor Dec 2018

Prosthetic Rehabilitation Of Edentulous Mandible With Two-Implant Retained Fixed Hybrid Prosthesis: A Case Report, Meisha Gul, Muhammad Rizwan Nazeer, Rabia Ghafoor

Section of Dental-Oral Maxillofacial Surgery

Removable complete dentures have been the most costeffective treatment option for edentulous jaws since decades. However, certain problems are encountered by the patients such as stability of the lower dentures resulting in poor masticatory efficiency. Ridge resorption and inadequate bony support are the long-term complications comprising the stability of the denture and patient finding it difficult to control denture movement during speaking and eating reducing patient compliance. Mandibular implant retained over dentures or hybrid dentures have shown to be better alternatives in terms of retention, stability and patient satisfaction. Two implants provide cost-effective, stabilized and comfortable treatment options. The present …


Reducing Thirty-Day Hospital Readmissions In Drug And Medication Poisoning: An Observational Study, Jenna M. Evans Dec 2018

Reducing Thirty-Day Hospital Readmissions In Drug And Medication Poisoning: An Observational Study, Jenna M. Evans

Seton Hall University Dissertations and Theses (ETDs)

A common and costly occurrence in the United States is thirty-day hospital readmissions. Awareness of 30-day hospital readmissions is currently a national priority. To reduce avoidable readmissions, the Patient Protection and Affordable Care Act of 2010 established a “Hospital Readmission Reduction Program” implemented to provide possible solutions for preventable thirty-day readmissions. Part of this policy states that hospitals with higher than expected adjusted re-hospitalization rates have lower reimbursement rates. One specific area known to be a cause of thirty-day hospital readmissions is drug and medication poisoning. An observational study of data from the Nationwide Readmissions Database is being used to …


Law Enforcement Employees’ Perceptions Of Performance Appraisals In A Medium-Size, Suburban Police Department, Christopher C. Zimmerman Dec 2018

Law Enforcement Employees’ Perceptions Of Performance Appraisals In A Medium-Size, Suburban Police Department, Christopher C. Zimmerman

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this qualitative case study was to investigate how police officers in a medium-size, suburban police department perceived performance appraisals and the effects of performance appraisals on job satisfaction and job performance. This study also examined the impacts of job satisfaction and job performance on organizations. One-on-one participant interviews were conducted, and thematic coding was utilized to capture the dominant themes associated with the police officers’ perceptions of performance appraisals. Twelve police officers from a medium-size, suburban police department in New Jersey participated in the study, and their anonymity was maintained to elicit transparent responses. This dissertation was …


A Virus-Encoded Type I Interferon Decoy Receptor Enables Evasion Of Host Immunity Through Cell-Surface Binding., Bruno Hernáez, Juan Manuel Alonso-Lobo, Imma Montanuy, Cornelius Fischer, Sascha Sauer, Luis J. Sigal, Noemí Sevilla, Antonio Alcamí Dec 2018

A Virus-Encoded Type I Interferon Decoy Receptor Enables Evasion Of Host Immunity Through Cell-Surface Binding., Bruno Hernáez, Juan Manuel Alonso-Lobo, Imma Montanuy, Cornelius Fischer, Sascha Sauer, Luis J. Sigal, Noemí Sevilla, Antonio Alcamí

Department of Microbiology and Immunology Faculty Papers

Soluble cytokine decoy receptors are potent immune modulatory reagents with therapeutic applications. Some virus-encoded secreted cytokine receptors interact with glycosaminoglycans expressed at the cell surface, but the biological significance of this activity in vivo is poorly understood. Here, we show the type I interferon binding protein (IFNα/βBP) encoded by vaccinia and ectromelia viruses requires of this cell binding activity to confer full virulence to these viruses and to retain immunomodulatory activity. Expression of a variant form of the IFNα/βBP that inhibits IFN activity, but does not interact with cell surface glycosaminoglycans, results in highly attenuated viruses with a virulence similar …