Digital Commons Network^™

Allogeneic Stem Cell Transplantation As Part Of Front Line Therapy For Mantle Cell Lymphoma., S Rule, G Cook, Nh Russell, A Hunter, Et Al

Peninsula Medical School

Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin lymphoma that remains incurable for the majority of patients. Allogeneic stem cell transplantation (alloSCT) produces long-term disease-free remissions for around 30-40% patients, however it is reserved for the treatment of relapsed disease. This study examined the use of front line transplantation for young patients in an attempt to improve outcomes. Twenty-five patients received an alloSCT using BEAM [BCNU (carmustine), etoposide, cytarabine, melphalan)-Campath conditioning following permissive induction therapy from both related and unrelated donors. This was a multi-centre prospective trial. Twenty-four of 25 patients engrafted with no non-relapse mortality events by …

Navigating The Predator Gauntlet: Consumption Of Hatchery- And Wild-Born Juvenile Chum Salmon (Oncorhynchus Keta) By Common Nearshore Marine Fishes In Southeast Alaska, Douglas H. Duncan

Fisheries

Juvenile chum salmon (Oncorhynchus keta) undergo extensive mortality at marine entry, a period which is believed to be a potential population bottleneck. Although this early mortality has been consistently observed, our understanding of the mechanisms responsible is limited. Furthermore, the implications of large-scale salmon hatchery releases for the ecology of juvenile chum salmon and their consumers is another important knowledge gap. To better understand the predation responses of abundant consumers to hatchery- and wild-born juvenile chum salmon, we examined the diets of Pacific staghorn sculpin (Leptocottus armatus) and Dolly Varden (Salvelinus malma) near Juneau, Alaska, in 2016 and 2017. Chum …

Impacts Of A Top Predator (Esox Lucius) On Salmonids In Southcentral Alaska: Genetics, Connectivity, And Vulnerability, Chase S. Jalbert

Fisheries

Worldwide invasion and range expansion of northern pike (pike; Esox lucius) have been linked to the decline of native fishes and new techniques are needed to assess the effects of invasion over broad geographic scales. In Alaska, pike are native north and west of the Alaska Mountain Range but were introduced into Southcentral Alaska in the 1950s and again in the 1970s. To investigate the history of the invasion into Southcentral Alaska, I identified 7,889 single nucleotide polymorphisms (SNPs) from three native and seven introduced populations in Alaska and examined genetic diversity, structure, and affinities of native and invasive pike. …

Factors Influencing Chinook Salmon Spawning Distribution In The Togiak River, Alaska, Stephanie L. Meggers

Fisheries

Salmonids are heavily dependent on specific habitat characteristics for survival, yet few studies in Alaska have examined the relationship between habitat and spawning distribution, using remote sensing approaches. To better understand the relationship between Chinook Salmon Oncorhynchus tshawytscha spawning distribution and environmental variables like habitat type (e.g., run, riffle, pool), temperature, and proximity to channel islands, optical and thermal imagery were collected on the Togiak and Ongivinuk rivers in southwest Alaska. Object-based image analysis was used to classify and quantify habitat types, while thermal characteristics and the proximity of spawning locations to channel islands were determined in a GIS framework. …

Distribution Of Hunter Groups And Environmental Effects On Moose Harvest In Interior Alaska, Tessa R. Hasbrouck

Biological Sciences

Moose (Alces alces) is one of the most valuable wild game resources in Interior Alaska. In recent years, residents of rural indigenous communities have expressed concern that climate change and competition from non-local hunters are challenging local moose harvest opportunities. I collaborated with wildlife agencies and village tribal councils to co-design two studies to address rural community hunter concerns. The first study assessed the spatial and temporal distribution of local and non-local hunter groups to examine areas of potential competition. The second study addressed changing environmental factors and their impacts on moose harvest. Although competition among local hunters or among …

Shining Light On Hibernator Genomes: Using Radiation To Reveal Dna Damage And Repair Dynamics In Arctic Ground Squirrels, Krysta L. Yancey

Biological Sciences

Mammalian hibernation is characterized by dynamic changes in metabolism and body temperature; it may be sustained for up to nine months in some species. The majority of hibernation is spent in torpor, a dormant state, which is regularly interrupted by brief periods of activity referred to as interbout arousal. Upon arousal thermogenesis begins in vascularized fat and ends with whole-body shivering until the animal reaches a body temperature around 36-37 °C. Interbout arousal is usually less than a day long and is commonly thought to be necessary for maintenance and repair of tissues, in addition to the cycling and replenishment …

Nh Veterinary Diagnostic Lab Partners With Seacoast Science Center Marine Mammal Rescue, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Registration Open For 5th Live Free Or Die Writing Boot Camp, Kristen Melamed

UNH Today Archive

No abstract provided.

Unh Moments 2018, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

State V. Caldwell Respondent's Brief Dckt. 46166

Not Reported

No abstract provided.

Awareness Of Supporting Elderly Parents By Family Caregivers In Households With Home-Bound Elderly With Dementia, Keiko Matsumoto, Misae Ito, Claudia Kam Yuk Lai, Daphne Cheung, Siok Bee Tan, Yasuyo Kametaka, Yoshimi Tsunekuni, Sadao Katayama, Masafumi Kirino

International Nursing Research Congress (INRC)

This research aims to investigate the relevancy between the attributes of caregivers and their awareness of supporting their elderly parents. This research investigated the relevancy between caregivers' attributes and their awareness of supporting their elderly parents.

Consumer Perceptions: From Myths To Action, Michael P. Vandenbergh, Kristian Steensen Nielsen

Vanderbilt Law School Faculty Publications

Rapid and transformative changes are required to reduce the adverse consequences of climate change. A growing literature suggests that households can be an important part of efforts to reduce GHG emissions. Transformative change implies modifying actions across different life and consumption domains, but not all actions are equally important. The most promising efforts focus on behaviours with high technical potential (the total emissions reductions possible from the behaviour change) and behavioural plasticity (the extent to which the behaviour can be changed in a given decision environment). Shifting towards a plant-based diet has technical potential that is among the highest of …

United States Department Of Defense Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

US DOD SIP

A Grand Challenges-Based Research Agenda For Scholarly Communication And Information Science [Mit Grand Challenge Pubpub Participation Platform], Micah Altman, Chris Bourg

Copyright, Fair Use, Scholarly Communication, etc.

Identifying Grand Challenges

A global and multidisciplinary community of stakeholders came together in March 2018 to identify, scope, and prioritize a common vision for specific grand research challenges related to the fields of information science and scholarly communications. The participants included domain researchers in academia, practitioners, and those who are aiming to democratize scholarship. An explicit goal of the summit was to identify research needs related to barriers in the development of scalable, interoperable, socially beneficial, and equitable systems for scholarly information; and to explore the development of non-market approaches to governing the scholarly knowledge ecosystem.

To spur discussion and …

Instructor Assessment Of Adult Cpr Skills: A Comparison Between Subjective And Objective Measures, Emily Evans

Graduate Dissertations and Theses

Providing accurate feedback is an important component of teaching CPR skills. An important part of providing accurate feedback is being able to accurately assess specific skills. In a cross- sectional experimental design, 33 CPR instructors were recruited to assess six 2-minute pre- recorded videos of 2-person CPR skills. The subjective assessment measures were compared to the objective manikin measures from a Laerdal Resusci-Anne® QCPR manikin. Results indicated statistically significant differences between the subjective and objective measures in all skills assessed (chest compression rate, chest compression depth, chest recoil, hand placement, ventilation volume, and total cycles). Instructor teaching experience (in years …

The Effects Of Inhibiting Pi3k On Tumor Suppressor Gene P53 And Cell Proliferation, Kelsi Peters

Undergraduate Theses and Capstone Projects

When the cell surface molecule, Human EGF Receptor (HER2), is overexpressed, the cell can become cancerous. MDA-MB-453 is an established breast cancer cell line made cancerous by HER2 overexpression. This mutation that causes HER2 overexpression affects the cell signaling pathway of phosphoinositide 3-kinase (PI₃K), Akt, MDM2, and p53. We predicted that PI₃K would be inhibited with the compound, LY294002, sending signals for Akt and MDM2 to be deactivated in MDA-MB-453 cells. Deactivated MDM2 signals for p53 to be activated. P53 is a tumor suppressor protein that exists in low quantities in normal cells, but when damage …

Brain Candy: Wayne State University School Of Medicine Journal Of Arts And Culture, Special Edition: The Renaissance, Wayne State University School Of Medicine Gold Humanism Honor Society

Gold Humanism Honor Society

Brain Candy collects poetry, nonfiction essays, short fiction, photographs, and drawings to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. Each issue features submissions from medical students, physicians, and School of Medicine staff.

This year marks a special edition to celebrate Wayne State University’s existence for 150 years. With generous funding support from an alumnus, Dr. Thomas Janisse, Class of 1975, the journal was started in print in 2016.

The Seasonal Dynamics Of Coastal Arctic Lagoons In Northwest Alaska, Marguerite Tibbles

Fisheries

Lagoons are zones of habitat transitions between freshwater and marine ecosystems, providing safe and productive feeding habitats for whitefishes in Northwest Alaska, important to subsistence users in the region. However, many important lagoon processes are not understood. Therefore, the goal of this thesis was to gain a baseline understanding of two important seasonal processes of lagoons in Northwest Alaska. First, I attempted to identify environmental processes correlated with Arctic lagoon breaching for three indicator lagoons that represent a range of environmental characteristics using generalized linear models (GLM) in an information theoretic approach and model averaging. Second, I developed a habitat …

Increasing Revenue By Applying Machine Learning To Congestion Management In Sdn, Nabarun Jana

Theses

With the advent of 5G, IoT and 4k videos, online gaming, movie streaming and other data intensive applications, the demand for data is sky rocketing. Due to this surge in data, the load on the network increases. This heightened network load causes degradation in network performance. Which can lead to the customer Service Provider (CSP)s loosing revenue if the Service Level Agreement (SLA) are not met.

This report describes how machine learning techniques such as tit for tat can be applied to telecom networks. Machine learning applied to telecom networks help detect congestion and maintain SLAs while increasing yield (revenue). …

A Two-Layer Energy-Efficient Wireless Sensor Network For Precision Agriculture Applications, Osiris V. Ntarugera

Engineering

The agriculture industry has benefited from the recent technological evolution; for example, farmers now use satellite images to monitor large fields. The use of technology in agriculture, generally referred to as Precision Agriculture, has attracted a lot of research interest from electrical engineers. One particular area of Precision Agriculture is the application of embedded systems in monitoring large crop fields. Sensor nodes are placed at various locations in the field where they measure different parameters, such as temperature and soil moisture. The collected measurements are sent to a central hub outside of the field where they can be further processed …

Design Of A Multichannel Outdoor Data Logger For Precise Temperature Measurements, Kirill Dolgikh

Engineering

In this thesis, we present the prototype of a multichannel data logger (the Logger) for precise temperature measurements. Its intended application is to take soil (permafrost) temperature measurements with a thermistor probe or thermistor string. However, its hardware and firmware architectures are quite flexible, so it can be used in other applications. The Logger has 16 channels. In addition to the internal memory, it supports microSD-cards of up to 2 GB, which allows it to store up to 41.9 million measurements for each channel. The Logger's estimated battery life is 8 years when making measurements once per hour. It has …

The Rational Basis Test And Why It Is So Irrational: An Eighty-Year Retrospective, James M. Mcgoldrick Jr.

San Diego Law Review

The Rational Basis test is one of the most common and yet perhaps the most insignificant United States Supreme Court test in the history of the constitution, yet year in year out clients and lawyers will submit another brief hoping against hope that this time there might be a meaningful outcome. There will not be.

This article attempts to explain why the rational basis test is so irrational in its outcome, why basic interests are disregarded in the name of judicial respect for the legislative process, and how easy it would be for there to be a better outcome. The …

Mapping Territorial Limitations On Insurance Coverage, Douglas R. Richmond

San Diego Law Review

Globalization has come to financial markets and to innumerable industries. U.S. businesses export and import goods and products; many have done so for decades. Domestic companies that sell materials online almost certainly do some international business. American corporations have foreign facilities or operations. Americans travel internationally with relative ease. For those living in states that adjoin Canada or Mexico, international travel can be accomplished simply by driving across the border.

At the same time, insurance policies sold in the United States frequently contain territorial limitations on coverage that superficially seem out of place when compared to many aspects of modern …

Workflow Simulation Aware And Multi-Threading Effective Task Scheduling For Heterogeneous Computing, Vasilios Kelefouras, Karim Djemame

School of Engineering, Computing and Mathematics

No abstract provided.

Bounded Rationality, Paternalism, And Trademark Law, Stacey Dogan

Faculty Scholarship

We don’t need behavioral economics to understand that trade marks can shape consumer preferences in ways that have little to do with objectively measurable differences in product quality. Scholars, judges, economists, and policymakers have long recognized the tendency of strong marks to skew consumer decisions. The concern lies not only in price effects but with the allocative effects of encouraging investment in persuasive advertising, rather than product innovation or similar “productive” pursuits. While informative advertising can benefit consumers, advertising that creates artificial brand-based differences between otherwise identical products appears not only costly to consumers but also socially wasteful.

This Essay …

Word Sense Disambiguation Using Fuzzy Semantic-Based String Similarity Model, Amir Abd-Rashid, Shuzlina Abdul-Rahman, Nor Nadiah Yusof, Azlinah Mohamed

Malaysian Journal of Computing (MJoC)

Sentences are the language of human communication. This communication medium is so fluid that words and meaning can have many interpretations by readers. Besides, a document that consists of thousands of sentences would be tough for the reader to understand the content. In this case, computer power is required to analyse the gigantic batch size of the text. However, there are several arguments that actively discuss regarding the output generated by a computer toward the meaning of the passage in terms of accuracy. One of the reasons for this issue is the existing of the ambiguous word with multiple meanings …

Mismatch Between Older Adults’ Expectation And Smartphone User Interface, Chui Yin Wong, Rahimah Ibrahim, Tengku Aizan Hamid, Evi Indriasari Mansor

Malaysian Journal of Computing (MJoC)

Smartphones have become ubiquitous communication tools for everybody, including older adults to stay connected with their family and access to information. However, mobile operators and developers mainly target the youngster cohort in mobile industry. With the rising ageing population, smartphone user interface and some mobile apps are not designed to cater the needs of older adults. This could hinder them from fully utilizing the smartphone functions and its services. A mobile-user interaction study using mixed-methods (questionnaire, interview and observation) was conducted to examine usability and user interface design issues of smartphone and mobile apps among 80 older adults in Malaysia. …

Devon Tourism: The Story Of The County’S Economic Leviathan, Stephen Essex, Mark Brayshay

School of Geography, Earth and Environmental Sciences

Over the past 149 volumes of these Transactions, fewer than half a dozen papers have focused directly on tourism in Devon. Given its key role in shaping the county’s history, landscape and infrastructure, and its contemporary social and economic character, such a dearth of studies is striking and contrasts with the burgeoning body of scholarly work on Devon tourism aired elsewhere. The aim of this paper is to offer a broad, benchmark review of the origins, historical growth and changing character, as well as the contemporary state and future prospects, of tourism in the county. The analysis demonstrates how the …

Bjc Today

BJC Today

No abstract provided.

Defying Contextual Embeddedness: Evidence From Displaced Women Entrepreneurs In Jordan, H Al-Dajani, H Akbar, S Carter, E Shaw

Plymouth Business School

Although entrepreneurial practices and processes are evolving and changing globally, models of entrepreneurship remain masculinized, embedded in advanced economies and associated with notions of individual agency, heroism and control. Rarely is defiance considered. In this paper, we explore the defiance practices of displaced women operating in the Jordanian patriarchal economy and society and consider how this enabled their nurturing of entrepreneurship. Indeed, we argue that socially excluded women actually defy their contextual embeddedness through their entrepreneurial activities. In so doing, we respond to calls for research that explores the contextual embeddedness of women’s entrepreneurship, and contribute to shifting the focus …