Digital Commons Network^™

Rare But Recurrent Ros1 Fusions Resulting From Chromosome 6q22 Microdeletions Are Targetable Oncogenes In Glioma., Monika A Davare, Jacob J Henderson, Anupriya Agarwal, Jacob P Wagner, Sudarshan R Iyer, Nameeta Shah, Randy Woltjer, Romel Somwar, Stephen W Gilheeney, Ana Decarvalo, Tom Mikkelson, Erwin G Van Meir, Marc Ladanyi, Brian J Druker

Articles, Abstracts, and Reports

PURPOSE: Gliomas, a genetically heterogeneous group of primary central nervous system tumors, continue to pose a significant clinical challenge. Discovery of chromosomal rearrangements involving kinase genes has enabled precision therapy, and improved outcomes in several malignancies.

EXPERIMENTAL DESIGN: Positing that similar benefit could be accomplished for patients with brain cancer, we evaluated The Cancer Genome Atlas (TCGA) glioblastoma dataset. Functional validation of the oncogenic potential and inhibitory sensitivity of discovered ROS1 fusions was performed using three independent cell-based model systems, and an

RESULTS:

CONCLUSIONS: Our findings highlight that CNS tumors should be specifically interrogated for these rare intrachromosomal 6q22 microdeletion …

2018 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Measuring Hpv Vaccine Worry: Development And Validation Of A Scale In Parents With Hpv Vaccine Eligible Children, Catherine Rochefort

Psychology Theses and Dissertations

Worry is a negatively-valenced emotion associated with risk-related cognitions. In the context of HPV vaccination, it is likely that parents worry about giving their child the vaccine because some vaccine outcomes may be perceived as uncertain. Therefore, worry may be an important factor predicting HPV vaccination outcomes. This study’s purpose was to (1) develop a measure of HPV vaccine worry, (2) examine whether parents worry more about the HPV vaccine than other adolescent vaccines, and (3) determine whether HPV vaccine worry is associated with HPV vaccination intentions. In Study 1, a HPV vaccine worry item pool based on the three-process …

Fast Forward-Backward Channel Estimation For Mimo Stbc-Ofdm Systems, Lena Chang

Journal of Marine Science and Technology–Taiwan

In the study, we develop a fast forward-backward estimation (FFBE) method for multiple input multiple output (MIMO) space time block code (STBC) orthogonal frequency division multiplexing (OFDM) systems. We examined the matrix structure of the forward-backward (FB) correlation matrix and observed this matrix possessing permutation invariant (PI) property. We also investigated the eigen-property of a matrix with PI property and proved its eigenvectors possessing symmetric property, which can be calculated from two half dimensionality submatrices. Based on these analyses, we propose a fast eigen-decomposition algorithm to reduce the computations required in the eigendecomposition of FB correlation matrix. Then, the symmetric …

169th Commencement, Fall

Commencement Programs

No abstract provided.

The Role Of Virtual Communication Platforms In Academically Supporting Post-Secondary Students, Eldora M. Fosmire

CUP Ed.D. Dissertations

While many consider college students to be digital natives, who are at ease with multiple forms of technology, many of these students do not adapt these skills for academic purposes. Retention concerns for college students often prompt support staff to seek out and adopt technology approaches to promote completion. This study provided a virtual learning platform to deliver academic support and sought to promote learning community interaction for rural and urban post-secondary students. A subset of vocational major programs that prepare students for employment after completion served as a participant pool. However, participants in the study chose not to use …

Social Media And Academic Performance: Assisting Academic Achievement For English Language Learners, Eduardo D. Moreno

CUP Ed.D. Dissertations

The purpose of this quantitative retrospective, causal-comparative study was to examine what, if any, statistically significant difference existed between Measures of Academic Progress (MAP) mathematical and reading achievement of English Language Learners (ELL) in a school using Seesaw—a social media platform—and those in a school not using Seesaw in an elementary school setting in Northern California. The population of ELL third and fourth-grade students within each participating school was 52, for a total of 104 participants. All ELL students in this study come from Spanish speaking homes and were Spanish speakers. Collection of data occurred through the MAP Growth assessments. …

Blended Learning In Middle School Art: A Qualitative Case Study, Michele Mars

CUP Ed.D. Dissertations

The purpose of this exploratory qualitative case study was to explore the actions of one middle school art teacher implementing blended learning methods in an eighth grade art class to understand what effect the art teacher perceives blended learning has on eighth grade middle school art students’ engagement in the subject matter. Mezirow’s Transformational Theory was the framework that guided the study. The study was conducted in a rural middle school located in the Midwest region of the United States over a nine-week period focusing on one middle school art teacher and an eighth grade art class using blended learning …

A Case Study Of Fine Arts Teachers’ Perceptions Of Eportfolio Evaluation As Professional Development, Jacquelynn S. Demontmollin

CUP Ed.D. Dissertations

This qualitative case study illustrated perceptions of seven fine arts teachers who were veteran participants in an ePortfolio evaluation method (with three or more years participation). The research questions centered on professional growth, reflection, and the impact ePortfolio had on the craft of teaching. A blended conceptual framework of Schön’s (1983, 1987) theory of reflection-in-action and reflection-on-action, and Mezirow’s (1991) transformative learning theory was applied to analyze the data. The researcher explored types of reflection fine arts teachers perceive through ePortfolio evaluation, and how the process of ePortfolio evaluation doubled as a professional development for some teachers. Through three phases …

Community College Students’ Perceived Value Of High School Career And Technical Education Program Experiences, Martin Douglass

CUP Ed.D. Dissertations

The goal of this qualitative, narrative inquiry study was to explore the voices of community college students who have taken Career and Technical Education (CTE) while in high school, investigate if they perceived value from their high school CTE classes, and determine how those experiences impacted their high school and college educations (cf. Association for Career and Technical Education, 2016; American Institutes for Research, 2013; Southern Regional Education Board, 2008). The central research question for the dissertation was: What value do local community college students believe their high school Career and Technical Education program participation provided? The screening survey had …

Arts Integration In The Public Elementary School General Education Classroom, Norma Quinones

Theatre & Dance ETDs

ABSTRACT

In 2017, the U.S. Department of Education’s Nations Report Card disclosed performance trends among fourth and eighth grade students in New Mexico. Fourth graders were significantly below the national average in math and reading, while eighth graders were also performing below the national average (U.S. Department of Education). How can New Mexico public elementary school students fulfill their learning potential? Extensive research shows that arts integrated instruction is associated with student achievement. It outlines arts integration as a multidisciplinary form of teaching across the curriculum to transform teaching and learning at the elementary school level to change such statistics. …

Spatial Exploration Of Trace Metals In Near-Surface Water And Soil In The Bolivian Altiplano, Lizzie Wilson

Civil and Environmental Engineering Theses and Dissertations

We analyzed soil and groundwater samples from the Bolivian Altiplano for trace metal concentrations, correlations and partitioning trends. Total digestion, sequential extraction and loss on ignition experiments were performed on soil samples. We ran aqueous samples on an ICP-MS. Results were analyzed to identify trace metal concentrations and find any significant correlations. We generated interpolated maps in ArcGIS to spatially analyze results. Results for elevated concentrations of interest were divided into sub-groups of organophilic metals, oxoanions and divalent metals and include vanadium, arsenic, selenium, zinc, nickel, lead, cobalt, uranium, copper and manganese. These elements are likely naturally sourced. We found …

Measurement Of The Radial Mode Spectrum Of Photons Through A Phase-Retrieval Method, Saumya Choudhary, Rachel Sampson, Yoko Miyamoto, Omar S. Magaña-Loaiza, Seyed Mohammad Hashemi Rafsanjani, Mohammad Mirhosseini, Robert W. Boyd

Faculty Publications

We propose and demonstrate a simple and easy-to-implement projective-measurement protocol to determine the radial index p of a Laguerre–Gaussian (LGlp) mode. Our method entails converting any specified high-order LG0p mode into a near-Gaussian distribution that matches the fundamental mode of a single-mode fiber (SMF) through the use of two phase screens (unitary transforms) obtained by applying a phase-retrieval algorithm. The unitary transforms preserve the orthogonality of modes before the SMF and guarantee that our protocol can, in principle, be free of crosstalk. We measure the coupling efficiency of the transformed radial modes to the SMF for different pairs of phase …

The Installation Of The Human: Whiteness, Religion, And Racial Capitalism, Benjamin Robinson

Religious Studies Theses and Dissertations

Over the past thirty to forty years, the academic study of religion has brought the category of religion into crisis, unveiling its Christian architecture and its formation as a settler-colonial category of European expansion. While the proliferation of research on the genealogy of religion has opened new and important vantages for study, we remain conflicted about what is at stake. In this dissertation, I argue that the modern-colonial construction of religion is organized by a racial-theological operation that categorically separates people into humans, subhumans, and nonhumans, by which the social, economic, and political inequalities of racial capitalism have been made …

Racial Integration And White Supremacy In America: Can America Integrate Its Power Structures And Liberate Them From White Supremacy, Billy Lane

Graduate Liberal Studies Theses and Dissertations

Neither the presence of black people in predominantly white spaces nor the appropriation of black culture are indicators of racial justice. Power structures must be integrated even more so than subdivisions, classrooms, breakrooms, church pews, and pop culture. This thesis will explore the absence of African-American leadership from the highest ranks of our power structures that are central to contemporary life and the dynamics within each of these power structures that help to protect white supremacy and therefore maintain segregation.

Leveraging Grammars For Openmp Development In Supercomputing Environments, Samuel Hunter

Computer Science and Engineering Theses and Dissertations

This thesis proposes a solution to streamline the process of using supercomputing re- sources on Southern Methodist University’s ManeFrame II supercomputer. A large segment of the research community that uses ManeFrame II belong outside of the computer science department and the Lyle School of Engineering. While users know how to apply compu- tation to their field, their knowledge does not necessarily extend to the suite of tools and operating system that are required to use ManeFrame II. To solve this, the thesis proposes an interface for those who have little knowledge of Linux and SLURM to be able to use …

Resistance Beyond The Frontier: Concepts And Policies For The Protection Of Isolated Indigenous Peoples Of The Amazon, Minna Opas, Luis Felipe Torres, Felipe Milanez, Glenn Shepard Jr.

Tipití: Journal of the Society for the Anthropology of Lowland South America

No abstract provided.

2018 Fall Commencement, Harding University

Commencement Programs

Program for the Harding University Commencement on December 15.

Commencement Speaker: Joel Anderson

The Esquire Case: A Lost Free Speech Landmark, Samantha Barbas

William & Mary Bill of Rights Journal

No abstract provided.

Between Developed And Emerging Markets: Globalization Of Large Consumer Good Enterprises, Christine Savino Ms.

Honors Scholar Theses

A few years ago, The Economist promulgated that “the only way that companies can prosper in [emerging] markets is to cut costs relentlessly and accept profit margins close to zero” (The Economist, 2010). Likewise, according to the World Bank’s 2018 Ease of Doing Business Index[1], the least ranked countries (#94 and under out of 190 countries) are solely undeveloped and developing, while the top 20 countries are solely developed economies (World Bank, 2018). It has been long held that emerging markets[2][3] are non-strategic investments for multinational expansion, and that business giants from …

Corporate Social Responsibility To-Come: A Derridean Interruption Of Transparency, Robert Foschia

Electronic Theses and Dissertations

This study investigated the relation between rhetorics of transparency and organizational action. Digging into CSR literature from a philosophy of communication perspective, this project seeks to determine if corporate social responsibility delivers on the promises it makes of a better world.

Drawing on the work of Jacques Derrida, the research first lays out his often overlooked contribution to the philosophy of communication, and then moves towards possible applications in deconstructing the perceived benefits of CSR, particularly in its transparent nature. By looking at organizational life from the Triple Bottom Line, this dissertation peels back the underlying rhetoric of planet, people, …

Tangibility And Symbolism Along Historic Highway 66 In Albuquerque, Donatella Davanzo

American Studies ETDs

This dissertation is an interdisciplinary exploration of Highway 66 heritage in order to understand what makes the historic American route distinctive in the contemporary capitalist scenario. Although deterioration of the road is evident, it continues to epitomize an historic American infrastructure as well as a fascinating conceptualization of the United States in the American imagination and in the international consciousness. Historical evidence indicates that the formation of Highway 66 largely depended on a conjuncture of political, cultural, and socio-economic factors under capitalism and institutional forces and ideological principles of Manifest Destiny and American Exceptionalism. As an incarnation of these relationships …

Video-Based Diabetes Education For A Culturally Diverse Population, Heather Harris

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Immigrants and refugees represent an underserved population in need of quality, accessible, and culturally appropriate healthcare and education. Diabetes is a chronic condition frequently seen in this population. The author utilized the Wagner Chronic Care Model (CCM) as a theoretical framework for planning diabetes education delivery in this diverse population. Studies report significant health disparities in diabetes care and subsequent poor diabetes quality indicators in refugees and immigrants. Research has found that culturally sensitive diabetes education can improve diabetes outcomes in ethnically diverse populations. The author implemented a translational project to develop and evaluate a video-based diabetes health education intervention …

"Who Are These Wild Indians": On The Foreign Policies Of Some Voluntarily Isolated Peoples In Amazonia, Peter Gow

Tipití: Journal of the Society for the Anthropology of Lowland South America

This paper is a reflection on the phenomenon of voluntary isolation in Amazonia, about anthropology’s implication in its formation as a concept, and what anthropologists might profitably say about it as a concrete phenomenon in the world. While knowledge based on ethnographic fieldwork might by minimal or even totally absent for people in voluntary isolation, anthropological research has produced a very impressive understanding of indigenous Amazonian social forms in general, knowledge that can be brought to bear on the question.

2018-December-15-New Employees, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

2018-December-15-Percipio, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

The Library Book, Kylie Bean

Departmental Honors & Graduate Capstone Projects

I wrote my novella, The Library Book, in partial fulfillment of my creative writing seminar. The majority of the coursework of this seminar consisted of writing and revising an entire novella from initial conception and outlining to final revisions. I am submitting my revised copy of The Library Book, which I submitted as the final project of my ENGL 470B seminar. I received an A on this project and will be reading a section of my novella at the 2019 Kemp Symposium this Friday. The Library Book is a forty-eight-page fantasy novella written for a middle grade audience. …

Neural And Behavioral Associations Of Drinking And Empathic Processing, Charles Samuel Henry Robinson

Psychology ETDs

Alcohol Use Disorder (AUD) is a major health problem, yet most individuals with AUD do not perceive a need for formal treatment and do not receive treatment. The lack of treatment seeking among individuals with AUD may suggest a lack of self-awareness and insight into the seriousness of AUD related problems. Moreover, individuals who have lost or are at risk of losing major relationships are especially likely to perceive the need for help. Thus, it may be the case that awareness of the influence of one’s drinking on social relationships and the feelings of others (i.e., empathy) could improve treatment …

Making Space For Makerspace: How Adding A Makerspace Can Benefit Art Museum Education Programming, Kaeleigh Thorp

Master's Projects and Capstones

In this capstone project, I advocate for adding makerspaces to art museum education programming. I review the foundational educational concepts of a makerspace which help explain why it is a modern strategy to increasing visitor learning. This includes John Dewey’s theories of experience and education, Howard Gardner’s multiple intelligences theory, George Hein’s studies of museum visitor behavior, and the physiological science of learning. I then propose four key terms essential for visitor learning, and explain how makerspaces successfully incorporate them. The four key terms are: 1. multiple intelligences, 2. direct experience, 3. inquiry based and open ended learning, and 4. …

The Relationship Between Challenge Courses And The, Christopher Luna

Health, Exercise, and Sports Sciences ETDs

There has been an increasing demand among education agencies to utilize challenge courses, also known as ropes courses, for personal growth opportunities among students of all ages. Teachers often tell students how they want students to work as a “team” and “get along” without providing the experiences for them to practice such behaviors. A low ropes experience allows students to practice cooperative skills. The focus of garnering participants for this study was to identify a specific target of first-generation college students from two separate classroom settings. The research focused on identifying the relationship between first-generation college students and low ropes …