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The Ecology Of A Tallgrass Treasure: Audubon’S Spring Creek Prairie, Paul A. Johnsgard Aug 2018

The Ecology Of A Tallgrass Treasure: Audubon’S Spring Creek Prairie, Paul A. Johnsgard

Zea E-Books Collection

This book describes the major plant and animal components of Spring Creek Prairie Audubon Center, an 850-acre National Audubon Society tallgrass prairie in Lancaster County, southeastern Nebraska. In addition to providing a species list of the area’s plants (368 species), there are comprehensive annotated lists of its birds (240), mammals (43), reptiles (23), and amphibians (10). There are also variably complete annotated lists of the area’s butterflies (76), sphinx moths (30), silk moths (7), dragonflies (24), damselflies (11), grasshoppers (9), katydids (11), mantids (2), and walkingsticks (2). Brief profiles of life histories and ecologies of 55 animal and 7 plant …


Comparison Of Mortality And Therapy In Community Acquired Pneumonia, Gina Maki, Daniela Moreno, Anthony Harris, Steven Lawrence, Andrew Masica, Lois Lamerato, Marcus J. Zervos Aug 2018

Comparison Of Mortality And Therapy In Community Acquired Pneumonia, Gina Maki, Daniela Moreno, Anthony Harris, Steven Lawrence, Andrew Masica, Lois Lamerato, Marcus J. Zervos

The University of Louisville Journal of Respiratory Infections

Background: Community associated pneumonia (CAP) is one the most common causes of hospital admissions, exceeding more than one million per year in the United States, contributing to 3.4% of inpatient mortality. Our objective was to compare 30-day mortality using therapies recommended for treatment of CAP.

Methods: A multicenter retrospective analysis from four different hospitals was assessed from 2008 to 2013. The data was obtained from electronic medical records which included more than 70,000 patients. CAP patients were identified using discharge diagnostic codes during the years 2008-2013, as well as receiving therapy with ceftriaxone and azithromycin or a respiratory fluoroquinolone. Demographic …


The Influence Of Conversational Agent Embodiment And Conversational Relevance On Socially Desirable Responding, Ryan M. Schuetzler, Justin Scott Giboney, G. Mark Grimes, Jay F. Nunamaker Jr. Aug 2018

The Influence Of Conversational Agent Embodiment And Conversational Relevance On Socially Desirable Responding, Ryan M. Schuetzler, Justin Scott Giboney, G. Mark Grimes, Jay F. Nunamaker Jr.

Information Systems and Quantitative Analysis Faculty Publications

Conversational agents (CAs) are becoming an increasingly common component in a wide range of information systems. A great deal of research to date has focused on enhancing traits that make CAs more humanlike. However, few studies have examined the influence such traits have on information disclosure. This research builds on self-disclosure, social desirability, and social presence theories to explain how CA anthropomorphism affects disclosure of personally sensitive information. Taken together, these theories suggest that as CAs become more humanlike, the social desirability of user responses will increase. In this study, we use a laboratory experiment to examine the influence of …


Daily Eastern News: August 29, 2018, Eastern Illinois University Aug 2018

Daily Eastern News: August 29, 2018, Eastern Illinois University

August

No abstract provided.


Hypoglycemic, Hypolipidemic And Antioxidant Effects Of Iridoid Glycosides Extracted From: Corni Fructus: Possible Involvement Of The Pi3k-Akt/Pkb Signaling Pathway, Jiefang Kang, Chen Guo, Rodolfo Thome, Ning Yang, Yuan Zhang, Xing Li, Xiaoyan Cao Aug 2018

Hypoglycemic, Hypolipidemic And Antioxidant Effects Of Iridoid Glycosides Extracted From: Corni Fructus: Possible Involvement Of The Pi3k-Akt/Pkb Signaling Pathway, Jiefang Kang, Chen Guo, Rodolfo Thome, Ning Yang, Yuan Zhang, Xing Li, Xiaoyan Cao

Department of Neurology Faculty Papers

Iridoid glycosides (CIG) are the major component of Corni fructus. In this work, we researched the antioxidative, hypoglycemic and lowering blood lipids effects of CIG on diabetic mice induced by a high-fat diet (HFD) and streptozotocin (STZ). Furthermore, to investigate the molecular mechanism of action, the phosphorylation and protein expression of phosphoinositide 3-kinase (PI3K) and its downstream proteins, such as insulin receptor (INSR), protein kinase B (Akt/PKB) and glucose transporter 4 (GLUT4) have been detected. The results showed that CIG significantly improved oral glucose tolerance in diabetic mice. Biochemical indices also revealed that CIG had a positive effect on lipid …


Large-Scale Social And Behavior Change Communication Interventions Have Sustained Impacts On Infant And Young Child Feeding Knowledge And Practices: Results Of A 2-Year Follow-Up Study In Bangladesh, Sunny S. Kim, Phuong Hong Nguyen, Lan Mai Tran, Tina Sanghvi, Zeba Mahmud, Mohammad Raisul Haque, Kaosar Afsana, Edward A. Frongillo Jr., Marie T. Ruel, Purnima Menon Aug 2018

Large-Scale Social And Behavior Change Communication Interventions Have Sustained Impacts On Infant And Young Child Feeding Knowledge And Practices: Results Of A 2-Year Follow-Up Study In Bangladesh, Sunny S. Kim, Phuong Hong Nguyen, Lan Mai Tran, Tina Sanghvi, Zeba Mahmud, Mohammad Raisul Haque, Kaosar Afsana, Edward A. Frongillo Jr., Marie T. Ruel, Purnima Menon

Faculty Publications

Background: Sustained improvements in infant and young child feeding (IYCF) require continued implementation of effective interventions. From 2010-2014, Alive & Thrive (A&T) provided intensive interpersonal counseling (IPC), community mobilization (CM), and mass media (MM) in Bangladesh, demonstrating impact on IYCF practices. Since 2014, implementation has been continued and scaled up by national partners with support from other donors and with modifications such as added focus on maternal nutrition and reduced program intensity. Objective: We assessed changes in intervention exposure and IYCF knowledge and practices in the intensive (IPC + CM + MM) compared with nonintensive areas (standard nutrition counseling + …


A Continuum Of Disease From Community-Acquired Pneumonia To Multiple Organ Dysfunction Syndrome, Julio A. Ramirez Aug 2018

A Continuum Of Disease From Community-Acquired Pneumonia To Multiple Organ Dysfunction Syndrome, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Lemierre’S Syndrome, A Case Report And Review Of Literature, Casmiar I. Nwaigwe, Jason Greenwood Aug 2018

Lemierre’S Syndrome, A Case Report And Review Of Literature, Casmiar I. Nwaigwe, Jason Greenwood

The University of Louisville Journal of Respiratory Infections

Lemierre’s syndrome is a suppurative thrombophlebitis of the internal jugular vein. In this paper we describe a case of severe Lemierre’s syndrome in a healthy 18 year-old woman. She initially presented with sore throat, and failed outpatient antibiotic therapy. She quickly progressed to septic shock, internal jugular vein septic thrombophlebitis, septic pulmonary emboli, empyema and respiratory failure. Successful treatment included intravenous antibiotics and thoracotomy. It is a rare disease that has been kept at bay with the widespread use of antibiotics for upper respiratory infections. However in recent years there seems to be an increase in number of cases being …


Clearing A Xenotransplantation Hurdle: Detecting Infectious Agents In Pigs, Staff Aug 2018

Clearing A Xenotransplantation Hurdle: Detecting Infectious Agents In Pigs, Staff

Browse All News

No abstract provided.


Offspring Dependence On Parental Care And The Role Of Parental Transfer Of Oral Fluids In Burying Beetles, Scott K. Sakaluk, Alexandra Capodeanu-Nägler, Madlen A. Prang, Stephen T. Trumbo, Heiko Vogel, Anne-Katrin Eggert, Sandra Steiger Aug 2018

Offspring Dependence On Parental Care And The Role Of Parental Transfer Of Oral Fluids In Burying Beetles, Scott K. Sakaluk, Alexandra Capodeanu-Nägler, Madlen A. Prang, Stephen T. Trumbo, Heiko Vogel, Anne-Katrin Eggert, Sandra Steiger

Faculty Publications – Biological Sciences

Background

Immature stages of many animals can forage and feed on their own, whereas others depend on their parents’ assistance to obtain or process food. But how does such dependency evolve, and which offspring and parental traits are involved? Burying beetles (Nicrophorus) provide extensive biparental care, including food provisioning to their offspring. Interestingly, there is substantial variation in the reliance of offspring on post-hatching care among species. Here, we examine the proximate mechanisms underlying offspring dependence, focusing on the larvae of N. orbicollis, which are not able to survive in the absence of parents. We specifically asked …


Congenital Zika Virus Infection In Immunocompetent Mice Causes Postnatal Growth Impediment And Neurobehavioral Deficits, Amber M. Paul, Dhiraj Acharya, Biswas Neupane, E. Ashley Thompson, Gabriel Gonzalez-Fernandez, Katherine M. Copeland Aug 2018

Congenital Zika Virus Infection In Immunocompetent Mice Causes Postnatal Growth Impediment And Neurobehavioral Deficits, Amber M. Paul, Dhiraj Acharya, Biswas Neupane, E. Ashley Thompson, Gabriel Gonzalez-Fernandez, Katherine M. Copeland

Publications

A small percentage of babies born to Zika virus (ZIKV)-infected mothers' manifest severe defects at birth, including microcephaly. Among those who appeared healthy at birth, there are increasing reports of postnatal growth or developmental defects. However, the impact of congenital ZIKV infection in postnatal development is poorly understood. Here, we report that a mild congenital ZIKV-infection in pups born to immunocompetent pregnant mice did not display apparent defects at birth, but manifested postnatal growth impediments and neurobehavioral deficits, which include reduced locomotor and cognitive deficits that persisted into adulthood. We found that the brains of these pups were smaller, had …


Metabolic Comparison Of One-Anastomosis Gastric Bypass, Single-Anastomosis Duodenal-Switch, Roux-En-Y Gastric Bypass, And Vertical Sleeve Gastrectomy In Rat, Deanna M. Arble, Simon S. Evers, Nadajda Bozadjieva, Henriette Frikke-Schmidt, Andriy Myronovych, Alfor Lewis, Mouhamadoul Habib Toure, Randy J. Seeley Aug 2018

Metabolic Comparison Of One-Anastomosis Gastric Bypass, Single-Anastomosis Duodenal-Switch, Roux-En-Y Gastric Bypass, And Vertical Sleeve Gastrectomy In Rat, Deanna M. Arble, Simon S. Evers, Nadajda Bozadjieva, Henriette Frikke-Schmidt, Andriy Myronovych, Alfor Lewis, Mouhamadoul Habib Toure, Randy J. Seeley

Biological Sciences Faculty Research and Publications

Background

One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.

Objectives

To examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model.

Setting

Academic research laboratory, United States.

Methods

Surgeries were performed in diet-induced obese Long-Evans rats, and metabolic outcomes were monitored before and for 15 weeks after surgery.

Results

All bariatric procedures induced weight loss compared with sham that lasted throughout the course of the study. …


The (B)Link Between Amotivation And Dopamine In Psychosis: What Phasic Eye Blink Rate Reveals, Jessica Elaina Mcgovern Aug 2018

The (B)Link Between Amotivation And Dopamine In Psychosis: What Phasic Eye Blink Rate Reveals, Jessica Elaina Mcgovern

LSU Doctoral Dissertations

Motivation deficits (i.e., avolition or amotivation) are a cardinal feature of schizophrenia spectrum disorders (SSDs) and are linked to worse functional outcomes. Accumulating evidence implicates underactive dopamine responses in reward areas of the brain (e.g., striatum) in the etiology of amotivation. Phasic dopamine firing in the striatum purportedly has a role in increasing the perceived value of a potential reward that, in effect, helps “push” the organism toward initiating and persisting in the action to pursue rewards. Previous research has suggested that eye blink rate (EBR) may be a reliable and valid index of striatal dopamine. Amotivation (clinician-rated and self-reported) …


Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt Aug 2018

Recombinant Human Proteoglycan-4 Reduces Phagocytosis Of Urate Crystals And Downstream Nuclear Factor Kappa B And Inflammasome Activation And Production Of Cytokines And Chemokines In Human And Murine Macrophages, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt

Pharmacy Faculty Articles and Research

Microbial biofilms are organized communities of cells that are associated with a wide spectrum of resistant and chronic infections that lead to the treatment failure. Accordingly, there is an urgent demand to create novel effective therapeutic drugs that can inhibit biofilm formation with new mechanisms of action to surmount the current escalating resistance. In this study, in silico hybrid model was utilized to develop three novel short linear peptides (4, 5, and 6) with potential biofilm inhibiting activities (scores > 1.0). The peptides were composed of cationic and hydrophobic residues. They were synthesized using solid-phase strategy. Synthesized peptides were purified and …


A Qualitative Study On How Students With Visual Impairments Perceive Environmental Issues, Mustafa Ürey, Maşide Güler Mrs. Aug 2018

A Qualitative Study On How Students With Visual Impairments Perceive Environmental Issues, Mustafa Ürey, Maşide Güler Mrs.

Journal of Science Education for Students with Disabilities

Although there is a growing emphasis on determining how people perceive environmental issues, the studies composed of functioning members of society who happen to have visual impairments are still scarce. The scope of this current paper is aimed at revealing the environmental issue perceptions of middle school students with such conditions. As a part of a large-scale study, this paper presents qualitative data gathered from a well-structured interview protocol. The participants of the study were fifteen Turks from different regions who fell into the aforementioned group. In order to analyse the data, a content analysis technique has been adopted. The …


Green Burials: The Deinstitutionalization Of Death, A A. Bouverette 3906173 Aug 2018

Green Burials: The Deinstitutionalization Of Death, A A. Bouverette 3906173

The Hilltop Review

Abstract

Methods for preparing and burying the dead vary widely across time and cultures, but an enduring theme persists in ritualistic deposition. Some forms of disposal include inhumation, cremation, entombment, sea submersion and methods of exposure (Spellman, 2014). For many cultures, an exposed corpse or one that had not been given ritualized funeral rites was viewed as improper or neglectful. Exposed or rotting bodies is also associated with disease and illness (Feagan. 2007).

The transition from natural burial to preservative practices is a recent invention created in response to mass death during a wartime period (Stowe, Schmidt & Green, 2001). …


An Overview Of Four Traditions On War And Peace In Christian History, Joseph J. Fahey Aug 2018

An Overview Of Four Traditions On War And Peace In Christian History, Joseph J. Fahey

The Journal of Social Encounters

This essay examines four traditions on war and peace that have developed in Christian history. They are: Pacifism, Just War, Total War, and World Community.Pacifism characterized the earliest Christians; Just War appeared in the late fourth and fifth centuries; Total War in the eleventh century; and World Community began in the sixteenth century. All four positions continue today and are held by people who sincerely call themselves Christian.


Employee Manual On Substance Abuse, Blue Cross And Blue Shield Of Florida, Inc. Aug 2018

Employee Manual On Substance Abuse, Blue Cross And Blue Shield Of Florida, Inc.

Florida Blue Archives Printed Materials

Employee manual on substance abuse informational guide. Attachment included: Employee Education Session on Substance Abuse Agenda, circa 1988-1995.


Oakwood Aug 2018

Oakwood

Oakwood

No abstract provided.


Review Of The Genus Babycurus Karsch, 1886 (Arachnida, Scorpiones, Buthidae), With Descriptions Of Barbaracurus Gen. N. And Two New Species From Oman And Yemen, František Kovařík, Graeme Lowe, František Šťáhlavský Aug 2018

Review Of The Genus Babycurus Karsch, 1886 (Arachnida, Scorpiones, Buthidae), With Descriptions Of Barbaracurus Gen. N. And Two New Species From Oman And Yemen, František Kovařík, Graeme Lowe, František Šťáhlavský

Euscorpius

The genus Babycurus Karsch, 1886 sensu lato is split into two genera, a strictly African genus Babycurus, and the new genus Barbaracurus gen. n., which mainly includes species from the Horn of Africa and Arabian Peninsula. Two new species Barbaracurus winklerorum sp. n. from Oman and B. yemenensis sp. n. from Yemen are described, compared with other species, and fully illustrated with color photos of morphology, habitus, live specimens and collection localities. Males of Barbaracurus somalicus (Hirst, 1907) comb. n. and Barbaracurus zambonellii (Borelli, 1902) comb. n. are recorded for the first time and fully illustrated. Babycurus ornatus …


The Utah Statesman, August 28, 2018, Utah State University Aug 2018

The Utah Statesman, August 28, 2018, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.


Gain-Of-Function Experiments With Bacteriophage Lambda Uncover Residues Under Diversifying Selection In Nature, Rohan Maddamsetti, Daniel T. Johnson, Stephanie J. Spielman, Katherine L. Petrie, Debora S. Marks, Justin R. Meyer Aug 2018

Gain-Of-Function Experiments With Bacteriophage Lambda Uncover Residues Under Diversifying Selection In Nature, Rohan Maddamsetti, Daniel T. Johnson, Stephanie J. Spielman, Katherine L. Petrie, Debora S. Marks, Justin R. Meyer

College of Science & Mathematics Departmental Research

Viral gain‐of‐function mutations frequently evolve during laboratory experiments. Whether the specific mutations that evolve in the lab also evolve in nature and whether they have the same impact on evolution in the real world is unknown. We studied a model virus, bacteriophage λ, that repeatedly evolves to exploit a new host receptor under typical laboratory conditions. Here, we demonstrate that two residues of λ’s J protein are required for the new function. In natural λ variants, these amino acid sites are highly diverse and evolve at high rates. Insertions and deletions at these locations are associated with phylogenetic patterns indicative …


App21 Transgenic Rats Develop Age-Dependent Cognitive Impairment And Microglia Accumulation Within White Matter Tracts, Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead Aug 2018

App21 Transgenic Rats Develop Age-Dependent Cognitive Impairment And Microglia Accumulation Within White Matter Tracts, Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead

Anatomy and Cell Biology Publications

Background: Most of the animal models commonly used for preclinical research into Alzheimer's disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that does not develop AD-like pathology spontaneously with age, but does develop pathology following vascular stress. To further the potential of this novel rat model as a much-needed pre-clinical animal model of sporadic AD, we characterize APP21 transgenic rats behaviorally and histologically up to 19 months of age. Methods: The open field test was used as …


App21 Transgenic Rats Develop Age-Dependent Cognitive Impairment And Microglia Accumulation Within White Matter Tracts., Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead Aug 2018

App21 Transgenic Rats Develop Age-Dependent Cognitive Impairment And Microglia Accumulation Within White Matter Tracts., Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead

Paediatrics Publications

Background

Most of the animal models commonly used for preclinical research into Alzheimer's disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that does not develop AD-like pathology spontaneously with age, but does develop pathology following vascular stress. To further the potential of this novel rat model as a much-needed pre-clinical animal model of sporadic AD, we characterize APP21 transgenic rats behaviorally and histologically up to 19 months of age.

Methods

The open field test was used as …


Ua12/2/1 College Heights Herald, Vol. 94, No. 1, Wku Student Affairs Aug 2018

Ua12/2/1 College Heights Herald, Vol. 94, No. 1, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

  • Ziege, Nicole. WKU Alum, Churchill Downs Vice President Dies at 62 – John Asher
  • Ziege, Nicole. Top Performers Could Get Up to 6% - Salaries
  • Deletter, Emily. University Senate Welcomes WKU’s New Provost – Terry Ballman
  • Ziege, Nicole. 6 Important Stories You Missed This Summer – Tuition, Admissions, Provost, Lawsuits, Strategic Planning, Budget
  • Fleming, Kayla. Money More Money
  • Edwards, Brandon. Editorial Cartoon re: Timothy Caboni’s Budget
  • Doubling Down: Lawsuit Inhibits Important Journalism – Open Records
  • Gabhart, Ebonne. In Case You Missed Barak Obama’s Keynote Speech …


Predicting Impacts Of Chemicals From Organisms To Ecosystem Service Delivery: A Case Study Of Endocrine Disruptor Effects On Trout, Valery E. Forbes, Steve Railsback, Chiara Accolla, Bjorn Birnir, Randall J.F. Bruins, Virginie Ducrot, Nika Galic, Kristina Garber, Bret C. Harvey, Henriette I. Jager, Andrew Kanarek, Robert Pastorok, Richard Rebarber, Pernille Thorbek, Chris J. Salice Aug 2018

Predicting Impacts Of Chemicals From Organisms To Ecosystem Service Delivery: A Case Study Of Endocrine Disruptor Effects On Trout, Valery E. Forbes, Steve Railsback, Chiara Accolla, Bjorn Birnir, Randall J.F. Bruins, Virginie Ducrot, Nika Galic, Kristina Garber, Bret C. Harvey, Henriette I. Jager, Andrew Kanarek, Robert Pastorok, Richard Rebarber, Pernille Thorbek, Chris J. Salice

Department of Mathematics: Faculty Publications

We demonstrate how mechanistic modeling can be used to predict whether and how biological responses to chemicals at (sub)organismal levels in model species (i.e., what we typically measure) translate into impacts on ecosystem service delivery (i.e., what we care about). We consider a hypothetical case study of two species of trout, brown trout (Salmo trutta; BT) and greenback cutthroat trout (Oncorhynchus clarkii stomias; GCT). These hypothetical populations live in a high-altitude river system and are exposed to human-derived estrogen (17α‑ethinyl estradiol, EE2), which is the bioactive estrogen in many contraceptives. We use the individual based model in STREAM …


Perspectives On Natural Philosophy, Stanley N. Salthe Aug 2018

Perspectives On Natural Philosophy, Stanley N. Salthe

Publications and Research

This paper presents a viewpoint on natural philosophy focusing on the organization of substance, as well as its changes as invited by the Second Law of thermodynamics. Modes of change are pointed to as definitive of levels of organization; these include physical, chemical, and biological modes of change. Conceptual uses of the subsumptive hierarchy format are employed throughout this paper. Developmental change in dissipative structures is examined in some detail, generating an argument for the use of final causality in studies of natural systems. Considerations of ‘internalism’ in science are presented along the way.


Leveraging Pet To Image Folate Receptor Α Therapy Of An Antibody-Drug Conjugate, Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangagari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Joseph A. Konner, Thomas Reiner Aug 2018

Leveraging Pet To Image Folate Receptor Α Therapy Of An Antibody-Drug Conjugate, Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangagari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Joseph A. Konner, Thomas Reiner

Publications and Research

Background: The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an antibody-derived immuno-PET imaging agent strategy for targeting FRα in ovarian cancer as a predictor of treatment success. Methods: We developed [89Zr]Zr-DFO-M9346A, a humanized antibody-based radiotracer targeting tumorassociated FRα in the preclinical setting. [89Zr]Zr-DFO-M9346A’s binding ability was tested in an in vitro uptake assay using cell lines with varying FRα expression levels. The diagnostic potential of [89Zr]Zr-M9346A was evaluated in KB and …


Studies On Α-Lipoic Acid Molecularly Imprinted Membrane And Its Antioxidant Properties, Yang Bowen, Chen Yuqin, Zhu Qiujin Aug 2018

Studies On Α-Lipoic Acid Molecularly Imprinted Membrane And Its Antioxidant Properties, Yang Bowen, Chen Yuqin, Zhu Qiujin

Food and Machinery

Thermo-sensitive α-lipoic acid molecularly imprinted polymers (ALA-MIPs) were synthesized through pre-polymerization using α-lipoic acid as a functional monomer and N-vinylcaprolactam (NVCL) as both thermo-sensitive monomer and functional monomer. Poly(acrylonitrile) (PAN) and Poly(vinylidene fluoride) (PVDF) were used as the main raw material to synthesis molecularly imprinted membranes through the heterogeneous particle-filling method by adding ALA-MIPs. The morphology of the molecularly imprinted membrane(MIM) was investigated by scanning electron microscopy. The mechanical properties, hydrophilic properties, water absorption abilities, and ALA release properties of the membrane were also investigated. The results show that the PVDF membrane has better mechanical properties and hydrophobic properties when …


Research Progress On The Detection Method Of Swine Source Components In Food, Cheng Hao, Li Mingsheng, Chen Shien, Ding Gongtao, Tian Xiaojing, Saimaiti Reziwanguli, Du Jianglong, Gao Dandan Aug 2018

Research Progress On The Detection Method Of Swine Source Components In Food, Cheng Hao, Li Mingsheng, Chen Shien, Ding Gongtao, Tian Xiaojing, Saimaiti Reziwanguli, Du Jianglong, Gao Dandan

Food and Machinery

In the food industry, pork adulteration in meat products is comparatively serious due to the economic interests and moral standards, etc., which not only bring hidden dangers to the health of consumers, but also may cause the damage to the social harmony. In this study, the latest application progress and advantages and disadvantages of various detection methods based on DNA, protein, artificial olfactory system, spectroscopic technology, electronic nose and other food stuff were reviewed. This review would provide the basis of the detection of porcine-derived materials andcomponents in food in the future.