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Fluid Structure Interaction Study Of The Obstructive Sleep Apnea And Surgical Treatment Using Suture-Patch Device On The Patient’S Tongue, Yang Liu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Up to 14% of the U.S. population is estimated to have obstructive sleep apnea (OSA) related to obesity, and there is increased incidence occurring worldwide. While treatment with continuous positive airway pressure (CPAP) resolves airway obstruction, patient compliance is relatively low. Alternative interventions are available to treat OSA patients; however, their outcomes have had variable results. For example, current technologies have demonstrated an inability to define and treat the specific anatomical site(s) causing the obstruction, resulting in suboptimal modifications of the airway and poor control of OSA.

In the current study, a three-dimensional (3-D) fluid-structure interaction (FSI) numerical simulation has …

The Roles Of Biophilic Attitudes And Auditory Stimuli Within Attention Restoration Theory, Jason B. Boggs

UNLV Theses, Dissertations, Professional Papers, and Capstones

Attention Restoration Theory indicates that interacting with nature allows one’s fatigued, directed attention to be restored. This effect has been documented and produced through directed interaction with nature, such as a walk in the park, as well as through indirect interactions (e.g., photographs). The current dissertation was designed to: 1) investigate whether and how biophilic attitudes affect the attention-restoring effects incurred from interactions with nature, and 2) extend the research on ART by assessing the impact of nature-related audio stimuli. A total of 184 participants completed an assessment of biophilic attitudes, engaged in attention fatiguing exercises, and participated in one …

Mob-Ndr Kinase Signaling Components Are Required For Epithelial Tube Formation In The Drosophila Follicular Epithelium, Juan Carlos Duhart

UNLV Theses, Dissertations, Professional Papers, and Capstones

A major goal of developmental biology is to understand how a single fertilized cell can give rise to the many functional tissues and organs, of specific sizes and shapes, that make up the adult body plan. Over the last 25 years, developmental geneticists have uncovered much concerning the cell-to-cell communication systems that are necessary to build complex tissues and organs. For example, throughout development, cells communicate with their neighbors using specialized signaling molecules. These signals are instructive and provide “signal-receiving” cells with information about space and time. That is, signal-receiving cells “learn” precisely where they are located, and, how far …

Identifying Youth At Risk For Problematic Absenteeism Using Nonparametric Modeling: The Impact Of Youth Psychopathology And Family Environment Risk Factors, Mirae Fornander

UNLV Theses, Dissertations, Professional Papers, and Capstones

The best cutoff to differentiate problematic school absenteeism from nonproblematic school absenteeism has yet to be identified in the literature (Lyon & Cotler, 2007). Contemporary classification systems, including Multi-Tiered Systems of Support (MTSS), depend upon cutoffs to clearly define the various tiers (Jimerson, Burns, & VanDerHeyden, 2016). The current study aimed to inform the MTSS approach while also contributing to early identification, assessment, and intervention methods for those youth and families at the highest risk of problematic school absenteeism and its negative consequences. The current study identified subgroups of youth at the highest risk of problematic absenteeism, defined as equal …

Influencing Hawai‘I Hotel Patrons To Use Reef-Safe Sunscreens, Rochelle Good

UNLV Theses, Dissertations, Professional Papers, and Capstones

The health of Hawaiian coral reefs is threatened by pollution from common sunscreen ingredients such as oxybenzone. Hawai‘i hotel patrons using sunscreens with harmful ingredients contaminate coral reefs when these products wash off while swimming or bathing. Reef-safe sunscreens are alternative sunscreens that provide effective sun protection while averting damage to coral reefs. The purpose of this research was to determine the dominant factors leading to the pro-environmental behavior of using reef-safe sunscreen and identify practices that Hawai‘i hotel operators could implement to influence patrons to engage in this behavior. This research applied an integrative conceptual framework to model pro-environmental …

Westview: Vol. 34, Iss. 2 (Winter 2018), Westview Staff

Westview

No abstract provided.

Stitch-By-Stitch, Katacha Diaz

Westview

Many years ago while on vacation in Santa Fe, New Mexico, I decided to take an early morning stroll in the city’s art district.

Theorizing Development Of Parasocial Engagement, Riva Tukachinsky, Gayle S. Stever

Communication Faculty Articles and Research

The article proposes a theoretical model of the development of parasocial relationships (PSRs) building on Knapp’s model of relationship development. Through synthesis of research across disciplines, the model conceptualizes the relational goals and parasocial interactions (PSIs) specific to the PSR. The model identifies variables that predict engagement at that level, describes the stage’s outcomes/effects, and considers the utility of existing measures to assess these stages. The conceptualization of PSRs as a dynamic process rather than intensity of a monolithic experience offers new directions worthy of empirical examination.

Watch & Learn - A Teacher's Guidebook For Film-Based Esl Course, Xiaoxue Zhu

Master's Projects and Capstones

Educators in the 21st century are continuously discovering more engaging teaching tools to facilitate language learners. In today's increasingly developing visual world, film stands out from other traditional materials for its unique features, such as the visuality and authenticity. With appropriately designed activities, film could be a valuable resource in teaching English as a second language (TESOL) setting, and also a perfect tool for inspiring cross-cultural communication and promoting critical thinking skills.

However, research has shown that ESL teachers feel reluctant to use film as a significant component in their classrooms even though they have recognized and affirmed the benefit …

Chemically Modified Monolayer Surfaces Influence Valvular Interstitial Cell Attachment And Differentiation For Heart Valve Tissue Engineering, Matthew N. Rush

Nanoscience and Microsystems ETDs

As a cell mediated-process, valvular heart disease (VHD) results in significant morbidity and mortality world-wide. In the US alone, valvular heart disease VHD is estimated to affect 2.5% of the population with a disproportionate impact on an increasing elderly populous. It is well understood that the primary driver for valvular calcification is the differentiation of valvular interstitial cells (VICs) into an osteoblastic-like phenotype. However, the factors leading to the onset of osteoblastic-like VICs (obVICs) and resulting calcification are not fully understood and a more complete characterization of VIC differentiation and phenotypic change is required before treatment of valve disease or …

Improve The Low Energy Sensitivity Of The Hawc Observatory, Zhixiang Ren

Optical Science and Engineering ETDs

The high altitude water cherenkov gamma-ray observatory (HAWC) has been fully operational since March of 2015 in Mexico at 4,100 meters above sea level on the hillside of the Sierra Negra Volcano. It consists of an array of 300 water cherenkov detectors, each equipped with four photo-multiplier tubes. HAWC operates 24-hours per day with a wide field-of-view (FOV, ∼ 2 sr) and a high duty cycle (∼ 95%). These make it a powerful survey and monitoring experiment for mapping the gamma ray sky at very high energies (VHE, 100 GeV to 100 TeV) and to study sources with varying intensities. …

Clinical Pharmacology Of Tisagenlecleucel In B-Cell Acute Lymphoblastic Leukemia., Karen Thudium Mueller, Edward Waldron, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith August, Jason Hamilton, Rakesh Awasthi, Andrew M. Stein, Denise Sickert, Abhijit Chakraborty, Bruce L. Levine, Carl H. June, Lori Tomassian, Sweta S. Shah, Mimi Leung, Tetiana Taran, Patricia A. Wood, Shannon L. Maude

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).

PATIENTS AND METHODS: We evaluated the cellular kinetics of tisagenlecleucel, the effect of patient factors, humoral immunogenicity, and manufacturing attributes on its kinetics, and exposure-response analysis for efficacy, safety and pharmacodynamic endpoints in 79 patients across two studies in pediatric B-ALL (ELIANA and ENSIGN).

RESULTS: Using quantitative polymerase chain reaction to quantify levels of tisagenlecleucel transgene, responders (N = 62) had ≈2-fold higher tisagenlecleucel expansion in peripheral blood than nonresponders ( …

Looming Large: An Analysis And Evaluation On The Growth Of The Urban Informal Economy In Nigeria., Tamunotonye A. Sekibo Iii

Master's Theses

The Informal Economy looms large! The importance, magnitude and significance of the vast range of socio-economic activities taking place within and across diverse spaces of informality, particularly in nations situated in the Global South; can neither be overstated or underestimated. According to the International Labor Organization (ILO, 2018 p.v), approximately 60% of the world’s employed population - 2 billion people - obtain their source of income through their engagement in informal spaces.

Science In The News - Nicotinamide Exacerbates Motor Symptoms Of Parkinson's Disease In Mice., Layth A. Tabbaa

CHEM151

Melão, A. (2018, October 17). Nicotinamide Exacerbates Motor Symptoms of Parkinson's Disease in Mice. Retrieved November 7, 2017, from https://parkinsonsnewstoday.com/2018/10/10/nicotinamide-exacerbates-motor-symptoms-of-parkinsons-disease-in-mice/

Working Paper No. 10, The Epic Rise And Subtle Fall Of American Herbalism, Julia Schweid

Working Papers in Economics

This inquiry seeks to establish that we can track the development and evolution of herbalism as the initial form of medicine in American economic history. Upon colonization of North America, the indigenous people generously shared their knowledge of plant medicine with the settlers from Europe. The indigenous knowledge combined with the translation of ancient herbal texts created a synthesis of understanding and an important form of cultural exchange. People then began making attempts to standardize the medicine and its potency was compromised with the rise of the industry in patent medicine, or what I have named pseudo herbalism. It was …

Working Paper No. 22, Coffee And The American Independence Movement, Ross Bradner

Working Papers in Economics

Coffee has a long history as a motivating force in society, as can be seen through its history in different parts of the world. The introduction of coffee houses to western culture would promote the emergence of a public sphere, and would come to influence revolutionary behavior in both Western Europe and the North American colonies.

Cocoa, Postprandial Lipoproteins, And Inflammation In Type 2 Diabetes: A Secondary Data Analysis, Rickelle Tallent

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Type 2 Diabetes (T2D) is associated with dyslipidemia and chronic low-grade inflammation, which greatly increases the risk of cardiovascular disease (CVD) in this population. Hyperlipidemia and inflammation in the postprandial state substantially contribute to atherosclerosis development and CVD risk, and have shown to be exacerbated by high-fat meals. Dietary cocoa is a rich source of flavanols that is associated with favorable effects on cardiovascular health, such as improvements in the lipid profile and chronic inflammation, in non-diabetic adults.

Objective: To conduct a secondary data analysis using unpublished data from a previously conducted clinical study to determine whether acute cocoa …

Corporate Social Responsibility And Consumer Purchase Behavior: The Moderating Role Of Self-Presentation, Mandy May Walsh

UNLV Theses, Dissertations, Professional Papers, and Capstones

In recent years, companies have experienced increasing pressure to integrate corporate social responsibility (CSR) into their organizational structure. The relationship between a company's investment in CSR and overall revenue, however, is still under debate in the current literature as research has focused on correlations and consumer purchase intentions (e.g., Auger, Burke, Devinney, & Louviere, 2003; Dutta & Singh, 2013; Klein & Dawar, 2004; Maignan, 2001; Mohr & Webb 2005; Mohr, Webb, & Harris, 2001; Nanda, 2015; Wigley, 2008). Findings from previous studies have not yet assessed actual purchase behavior or potential moderating variables impacting this relationship. Therefore, this dissertation examined …

Mechanisms Of Calcium Phosphate Mineralization On Biological Interfaces And Their Engineering Applications, Doyoon Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

All living organisms utilize phosphorus (P) as an essential component of their cell membranes, DNA and RNA, and adenosine triphosphate. Bones, in addition to bearing loads, play an important role in balancing P levels in our bodies. In bones, a network of collagen templates and calcium phosphate (CaP) nanocrystals builds hierarchical levels, from nano- to macroscale. Within this architecture, the thermodynamic properties of CaP minerals are influential. Despite the importance of nucleation, growth, and crystallization in collagen structures for tissue development, little kinetic study of these processes has been conducted due to the limited in situ techniques for monitoring these …

Information-Based Analysis And Control Of Recurrent Linear Networks And Recurrent Networks With Sigmoidal Nonlinearities, Deslin Menolascino

McKelvey School of Engineering Graduate Student Theses & Dissertations

Linear dynamical models have served as an analytically tractable approximation for a variety of natural and engineered systems. Recently, such models have been used to describe high-level diffusive interactions in the activation of complex networks, including those in the brain. In this regard, classical tools from control theory, including controllability analysis, have been used to assay the extent to which such networks might respond to their afferent inputs. However, for natural systems such as brain networks, it is not clear whether advantageous control properties necessarily correspond to useful functionality. That is, are systems that are highly controllable (according to certain …

Molecular Basis Of Class Ib Drug Interactions With The Nav Channel Macromolecular Complex: A Route To Personalized Medicine For Cardiac Arrhythmia, Wandi Zhu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The heart rhythm is precisely controlled by the electrical impulse that propagate in the cardiac tissue. In single cardiomyocytes, the electrical activity generated by action potentials (AP). Cardiac NaV channels (NaV1.5) carry a large influx of Na+ that mediates the initiation and propagation of the AP in both atria and ventricles. Disruption of NaV1.5 function by genetic variants or external factors can result in deadly arrhythmias, such as long QT syndrome and Brugada syndrome. Thus, NaV channels are import therapeutic targets. The class I antiarrhythmics are the modulators of the NaV channels. Although they have been used clinically for over …

The Role Of Fibrillin-1 In Eye Development And Disease, Wendell Brooks Jones

Arts & Sciences Graduate Student Theses and Dissertations

The ciliary zonule of the human eye consists of a circumferential array of fibers that connect the ocular lens to the nonpigmented ciliary epithelium (NPCE) located at the inner wall of the eye. Zonular fibers consist of bundles of beaded filaments called microfibrils. Microfibrils are major structural elements of the extracellular matrix and are present in pure form in the ciliary zonule. Microfibrils are composed principally of fibrillin-1 (FBN-1); a large extracellular matrix glycoprotein. In humans, mutations in FBN1 underlie Marfan syndrome; a pleiotropic connective tissue disorder that profoundly affects the eye. Ocular manifestations include ectopia lentis (dislocated lenses), cataracts, …

Mechanistic Characterization Of Resistome And Microbiome Dynamics Across Diverse Microbial Habitats, Andrew John Gasparrini

Arts & Sciences Graduate Student Theses and Dissertations

Increasing antibiotic resistance in pathogens is a serious public health challenge, with over two million antibiotic resistant infections in the United States leading to at least 23,000 deaths and an estimated $55 billion in excess healthcare and societal costs. Antibiotic resistance has risen steadily in both pathogenic and benign bacteria since antibiotics’ introduction to agriculture and medicine 70 years ago. A dramatic reduction in the number of antibiotics approved for human use has accompanied this rise in antibiotic resistance, leading to the alarming prospect of a post-antibiotic era. Understanding the evolutionary origins, genetic contexts, and molecular mechanisms of antibiotic resistance …

Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern

Arts & Sciences Graduate Student Theses and Dissertations

Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body. Tailoring medicine to the individual allows for higher quality of care with better diagnosis and treatment and is a key purpose for advancing research into developing new platforms for PET imaging agents. A PET nuclide of high interest for the development of these agents is 89Zr. This can be attributed to the long half-life of 3.27 days and low positron energy of 89Zr.In this work, we developed a production method for 89Zr using Y sputtered coins that is …

Understanding Adolescent Physical Activity In The Early Nutrition Transitioning Country Of Haiti, Haley V. Becker

Arts & Sciences Graduate Student Theses and Dissertations

The nutrition transition is underway in Haiti, giving rise to the dual burden of malnutrition. Physical activity (PA) plays an important role in mitigating the negative health consequences of nutrition transition and the dual burden, but heretofore this data has been unavailable for Haiti. This dissertation undertook an exploratory needs assessment providing baseline PA data for Haitian adolescents. It evaluated two different PA data collection methodologies: a cross-sectional survey adapted from the IPAQ long-form and objectively measured PA via Actigraph GT1M accelerometers. Next, it identified initial covariates of self-reported and objectively-assessed PA behaviors; data was operationalized as meeting the World …

Examining Environmental Hazards In Rental Homes And Habitability Laws In Clark County, Nevada, Jorge Luis Bertran

UNLV Theses, Dissertations, Professional Papers, and Capstones

It is well established that home conditions are linked to the health outcomes of occupants. There are over 880,000 housing units in Clark County, Nevada; nearly half of those are renter-occupied units (ROUs). Currently, there is limited research on the characteristics of environmental hazards found in Clark County ROUs and the strength of habitability statutes created to protect tenants from substandard housing. Understanding how renters in Clark County are affected by environmental hazards in ROUs and the processes by which landlords and tenants resolve grievances related to those hazards would benefit public health. It would enhance the ability to quickly …

Tall Tales Of Danger And Security: How A Critical Human Security Approach Can Address Major Contradictions Revealed Through A Critical Narrative Analysis Of Dominant U.S. Security Strategies, Stephen Schneider

Master's Theses

Over many generations, humans have developed many perspectives and practices regarding the best ways to recognize and address what they perceive to be dangerous. Stories are used to help shape and narrate perceptions about the world, and they serve to pass on vital information that impacts how a society responds to threats and vulnerabilities. These narratives of danger and security are subjective to the experiences and political intentions of society, and therefore in many ways are partial and biased in their assessments and policies. This results in flawed security practices that may actually exacerbate threats or create new insecurities. What …

Comparing Pollen And Archaeobotanical Data For Chalcolithic Cereal Agriculture At Çatalhöyük, Turkey, Warren J. Eastwood, Andrew Fairbairn, Elizabeth Stroud, Neil Roberts, Henry Lamb, Hakan Yiğitbaşıoğlu, Çetin Şenkul, Andrew Moss, Rebecca Turner, Peter Boyer

More Faculty of Science and Engineering Research

© 2018 Establishing agricultural activity using pollen analysis is one of the prime challenges of a palaeoecological investigation. Here we report combined pollen and archaeobotanical data originating from a waterlogged off-site organic-rich fill radiocarbon dated to ∼8 ka Cal BP located between the two occupation mounds at Neolithic-Chalcolithic Çatalhöyük, south central Turkey in order to investigate the record of Early Chalcolithic agricultural activity. Pollen results indicate extremely high abundances of Cerealia-type pollen (30->70%) and critical measurements of these show them to be Triticum-type, Avena/Triticum-type, Secale-type and Hordeum-type. Pollen data are also compared with archaeobotanical data retrieved from the same …

Tangibility And Symbolism Along Historic Highway 66 In Albuquerque, Donatella Davanzo

American Studies ETDs

This dissertation is an interdisciplinary exploration of Highway 66 heritage in order to understand what makes the historic American route distinctive in the contemporary capitalist scenario. Although deterioration of the road is evident, it continues to epitomize an historic American infrastructure as well as a fascinating conceptualization of the United States in the American imagination and in the international consciousness. Historical evidence indicates that the formation of Highway 66 largely depended on a conjuncture of political, cultural, and socio-economic factors under capitalism and institutional forces and ideological principles of Manifest Destiny and American Exceptionalism. As an incarnation of these relationships …

World's Best (And Worst) Animal Jokes, Mavanee Farnsworth

Children's Book and Media Review

World’s Best (and Worst) Animal Jokes really lives up to its name. This joke book is filled with everything animal. There are many different types of jokes, from question-and-answer to knock-knock jokes. There are great, laugh-out-loud jokes, as well as others labeled as “groaner jokes” that are meant to make you sigh and laugh. Each page has several fun jokes that will get the reader thinking about other animal jokes that could be found on the next page. There are many types of animals included, ranging from ocean creatures to cave creatures to mountain creatures. Animal lovers will love laughing …