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2018

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Methods, Antibodies, And Vaccines Utilizing Epitopes Of Alpha Synuclein For Treatment Of Parkinsons Disease, Chuanhai Cao, Xiaoyang Lin Dec 2018

Methods, Antibodies, And Vaccines Utilizing Epitopes Of Alpha Synuclein For Treatment Of Parkinsons Disease, Chuanhai Cao, Xiaoyang Lin

USF Patents

The present invention pertains to a dendritic cell-based vaccine against rh-α-Syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, preventing, and/or vaccinating against Parkinson's Disease (PD), or symptoms thereof.

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Historic Jennings House Gets A Facelift (December 18, 2018), University Communications And Marketing Dec 2018

Historic Jennings House Gets A Facelift (December 18, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

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Does Channel Island Acmispon (Fabaceae) Form Cohesive Evolutionary Groups?, Mitchell E. Mcglaughlin, Lynn Riley, Kaius Helenurm, Lisa E. Wallace Dec 2018

Does Channel Island Acmispon (Fabaceae) Form Cohesive Evolutionary Groups?, Mitchell E. Mcglaughlin, Lynn Riley, Kaius Helenurm, Lisa E. Wallace

Western North American Naturalist

The California Channel Islands are unique relative to other island chains due to their close proximity to the California mainland and the fact that individual islands, or groups of islands, vary in their distance to the mainland and other islands. This orientation raises questions about whether island taxa with widespread distributions form cohesive evolutionary units, or if they are actually composed of several distinct evolutionary entities, either derived from independent mainland-to-island colonization events or divergence due to prolonged allopatric isolation. The 4 northern islands are clustered in a line (6–8 km separation among islands), while the 4 southern islands are …

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Deep Visual Recommendation System, Raksha Sunil Dec 2018

Deep Visual Recommendation System, Raksha Sunil

Master's Projects

Recommendation system is a filtering system that predicts ratings or preferences that a user might have. Recommendation system is an evolved form of our trivial information retrieval systems. In this paper, we present a technique to solve new item cold start problem. New item cold start problem occurs when a new item is added to a shopping website like Amazon.com. There is no metadata for this item, no ratings and no reviews because it’s a new item in the system. Absence of data results in no recommendation or bad recommendations. Our approach to solve new item cold start problem requires …

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From Sex Objects To Sisters-In-Arms: Reducing Military Sexual Assault Through Integrated Basic Training And Housing, Gabrielle Lucero Dec 2018

From Sex Objects To Sisters-In-Arms: Reducing Military Sexual Assault Through Integrated Basic Training And Housing, Gabrielle Lucero

Duke Journal of Gender Law & Policy

No abstract provided.

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Repeats Of Unusual Size In Plant Mitochondrial Genomes: Identification, Incidence And Evolution, Emily L. Wynn, Alan C. Christensen Dec 2018

Repeats Of Unusual Size In Plant Mitochondrial Genomes: Identification, Incidence And Evolution, Emily L. Wynn, Alan C. Christensen

School of Biological Sciences: Faculty Publications

Plant mitochondrial genomes have excessive size relative to coding capacity, a low mutation rate in genes and a high rearrangement rate. They also have abundant non-tandem repeats often including pairs of large repeats which cause isomerization of the genome by recombination, and numerous repeats of up to several hundred base pairs that recombine only when the genome is stressed by DNA damaging agents or mutations in DNA repair pathway genes. Early work on mitochondrial genomes led to the suggestion that repeats in the size range from several hundred to a few thousand base pair are underrepresented. The repeats themselves are …

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State V. Washington Appellant's Reply Brief Dckt. 45947 Dec 2018

State V. Washington Appellant's Reply Brief Dckt. 45947

Not Reported

No abstract provided.

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Transgenic Mice Overexpressing Human Tnf-Α Experience Early Onset Spontaneous Intervertebral Disc Herniation In The Absence Of Overt Degeneration., Deborah J. Gorth, Irving M. Shapiro, Makarand V. Risbud Dec 2018

Transgenic Mice Overexpressing Human Tnf-Α Experience Early Onset Spontaneous Intervertebral Disc Herniation In The Absence Of Overt Degeneration., Deborah J. Gorth, Irving M. Shapiro, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

There is a well-established link between cytokine expression and the progression of intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are the most commonly studied. To investigate whether systemic hTNF-α overexpression affects intervertebral disc health, we studied the spine phenotype of Tg197 mice, a widely used hTNF-α transgenic line. These mice were studied at 12-16 weeks of age using comprehensive histochemical and immunohistological analysis of the spinal motion segment. Micro-CT analysis was performed to quantify vertebral trabecular bone architecture. The Tg197 mice evidenced spontaneous annular tears and herniation with increased vascularity in subchondral bone and …

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From The Streets To The Chamber: Social Movements And The Mining Ban In El Salvador, Rose J. Spalding Dec 2018

From The Streets To The Chamber: Social Movements And The Mining Ban In El Salvador, Rose J. Spalding

College of Liberal Arts and Social Sciences Faculty and Staff Works

Following an extended anti-mining campaign, El Salvador became the first country to adopt a legal ban on all forms of metallic mining. This article uses process tracing to map direct, indirect and mediated linkages between the anti-mining mobilization and the formal adoption of a mining prohibition by the national legislature in 2017. It draws on 78 interviews with campaign activists, legislators, government officials, business leaders and legal teams, and combines this information with legislative documents and reports, public opinion data, legal documents from an investment dispute filed against the Salvadoran government, and blogs and website of the Mesa Nacional Frente …

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Predator Cues Increase Silkmoth Mortality, Alex K. Baranowski, Evan L. Preisser Dec 2018

Predator Cues Increase Silkmoth Mortality, Alex K. Baranowski, Evan L. Preisser

Biological Sciences Faculty Publications

While prey responses to predators reduce the threat of consumption, the physiological costs of these responses can be considerable. This is especially true for organisms that lack effective anti-predator defenses and must rely on camouflage or mimicry for protection. The luna moth, Actias luna, is a large saturniid native to Eastern North America that is preyed on and parasitized by a wide variety of predators and parasitoids. We report the results of two separate experiments assessing the responses of Actias larvae to predatory wasps (Vespula maculifrons) that were rendered non-lethal but remained able to move freely, as …

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Trypanosoma Brucei Prmt1 Is A Nucleic Acid Binding Protein With A Role In Energy Metabolism And The Starvation Stress Response., Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, Laurie K. Read Dec 2018

Trypanosoma Brucei Prmt1 Is A Nucleic Acid Binding Protein With A Role In Energy Metabolism And The Starvation Stress Response., Lucie Kafková, Chengjian Tu, Kyle L. Pazzo, Kyle P. Smith, Erik W. Debler, Kimberly S. Paul, Jun Qu, Laurie K. Read

Department of Biochemistry and Molecular Biology Faculty Papers

In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant regulators of gene expression. Arginine methylation is a posttranslational modification that preferentially targets RNA binding proteins and is, therefore, likely to have a substantial impact on T. brucei biology. The data presented here demonstrate that cells depleted of T. brucei PRMT1 (TbPRMT1), a major type I protein arginine methyltransferase, exhibit decreased virulence in an animal model. To understand the basis of this phenotype, quantitative global proteomics was employed …

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Proteomic Profile Of Carbonylated Proteins Screen Regulation Of Apoptosis Via Camk Signaling In Response To Regular Aerobic Exercise, Wenfeng Liu, Li Li, Heyu Kuang, Yan Xia, Zhiyuan Wang, Shaopeng Liu, Dazhong Yin Dec 2018

Proteomic Profile Of Carbonylated Proteins Screen Regulation Of Apoptosis Via Camk Signaling In Response To Regular Aerobic Exercise, Wenfeng Liu, Li Li, Heyu Kuang, Yan Xia, Zhiyuan Wang, Shaopeng Liu, Dazhong Yin

Health Sciences & Kinesiology: Faculty Publications

To research carbonylated proteins and screen molecular targets in the rat striatum on regular aerobic exercise, male SpragueDawley rats (13 months old, n = 24) were randomly divided into middle-aged sedentary control (M-SED) and aerobic exercise (M-EX) groups (n = 12 each). Maximum oxygen consumption (VO2max) gradually increased from 50%–55% to 65%–70% for a total of 10 weeks. A total of 36 carbonylated proteins with modifed oxidative sites were identifed by Electrospray IonizationQuadrupole-Time of Flight-Mass Spectrometer (ESI-Q-TOF-MS), including 17 carbonylated proteins unique to the M-SED group, calcium/calmodulin-dependent protein kinase type II subunit beta (CaMKII�), and heterogeneous nuclear ribonucleoprotein A2/B1 (Hnrnpa2b1), …

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Immigration Law Under The Mclachlin Court, Catherine Dauvergne Dec 2018

Immigration Law Under The Mclachlin Court, Catherine Dauvergne

All Faculty Publications

No abstract provided.

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Revision Of The Central Asian Scorpion Genus Anomalobuthus Kraepelin, 1900, With Descriptions Of Three New Species And A Generic Synonymy (Scorpiones: Buthidae), Rolando Teruel, František Kovařík, Victor Fet Dec 2018

Revision Of The Central Asian Scorpion Genus Anomalobuthus Kraepelin, 1900, With Descriptions Of Three New Species And A Generic Synonymy (Scorpiones: Buthidae), Rolando Teruel, František Kovařík, Victor Fet

Euscorpius

We revise the Central Asian endemic genus Anomalobuthus Kraepelin, 1900, which was considered monotypic for more than 100 years until the recent addition of a second species from Iran (Teruel et al., 2014). We redefine the generic diagnosis of Anomalobuthus and reveal that it is composed of no less than six species, three of which are described as new: A. krivochatskyi, sp. n. (central Uzbekistan and extreme southern Kazakhstan), A. lowei, sp. n. (southeastern Kazakhstan), and A. pavlovskyi, sp. n. (south-central Kazakhstan and extreme northern Turkmenistan). The monotypic genus Psammobuthus Birula, 1911 (described from the Ferghana Valley …

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Zoom In On Science Concepts: Living And Nonliving, Ariel Woodbury Dec 2018

Zoom In On Science Concepts: Living And Nonliving, Ariel Woodbury

Children's Book and Media Review

Living and Nonliving is a great book to introduce the concept that somethings (even inanimate objects) can be living things. Things that have never been alive are nonliving. They are things like rocks and sand. Living things are or have been alive. Things like plants and animals are living things. Living things all need energy, reproduce, grow and breathe.

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Tractor Mac School Day, Sydnee Burr Dec 2018

Tractor Mac School Day, Sydnee Burr

Children's Book and Media Review

When Betty the school bus visits her friends after a rough first day of school, she's feeling pretty low. She made so many mistakes. She forgot where to go, didn't use her blinkers, and she even got lost! She's feeling sad, embarrassed, and unsure if she should go back for the second day of school. Luckily, her friends cheer her up and boost her confidence. Tractor Mac and the other vehicles and animals on the farm help Betty come up with tricks for remembering her route. They rally behind her and let her know that they believe in her, which …

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The Amazing Hamweenie Escapes!, Samantha Bullock Dec 2018

The Amazing Hamweenie Escapes!, Samantha Bullock

Children's Book and Media Review

Hamweenie the cat knows exactly what he wants, thank you very much. What some would call a posh existence is not at all up to Hamweenie’s liking, and he’s determined to do something about it. His quest for fame and adoration leads him to escape and join the circus, where he has some hilariously misinterpreted encounters with the residents of New York City and, later, the animals in the circus troupe. Eventually, Hamweenie’s five minutes of fame pass and he is once again in captivity. The change of venue does not stop Hamweenie though, and he continues to perform—right in …

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Platypuses: Web-Footed Billed Mammals, Jamie Greenwood Dec 2018

Platypuses: Web-Footed Billed Mammals, Jamie Greenwood

Children's Book and Media Review

Platypuses: Web-Footed Billed Mammals includes an introduction and four chapters, titled “Meet the Platypus,” “What Do Platypuses Look Like,” “Where Do Platypuses Live,” “Platypus Hunting Behavior,” and “The Life Cycle of Platypuses.” Each chapter opens with factual information on the chapter’s individual subject. The information is brief, to the point, easy to understand, and captivating. In each chapter the author compares a platypus with a similar animal and with a dissimilar animal. The end of the book provides a chart that lists the similar and dissimilar traits between platypuses and all the other animals with which it was previously compared.

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Neighborhood Sharks: Hunting The Great Whites Of California's Farallon Islands, Haley Singleton Dec 2018

Neighborhood Sharks: Hunting The Great Whites Of California's Farallon Islands, Haley Singleton

Children's Book and Media Review

Great white sharks are plentiful near the Farallon islands outside of California. Their bodies are designed to successfully catch their prey, the northern elephant seals. Sharks lie in wait for seals to come into the water, and then with two thrusts of their powerful tail they reach speeds of up to twenty-five miles per hour and snatch their prey. Scientists study these sharks to learn more about their feeding habits and their unique physical traits.

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Natalie's Hair Was Wild, Ariel Woodbury Dec 2018

Natalie's Hair Was Wild, Ariel Woodbury

Children's Book and Media Review

Natalie's hair is wild, and all sorts of animals make it their home. Natalie doesn't mind, but soon all the animals become too loud and Natalie can't get any sleep. Natalie calls for help, and the zoo teams up with the firefighters to get the animals out of Natalie's hair and make it tame once more. But that won't last long.

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Going For A Sea Bath, Cynthia Phillips Dec 2018

Going For A Sea Bath, Cynthia Phillips

Children's Book and Media Review

It’s time for her bath, but Leanne would rather continue to play in the ocean waves. The bathtub is too boring. Suddenly her father has a brilliant idea. Why not bring the ocean to her? Soon enough, the tub is filled to the brim with sea creatures of all kinds. Now the tub is not so boring. But when the ten octopi are brought in, Leanne realizes that maybe a bath in the sea would be better.

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Every Girl Is A Princess, Nan Rao Dec 2018

Every Girl Is A Princess, Nan Rao

Children's Book and Media Review

Every girl is a princess and every princess has a special crown. The book takes the reader through five different princesses around the world, identified by the special item that adorns their crown as well as the animal they adore. The interactive flap for each character lets the reader reveal the crown that belongs to the princess. The end of the story gives the reader a pleasant surprise showing that she is also a princess by looking into a mirror.

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Draw Like An Ancient Egyptian, Ariel Woodbury Dec 2018

Draw Like An Ancient Egyptian, Ariel Woodbury

Children's Book and Media Review

Many Egyptian gods are represented by animals and have great powers. The Egyptians would draw people from the front with their heads and legs in profile. What would you look like as an Egyptian god? Their alphabet had thousands of hieroglyphs. Try to write your name using a simplified version of their alphabet. Their canopic jars, death masks, coffins and sarcophagi were all decorated elaborately and works of art. They had many styles, and with this book you can try to design your own!

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Dinner Time, Karen Abbott Dec 2018

Dinner Time, Karen Abbott

Children's Book and Media Review

Animals get hungry too! In this hungry picture book, readers follow a dinner menu up the jungle food chain as one animal eats another from one page to the next. Each hungry creature eats the last before winding on their own way into the jungle and meeting the next predator who greets them and gobbles them. All but the last apex predator, who chooses to eat without conversation!

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A Is For Australian Animals, Megan Hall Dec 2018

A Is For Australian Animals, Megan Hall

Children's Book and Media Review

When we think of Australian animals, a kangaroo or a koala most often come to mind. But have you ever heard of a Quokka or a Yabby? A Is for Australian Animals covers thirty-eight of the captivating and interesting animals found only in Australia. For each letter of the alphabet, the author describes one or two Australian animals that start with that letter. Each page has a description of that animal and includes additional facts for those who want to learn more. There are many amazing animals to be discovered only in Australia.

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100 Bugs! A Counting Book, Sydnee Burr Dec 2018

100 Bugs! A Counting Book, Sydnee Burr

Children's Book and Media Review

Learn to count alongside two explorers who are searching for bugs. A different bug, as well as a unique way to count to ten, greets readers on each page. By the end of the book, readers have counted to ten in ten different ways. For advanced students, there is even a page offering the opportunity to count as high as fifty! At the end of the book, readers can learn more about the bugs they just counted in a glossary. Each bug is listed with its full name, as well as its scientific name and a small paragraph enlightening the …

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Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator-Activated Receptor Signaling As Driver Of Cancer-Induced Muscle Fatigue, Hannah E. Wilson, Kacey K. Rhodes, Daniel Rodriguez, Ikttesh Chahal, David A. Stanton, Joseph Bohlen, Mary Davis, Aniello M. Infante, Hannah Hazard-Jenkins, David J. Klinke, Elena N. Pugacheva, Emidio E. Pistilli Dec 2018

Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator-Activated Receptor Signaling As Driver Of Cancer-Induced Muscle Fatigue, Hannah E. Wilson, Kacey K. Rhodes, Daniel Rodriguez, Ikttesh Chahal, David A. Stanton, Joseph Bohlen, Mary Davis, Aniello M. Infante, Hannah Hazard-Jenkins, David J. Klinke, Elena N. Pugacheva, Emidio E. Pistilli

Clinical and Translational Science Institute

Purpose: This study tested the hypothesis that a patient-derived orthotopic xenograft (PDOX) model would recapitulate the common clinical phenomenon of breast cancer–induced skeletal muscle (SkM) fatigue in the absence of muscle wasting. This study additionally sought to identify drivers of this condition to facilitate the development of therapeutic agents for patients with breast cancer experiencing muscle fatigue. Experimental Design: Eight female BC-PDOX–bearing mice were produced via transplantation of tumor tissue from 8 female patients with breast cancer. Individual hind limb muscles from BC-PDOX mice were isolated at euthanasia for RNA-sequencing, gene and protein analyses, and an ex vivo muscle contraction …

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Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien M. Adriaenssens, Bas E. Dutilh, Eugene V. Koonin, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, J Rodney Brister, Arvind Varsani, Clara Amid, Ramy K. Aziz, Seth R. Bordenstein, Peer Bork, Mya Breitbart, Guy R. Cochrane, Rebecca A. Daly, Christelle Desnues, Melissa B. Duhaime, Joanne B. Emerson, François Enault, Jed A. Fuhrman, Pascal Hingamp, Philip Hugenholtz, Bonnie L. Hurwitz, Natalie N. Ivanova, Jessica M. Labonté, Kyung-Bum Lee, Rex R. Malmstrom, Manuel Martinez-Garcia, Ilene Karsch Mizrachi, Hiroyuki Ogata, David Páez-Espino, Marie-Agnès Petit, Catherine Putonti, Thomas Rattei, Alejandro Reyes, Francisco Rodriguez-Valera, Karyna Rosario, Lynn Schriml, Frederik Schulz, Grieg F. Steward, Matthew B. Sullivan, Shinichi Sunagawa, Curtis A. Suttle, Ben Temperton, Susannah G. Tringe, Rebecca Vega Thurber, Nicole S. Webster, Katrine L. Whiteson, Steven W. Whilhelm, K Eric Wommack, Tanja Woyke, Kelly C. Wrighton, Pelin Yilmaz, Takashi Yoshida, Mark J. Young, Natalya Yutin, Lisa Zeigler Allen, Nikos C. Kyrpides, Emiley A. Eloe-Fadrosh Dec 2018

Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien M. Adriaenssens, Bas E. Dutilh, Eugene V. Koonin, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, J Rodney Brister, Arvind Varsani, Clara Amid, Ramy K. Aziz, Seth R. Bordenstein, Peer Bork, Mya Breitbart, Guy R. Cochrane, Rebecca A. Daly, Christelle Desnues, Melissa B. Duhaime, Joanne B. Emerson, François Enault, Jed A. Fuhrman, Pascal Hingamp, Philip Hugenholtz, Bonnie L. Hurwitz, Natalie N. Ivanova, Jessica M. Labonté, Kyung-Bum Lee, Rex R. Malmstrom, Manuel Martinez-Garcia, Ilene Karsch Mizrachi, Hiroyuki Ogata, David Páez-Espino, Marie-Agnès Petit, Catherine Putonti, Thomas Rattei, Alejandro Reyes, Francisco Rodriguez-Valera, Karyna Rosario, Lynn Schriml, Frederik Schulz, Grieg F. Steward, Matthew B. Sullivan, Shinichi Sunagawa, Curtis A. Suttle, Ben Temperton, Susannah G. Tringe, Rebecca Vega Thurber, Nicole S. Webster, Katrine L. Whiteson, Steven W. Whilhelm, K Eric Wommack, Tanja Woyke, Kelly C. Wrighton, Pelin Yilmaz, Takashi Yoshida, Mark J. Young, Natalya Yutin, Lisa Zeigler Allen, Nikos C. Kyrpides, Emiley A. Eloe-Fadrosh

Bioinformatics Faculty Publications

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. In turn, this should enable more robust comparative …

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Movement Activities For Kindergarten Through Second Grade Teachers In An Alaska Classroom, Krista K. Borba Dec 2018

Movement Activities For Kindergarten Through Second Grade Teachers In An Alaska Classroom, Krista K. Borba

Education

Physical activities in the classroom are very important for student growth and learning. Classroom teachers often teach physical activities in between core subjects in order to meet the Alaska Physical Activity in Schools Law which states that children should be getting 54 minutes of movement a day. However, many schools throughout Alaska do not have a designated PE teacher. Subsequently, this puts the responsibility of these standards on the general education teacher. However, few elementary teachers have a background in physical education, making it more challenging to know how to integrate meaningful physical activities in the classroom. The purpose of …

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Inside Out: An Invisible Illness Explored Through Art, Jennifer Chamberlain Dec 2018

Inside Out: An Invisible Illness Explored Through Art, Jennifer Chamberlain

Art

Inside Out: A Hidden Illness Explored Through Art is a thesis Project to fulfill the requirements of an MFA degree in visual arts. This project focused on ceramics and photography inspired by the unusual combination of medical imagery and heavily textured ocean landscapes. Through this body work, a better understanding of invisible illness is revealed. During my first year as an MFA student at the University of Alaska Fairbanks, I was invited to be an apprentice to Simon Levin, a woodfire potter specializing in functional wares fired in a Japanese style Anagama Kiln. One month into my apprenticeship I was …

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