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When God Was A Bird [Table Of Contents], Mark I. Wallace

Religion

In a time of rapid climate change and species extinction, what role have the world’s religions played in ameliorating—or causing—the crisis we now face? One can point to Christianity’s otherworldly theologies, which privilege our spiritual aspirations over our natural origins, as bearing a disproportionate burden for creating humankind’s exploitative attitudes toward nature.

And yet, buried deep within the Christian tradition are startling portrayals of God as the beaked and feathered Holy Spirit—the “animal God” of historic Christian witness. Through biblical readings, historical theology, continental philosophy, and personal stories of sacred nature, this book recovers the Christian God as a creaturely, …

Sjsu Erfa News, Winter 2018, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 32, Number 2

Mertk Is A Therapeutic Target In Combination With Radiation To Promote Adaptive Immune Tumor Responses, Garth Tormoen, Jason R Baird, Gwen Kramer, Shelly Bambina, Marka R Crittenden, Michael J. Gough

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Mertk is a member of the Tyro3-Axl-Mertk (TAM) family of receptors and regulates phagocytosis of dying cells by macrophages. Cancer cells killed by radiation therapy direct repolarization of macrophages into immune suppressive phenotypes. Mertk-/- mice grafted with immunogenic tumors have enhanced tumor control following ionizing radiation compared to Mertkwt mice. Gas6 is the endogenous ligand for Mertk and its ability to signal through Mertk requires a post-translational vitamin k-dependent modification that is inhibited by warfarin.

Methods: Mertk-/- and WT mice were injected subcutaneously in the flank with 5E4 CT26 cells (BALB/c) or 5E6 Panc02-SIY cells (C57BL/6) and allowed to …

Mv-626, A Potent And Selective Inhibitor Of Enpp1 Enhances Sting Activation And Augments T-Cell Mediated Anti-Tumor Activity In Vivo, Jason Baird, Gregory Dietsch, Vincent Florio, Michael Gallatin, Clayton Knox, Joshua Odingo, Marka Crittenden, Michael J. Gough

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: STING is an endogenous sensor of cGAMP, which is synthesized by cGAS following detection of cytoplasmic DNA. STING activation leads to interferon production and activation of inflammatory pathways that facilitate cytolytic T cell priming. STING agonists administered intratumorally show potent anti-tumor efficacy in a range of preclinical models; several agonists are in clinical development. Radiation therapy also increases cytoplasmic DNA levels in cancer cells, resulting in STING activation and secretion of inflammatory cytokines. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the phosphodiesterase that negatively regulates STING by hydrolyzing cGAMP. MV-626, a highly potent and selective ENPP1 inhibitor with 100% oral bioavailability …

Pegzilarginase In Combination With Agonist Anti-Ox40 Therapy Enhances T Cell Priming And Effector Function Leading To Improved Tumor Regression And Survival, Melissa Kasiewicz, Annah Rolig, Elizabeth Sturgill, Mark Badeaux, Scott Rowlinson, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Tumor cells defective in enzymes required for arginine biosynthesis are dependent upon arginine uptake from the environment. Extracellular depletion of arginine directly affects tumor cells, inducing autophagy and apoptosis. Pegzilarginase (AEB1102) is a bioengineered, pegylated, human arginase 1 (Aeglea Biotherapeutics) currently in phase I clinical trials. This arginine-depleting agent has been shown to both inhibit arginine auxotrophic tumor growth and to enhance the efficacy of PD-L1 blockade in preclinical models. In the current study, we investigated the therapeutic efficacy and mechanism of action of combined pegzilarginase/anti-OX40 (aOX40) immunotherapy. We hypothesized that pegzilarginase/aOX40 treatment would synergize to enhance T cell …

Archarios, 2018 Fall / 2019 Spring, Office Of Student Life

Archarios Literary Art Magazine

Archarios 27. Editor: Rob Sperduto. Faculty Advisor: Jeff Case. Cited as 27th edition. Printed by Sheriar Press.

Temperature Forecasting: A Comparison Between Parametric And Non-Parametric Models, Alaa Sheta, Ajay Katangur, Abdelkarim Baareh

Applied Mathematics & Information Sciences

The development of accurate temperature prediction models is essential for not only human life but also for agricultural, animal life, tourism, and many others. Power consumption and achieving energy efficiency in buildings also depends on temperature. Although modeling-based regression is one of the most popular approaches, it still suffers from many difficulties related to the number of available measurements, the order of the model and the non-linearity of the data. In this paper, we provide a comparison between parametric and non-parametric models for temperature forecasting. We propose three-model structures to estimate the temperature in Mumbai, the business capital of India. …

Graphene Quantum Dots Potently Block Copper-Mediated Oxidative Dna Damage: Implications For Cancer Intervention, Rachel E. Li, Y R. Li, Hong Zhu, Zhenquan Jia

Osteopathic Medicine, Jerry M. Wallace School of

Our early work suggested that graphene quantum dots (GQDs) block Cu(II)/Cu(I) redox cycle in biological systems. Here we report that GQDs could also potently protect against copper redox-mediated oxidative DNA damage. Using Cu(II)/hydrogen peroxide, Cu(II)/hydroquinone, and Cu(II)/ascorbic acid as three biologically relevant systems for inducing oxidative DNA damage, we demonstrated that GQDs protected against the above system-induced DNA strand breaks in ϕx-174 plasmid DNA in a concentration-dependent manner. Notably, a significant protection was observed with GQDs at 1 μg/ml, and a nearly complete protection was shown with 10 and 100 μg/ml of GQDs. Using electron paramagnetic resonance (EPR) spectrometry in …

Nktr-214 (Cd122-Biased Agonist) And Nktr-262 (Tlr7/8 Agonist) Combination Treatment Pairs Local Innate Immune Activation With Systemic Cd8+ T Cell Expansion To Enhance Anti-Tumor Immunity, Annah S. Rolig, Daniel Rose, Saul Kivimäe, Deborah Charych, Werner Rubas, Jonathan Zalevsky, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Radiation therapy (RT) remains the standard of care for many human cancers. Combining NKTR-214, a CD122-biased cytokine agonist conjugated with releasable polyethylene-glycol (PEG) chains, with local RT significantly enhanced therapeutic efficacy in preclinical models. Mechanistically, NKTR-214 provides sustained signaling through the IL-2 receptor pathway (IL-2Rβγ) to preferentially activate and expand effector CD8+ T and NK cells and RT modulates the tumor microenvironment (TME) to induce antigen-release. Together, NKTR-214/RT treatment resulted in improved therapeutic responses compared to either treatment alone. However, abscopal responses in murine tumors were modest, leading us to explore alternative approaches with the potential to elicit more …

Combined Anti-Pd-1 And Anti-Lag-3 Checkpoint Blockade Enhances Cd8+ Til Effector Function While Reducing Tregs Leading To Reduced Immune Suppression And Improved Overall Survival, Elizabeth Sturgill, Courtney Mick, David Jenkins, Johanna Kaufmann, William L. Redmond

Society for Immunotherapy of Cancer 2018 Annual Meeting Posters

Background: Checkpoint inhibition is a potent strategy to reinvigorate T cells. However, aCTLA-4 or aPD-1 monotherapy has not been effective for the majority of patients, resulting in the exploration of combinatorial approaches to improve treatment efficacy. One such target is LAG-3, which is upregulated on T cells that have experienced repeated antigen exposure, such as in the tumor microenvironment (TME), and is associated with reduced T cell effector function. In addition, high LAG-3 expression on regulatory T cells (Tregs) has been reported for patients with varying cancer types, providing an additional rationale for targeting LAG-3 with the aim of reducing …

Humboldt Bay Area Plan Communities At Risk Sea Level Rise Vulnerability Assessment, Aldaron Laird

Local Reports and Publications

Humboldt County received a grant from the California Coastal Commission to engage at-risk communities from sea level rise by initiating the process of educating stakeholders of their vulnerability. In August of 2018, two workshops were held for at risk communities: one workshop for King Salmon and Fields Landing, and another for Fairhaven and Finntown. A comprehensive sea level rise vulnerability assessment was prepared for the County’s Humboldt Bay Area Plan (HBAP) jurisdiction, including these at-risk communities.

From Sagebrush Law To A Modern Profession, Kristina J. Running

Articles

No abstract provided.

Managing Lake Fertility Within The Guidelines Of A Nutrient Management Plan And Based On Algal Nutrient Limitation, Bradley J. Austin, J. Thad Scott, Brian E. Haggard

Arkansas Water Resources Center Technical Reports

The specific objectives were to first, monitor nutrients, algal biomass, and water clarity in lakes Cove, Spring, and Wedington. Second, evaluate whether algal growth in each of the lakes was limited by N, P, or both N and P. This research was conducted to help USFS better manage lake fertilization to maximize algal growth and improve the fisheries within these lakes.

Executive Authority And The Take Care Clause, Colleen E. O'Connor

Notre Dame Law Review

Part I of this Note will discuss the Department of Homeland Security’s authority to regulate immigration and focuses on DACA and DAPA. Part II will address the U.S. Department of Justice’s Office of Legal Counsel Opinion on DAPA’s legality. Part III will turn to the lack of judicial constraints on or legislative responses to the executive branch’s enforcement discretion. Part IV will propose that the executive branch should take a more active role in ensuring that the President remains faithful to the Take Care Clause when exercising prosecutorial discretion. Expounding upon the Office of Legal Counsel’s multifactor framework is a …

Taking A Day Off To Pray: Closing Schools For Religious Observance In Increasingly Diverse Schools, Ann E. Blankenship-Knox, Brett A. Geier

Brigham Young University Education and Law Journal

No abstract provided.

Touro Torah Volume 4 Issue 8, Lander College For Women

Yearbooks and Newsletters

Kislev Issue, Divrei Torah Newsletter.

Spartan Daily, November 1, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 32

Women's Tennis Media Guide 2018-19, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Nov2018, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Animal Science E-Newsletter, November 2018, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

Trex1 Is Expressed By Microglia In Normal Human Brain And Increases In Regions Affected By Ischemia, Parul H. Kothari, Grant R. Kolar, Joanna C. Jen, Rula Hajj-Ali, Paula Bertram, Robert E. Schmidt, John P. Atkinson

Biological Sciences Faculty Research & Creative Works

Background: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL). However, the endogenous expression of TREX1 in human brain has not been studied. Methods: We produced a rabbit polyclonal antibody (pAb) to TREX1 to characterize TREX1 by Western blotting (WB) of cell lysates from normal controls and subjects carrying an RVCL frame-shift mutation. Dual staining was performed to determine cell types expressing TREX1 in human brain tissue. TREX1 distribution in human brain was further evaluated by immunohistochemical analyses of formalin-fixed, paraffin-embedded samples from normal controls and patients …

The Setonian, November 1, 2018, Seton Hall University

2018

No abstract provided.

Front Cover And Publication Information, Volume 51, Issue 4

Word Ways

The front cover and publication information for this issue, including the table of contents.

Word Ways V.51 No.4 Complete Issue

Word Ways

All of the articles in this issue in one complete document.

Amjambo Africa! (November 2018), Kathreen Harrison

Amjambo Africa!

In This Issue...

Migration Art..........................Page 2

Isuken ..............................Pages 8 & 9

Election Special ...........Page 12 & 13

In Stitches Documentary .....Page 15

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

No. 16: Cheap Industrial Food And The Urban Margins, Tony Weis, Marylynn Steckley, Bruce Frayne

Hungry Cities Partnership

From the middle of the 20th century onwards, the productivity gains associated with high-input, high-yield monocultures and livestock operations have become increasingly central to global food security and to dynamics of urbanization across the global south. On one hand, competition has deflated prices and helped undermine the viability of small farm livelihoods in many places. On the other hand, rising flows of cheap food have effectively subsidized urban migration in impoverished urban and peri-urban settings. But this cheapness is highly deceptive, as it hinges on the failure to account for an array of biological and physical costs – which can …

Kentucky Warbler (Vol. 94, No. 4), Kentucky Library Research Collections

The Kentucky Warbler

No abstract provided.

Reactive Ion Plasma Modification Of Poly(Vinyl‐Alcohol) Increases Primary Endothelial Cell Affinity And Reduces Thrombogenicity, Patrick Jurney, Deirdre Anderson, Grace Pohan, Evelyn Yim, Monica Hinds

Faculty Publications

Bulk material properties and luminal surface interaction with blood determine the clinical viability of vascular grafts, and reducing intimal hyperplasia is necessary to improve their long‐term patency. Here, the authors report that the surface of a biocompatible hydrogel material, poly(vinyl alcohol) (PVA) can be altered by exposing it to reactive ion plasma (RIP) in order to increase primary endothelial cell attachment. The power and the carrier gas of the RIP treatment are varied and the resultant surface nitrogen, water contact angle, as well as the ability of the RIP‐treated surfaces to support primary endothelial colony forming cells is characterized. Additionally, …

Humboldt Bay Area Plan Communities At Risk Sea Level Rise Vulnerability Assessment, Aldaron Laird

Local Reports and Publications

Humboldt County received a grant from the California Coastal Commission to engage at-risk communities from sea level rise by initiating the process of educating stakeholders of their vulnerability. In August of 2018, two workshops were held for at risk communities: one workshop for King Salmon and Fields Landing, and another for Fairhaven and Finntown. A comprehensive sea level rise vulnerability assessment was prepared for the County’s Humboldt Bay Area Plan (HBAP) jurisdiction, including these at-risk communities.

Odontogenic Abscesses In Rhesus Macaques (Macaca Mulatta) Of Cayo Santiago, Hong Li, Wenjing Luo, Anna Feng, Michelle L. Tang, Terry B. Kensler, Elizabeth Maldonado, Octavio A. Gonzalez, Matthew J. Kessler, Paul C. Dechow, Jeffrey L. Ebersole, Qian Wang

Center for Oral Health Research Faculty Publications

Objectives
Odontogenic abscesses are one of the most common dental diseases causing maxillofacial skeletal lesions. They affect the individual's ability to maintain the dental structures necessary to obtain adequate nutrition for survival and reproduction. In this study, the prevalence and pattern of odontogenic abscesses in relation to age, sex, matriline, and living periods were investigated in adult rhesus macaque skeletons of the free-ranging colony on Cayo Santiago, Puerto Rico.

Materials and Methods
The skulls used for this study were from the skeletons of 752 adult rhesus macaques, aged 8–31 years, and born between 1951 and 2000. They came from 66 …