Digital Commons Network^™

Pvsripo Effect On Cancer, Vishal Jindal, Matthew Lee, Darshan Rola, Mir Saleem

Biology Faculty Articles

PVSRIPO, a variant of the poliovirus, is a revolutionary virus that demonstrates key characteristics for oncolytic virotherapy due to its ability to attack glioblastomas. The first criteria that PVSRIPO demonstrates is tumor-targeting tropism. PVSRIPO binds to nectin-like molecule 5 (Necl-5), a poliovirus receptor (PVR), found on different types of cancers such as lung cancer, colorectal cancer, and glioblastomas. This allows the virus to have a high binding affinity to tumor cells. Secondly, after modifying the poliovirus by substituting its internal ribosome entry site (IRES) with the Human Rhinovirus 2's (HRV2) IRES, the poliovirus becomes PVSRIPO, an attenuated version of the …

Biochemical And Anti-Triple Negative Metastatic Breast Tumor Cell Properties Of Psammaplins, Yu-Dong Zhou, Jun Li, Lin Du, Fakhri Mahdi, Thuy P. Le, Wei-Lun Chen, Steven M. Swanson, Kounosuke Watabe, Dale G. Nagle

Faculty and Student Publications (Open Access)

Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast tumor cells often metastasize to the brain, bone, lung and liver. Massagué and colleagues isolated organotropic subclones and established organ-specific gene signatures associated with lung-, bone-, and brain-specific metastatic triple-negative breast cancer (TNBC) MDA-MB-231 cells. Using these genetically characterized metastatic subclones specific to lung (LM4175), bone (BoM1833), and brain (BrM-2a), we evaluated marine natural products for the ability to differentially suppress metastatic breast cancer cells in a target organ-dependent manner. Psammaplin-based histone …

Modeling Surface Tension Of A Two-Dimensional Droplet Using Smoothed Particle Hydrodynamics, Nowoghomwenma Noel Ehigiamusoe, Samat Maxutov, Yeaw Chu Lee

School of Engineering, Computing and Mathematics

Surface tension plays a significant role at the dynamic interface of free-surface flows especially at the microscale in capillary-dominated flows. A model for accurately predicting the formation of two-dimensional viscous droplets in vacuum or gas of negligible density and viscosity resulting from axisymmetric oscillation due to surface tension is solved using smoothed particle hydrodynamics composed of the Navier-Stokes system and appropriate interfacial conditions for the free-surface boundaries. The evolution of the droplet and its free-surface interface is tracked over time to investigate the effects of surface tension forces implemented using a modified continuous surface force method and is compared with …

Introduction: Yeats And Mass Communications, David Dwan, Emilie Morin

International Yeats Studies

W. B. Yeats’s pursuit of an audience led him into the world of mass media—a landscape populated first by newspapers and later by radios, which he learned to navigate with shrewdness and skill. The purpose of this special issue is to examine Yeats’s various ventures in mass communication. Enlisting a broad range of critical approaches, contributors to this volume show how the demands of print journalism and radio broadcasting informed Yeats’s poetics, his thinking about the social vocation of art, and his ideas about how literature might be best received and structured. The essays also examine the reception and legacies …

International Yeats Studies, Volume 3, Issue 1

International Yeats Studies

No abstract provided.

Environmental Impact- Using Digital Media To Focus Student Learning, Crystal Randall, Sowmya Anjur, Donald Dosch

Faculty Publications & Research

Environmental issues are global challenges that our students will have to address in their future. Addressing these issues through curriculum helps bring purpose to students’ learning. We have developed a capstone project in our introductory biology class that allows students to engage in these issues in a creative and personalized manner, and which asks students to not only address the biology at the core of these issues but also suggest possible solutions to the problem. In this session, we will share how we scaffold our curriculum to prepare students for this experience, as well as show examples of student work.

Factors Affecting Trailer Thermal Environment Experienced By Market Pigs Transported In The Us, Y Xiong, Richard S. Gates, Angela R. Green-Miller

Department of Animal Science: Faculty Publications

Extreme weather conditions challenge pig thermoregulation during transport and are addressed by the National Pork Board (NPB) Transport Quality Assurance® (TQA) program that provides guidelines for trailer boarding, bedding, and misting. These guidelines are widely applied, yet very little is known about the microenvironment within the trailer. In this study, TQA guidelines (V4) were evaluated via extensive thermal environment measurements during transport in order to evaluate spatial variability and implications on ventilation pattern. Effects of trailer management strategies including bedding, boarding, and misting were examined and the trailer was monitored for interior temperature rise and THI responses within six separate …

Systems Thinking In A Second Grade Curriculum: Students Engaged To Address A Statewide Drought, Margaret Sauceda Curwen, Amy Ardell, Laurie Macgillivray, Rachel Lambert

Education Faculty Articles and Research

Faced with issues, such as drought and climate change, educators around the world acknowledge the need for developing students’ ability to solve problems within and across contexts. A systems thinking pedagogy, which recognizes interdependence and interconnected relationships among concrete elements and abstract concepts (Meadows, 2008; Senge et al., 2012), has potential to transform the classroom into a space of observing, theorizing, discovering, and analyzing, thus linking academic learning to the real world. In a qualitative case study in one school located in a major metropolitan area in California, USA teachers and their 7- and 8-year-old students used systems thinking in …

A Secure Computing Platform For Building Automation Using Microkernel-Based Operating Systems, Xiaolong Wang

USF Tampa Graduate Theses and Dissertations

Building Automation System (BAS) is a complex distributed control system that is widely deployed in commercial, residential, industrial buildings for monitoring and controlling mechanical/electrical equipment. Through increasing industrial and technological advances, the control components of BAS are becoming increasingly interconnected. Along with potential benefits, integration also introduces new attack vectors, which tremendous increases safety and security risks in the control system. Historically, BAS lacks security design and relies on physical isolation and "security through obscurity". These methods are unacceptable with the "smart building" technologies. The industry needs to reevaluate the safety and security of the current building automation system, and …

Batman In My Belfry, Kaye Curren

Erma Bombeck Writers' Workshop Blog

I was composing a new blog post on my computer when I heard a clunk, chunk coming from my outdated air conditioner. Because the wall AC unit faced the outside, occasional bugs would appear in my living space. Sometimes a random bird would fly into the unit, but they were too big to break through. What came through the vent now was not a bug or a bird. A bat with a wingspan of about 12 inches had somehow squeezed through a small opening and was now speeding in circles around my living room.

Ecofeminism And Cultural Ecology: A Framework Of Connections And Intersections For Reading Margret Atwood’S “Habitation”, “The City Planners”, “Morning In The Burned House”, “February”, And “Night Poem”, Maha M. Munib Abdelmotaleb

English Language and Literature

Cultural ecology and Ecofeminism are two concepts that intersect with each other. Both concepts define and reinforce each other. It could be claimed that, Ecofeminism is one manifestation of cultural ecology since the former tackles issues about feminism’s relationship with nature including nature domination and the duality of nature which find their echoes in cultural ecology as well. The whole idea of the earth’s subjugation and male domination as well as the male/ female duality of nature in general find resonance in feminist resistance to patriarchal domination which develop under the umbrella of Ecofeminism to be part of the struggle …

N-Substituted Aminoquinoline-Pyrimidine Hybrids: Synthesis, In Vitro Antimalarial Activity Evaluation And Docking Studies, Shiv Maurya, Aparna Bahuguna, Shabana I. Khan, Deepak Kumar, Rohit Kholiya, Diwan S. Rawat

Faculty and Student Publications (Open Access)

No abstract provided.

Portland’S Transportation Wallet: How Pricing Parking Can Create New Mobility Options, Sarah Goforth

PSU Transportation Seminars

The Transportation Wallet is one of Portland’s newest parking and transportation demand management (TDM) strategies, designed to reduce parking demand while simultaneously offering new mobility options by bundling transit and bike share passes into one consumer product. Two of Portland’s managed parking districts have elected to add a surcharge to the cost of on-street parking permits, a portion of which is used to subsidize the cost of the Transportation Wallet. Residents and employees in the parking districts are eligible to purchase the Transportation Wallet at a fraction of the retail cost. As an added incentive to increase parking supply, people …

November 9, 2018, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Preventing Reverse Engineering Of Black-Box Classifiers, Laura Eidem, Alex Jacobson

Defensive Publications Series

Machine learning (ML) models trained for various purposes are generally kept confidential, e.g., due to their commercial value, proprietary nature of training data, etc. Therefore, commercial cloud-based machine-learning service providers protect their ML models even as they provide one or more services to customers that employ ML models. For example, a service enables a customer to upload an observation, e.g., an image, and receive a label for the observation, generated by a ML model that’s trained to determine labels for images. Recent research has shown that given a sufficient number of observations and returned labels, it is possible to reverse …

In Vivo Extracellular Ph Mapping Of Tumors Using Electron Paramagnetic Resonance, Denis A. Komarov, Yuki Ichikawa, Kumiko Yamamoto, Neil J. Stewart, Shingo Matsumoto, Hironobu Yasui, Igor A. Kirilyuk, Valery V. Khramtsov, Osamu Inanami, Hiroshi Hirata

Clinical and Translational Science Institute

An electron paramagnetic resonance (EPR)- based method for noninvasive three-dimensional extracellular pH mapping was developed using a pH-sensitive nitroxyl radical as an exogenous paramagnetic probe. Fast projection scanning with a constant magnetic field sweep enabled the acquisition of four-dimensional (3D spatial +1D spectral) EPR images within 7.5 min. Three-dimensional maps of pH were reconstructed by processing the pH-dependent spectral information on the images. To demonstrate the proposed method of pH mapping, the progress of extracellular acidosis in tumor-bearing mouse legs was studied. Furthermore, extracellular pH mapping was used to visualize the spatial distribution of acidification in different tumor xenograft mouse …

Vol.46 N.16 November 8th 2018, Voice Media Ventures

Black Voice News

No abstract provided.

The Indiana Statesman, November 8, 2018, Indiana State University

Student Newspaper

PIZZA AND POLITICS: Students watch midterm results roll in; She’s the First hosts charity dinner, auction; ISU awards Hulman Center renovation contract to Hannig Construction

Embryonic Origin And Genetic Basis Of Cave Associated Phenotypes In The Isopod Crustacean Asellus Aquaticus., Hafasa Mojaddidi, Franco Fernandez, Priscilla A. Erickson, Meredith E. Protas

Natural Sciences and Mathematics | Faculty Scholarship

Characteristics common to animals living in subterranean environments include the reduction or absence of eyes, lessened pigmentation and enhanced sensory systems. How these characteristics have evolved is poorly understood for the majority of cave dwelling species. In order to understand the evolution of these changes, this study uses an invertebrate model system, the freshwater isopod crustacean, Asellus aquaticus, to examine whether adult differences between cave and surface dwelling individuals first appear during embryonic development. We hypothesized that antennal elaboration, as well as eye reduction and pigment loss, would be apparent during embryonic development. We found that differences in pigmentation, eye …

Variation In Regional And Landscape Effects On Occupancy Of Temperate Bats In The Southeastern U.S.., Benjamin D. Neece, Susan C. Loeb, David S. Jachowski

KIP Articles

Habitat loss, wind energy development, and the disease white-nose syndrome are major threats contributing to declines in bat populations in North America. In the southeastern US in particular, the recent arrival of white-nose syndrome and changes in landscape composition and configuration have driven shifts in bat species populations and distributions. Effective management strategies which address these large-scale, community-level threats require landscape-scale analyses. Our objective was to model the relationship between ecoregional and landscape factors and occupancy by all bat species in South Carolina, USA, during summer. We conducted acoustic surveys from mid-May through July 2015 and 2016 and evaluated temporally …

Collecting Standards For Scholarship, Organization, Industry, And Innovation, Julia Gelfand, Ibironke Lawal, Jill Powell, Anne Rauh

Librarian Publications

Building on the successful 2017 presentation, A Primer in Science and Engineering Collection Development, this presentation will explore a content type that stumps the engineering librarian and acquisitions librarian alike - standards. Technical standards are documents that establish a uniform practice or process for materials, procedures, and products. Each of us uses standards daily - from USB ports to elevators to lights, automobiles, bridges, standardized train tracks, and much more. Standards are prepared and issued by a professional groups, committees, societies, or governmental agencies, and can influence safety and performance and the role of business and manufacturing.

Four librarians from …

Support For The Development Of Agribusiness In The European Union Programmes, Eugeniusz K. Chyłek

European Management Studies

Reinforcing innovation and competitiveness of the EU economy, including agribusiness, closer relations between science and business, and sustainable economic growth are key objectives set by the European Commission. In the process of building an innovative and competitive economy based on an intelligent use of natural resources, entrepreneurs need to benefit from cooperation with science and research institutions, both public and private. The primary purpose of documents prepared by the European Commission, including the Multiannual Financial Framework (MFF) for 2021-2027, COM(2018)435 and COM(2018)436, defining rules for the implementation of Horizon Europe – the 9th Framework Programme for Research and Innovation for …

Chanticleer | November 8, 2018, Jacksonville State University

Chanticleer

No abstract provided.

Ohio University Professor Develops Life-Saving Technology With Cranfield University, Gates Foundation (November 8, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Fractionation And Characterization Of Lignin Streams From Unique High-Lignin Content Endocarp Feedstocks, Wenqi Li, Kirtley Amos, Mi Li, Yunqiao Pu, Seth Debolt, Arthur J. Ragauskas, Jian Shi

Biosystems and Agricultural Engineering Faculty Publications

Background: Lignin is a promising source of building blocks for upgrading to valuable aromatic chemicals and materials. Endocarp biomass represents a non-edible crop residue in an existing agricultural setting which cannot be used as animal feed nor soil amendment. With significantly higher lignin content and bulk energy density, endo-carps have significant advantages to be converted into both biofuel and bioproducts as compared to other biomass resources. Deep eutectic solvent (DES) is highly effective in fractionating lignin from a variety of biomass feedstocks with high yield and purity while at lower cost comparing to certain ionic liquids.

Results: In the present …

Hawks' Herald -- Nov. 8, 2018, Roger Williams University

Hawk's Herald

No abstract provided.

Bats Of The California Channel Islands: New Records With New Methods, Patricia E. Brown, William E. Rainey

Western North American Naturalist

Eight bat species were known and documented from the California Channel Islands when J.C. Von Bloeker (1967) presented at the First California Islands Symposium in 1965. Additional bat surveys by P.E. Brown (1980) in the 1970s resulted in “Distribution of bats of the California Channel Islands,” which was presented at the second symposium in 1978. Methods of detecting and identifying bats have changed over the past century. Museum collection methods using shotguns have been replaced by mist-netting and recording of echolocation calls. Currently, capture or acoustic records have identified 14 bat species (56% of the 25 species known to occur …

Challenging Hazards Amidst Observational Simulation In The Emergency Department: Advancing Gamification In Simulation Education Through A Novel Resident-Led Skills Competition., Nicholas Salerno, Dimitrios Papanagnou, Md, Priyha Mahesh, Kaitlin M Bowers, Scott H Pasichow, Sara Paradise, Xiao Chi Zhang

Department of Emergency Medicine Faculty Papers

Medical simulation competitions have become an increasingly popular method to provide a hands-on "gamified" approach to education and training in the health professions. The most well-known competition, SimWars, consists of well-coordinated teams that are tasked with completing a series of mind-bending clinical scenarios in front of a live audience through 'bracket-style' elimination rounds. Similarly, challenging hazards amidst observational simulation (CHAOS) in the emergency department (ED) is another novel approach to gamification in both its structure and feel. Conducted at the Council of Emergency Medicine Resident Directors (CORD) 2018 National Assembly in San Antonio, Texas, instead of assigning premeditated teams, it …

Mutant Ubqln2p497h In Motor Neurons Leads To Als-Like Phenotypes And Defective Autophagy In Rats, Tianhong Chen, Bo Huang, Xinglong Shi, Limo Gao, Cao Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear. Using a tetracycline-regulated gene expression system, the ALS-linked UBQLN2P497H mutant was selectively expressed in either the spinal motor neurons or astrocytes in rats. We found that selectively expressing mutant UBQLN2P497H in the spinal motor neurons caused several core features of ALS, including the progressive degeneration of motor neurons, the denervation atrophy of skeletal muscles, and the abnormal protein accumulation. Furthermore, mutant UBQLN2P497H accumulation was associated with an age-dependent decrease in several core autophagy-related proteins. ALS-like phenotypes …

The Colby Echo (2018-11-08), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.