Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2018

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 20041 - 20070 of 24027

Full-Text Articles in Entire DC Network

Reducing T Cell-Mediated Cardiac Injury With Cpg Oligodeoxynucleotides, Erik Alexander Barfod Levinsohn Jan 2018

Reducing T Cell-Mediated Cardiac Injury With Cpg Oligodeoxynucleotides, Erik Alexander Barfod Levinsohn

Yale Medicine Thesis Digital Library

Lymphocytic myocarditis is a common condition associated with both infectious diseases and immunological disorders, and is often associated with severe morbidity and mortality, but few effective treatments. In many cases, the pathophysiology involves a failure of central and/or peripheral immune tolerance leading to a cardiac-specific autoimmune T cell response. Previous studies indicate that the PD-1:PD-L1 axis plays an important role in limiting inflammation in the heart. CpG ODN are TLR9 agonists with known immunoregulatory capacity, in part through their potent induction of type I IFN, a known inducer of PD-L1. In this study, we used human tissue to determine the …

Go to article

Managing Wicked Herbicide-Resistance: Lessons From The Field, Jill Schroeder, Michael Barrett, David R. Shaw, Amy B. Asmus, Harold Coble, David Ervin, Raymond A. Jussaume Jr., Michael D. K. Owen, Ian Burke, Cody F. Creech, A. Stanley Culpepper, William S. Curran, Darrin M. Dodds, Todd A. Gaines, Jeffrey L. Gunsolus, Bradley D. Hanson, Prashant Jha, Annie E. Klodd, Andrew R. Kniss, Ramon G. Leon, Sandra Mcdonald, Don W. Morishita, Brian J. Schutte, Christy L. Sprague, Phillip W. Stahlman, Larry E. Steckel, Mark J. Vangessel Jan 2018

Managing Wicked Herbicide-Resistance: Lessons From The Field, Jill Schroeder, Michael Barrett, David R. Shaw, Amy B. Asmus, Harold Coble, David Ervin, Raymond A. Jussaume Jr., Michael D. K. Owen, Ian Burke, Cody F. Creech, A. Stanley Culpepper, William S. Curran, Darrin M. Dodds, Todd A. Gaines, Jeffrey L. Gunsolus, Bradley D. Hanson, Prashant Jha, Annie E. Klodd, Andrew R. Kniss, Ramon G. Leon, Sandra Mcdonald, Don W. Morishita, Brian J. Schutte, Christy L. Sprague, Phillip W. Stahlman, Larry E. Steckel, Mark J. Vangessel

Department of Agronomy and Horticulture: Faculty Publications

Herbicide resistance is ‘wicked’ in nature; therefore, results of the many educational efforts to encourage diversification of weed control practices in the United States have been mixed. It is clear that we do not sufficiently understand the totality of the grassroots obstacles, concerns, challenges, and specific solutions needed for varied crop production systems. Weed management issues and solutions vary with such variables as management styles, regions, cropping systems, and available or affordable technologies. Therefore, to help the weed science community better understand the needs and ideas of those directly dealing with herbicide resistance, seven half-day regional listening sessions were held …

Go to article

Medicine@Yale September/October 2018 Volume 14, Issue 3, Yale School Of Medicine Office Of Communications Jan 2018

Medicine@Yale September/October 2018 Volume 14, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Go to article

The Role Of Endothelial Nitric Oxide Synthase (Enos) Coupling Status During Acute Hyperglycemia As Determined By Real-Time Measurements Of Blood Nitric Oxide And Hydrogen Peroxide In Rat, Matthew Bertolet Jan 2018

The Role Of Endothelial Nitric Oxide Synthase (Enos) Coupling Status During Acute Hyperglycemia As Determined By Real-Time Measurements Of Blood Nitric Oxide And Hydrogen Peroxide In Rat, Matthew Bertolet

PCOM Biomedical Studies Student Scholarship

Acute hyperglycemia can impair vascular endothelial function in non-diabetic subjects in addition to diabetic patients. Decreased endothelial-derived nitric oxide (NO) bioavailability and increased concentrations of reactive oxygen species (ROS), such as superoxide (SO) and hydrogen peroxide (H202), are the major characteristics of vascular endothelial dysfunction. Normally, vascular endothelial function depends on NO production from coupled endothelial NO synthase (eNOS) in the presence of 5,6,7,8- tetrahydrobiopterin (BH4). By contrast, 7,8-dihydrobiopterin (BH2, Oxidized form of BH4) and/or lack ofL-arginine (coupled eNOS substrate) causes eNOS uncoupling to produce SO, which can be quickly converted to H202. The role of eNOS uncoupling in acute …

Go to article

A Histopathologic Study Of The Controlling Role Of T Cells On Experimental Periodontitis In Rats, Satoshi Izumi, Yasunori Yoshinaga, Hirotaka Nakamura, Akiko Takamori, Yuzo Takamori, Takashi Ukai, Chiaki Shiraishi, Yoshitaka Hara Jan 2018

A Histopathologic Study Of The Controlling Role Of T Cells On Experimental Periodontitis In Rats, Satoshi Izumi, Yasunori Yoshinaga, Hirotaka Nakamura, Akiko Takamori, Yuzo Takamori, Takashi Ukai, Chiaki Shiraishi, Yoshitaka Hara

Journal of Dental Sciences

Abstract Background/purpose The onset and progression of periodontitis involve bacterial infection and the immune response. T cells function in the immune response and reportedly induce bone resorption in inflammatory bone loss. However, the exact role of T cells in periodontal destruction remains unclear. Using our experimental model of periodontitis, we aimed to investigate the influence of T cells on periodontal destruction. Materials and methods Male athymic nude (Nu) and euthymic wild-type (WT) rats were divided into the immunized (I-Nu and I-WT), non-immunized (nI-Nu and nI-WT). The immunized groups were immunized intraperitoneally with lipopolysaccharide (LPS). The non-immunized groups received phosphate-buffered saline …

Go to article

Martha Fineman, More Transformative Than Ever, Michéle Alexandre Jan 2018

Martha Fineman, More Transformative Than Ever, Michéle Alexandre

Emory Law Journal

The breadth and depth of Fineman¿s work are such that it would be impossible to discuss all the layers of her ongoing legacy in this short Essay. For the sake of brevity, I confine my discussion to three points. Specifically, the foundations laid by Martha¿s work reverberate culturally and globally in three ways: (1) valuation of invisible labor, (2) normalization of uncomfortable conversations, and (3) universalization and destigmatization of vulnerability. While I focus solely on these key contributions, I could go on forever about the breath and scope of Fineman¿s influence and the impact of her mentorship. To trace Martha¿s …

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Small bottle has an in-folded rim. The neck of 1.9 cm. opens smoothly into a teardrop-shaped body. The bottom is flat; the object is free-standing at a slight angle. The neck appears to have been broken and repaired at the site of a 1.1 by 0.5 cm. hole.

Go to article

Ewer, Unknown Jan 2018

Ewer, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Large pitcher has a trefoil mouth. The neck tapers slightly before expanding into the globular body. The base is a narrow ridge. The handle is round; it is attached at the rim and high on the shoulder. The pitcher was thrown on a wheel and the separately worked handles were applied later.

Go to article

Jar, Unknown Jan 2018

Jar, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Jar has a flared mouth and tubular rim, folded evenly inward. Below the broad neck, the globular body is decorated with seven pressed indentions, some more pronounced than others. Black grit and long bubbles are evident in the neck and rim. The base is concave with no palpable pontil mark.

Go to article

Square Bottle, Unknown Jan 2018

Square Bottle, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Square-shouldered bottle tapers to a smaller 1.6 x 1.7 cm base. A short, round neck sits atop the sloping shoulders. The neck has a visible horizontal gap where the neck has been glued to the bottle. The pitting and color of the neck is dissimilar to that of the body. The vessel rests slightly unevenly on the base and stands askew.

Go to article

Bottle, Unknown Jan 2018

Bottle, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Bottle has a small mouth, an inverted funnel neck and a globular body. The mouth flares and terminates in a simple rim which is uneven in depth. The bottom is broad and sharply concave with a prominent pontil mark.

Go to article

Head Of A Young Man, Unknown Jan 2018

Head Of A Young Man, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Head with neck and shoulder depicts a young man gazing forward, his head inclined toward his left shoulder. Hair is arranged in ringlets around his face, held by a filet. The hair behind the filet radiates in rows toward the crown. At the nape, the hair is rolled up in large curls over the filet. Part of the crown of the head is broken away. The face is smooth. The eyes seem vacant; they are defined by the eyelids and set high in the face. The nose and lips are small but well-defined. A garment is draped over the left …

Go to article

Pilgrim Bottle, Unknown Jan 2018

Pilgrim Bottle, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

The body is flat front-to-back. Rim is rounded but broken, as if recently broken. Neck is cylindrical for 6.5 cm., after which it flattens to join the body section. There is no palpable pontil mark. The bottle cannot stand freely. The neck has some long bubbles and diagonal cracks.

Go to article

Garment Pin, Unknown Jan 2018

Garment Pin, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

The slender greenish-brown metal object tapers from the head to the sharp point. The head end has eight lobes which suggest a sharply involuted sphere, sometimes referred to as a poppy seed head. There is a forged hole 3.5 cm. below the head. A collar surrounds and reinforces the hole. Incised bands on the shaft extend to the hole and below it for 0.4 cm.

Go to article

Needle, Unknown Jan 2018

Needle, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

The greenish-brown metal object has a sharp end, an eye forged at the midsection and a rounded end. The object maintains a round cross-section throughout. The shaft bulges on either side of the eye, which is clear of debris. The object has 30 bands inscribed from the blunt end to 0.5 cm. below the eye.

Go to article

Spathomele, Unknown Jan 2018

Spathomele, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Slender tool with an olivate finial at one end and a trapezoidal blade at the other. The slender shaft is cylindrical and solid. The transition from a cylinder to a flat blade is marked by the edge of the cylinder.

Go to article

Ligula, Unknown Jan 2018

Ligula, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Slender tool with a cylindrical, solid shaft. One end terminates in a rounded point; the other end terminates in a small, shallow, round spoon.

Go to article

Spathomele, Unknown Jan 2018

Spathomele, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Slender tool with a rounded end tapers gently along the solid cylindrical shaft toward the flat blade. The narrow section of the shaft before the blade is embellished with an inscribed line that makes ten turns around the shaft over a distance of 1.8 cm. The tip of the blade is flat, rounded and chipped in two places.

Go to article

Spathomele, Unknown Jan 2018

Spathomele, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Sturdy object has an unadorned solid cylindrical handle that terminates at one end in a rounded point and at the other end in a flat, tear-drop shaped spatula. The spatula is in line with the handle.

Go to article

Probe, Unknown Jan 2018

Probe, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Long, slender object tapers from a rounded head at the thick end to a narrow rounded point. The shaft is pierced by a bore beginning 3.4 cm. below the rounded head. Heavy corrosion obscures the metal and creates a rough, lumpy surface.

Go to article

Alabastron, Unknown Jan 2018

Alabastron, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Alabaster bottle has a rounded bottom and cannot stand. The walls are thick and translucent. The rim has been repaired. A double line is incised above the inscription.

Go to article

Dropper Bottle, Unknown Jan 2018

Dropper Bottle, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

A flattened rim leads to a 4.5 cm. neck that tapers inward and then expands to the globular body. The rim is infolded and flattened. The narrow spout is attached to the shoulder of the body and tilts upward at a 60 degree angle. The tip of the spout is not finished and may have been broken. The bottle is free-standing on a flattened base.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a twist in the neck that resolves itself 1.9 cm. below the rim. The rim is in-folded and flattened. The bottom is slightly concave; the vessel is not free-standing. The pontil mark is palpable.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a prominent pontil mark at the base. The bottle is not free-standing. The rim is flared and in-folded unevenly. The cylindrical neck is constricted before widening into the piriform body.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle is free-standing but at an angle. The base is indented. Rim is in-folded evenly and flattened at an angle. Bottle has a cylindrical neck that terminates at an indentation 6.8 cm below the rim, before flaring toward the base.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a cracked-off rim that is out-of-round. The funnel mouth arises from a twist in the neck. The bottle is free-standing. The base is flattened with no evidence of a pontil mark.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a flattened bottom with a minor indentation but no palpable pontil mark. The vessel is free-standing although it lists. The neck and rim appear to be built up: evidence of repair material can be seen on the outside of the neck. The same material was used to create the rim. The long cylindrical neck dominates the profile of the vessel. The slender teardrop shape of the body begins below the midpoint of the bottle.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a flattened bottom with no palpable indentation or pontil mark. Bottle is free-standing. Cylindrical neck terminates in a slight indentation 3 cm. below the rim; below the indentation, the body adopts the piriform shape.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Teardrop-shaped bottle has a rounded base; the bottle cannot stand. The ledge rim is folded inward and flattened; the rim is uneven in depth and at a diagonal. Below the rim the bottle narrows slightly before expanding to a rounded body.

Go to article

Unguentarium, Unknown Jan 2018

Unguentarium, Unknown

Farid Karam M.D. Lebanon Antiquities Collection

Bottle has a three-part shape: the cylindrical neck descends to meet a semicircle which rests in turn on a squat globular body. The rim is in-folded unevenly. The bottom is flat; the object is free-standing at a slight angle.

Go to article

First Prev Next Last