Digital Commons Network^™

Can Free Speech Be Progressive?, Louis Michael Seidman

Georgetown Law Faculty Publications and Other Works

Free speech cannot be progressive. At least it can't be progressive if we are talking about free speech in the American context, with all the historical, sociological, and philosophical baggage that comes with the modern, American free speech right. That is not to say that the right to free speech does not deserve protection. It might serve as an important side constraint on the pursuit of progressive goals and might even protect progressives against the possibility of catastrophic outcomes. But the notion that our free speech tradition might be weaponized to advance progressive ends is fanciful. The American free speech …

Caremark And Compliance: A Twenty Year Lookback, Donald C. Langevoort

Georgetown Law Faculty Publications and Other Works

The Delaware Chancery Court’s decision in In re Caremark was and is a landmark decision. This brief Commentary takes a look back at Caremark on three issues that pertain to its contemporary relevance inside the corporate boardroom: (1) framing the cost-benefit assessment on the question of how much to spend on compliance; (2) how and when to force certain compliance matters to real-time board-level attention; and (3) using selection, promotion, and compensation decisions to influence the culture and risk-taking “temperature” of the firm.

The Law Of Deception: A Research Agenda, Gregory Klass

Georgetown Law Faculty Publications and Other Works

The law of deception is the body of laws that address acts and omissions that wrongfully cause others to hold false beliefs. So defined, the law of deception cuts across traditional doctrinal boundaries. It encompasses the torts of deceit and defamation, false advertising laws, labeling requirements, securities fraud and disclosure regulations, criminal fraud, perjury statutes, and a host of other generic and more targeted laws. This essay suggests that the law of deception constitutes a coherent body of law, and identifies four salient questions about it.

The questions are these: First, within the law of deception one finds several different …

Lurching From Complacency To Panic In The Fight Against Dangerous Microbes: A Blueprint For A Common Secure Future, Lawrence O. Gostin, Katharina Ó Cathaoir

Georgetown Law Faculty Publications and Other Works

Despite the clear lessons of history - most recently the West African Ebola Epidemic - the international community systematically underestimates the urgent global health hazards posed by emerging infectious diseases. Indeed, looming challenges – namely, rising populations, urbanization, mass migration, rapid travel and trade, climate change, weak states and ethno-nationalism – render pandemic preparedness more acute than ever before. This article details the urgent threats to global health security and argues that the international community must learn from previous outbreaks and urgently invest in preparedness.

The article offers a blueprint for a more secure future from pathogenic threats facing humankind. …

An Integrated Approach To Improving Rural Livelihoods: Examples From India And Bangladesh, Barry Croke, Wendy Merritt, Peter Cornish, Geoffrey J. Syme, Christian H. Roth

Research outputs 2014 to 2021

This paper presents an overview of work in West Bengal, Andhra Pradesh and SW Bangladesh through a series of projects from 2005 to the present, considering the impact of farming systems, water shed development and/or agricultural intensification on livelihoods in selected rural areas of India and Bangladesh. The projects spanned a range of scales spanning from the village scale (∼  1 km²) to the meso-scale (∼  100 km²), and considered social as well as biophysical aspects. They focused mainly on the food and water part of the food-water-energy nexus. These projects were in collaboration with a …

Conservation Systematics Of The Shield-Backed Trapdoor Spiders Of The Nigrum-Group (Mygalomorphae, Idiopidae, Idiosoma): Integrative Taxonomy Reveals A Diverse And Threatened Fauna From South-Western Australia, Michael G. Rix, Joel J. Huey, Steven J.B. Cooper, Andrew D. Austin, Mark S. Harvey

Research outputs 2014 to 2021

The aganippine shield-backed trapdoor spiders of the monophyletic nigrum-group of Idiosoma Ausserer s. l. are revised, and 15 new species are described from Western Australia and the Eyre Peninsula of South Australia: I. arenaceum Rix & Harvey, sp. n., I. corrugatum Rix & Harvey, sp. n., I. clypeatum Rix & Harvey, sp. n., I. dandaragan Rix & Harvey, sp. n., I. formosum Rix & Harvey, sp. n., I. gardneri Rix & Harvey, sp. n., I. gutharuka Rix & Harvey, sp. n., I. incomptum Rix & Harvey, sp. n., I. intermedium Rix …

The Weakening Of Kin Ties: Exploring The Need For Life-World Led Interventions, Gert Schout, Gideon De Jong

Research outputs 2014 to 2021

The protective features that families and wider social relationships can have are required to meet the demands of life in contemporary Western societies. Choice and detraditionalization, however; impede this source of solidarity. Family Group Conferencing (FGC) and other life-world led interventions have the potential to strengthen primary groups. This paper explores the need for such a social intervention, using insights from sociological and philosophical theories and empirical findings from a case study of the research project ‘FGC in mental health’. This need is understandable considering the weakening of kin ties, the poor qualities of state agencies to mobilise self-care and …

Flavonoid-Rich Apple Improves Endothelial Function In Individuals At Risk For Cardiovascular Disease: A Randomized Controlled Clinical Trial, Nicola P. Bondonno, Catherine P. Bondonno, Lauren C. Blekkenhorst, Michael J. Considine, Ghassan Maghzal, Roland Stocker, Richard J. Woodman, Natalie C. Ward, Jonathan M. Hodgson, Kevin D. Croft

Research outputs 2014 to 2021

Scope

The cardioprotective effects of apples are primarily attributed to flavonoids, found predominantly in the skin. This study aimed to determine if acute and/or chronic (4 weeks) ingestion of flavonoid-rich apples improves endothelial function, blood pressure (BP), and arterial stiffness in individuals at risk for cardiovascular diseases (CVD).

Methods and results

In this randomized, controlled cross-over trial, acute and 4 week intake of apple with skin (high flavonoid apple, HFA) is compared to intake of apple flesh only (low flavonoid apple, LFA) in 30 participants. The primary outcome is endothelial function assessed using flow-mediated dilation (FMD) of the brachial artery, …

Interpreting Signal Amplitudes In Surface Electromyography Studies In Sport And Rehabilitation Sciences, Andrew D. Vigotsky, Israel Halperin, Gregory J. Lehman, Gabriel S. Trajano, Taian M. Vieira

Research outputs 2014 to 2021

Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt to draw conclusions concerning the neuro- and electrophysiological underpinning of force production and hypothesize about possible longitudinal adaptations, such as strength and hypertrophy. However, such conclusions are frequently unsubstantiated and unwarranted. Hence, the goal of this review is to discuss what can and cannot be inferred from comparative research designs as it pertains to both the acute and …

Emotions Predict Policy Support: Why It Matters How People Feel About Climate Change, Susie Wang, Zoe Leviston

Research outputs 2014 to 2021

Current research shows that emotions can motivate climate engagement and action, but precisely how has received scant attention. We propose that strong emotional responses to climate change result from perceiving one's “objects of care” as threatened by climate change, which motivates caring about climate change itself, and in turn predicts behaviour. In two studies, we find that climate scientists (N = 44) experience greater emotional intensity about climate change than do students (N = 94) and the general population (N = 205), and that patterns of emotional responses explain differences in support for climate change policy. Scientists tied their emotional …

Nitrate, The Oral Microbiome, And Cardiovascular Health: A Systematic Literature Review Of Human And Animal Studies, Lauren C. Blekkenhorst, Nicola P. Bondonno, Alex H. Liu, Natalie C. Ward, Richard L. Prince, Joshua R. Lewis, Amanda Devine, Kevin D. Croft, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2014 to 2021

Background

Dietary nitrate is an important source of nitric oxide (NO), a molecule critical for cardiovascular health. Nitrate is sequentially reduced to NO through an enterosalivary nitrate-nitrite-NO pathway that involves the oral microbiome. This pathway is considered an important adjunct pathway to the classical l-arginine–NO synthase pathway.

Objective

The objective of this study was to systematically assess the evidence for dietary nitrate intake and improved cardiovascular health from both human and animal studies.

Design

A systematic literature search was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines by using key search terms in Medline and …

Understanding Subterranean Variability: The First Genus Of Bathynellidae (Bathynellacea, Crustacea) From Western Australia Described Through A Morphological And Multigene Approach, Giulia Perina, A. I. Camacho, Joel Huey, Pierre Horwitz, Annette Koenders

Research outputs 2014 to 2021

The number of subterranean taxa discovered in the north of Western Australia has substantially increased due to the requirements for environmental surveys related to mining development. Challenges in estimating subterranean biodiversity and distributions are related to lack of knowledge of taxa with convergent morphological characters in a largely unobservable ecosystem setting. An integrated approach is warranted to understand such complexity.

Bathynellidae occur in most Australian aquifers, but only one species has been described so far, and the group lacks a reliable taxonomic framework. A new genus and one new species from the Pilbara region of Western Australia, Pilbaranella ethelensis, …

Impact Of Aging On The Auditory System And Related Cognitive Functions: A Narrative Review, Dona M.P. Jayakody, Pete L. Friedland, Ralph Martins, Hamid R. Sohrabi

Research outputs 2014 to 2021

Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia. Here we review the …

Alzheimer's Disease: A Journey From Amyloid Peptides And Oxidative Stress, To Biomarker Technologies And Disease Prevention Strategies-Gains From Aibl And Dian Cohort Studies, Ralph Martins, Victor Villemagnen, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer Gupta, Stephanie Rainey-Smith, Eugene Hone, Steve Pedrini, Wei L. Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O’Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J. Fuller, Belinda Brown, Samantha Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon Laws, Anna M. Barron, Kathryn Goozee, Eka J. Wahjoepramono, Prita R. Asih, James D. Doecke, Olivier Salvado, Ashley I. Bush, Christopher C. Rowe, Samuel E. Gandy, Colin L. Masters

Research outputs 2014 to 2021

Worldwide there are over 46 million people living with dementia, and this number is expected to double every 20 years reaching about 131 million by 2050. The cost to the community and government health systems, as well as the stress on families and carers is incalculable. Over three decades of research into this disease have been undertaken by several research groups in Australia, including work by our original research group inWestern Australia which was involved in the discovery and sequencing of the amyloid-β peptide (also known as Aβ or A4 peptide) extracted from cerebral amyloid plaques. This review discusses the …

Process Simulation And Experimental Investigation Of Biofuel Production In A High Rate Anaerobic Digestion Process, Haider Al-Rubaye

Doctoral Dissertations

"The non-hazardous waste management hierarchy of the US EPA calls for “Reduce, Reuse, and Recycle” (or the three R’s) of wastes. The anaerobic digestion process is one of the most important methods that used to treat the wastes and at the same time generate energy out of it. The anaerobic digestion process generates a mixture of methane and carbon dioxide gases which is known as biogas.

The biogas composition is about 50-70% methane and 10-30% of carbon dioxide and trace amount of other gases like hydrogen and hydrogen sulfide. This biogas can be used in power generation, heating systems and …

Part I: Design, Synthesis, And Studies Of Novel Age-Inhibitors And Age-Breakers; Part Ii: Novel Synthetic Methods For Organofluorine Compound, Jatin Mehta

Doctoral Dissertations

"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their in vitro inhibitory activities have been studied by ¹³C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.

Organofluorine compounds have …

Advancement In Thermal Energy Storage Using Phase Change Materials, Rami Mohammad Reda Saeed

Doctoral Dissertations

"The dissertation is intended to study the fundamental physical behavior of phase change materials (PCMs) and provide a comprehensive overview of the state of the art in their design and applications for thermal energy storage. Standard, predictive and thermodynamic models were presented to develop new PCM eutectic mixtures in a more scientific design approach. As new eutectic PCMs were developed, further research efforts were initiated to develop functionalized PCMs with enhanced thermal and physical properties to create the next generation of PCMs. Further efforts have been expanded to review several high-temperature PCM candidates with phase transition temperatures in the range …

Hydrodynamics Study Of The Bubble Columns With Intense Vertical Heat-Exchanging Tubes Using Gamma-Ray Computed Tomography And Radioactive Particle Tracking Techniques, Abbas Jawad Sultan

Doctoral Dissertations

"Understanding the hydrodynamics of bubble columns with and without vertical heat-exchanging tubes is a necessity for the proper design, scale-up, and operation of these reactors. To achieve this goal, systematic experiments were performed to visualize and quantify the influence of the presence of vertical internal tubes on the gas holdup distributions and their profiles, axial liquid velocity, and turbulent parameters (i.e., normal and shear stresses; turbulent kinetic energy) by using advanced gamma-ray computed tomography (CT) and radioactive particle tracking (RPT). In this study, the experiments were conducted in 6- and 18-inch bubble columns with an air-water system as the working …

Characterization Of The Cylinderical Split Internal-Loop Photobioreactor With Scenedesmus Microalgae: Advanced Culturing, Modeling, And Hydrodynamics, Laith S. Sabri

Doctoral Dissertations

"Microalgae are fast growing photoynthetic microorganisms and it have very wide range of industrial applications such as biofuels and wastewater treatment. These cells can be grown in a wide variety of systems ranging from open culture systems (e.g., ponds) to closed culture systems of photobioreactor (e.g., airlift). The open culture systems exist in the external environment, and hence, are not intrinsically controllable. However, the microalgae production in enclosed photobioreactors faces prohibitively high production costs with special difficulty in reactor design and scale-up. The light availability and utilization efficiency in the photobioreactor in terms of design and scale-up consider as the …

Engineering Zeolite Catalysts Through Porosity And Surface Acidity Control For Selective Production Of Light Olefins, Xin Li

Doctoral Dissertations

"Zeolites are broadly used as heterogeneous catalysts in various chemical and petrochemical industries to produce value-added chemicals and fuels, mainly due to their large surface area, acid-base properties, high thermal stability, and excellent shape-selectivity. In this dissertation, various zeolite catalysts were engineered through fine-tuning micro-meso-macro-porosity and surface acidity. The engineered zeolites were used as heterogeneous catalysts for production of light olefins such as ethylene and propylene through alcohol dehydration and hydrocarbon cracking reactions.

To control the zeolite porosity and acidity, SAPO-34@ZSM-5 and SAPO-34@Silicalite-1 composites with core-shell structure were synthesized and evaluated in ethanol dehydration reaction. Analysis of catalytic performance revealed …

Ecological Uncertainty Influences Vigilance As A Marker Of Fear, Laurence E. A. Feyten, Grant E. Brown

Animal Sentience

We expand on the factors that may shape the predictability of risk and the potential impacts on the links between vigilance and fear, primarily in aquatic prey communities. Uncertainty in predation risks has been shown to induce increased levels of neophobia among prey. As a result of this phenotypically plastic response, prey are faced with risk assessment cues that may vary widely in their reliability. We argue that decomposing predictability may provide useful insights into the relationship between vigilance and fear.

Perinatal Hypoxic-Ischemic Encephalopathy And Neuroprotective Peptide Therapies: A Case For Cationic Arginine-Rich Peptides (Carps), Adam B. Edwards, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality and morbidity in neonates, with survivors suffering significant neurological sequelae including cerebral palsy, epilepsy, intellectual disability and autism spectrum disorders. While hypothermia is used clinically to reduce neurological injury following HIE, it is only used for term infants (>36 weeks gestation) in tertiary hospitals and improves outcomes in only 30% of patients. For these reasons, a more effective and easily administrable pharmacological therapeutic agent, that can be used in combination with hypothermia or alone when hypothermia cannot be applied, is urgently needed to treat pre-term (_36 weeks gestation) and …

Role Of The Gut Microbiota As A Natural Adjuvant For Vaccine, Nicole Benn, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Vaccines have provided the most beneficial contribution to public health. Generating antigen specific antibody responses and long lasting memory are crucial for the protective immunity offered by vaccination. Unfortunately, not all individuals respond in the same manner to vaccine formulations. The microbiota is established during postnatal development and remains relatively stable for long periods. Our understanding that the microbiota can have beneficial effects on human health has led immunologists to investigate how these organisms may shape the innate and adaptive immune responses of the host. In this review we examine the impact of the microbiota on the host immune responses …

Intraoperative Detection Of Blood Vessels With An Imaging Needle During Neurosurgery In Humans, Hari Ramakonar, Bryden C. Quirk, Rodney W. Kirk, Jiawen Li, Angela Jacques, Christopher R.P Lind, Robert A. Mclaughlin

Health Sciences Papers and Journal Articles

Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with …

Comparison Of Neuroprotective Efficacy Of Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Following Permanent Middle Cerebral Artery Occlusion In The Wistar Rat And In Vitro Toxicity Studies, Diego Melani, Megan C. Bakeberg, Jane L. Cross, Vince W. Clark, Ryan S. Anderton, David J. Blacker, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

We have previously demonstrated that arginine-rich and poly-arginine peptides possess potent neuroprotective properties, with poly-arginine peptide R18 identified as being highly effective at reducing infarct volume following middle cerebral artery occlusion (MCAO) in the Sprague Dawley rat. Since peptides synthesised using D-isoform amino acids have greater stability than L-isoform peptides due to increased resistance to proteolytic degradation, they represent potentially more effective peptide therapeutics. Therefore we compared the neuroprotective efficacy of R18 and its D-enantiomer R18D following permanent MCAO in the Wistar rat. Furthermore, as increased peptide stability may also increase peptide toxicity, we examined the effects of R18 and …

Is There A Link Between Vitamin B And Multiple Sclerosis?, Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch, Vasso Apostolopoulos

Health Sciences Papers and Journal Articles

Background: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiencies result in severe myelin degeneration, leading to loss in neuronal signal transmission.

Objective: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and remyelination, and reversal of MS symptoms.

Method: Here, we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in …