Digital Commons Network^™

How War Makes (And Unmakes) The Democratic State: Reading The Reluctant Fundamentalist And Exit West In A Populism Age, Aziz Z. Huq

Public Law and Legal Theory Working Papers

War makes the state, and war makes the state democratic—or so the conventional wisdom holds. But the wars of the twenty-first century will have a distinct complexion from wars of the century just passed. As war and democracy alike change, their relationship alters. This book chapter examines that relationship through the lens of two recent novels by Mohsin Hamid, The Reluctant Fundamentalist and Exit West. The protagonists of these novels stand in some fashion for the two main vectors by which war is perceived to, and indeed does, work a change to the democratic state—the terrorist and the migrant. The …

Criminal Justice, Inc., John Rappaport

Public Law and Legal Theory Working Papers

In the past decade, major retailers nationwide have begun to employ a private, for-profit system to settle criminal disputes, extracting payment from shoplifting suspects in exchange for a promise not to call the police. This Article examines what retailers’ decisions reveal about our public system of criminal justice and the concerns of the agents who run it, the victims who rely on it, and the suspects whose lives it alters. The private policing of commercial spaces is well known, as is private incarceration of convicted offenders. This Article is the first, however, to document how industry has penetrated new parts …

Methionine Sulfoximine: A Novel Anti Inflammatory Agent, Tyler Peters

Wayne State University Dissertations

ABSTRACT

METHIONINE SULFOXIMINE: A NOVEL ANTI-INFLAMMATORY AGENT

by

TYLER J. PETERS

October 2018

Advisor: William Brusilow

Major: Biochemistry and Molecular Biology

Degree: Doctor of Philosophy

The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peritoneal macrophages triggered with lipopolysaccharide (LPS). MSO significantly reduced the production of Interleukin 6 (IL-6) and Tumor Necrosis Factor Alpha (TNFα) at 4 and 6 hours after LPS-treatment. This reduction did not result from decreased transcription of IL-6 and TNFα genes, and therefore appeared to …

Non-Invasive Mitochondrial Modulation With Near-Infrared Light Reduces Brain Injury After Stroke, Christos Dionisos Strubakos

Wayne State University Dissertations

Acute ischemic stroke is a debilitating disease that causes significant brain injury.

While rapid restoration of blood flow is critical to salvage the ischemic brain, reperfusion

of tissue can further drive brain damage by inducing generation of mitochondrial reactive

oxygen species (Chouchani et al., 2014a). Recent studies by our group found that noninvasive

mitochondrial modulation (NIMM) with near-infrared (NIR) light can limit the

production of reactive oxygen species following global brain ischemia (T. H. Sanderson

et al., 2018). NIR interacts with the rate limiting step of the mitochondrial electron

transport chain (ETC), cytochrome c oxidase (COX), and modulates mitochondrial

respiration. …

Collaboration Between Health Sciences Librarians And Faculty As Reflected By Articles Published In The Journal Of The Medical Library Association, Katherine G. Akers, Molly Higgins, Jennifer A. Devito, Sally Stieglitz, Robert Tolliver, Clara Y. Tran

Library Scholarly Publications

A recent study by Higgins and colleagues reports that the Journal of the Medical Library Association (JMLA) had the highest percentage of articles with both librarian and faculty co-authors out of 13 peer-reviewed journals in STEM librarianship and education between 2005 and 2014. A deeper and updated analysis of JMLA research articles and case studies published between 2008 and 2017 revealed that 29% of articles had both librarian and faculty co-authors. The main topics of librarian-faculty collaboration as described in these articles were related to patient and consumer health information and clinical information-seeking and decision-making by healthcare providers. …

The Quixotic Quest For Gender Equality In The Workplace, Kingsley R. Browne

Law Faculty Research Publications

No abstract provided.

Wildlife Services Coyote Management Project: Owl Pellet Dissection, Grace Riggs

Center for Urban Resilience Research Posters

The “Wildlife Services Coyote Management Project” aims to advance the understanding of the urban coyote population in the Long Beach area. In addition to using pre-existing data already gathered by local wildlife services, the team is working to assemble more information on the behavior and distribution of urban coyotes by means of scat analysis. Now in its second year, the project will augment its data through gene=c analysis of scat and building up the repertoire of animal skeletons through means of owl pellets to further study coyote diet. Owl pellets have been proven to be an effective means of finding …

Coyote/Human Interactions In The City Of Long Beach, Ca, Hayley Hart, Nicole Infantino

Center for Urban Resilience Research Posters

No abstract provided.

A Temporal Analysis Of Urban Coyote (Canis Latrans) Activity In Long Beach, Ca, Stephen Gloudeman

Center for Urban Resilience Research Posters

The coyote (Canis latrans) is found across the United States in both rural and urban ecosystems. They have always filled a niche in the ecosystem in the wild as both scavengers and hunters, but in urban environments they have adapted to anthropogenic food sources and pose a threat to communities. In communities such as Long Beach, CA, the presence of a coyote can be dangerous to pets and humans, which is a concern of residents. This arm of the ongoing study includes the implementation of game cameras to understand daily coyote activity and movement throughout the community. The data give …

Humboldt County Humboldt Bay Area Plan Sea Level Rise Vulnerability Assessment, Aldaron Laird

Local Reports and Publications

No abstract provided.

Dual Inhibitors Of Kdm1a And Spermine Oxidase: A Novel Approach To Antitumor Therapy, Steven Lee Holshouser

MUSC Theses and Dissertations

The polyamine oxidase family of enzymes has been extensively studied and plays a critical role in cell development. These enzymes catalyze the oxidation of many different polyamines, and catalyze transformations on DNA-associated histones in order to alter the epigenetic code to modulate gene expression. Polyamines are known to be essential in all forms of living organisms at multiple sites, and they have been identified in animals, plants and fungi. Polyamine oxidases (PAOs), including enzymes such as lysine-specific demethylase 1 (LSD1, KDM1A), spermine oxidase (SMOX) and acetylpolyamine oxidase (APAO) oxidize a variety of polyamines and other amine-containing substrates. Each one of …

Implications For The 8p12-11 Genomic Locus In Breast Cancer Diagnostics And Therapy: Eukaryotic Initiation Factor 4e-Binding Protein, Eif4ebp1, As An Oncogene, Alexandria Colett Rutkovsky

MUSC Theses and Dissertations

The goal of this research was to elucidate the individual and cooperative role of oncogenes within the frequently amplified 8p12-11 genomic locus which is known to predict poor prognosis and resistance to endocrine therapy in breast cancer. The role of specific oncogenes from the 8p11-12 amplicon in breast tumors is highlighted and the construction of expression constructs for future studies is described. Further exploration of the oncogenic role of Eukaryotic Initiation Factor 4E-Binding Protein (4EBP1, EIF4EBP1) showed 4EBP1 is often highly overexpressed in malignant tumors and is predicted as an essential driving gene in many cancer cell lines in vitro, …

Using Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells To Study Liver Development And Diseases, Ran Jing

MUSC Theses and Dissertations

Studies on liver development and disease traditionally relied on using animal models. However, the difference in liver biology between human and animals prevented the animal models from fully recapitulating human liver dieases. Human induced pluripotent stem cells (iPSC) reprogramed from human somatic cells can self-renew and are capable of being differentiated into various cell types that originate from endoderm, mesoderm or ectoderm. Our lab previously developed a procedure to differentiate iPSCs into cells that resemble mature human hepatocytes. Here we aim to explore the application of iPSC-derived hepatocyte-like cells for the study of basic developmental biology, the generation of new …

The Role Of Soluble Guanylyl Cyclase Signaling In Mitochondrial Biogenesis And Renal Injury, Pallavi Bhargava

MUSC Theses and Dissertations

Soluble Guanylyl Cyclase (sGC) is responsible for converting GTP to cyclic GMP (cGMP). sGC function and regulation is complex and cell-type dependent. An increase in cGMP production can target phosphodiesterases (PDEs), cGMP gated ion channels, and protein kinase G (PKG). Increasing sGC activity and inhibiting the degradation of cGMP by targeting PDEs are two approaches to maintaining cGMP levels in a given system. Interestingly, cGMP can also regulate mitochondrial biogenesis (MB), the generation of new and functional mitochondria. Previously in our laboratory, we have shown that MB is suppressed after ischemia and reperfusion (I/R) injury and certain mitochondrial biogenic compounds …

Elucidation Of Erk1/2 Signaling Pathways Leading To Mitochondrial Biogenesis, Justin Brandon Collier

MUSC Theses and Dissertations

Acute kidney injury (AKI) is a rapid loss of normal kidney function and is accompanied by a dysregulation of cellular and mitochondrial metabolism, which can be observed before organ dysfunction. A hallmark of AKI is the early and persistent disruption of mitochondrial homeostasis. Mitochondrial biogenesis (MB), the process by which new mitochondria are generated, has been shown to prevent injury and increase the rate of recovery of ischemia-reperfusion injury (IRI)-induced renal dysfunction. However, the molecular mechanisms mediating MB and dysfunction following IRI remain unclear. We elucidated that extracellular signal-regulated kinase 1/2 (ERK1/2) regulates two key mitochondrial and cellular metabolism pathways …

Joint Dedication To Justice Lori S. Wilbur, Neil Fulton

Faculty Publications

No abstract provided.

Does Animal Assisted Therapy (Aat) Positively Increase Socialization Skills In Children Diagnosed With Autism Spectrum Disorder (Asd) Compared To No Interaction With Animals?, Tracey Smith

PCOM Physician Assistant Studies Student Scholarship

Objective- The objective of this selective EBM review is to determine whether or not “Animal Assisted Therapy (AAT) positively increases socialization skills in children diagnosed with Autism Spectrum Disorder (ASD) compared to no interaction with animals?”

Study Design- Systematic review of three randomized controlled trials (RCTs) published in English language peer reviewed journals between 2015 and 2016.

Data sources- One single blinded RCT and two double blinded RCTs were found through PubMed.

Outcome(s) Measured- All three studies measured change in social communication in children with ASD using a Social Responsiveness Scale, Pedagogical Analysis and Curriculum Test, and Vineland Adaptive Behavior …

Is Horse Antithymocyte Globulin (Atg) Plus Cyclosporine (Csa) The Most Effective Firstline Therapy For Patients With Bone Marrow Failure Disorders?, Samantha Alexis Miller

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective Evidence Based Medicine review is to determine whether or not Horse Antithymocyte Globulin (ATG) plus Cyclosporine (CsA) is the most effective first-line therapy for patients with bone marrow failure disorders.

STUDY DESIGN: Review of two randomized control trials (RCTs) and one single-center retrospective study, which were published between 2010 and 2013. All studies were published in the English language.

DATA SOURCES: Two randomized control trials and one single-center retrospective study published in peer-reviewed journals, which were found using PubMed.

OUTCOMES MEASURED: Each of the three trials measured the patient-oriented outcome of overall survival. Shin …

Will D-Amphetamine’S Effect On Impulsive Choice Be Consistent When The Environmental Context Changes By Using Decreasing Delays To Reinforcement?, Elizabeth M. Janeiro, Jenny E. Ozga, Karen G. Anderson

Modern Psychological Studies

Impulsivity (choosing a smaller, more immediate reward over a larger, more delayed reward) and substance abuse are positively correlated. It is important to understand how factors like delay to reward and drug effects determine impulsive choice, which can be studied using animal models. This study evaluated impulsive choice in rats, where delays to the larger reward (three food pellets) were presented in decreasing order versus one food pellet delivered immediately. Then, effects of d-amphetamine were assessed. It was found that in three of four rats, d-amphetamine increased impulsive choice when the larger option was presented with decreasing delays. This effect …

The Dmz Responds, Seo-Young J. Chu

Publications and Research

Seo-Young Chu’s “The DMZ Responds” appeared in Telos 184 (Fall 2018), a special issue on Korea edited by Haerin Shin.

The Effect Of Laboratory Manipulations Of Negative Affect On Alcohol Craving And Use: A Meta-Analysis, Konrad Bresin, Yara Mekawi, Edelyn Verona

Psychology Faculty Publications

Scientific and lay theories propose that negative affect plays a causal role in problematic alcohol use. Despite this common belief, supporting experimental evidence has been mixed. Thus, the goals of this study were to (a) meta-analytically quantify the degree to which experimentally manipulated negative affect influenced alcohol use and craving in the laboratory, (b) examine whether the size of this effect depended on key manipulation characteristics (i.e., self-relevance of the stressor, timing of the end of the stressor, and strength of negative affect induction) or sample characteristics (i.e., substance use history). Across 41 studies (N = 2,403), we found …

Vol. 45, No. 1: Table Of Contents, Transportation Law Journal

Transportation Law Journal

No abstract provided.

Fall Report: August-November 2017, Kevin E. Dailey

Florida Field Naturalist

No abstract provided.

Field Observations Spring Report: March-May 2018., Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Using Differing Levels Of Physical Activity As A Context Cue For Memory, Jami Swan

Undergraduate Honors Theses

The current study aimed to investigate the use of physical activity as a context cue for object location memory. The study included 49 undergraduate students who were asked to encode and recall a grid of 14 objects under three different physical activity conditions: rest, rolling a ping-pong ball, and pedaling on an exercise bike. It was expected that participants engaging in matching physical activity contexts at encoding and recall would have significantly higher rates of recall for object locations when compared to participants in the non-matching physical activity contexts. Results did not support my hypothesis as there was no evidence …

Representation, Radicalism, And Reform: Chicago's Public Education Reformers, 1890-1914, Laura Seiler

Undergraduate Honors Theses

No abstract provided.

Reconsidering Barriers To Wind Power Projects: Community Engagement, Developer Transparency And Place, Jeremy Firestone, Ben Hoen, Joseph Rand, Debi Elliot, Gundula Hübner, Johannes Pohl

Regional Research Institute for Human Services

In 2016, we undertook a nationally representative wind power perceptions survey of individuals living within 8?km of over 600 projects in the United States, generating 1705 telephone, web, and mail responses. We sought information on a variety of topics, including procedural fairness and its relationship to project attitude, the foci of the present analysis. We present a series of descriptive statistics and regression results, emphasizing those residents who were aware of their local project prior to construction. Sample weighting is employed to account for stratification and non-response. We find that a developer being open and transparent, a community being able …

Survival, Movements, And Resource Selection Of Female White-Tailed Deer In Missouri, Chloe A. Wright

Graduate Student Theses, Dissertations, & Professional Papers

White-tailed deer (Odocoileus virginianus) in Missouri are a socially and economically important game species generating annual revenue in excess of $1 billion. The last comprehensive deer study in Missouri was conducted in the 1980s – 1990s when deer populations were rapidly expanding. Since this time there has been a reduction in deer population size, declining growth rates, changes in harvest strategies, and the emergence and spread of chronic wasting disease (CWD). These changes have rendered prior survival estimates outdated, and the presence of CWD requires a deeper understanding of movement patterns and space use. We were interested in …

Storytime At North Side, Anuradha Desai

Intertext

No abstract provided.

Analysis Of Enzyme Activity Levels In Unfertilized, Fertilized, And Parthenogenically Activated Sea Urchin Eggs, Patrick Castle

Renée Crown University Honors Thesis Projects - All

No abstract provided.