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2018

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The Drug Innovation Paradox, Erika Lietzan Jan 2018

The Drug Innovation Paradox, Erika Lietzan

Missouri Law Review

No abstract provided.

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Goldilocks And The Rule 803 Hearsay Exceptions, Liesa L. Richter Jan 2018

Goldilocks And The Rule 803 Hearsay Exceptions, Liesa L. Richter

Faculty Articles

Criticism of the hearsay exceptions embodied in the Federal Rules of Evidence has reached a fever pitch in recent years. With scholars calling for the abrogation of the entire hearsay regime or of individual exceptions within it and the Advisory Committee on Evidence Rules exploring hearsay amendments, the time for genuine hearsay soul-searching may be at hand. This Article suggests that aggressive proposals to scuttle existing doctrine entirely in favor of alternative approaches to hearsay are overly broad, rejecting the benefits of significant portions of existing doctrine that are functioning well and threatening costly consequences that could make matters worse …

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Improved Insect-Proofing: Expressing Double-Stranded Rna In Chloroplasts, Julia Bally, Elane Fishilevich, Andrew J. Bowling, Heather E. Pence, Kenneth E. Narva, Peter M. Waterhouse Jan 2018

Improved Insect-Proofing: Expressing Double-Stranded Rna In Chloroplasts, Julia Bally, Elane Fishilevich, Andrew J. Bowling, Heather E. Pence, Kenneth E. Narva, Peter M. Waterhouse

Department of Entomology: Faculty Publications

RNA interference (RNAi) was discovered almost 20 years ago and has been exploited worldwide to silence genes in plants and animals. A decade later, it was found that transforming plants with an RNAi construct targeting an insect gene could protect the plant against feeding by that insect. Production of double-stranded RNA (dsRNA) in a plant to affect the viability of a herbivorous animal is termed trans-kingdom RNAi (TK-RNAi). Since this pioneering work, there have been many further examples of successful TK-RNAi, but also reports of failed attempts and unrepeatable experiments. Recently, three laboratories have shown that producing dsRNA in a …

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Indefinite Detention, Colonialism, And Settler Prerogative In The United States, Natsu Taylor Saito Jan 2018

Indefinite Detention, Colonialism, And Settler Prerogative In The United States, Natsu Taylor Saito

Faculty Publications By Year

The primacy accorded individual civil and political rights is often touted as one of the United States' greatest achievements. However, mass incarcerations of indefinite duration have occurred consistently throughout U.S. history and have primarily targeted people of color. The dominant narrative insists that the United States is a political democracy and portrays each instance of indefinite detention in exceptionalist terms. This essay argues that the historical patterns of indefinite detention are better explained by recognizing the United States as a settler colonial state whose claimed prerogative to expand its territorial reach and contain/control populations over which it exercises jurisdiction inevitably …

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Evaluating The Success And Monitoring The Usage Of Wildlife Crossing Structures In Bedminster, Nj, Nicole Heather Bergen Jan 2018

Evaluating The Success And Monitoring The Usage Of Wildlife Crossing Structures In Bedminster, Nj, Nicole Heather Bergen

Theses, Dissertations and Culminating Projects

Expanding road networks are detrimental to the populations of many reptile and amphibian species. The fragmenting of the landscape creates barriers, separating the populations of native organisms from the necessary resources. Wildlife crossing structures can be beneficial in aiding the movement of amphibians and reptiles across previously installed wildlife crossing culvert in Bedminster, New Jersey. The wildlife crossing culverts are located underneath River Road, which forms a barrier between the woods on one side of the road and the ponds on the other side. We used a combination of wildlife cameras and pitfall traps to determine the usage and success …

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Impacts Of Drainage Basin Characteristics On Aquatic Macroinvertebrate Communities In The Upper Passaic River, Michael J. Levinson Jan 2018

Impacts Of Drainage Basin Characteristics On Aquatic Macroinvertebrate Communities In The Upper Passaic River, Michael J. Levinson

Theses, Dissertations and Culminating Projects

Increase in development throughout the Northern Piedmont region of New Jersey since the 1970’s has greatly degraded much of the natural environment throughout the state. Certain regulations are currently in place to reduce this development’s impact on New Jersey’s streams at a local (riparian) scale, however it may also be important to examine these impacts at a regional (drainage basin) scale. We examined the aquatic macroinvertebrate assemblages at seven sites along the Upper Passaic River of New Jersey to assess their ecological health and compare to the corresponding drainage basin characteristics at each site. The sites ranged in location from …

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Textbook List, Fall 2018, Office Of Registrar Jan 2018

Textbook List, Fall 2018, Office Of Registrar

Semester Schedules and Information

No abstract provided.

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Older Adult Men’S Emotional Bonds With Their Dogs, Ranell L. Mueller Jan 2018

Older Adult Men’S Emotional Bonds With Their Dogs, Ranell L. Mueller

Theses and Dissertations--Gerontology

Knowledge of the deeper meanings of attachment to companion animals is limited, particularly in terms of older adults. This study employed a modified grounded theory method, a phenomenological lens and a life course perspective to gather and analyze data garnered from individual interviews and panel discussions in order to investigate the multiple dimensions of older adult men’s relationships with their companion animal dogs. Individual audio-recorded in-depth interviews and repeated panel discussions with a sub-group of the participants, convened as a panel over a three-month period, explored behavioral and emotional manifestations of attachment and the emotional bond to their companion animal …

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Music Training As A Neuro-Cognitive Protector For Brain Aging: Cognitive And Neuropsychological Profiles In Professional Musicians, Catherine E. Schneider Jan 2018

Music Training As A Neuro-Cognitive Protector For Brain Aging: Cognitive And Neuropsychological Profiles In Professional Musicians, Catherine E. Schneider

Theses and Dissertations--Gerontology

The proportion of older adults living with cognitive impairments is increasing rapidly. This shift will likely increase mortality rates, reduce perceived quality of life, and cause economic burden to patients and health care systems. Currently evidence of highly effective and noninvasive interventions that prevent or slow the onset of cognitive impairment are limited. This study aims to better understand what drives cognitive aging variability among musicians versus non-musicians. Music playing has been shown to improve brain and cognitive functions by engaging networks of brain areas, simultaneously involving cortical mechanisms associated with executive, high-level cognitive and motor functions, and multiple sensory …

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Semi-Confidential Settlements In Civil, Criminal, And Sexual Assault Cases, Saul Levmore, Frank Fagan Jan 2018

Semi-Confidential Settlements In Civil, Criminal, And Sexual Assault Cases, Saul Levmore, Frank Fagan

Cornell Law Review

Settlement is more likely if parties are free to set its terms, including a promise that these terms will remain secret between them. State sunshine-in-litigation laws work to defeat this incentive for confidentiality in order to protect third parties from otherwise unknown hazards. The intuition is that a wrongdoer should not be able to pay one plaintiff for silence at the expense of other victims. This Article begins by showing that the intuition is often wrong or overstated. A plaintiff who can assess a defendant’s vulnerability to future claims can extract a large enough settlement to provide substantial deterrence, and …

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Corporate Social Responsibility And Corporate Governance, Cynthia A. Williams Jan 2018

Corporate Social Responsibility And Corporate Governance, Cynthia A. Williams

Articles & Book Chapters

Corporate social responsibility has become a subject of growing importance in business and law. Today, no analysis of corporate governance systems would be complete without considering the pressures on companies to be seen as responsible corporate citizens. This chapter first provides a descriptive overview of developments in the field, including increasing voluntary and required environmental, social and governance (ESG) disclosure; and proliferating voluntary and multilateral standards for responsible corporate behavior. This chapter then reviews some of the more significant empirical evidence on the financial results of companies’ implementation of corporate responsibility initiatives, including the effects of such initiatives on innovation, …

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One Not Like The Other: An Examination Of The Use Of The Affirmative Action Analogy In Reasonable Accommodation Cases Under The Americans With Disabilities Act, Jamelia Morgan Jan 2018

One Not Like The Other: An Examination Of The Use Of The Affirmative Action Analogy In Reasonable Accommodation Cases Under The Americans With Disabilities Act, Jamelia Morgan

Faculty Articles and Papers

This Article discusses the debate within the courts regarding the employer's affirmative obligations under the ADA's reasonable accommodation clause by focusing on the use of the affirmative action analogy. The purpose of this Article is to examine the evolution of the affirmative-action analogy in reasonable-accommodation case law over time and to decipher its meaning and relevance. At the onset, it is important to establish a few definitions and assumptions. First, the affirmative-action analogy refers to cases where courts liken or compare the plaintiff's reasonable-accommodation request to affirmative action. Specifically, the Article examines cases where the term "affirmative action" explicitly appears …

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The Kantian Principle Of Treating Humanity As An End, Erjus Mezini Jan 2018

The Kantian Principle Of Treating Humanity As An End, Erjus Mezini

Legacy Theses & Dissertations (2009 - 2024)

This paper emphasizes the central role of the Formula of Humanity in Kantian ethics. It focuses mostly on Kant’s Groundwork of the Metaphysics of Morals, with hypotheses being tested on Kant’s Metaphysics of Morals as well. It starts with an analysis of the argument Kant offers for the Formula of Humanity in Groundwork II, explicating the meaning of this formula and its distinction from the Formula of the Universal Law. It further develops on comparing all the formulations of the categorical imperative, and it argues that not all formulations are equivalent. It concludes that the categorical imperative is exhausted by …

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Photonic Grating Coupler Designs For Optical Benching, Eng Wen Ong Jan 2018

Photonic Grating Coupler Designs For Optical Benching, Eng Wen Ong

Legacy Theses & Dissertations (2009 - 2024)

Background: Silicon Photonics has been rapidly developing as a field. The primary reason for this is its lower operating costs and faster switching rates for use in big data centres. Instead of microns-wide copper lines to transmit signals, silicon photonic chips use waveguides, usually of silicon or silicon nitride. Photonic signals bypass the issues of resistive-capacitance lag (RC-lag) and resistive-heating encountered by copper lines. Additionally, a single waveguide may transmit multiple signals along different carrier wavelengths.

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Modulation Of Cytokine Signaling In Optic Nerve Regeneration In Xenopus Laevis, Rupa Priscilla Choudhary Jan 2018

Modulation Of Cytokine Signaling In Optic Nerve Regeneration In Xenopus Laevis, Rupa Priscilla Choudhary

Legacy Theses & Dissertations (2009 - 2024)

The axons of the optic nerve, like other central nervous system (CNS) axons, tend to lose their capacity to regenerate following an injury in adult amniotes, but these axons are able to regenerate throughout life in anamniotes. In mammals, optic axon regeneration is promoted by inhibiting the increased expression in retinal ganglion cells of a cytokine signaling molecule, Suppressor of Cytokine Signaling 3 (SOCS3), that accompanies injury. In animals capable of regeneration, SOCS3 mRNA expression also increases dramatically in retinal ganglion cells after optic nerve injury, but somehow this increase is insufficient to block regeneration. To gain insights into how …

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Polychlorinated Biphenyls, Thyroid Hormones, And Neuropsychological Function Among Older Adults From Upstate New York, Eva M. Tanner Jan 2018

Polychlorinated Biphenyls, Thyroid Hormones, And Neuropsychological Function Among Older Adults From Upstate New York, Eva M. Tanner

Legacy Theses & Dissertations (2009 - 2024)

Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants linked to changes in cognitive function and thyroid hormone (TH) levels. However, most studies of PCBs and cognitive function were conducted among children. No studies among older adults have prospectively collected PCB and cognitive performance measurements to evaluate the association over time, and no longitudinal studies have evaluated the association between PCBs and THs over time among a non-occupationally exposed population. Further, the biological mechanism by which PCBs impact cognitive function is unknown, but may be mediated by THs. In addition, reliable self-reported survey data is necessary to obtain precise …

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The Influence Of Submandibular Salivary Gland Mesenchyme On The Proacinar Epithelial Cell Phenotype, Zeinab Farajallah Hosseini Jan 2018

The Influence Of Submandibular Salivary Gland Mesenchyme On The Proacinar Epithelial Cell Phenotype, Zeinab Farajallah Hosseini

Legacy Theses & Dissertations (2009 - 2024)

Current treatments for patients suffering from salivary hypofunction are insufficient and there is clinical need for regenerating the damaged tissue and restoring function of the gland. Reconstruction of 3D architecture is essential for stimulating secretory differentiation of epithelial progenitor cells in the salivary gland, which involves input from extracellular matrix and basement membrane as well as heterotypic cell interactions. However, the specific requirements for differentiation of secretory progenitor cells in salivary glands remain unclear. To determine what mechanisms and factors are required to promote proacinar differentiation, we isolated primary epithelial cells from embryonic day 16 (E16) submandibular salivary gland (SMG) …

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Stargazin And Gamma-4 Slow The Rate Of Channel Opening And Closing Of Glua4 Ampa Receptors, Vincen David Pierce Jan 2018

Stargazin And Gamma-4 Slow The Rate Of Channel Opening And Closing Of Glua4 Ampa Receptors, Vincen David Pierce

Legacy Theses & Dissertations (2009 - 2024)

The ionotropic glutamate receptors are localized in the pre- and postsynaptic membrane of neurons, and they mediate the majority of the fast excitatory synaptic transmission. These receptors are divided into three subtypes: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainic acid, and N-methyl-D-aspartic acid (NMDA) receptors. AMPA receptor properties are critically dependent on the presence of auxiliary transmembrane proteins, such as transmembrane AMPA receptors regulatory proteins (TARPs). TARPs are the most widespread and well-studied family of auxiliary proteins. For example, the co-assembly of TARPs with AMPA receptors increases the affinity for glutamate, and reduces voltage-dependent blockade by cytoplasmic polyamines in AMPA receptors that lack …

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Differentiation Of Potential False Positives From Human Saliva Using Raman Spectroscopy For Forensic Purposes, Selina Casadei Jan 2018

Differentiation Of Potential False Positives From Human Saliva Using Raman Spectroscopy For Forensic Purposes, Selina Casadei

Legacy Theses & Dissertations (2009 - 2024)

Traces of body fluids can be found at a crime scene. Being able to identify and differentiate the body fluids while preserving DNA is fundamentally important for forensic applications. Saliva is an important body fluid that can be found on bite marks, cigarette butts, and more, being an excellent source for DNA extraction. Current tests for saliva and other body fluids are destructive and body fluid specific, and are prone to false positives. Our laboratory has developed a universal method for identification of all main body fluids; saliva, semen, sweat, peripheral blood, and vaginal fluid, using Raman spectroscopy combined with …

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Technology Development For Detection Of Circulating Disease Biomarkers From Liquid Biopsies Using Multifunctional Nanomaterials, Mustafa Balcioglu Jan 2018

Technology Development For Detection Of Circulating Disease Biomarkers From Liquid Biopsies Using Multifunctional Nanomaterials, Mustafa Balcioglu

Legacy Theses & Dissertations (2009 - 2024)

Despite the advance health care, devastating health conditions such as cancer and infectious diseases that affect populations worldwide are too often not diagnosed until morbid symptoms become apparent in the late phase. Obtaining an early and accurate diagnosis that reveal a hidden lethal threat before the disease becomes complicated may dramatically reduce the severity of its impact on the patient’s life and increase the probability of survival. For example, in the case of ovarian cancer, which is the fifth most common malignancy and the fifth leading cause of cancer mortality in women in the US, the 5-year relative survival is …

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Cyclic Adenosine Monophosphate Signaling In Mycobacterium Tuberculosis : New Insights Into A Universal Second Messenger, Richard Mcpherson Johnson Jan 2018

Cyclic Adenosine Monophosphate Signaling In Mycobacterium Tuberculosis : New Insights Into A Universal Second Messenger, Richard Mcpherson Johnson

Legacy Theses & Dissertations (2009 - 2024)

Despite being the focus of intense research for many years Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the deadliest bacterial pathogen plaguing mankind today. Humans are the sole host and reservoir for Mtb, and Mtb has coevolved closely with its human host for thousands of years. Mtb currently infects over two billion people worldwide and over 1.5 million people die from TB each year, arguably making Mtb the most successful bacterial pathogen on the planet.

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A Consideration Of Ancient Residues And Their Analysis, Jennifer A. Cardinal Jan 2018

A Consideration Of Ancient Residues And Their Analysis, Jennifer A. Cardinal

Legacy Theses & Dissertations (2009 - 2024)

Identification of specific use(s) of ancient pottery vessels through empirical verification is currently very limited for archaeological investigations. Although we can postulate a range of purposes or functions for certain vessels, empirical confirmation of actual use has been determined only for a minuscule portion of the available vessels. This thesis will provide a broad review of organic analyses as applied to foodstuff residues left on ancient artifacts as well as discuss several considerations for such analysis that are unique to their application to archaeological specimens.

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Before Nature's Nation : Ecological Thought And Early American Poetry, Joshua Bartlett Jan 2018

Before Nature's Nation : Ecological Thought And Early American Poetry, Joshua Bartlett

Legacy Theses & Dissertations (2009 - 2024)

This project examines early American encounters with the natural world through the context of contemporary ecocriticism. In readings of Puritan poets Anne Bradstreet and Michael Wigglesworth, African-American poet Phillis Wheatley, and Mohegan minister Samson Occom, it demonstrates how poetic attentions to nature transformed collective antagonism toward the “howling wilderness” into personal feelings of affection and wonder. Likewise, it develops an understanding of the “ecological” that is both methodology, a way of thinking about specific things, such as trees or stones, and epistemology, a kind of thinking that emphasizes relational perception. It then situates these experiences amidst both canonical Americanist scholarship …

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Regulated Transcriptional Silencing Promotes Germline Stem Cell Differentiation In Drosophila Melanogaster, Pooja Flora Jan 2018

Regulated Transcriptional Silencing Promotes Germline Stem Cell Differentiation In Drosophila Melanogaster, Pooja Flora

Legacy Theses & Dissertations (2009 - 2024)

Germ cells are the only cell in an organism that have the capacity to give rise to a new organism and are passed from one generation to the next. Therefore, to maintain this unique ability of totipotency and immortality, germ cells execute specific functions, such as, repression of a somatic program and contour a germ line-specific pre- and post-transcriptional gene regulatory landscape. In many sexually reproducing organisms, germ cells are formed during the earliest stages of embryogenesis and undergoes several stages of development to eventually get encapsulated by the somatic cells of the gonad. Once, in the gonad, the germ …

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I Am A Branch In A Dark Room, Samuel Stenard Jan 2018

I Am A Branch In A Dark Room, Samuel Stenard

Legacy Theses & Dissertations (2009 - 2024)

"I Am a Branch in a Dark Room"–– the first of two intersecting novellas–– relays the consciousness of Edmund, a young man trapped in a waking coma. He is able to hear the sounds of the care facility yet unable to directly engage them. To him, he seems only a mind, drifting untethered from the world around him; to the world–– and even his own mother–– he seems little more than a corpse. As the narrative progresses, his bearing is fractured and he reels toward the void. The self reduces: from an interior monologue, to a cluster of perception, until, …

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Investigation Of The Ms2 Bacteriophage Capsid As An Mri-Capable, Brain-Targeted Nanoparticle Platform, Stephanie M. Curley Jan 2018

Investigation Of The Ms2 Bacteriophage Capsid As An Mri-Capable, Brain-Targeted Nanoparticle Platform, Stephanie M. Curley

Legacy Theses & Dissertations (2009 - 2024)

Novel methods are needed to traverse the blood-brain barrier (BBB) and deliver drugs to specific targets in the brain. To this end, MS2 bacteriophage was explored as a multifunctional transport and targeting vector. The MS2 capsid exterior was modified with two different targeting moieties for delivery across the BBB and targeting specific regions of interest in the brain. Successful modification of MS2 capsids with a brain targeting peptide and NMDAR2D-targeting antibody was confirmed by immunoblotting and fluorescence detection. To measure transport efficiency of MS2 particles across an in vitro BBB model, a highly sensitive RT-qPCR protocol was developed and implemented. …

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From Jim Crow To Diversity : Racial Formation As Institutional Logic In The U.S. National Park Service, 1935-2011, Rick Caceres-Rodriguez Jan 2018

From Jim Crow To Diversity : Racial Formation As Institutional Logic In The U.S. National Park Service, 1935-2011, Rick Caceres-Rodriguez

Legacy Theses & Dissertations (2009 - 2024)

This study uses the U.S. National Park Service (NPS) as case to study how racial formation in organizations is shaped by the changing institutional logics of race. It draws from the institutional logics perspective to advance theorizing on race in organizations as a multi-level process structured by societal race dynamics. It does so by studying three critical moments in the history of the NPS in which the organization was exposed, and had to respond to, varying logics of race.

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The Dissemination, Regulatory Role, And Evolution Of Mycobacterial Inteins, Danielle Skye Kelley Jan 2018

The Dissemination, Regulatory Role, And Evolution Of Mycobacterial Inteins, Danielle Skye Kelley

Legacy Theses & Dissertations (2009 - 2024)

Inteins are intervening protein elements, capable of coordinating escape from a host protein through a self-catalyzed mechanism, called protein splicing. This results in free intein and a mature host protein product. Inteins are also mobile elements and many contain homing endonucleases that enable the targeting to ectopic sites and invasion of novel niches. Inteins have been found across all three domains of life and are often present in replication, recombination, and repair proteins. However, it is unclear if the observed distribution is simply a factor of endonuclease preference or if inteins have been selectively maintained due to an adaptation that …

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Visual Variables On Mobile Devices : An Empirical Study Of Their Roles In Gaining Spatial Awareness, Andrew Donghyun Kim Jan 2018

Visual Variables On Mobile Devices : An Empirical Study Of Their Roles In Gaining Spatial Awareness, Andrew Donghyun Kim

Legacy Theses & Dissertations (2009 - 2024)

More people are used to and comfortable using mobile devices compared to traditional paper maps. Multiple studies have suggested that user's spatial awareness tends to decrease as the user passively follows directions on a mobile device with diminished screen size. One way to overcome the shortcoming of the small screen is through displaying discrete off-screen objects (landmarks) located beyond the extent of mobile map displays. The current study empirically examines the effectiveness of using visual variables including size, fuzziness, and transparency to embed distance and direction information in implicit icons of off-screen objects. This study investigates the effectiveness of these …

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Factors Associated With Candida Albicans Dissemination Via The Intestinal Mucosa, Emily Rochac Argueta Jan 2018

Factors Associated With Candida Albicans Dissemination Via The Intestinal Mucosa, Emily Rochac Argueta

Legacy Theses & Dissertations (2009 - 2024)

A murine model that established GI colonization of Candida albicans and eventual dissemination was identified to be lacking by Koh and others. Koh’s model specifically employed a tailored combination of neutropenia, intestinal damage, and microbiome dysbiosis that would allow C. albicans to gain an opportunistic advantage. His model provided new opportunities to study the details of C. albicans pathogenesis with a focus on the innate immune mechanisms responsible for controlling C. albicans within the intestinal mucosa. The long-term goal of this research project was to specifically study the factors associated with Candida albicans dissemination via the intestinal mucosa. The model …

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