Digital Commons Network^™

Reduced Orexin System Function Underlies Resilience To Repeated Social Defeat Stress, Laura A. Grafe, Darrell Eacret, Jane Dobkin, Seema Bhatnagar

Psychology Faculty Research and Scholarship

Exposure to stress increases the risk of developing affective disorders such as depression and post-traumatic stress disorder (PTSD). However, these disorders occur in only a subset of individuals, those that are more vulnerable to the effects of stress, whereas others remain resilient. The coping style adopted to deal with the stressor, either passive or active coping, is related to vulnerability or resilience, respectively. Important neural substrates that mediate responses to a stressor are the orexins. These neuropeptides are altered in the cerebrospinal fluid of patients with stress-related illnesses such as depression and PTSD. The present experi- ments used a rodent …

Shalom And Moral Imagination For Business Technologists, Jason M. Stansbury

University Faculty Publications and Creative Works

This essay addresses the problem “What are the ethical implications from a biblical perspective as technological changes reshape stakeholder relationships?” It characterizes the effects of technological change upon stakeholder relationships in microeconomic terms, so that various technologies can be understood in terms of their implications. It then describes the Christian ethical concept of “shalom,” and explores some of its implications for stakeholder relationships with biblical grounding. It next explores the microeconomic stakeholder implications of technological change in terms of shalom. It finally discusses moral imagination as a practical technique for understanding the ethical implications of a novel situation, envisioning practical …

Quest For New Drugs: A Way To Solve Anaesthesia Neurotoxicity?, L. Vutskits, J. R. Sneyd

More Faculty of Health Research

All contemporary general anaesthetics have been convincingly shown to produce neurotoxic effects in at least some experimental animal models, and many of the underlying mechanisms have been identified.1 Whilst the human relevance of these observations is still under intense scrutiny, the elaboration of protective strategies along with the development of new ‘non-toxic’ anaesthetic drug regimens have been identified as rational research directions to alleviate potential neurotoxicity.2 In this edition of the British Journal of Anaesthesia, Atluri and colleagues3 report preliminary animal experiments for a novel neurosteroid hypnotic. They describe the compound as ‘safe’ in comparison to ketamine, and suggest that …

Building The Future Of Nursing, Sally Brosz Hardin, Barbara Davenport

Books & Manuscripts

A history of USD's nursing school from its founding to 2017.

Lrrk2 Deficiency Impairs Trans-Golgi To Lysosome Trafficking And Endocytic Cargo Degradation In Human Renal Proximal Tubule Epithelial Cells, Nathan J. Lanning, Calvin Vanopstall, Megan L. Goodall, Jeffrey P. Mackeigan

University Faculty Publications and Creative Works

Defects in vesicular trafficking underlie a wide variety of human diseases. Genetic disruption of leucine-rich repeat kinase 2 (LRRK2) in rodents results in epithelial vesicular trafficking errors that can also be induced by treatment of animals with LRRK2 kinase inhibitors. Here we demonstrate that defects in human renal cells lacking LRRK2 phenocopy those seen in the kidneys of Lrrk2 knockout mice, characterized by accumulation of intracellular waste vesicles and fragmentation of the Golgi apparatus. This phenotype can be recapitulated by knockdown of N-ethylmaleimide-sensitive factor, which physically associates with LRRK2 in renal cells. Deficiency in either protein leads to a defect …

Les Aventures De Marie Anne Françoise Von Hohenzollern, Comtesse D'Isembourg, Jolene Vos-Camy

University Faculty Publications and Creative Works

No abstract provided.

The Craft Of Christian Higher Education, Susan M. Felch

University Faculty Publications and Creative Works

Although “the integration of faith and learning” quite rightly promotes holistic Christian higher education, the language itself may suggest two separate spheres that must be combined, thus subtly reinforcing the very dualism the phrase seeks to overcome. Understanding Christian higher education as a craft, situated within a tradition that extends historically across cultures but that is also locally inflected, counterbalances the abstract notion of “integration” by re-positioning our academic work as skilled labor. “Craft” focuses our attention on tradition, apprenticeship, well-chosen materials and tools, and artifacts, creating an image that can help to transform the modern university into an inculturated, …

Women And Technology In The Newsroom: Vision Or Reality From Data Journalism To The News Startup Era, Nik Usher

Communication: Faculty Scholarship

Journalism is now increasingly as technically inspired as it is editorially driven. From the rise of interactive journalists to product managers to user experience specialists, journalism in the places most likely to survive the economic fretful of the industry has moved closer to tech startup in culture and in practice. Some of the most promising new news startups, such as Buzzfeed and Vox, in fact, premise their identity as half-media and half-tech. In some cases, women are at the forefront as leaders in these newsrooms, but overall, demographics are not in their favor unless significant structural changes occur. Will what …

Face Size Biases Emotion Judgment Through Eye Movement, Shuo Wang

Faculty & Staff Scholarship

Faces are the most commonly used stimuli to study emotions. Researchers often manipulate the emotion contents and facial features to study emotion judgment, but rarely manipulate low-level stimulus features such as face sizes. Here, I investigated whether a mere difference in face size would cause differences in emotion judgment. Subjects discriminated emotions in fear-happy morphed faces. When subjects viewed larger faces, they had an increased judgment of fear and showed a higher specificity in emotion judgment, compared to when they viewed smaller faces. Concurrent high-resolution eye tracking further provided mechanistic insights: subjects had more fixations onto the eyes when they …

Cluster-Based Network Proximities For Arbitrary Nodal Subsets, Kenneth S. Berenhaut, Peter S. Barr, Alyssa M. Kogel, Ryan L. Melvin

Faculty & Staff Scholarship

The concept of a cluster or community in a network context has been of considerable interest in a variety of settings in recent years. In this paper, employing random walks and geodesic distance, we introduce a unified measure of cluster-based proximity between nodes, relative to a given subset of interest. The inherent simplicity and informativeness of the approach could make it of value to researchers in a variety of scientific fields. Applicability is demonstrated via application to clustering for a number of existent data sets (including multipartite networks). We view community detection (i.e. when the full set of network nodes …

Phytochemical Investigation Of A Native North American Species, “Acer Saccarinum” And An Endemic Saudi Arabian Species, “Euphorbia Saudiarabica”, Abdullatif Bin Muhsinah

Open Access Dissertations

The objectives of this work are the isolation, purification, structure elucidation, and biological evaluation of bioactive secondary metabolites, primarily tannins and diterpenoids, of two plant species: silver maple (Acer saccharinum) and Euphorbia saudiarabica, respectively.

Based on the ethnopharmacological literature, Acer saccharinum is a traditional medicinal plant that has been used by the people of North America. According to previous phytopharmacological studies by our group, over 70 phytochemicals, primarily tannins and flavonoids, have been discovered from three different maple species, including sugar (Acer saccharum), red (Acer rubrum), and sycamore (Acer pseudoplatanus) maples. …

Eastern Oyster Larval Transcriptomes In Response To Probiotic And Pathogenic Bacteria, Tejashree Modak

Open Access Dissertations

Oysters are described as keystone species serving an important ecological role. As filter-feeders they help in maintaining water quality. Oyster reefs provide refuge and support to different organisms. The eastern oyster, Crassostrea virginica, native to the East Coast of United States and Gulf of Mexico is a part of the rapidly growing aquaculture industry. Aquaculture production depends on a healthy and constant supply of oyster larvae that are provided by hatcheries. Several hatcheries on the east coast that provide C. virginica seed to oyster farms face significant losses owing to Vibrio infections causing massive larval mortalities. Use of antibiotics …

Compassion: Can Service Learning Make A Difference, And If So, How?, Edward Goldberg

Open Access Dissertations

The future of education is often framed in terms of bringing education into the second half of the 21^st century. Technology and along with it, faster and better ways to bring content to our students are important topics for discussion; but how our students treat each other and other members of their community is equally, if not more, important.

This study takes a look at how we may be able to encourage and foster compassion among our students. I wanted to know how compassionate thoughts and feelings develop following a service-learning experience focused on compassionate behavior. In this qualitative …

Pluralism And Regulatory Response To The Sharing Economy, Erez Aloni

All Faculty Publications

Providers use platforms in dissimilar ways. Some providers create new capacity and designate it for exclusively commercial use via platforms. For example, a provider buys a car that serves predominantly for driving paying passengers, converts a standard residential rental to a short-term rental, or works full-time via a platform. Conversely, other providers leverage their idle capacity and monetize it (e.g., a provider uses the family car to drive platform passengers in the evenings). This chapter argues that the distinction between new and idle capacity is a fundamental concept that should guide regulation of activities in the platform economy. Creating new …

Analysis Of Atp-Dependent Chaperone Protein Interactions With Misfolded Proteins, Amyloids, And Aggregated Proteins, Shannon May

Open Access Dissertations

Protein aggregation occurs when proteins adopt non-native conformations, exposing hydrophobic surfaces due to misfolding. The exposed regions of two or more proteins associate to form amorphous deposits or highly ordered, stable fibrillar structures called amyloid aggregates. Within the cell, a robust network of proteins safeguard against protein misfolding and aggregation. This network is referred to as the proteostasis network and includes molecular chaperone proteins, co-chaperone proteins, and the ubiquitin proteasome system. Molecular chaperone proteins function in various cellular processes including intracellular transport, oligomeric assembly, and efficient protein folding. Moreover, molecular chaperones are required for folding denatured, misfolded, and de novo …

Mechanisms Of Individual Variation In Glucuronidation, Sulfonation, And Amidation: Bisphenol A And Bile Acids, Adam Michael Auclair

Open Access Dissertations

The role of conjugation of chemicals and endogenous compounds is an important mechanism in detoxification and metabolic signaling. Specifically, amidation, sulfonation, and glucuronidation are necessary functions of the human body. Exposure to environmental toxins such as bisphenols must be conjugated in order to be excreted from the body. Bisphenol A was originally developed as a synthetic estrogen, however later found use as a monomer within the plastics industry allowing for wide-spread exposure to BPA through food and drink containers. While most healthy individuals are capable of metabolizing and excreting bisphenol A, this metabolism can be impacted by diet and disease. …

Wayfair: Substantial Nexus And Undue Burden, David Gamage, Darien Shanske, Adam Thimmesch

Articles by Maurer Faculty

This is the first of a series of essays wherein we analyze the U.S. Supreme Court’s decision in South Dakota v. Wayfair. In this essay, we tackle some of the more immediate interpretive questions raised by the Wayfair opinion, such as how a state should approach substantial nexus. As part of our analysis, we offer advice to state governments. Specifically, we recommend that states take note of the features of South Dakota’s law that appealed to the Court and replicate or improve on these to the extent possible. We advise states to consider simplifying their sales tax systems (and potentially …

The Bobcats Of West Virginia: How Many And Where Are They?, Thomas F Rounsville Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

No abstract provided.

Suffolk University Undergraduate Academic Catalog, College Of Arts And Sciences And Sawyer Business School, 2018-2019, Suffolk University

College of Arts and Sciences and Sawyer Business School Academic Catalogs

This catalog contains information for the undergraduate programs in the College of Arts and Sciences and the Sawyer Business School. The catalog is a PDF version of the Suffolk website, so many pages have repeated information and links in the document will not work.

The catalog is keyword searchable by clicking ctrl+f. A-Z course descriptions are also included here as separate PDF files with lists of CAS and SBS courses. Please contact the Archives if you need assistance navigating this catalog or finding information on degree requirements or course descriptions.

Exploring The Meaning Of Sustainability Within Three Selected Institutions Of The Graphic Design Field: A Phenomenological Study, Szilvia Kadas

Graduate Theses, Dissertations, and Problem Reports (ETD)

No abstract provided.

Effect Of Empagliflozin On Insulin Sensitivity In The Lean And Obese Zucker Rat: A Model Of Metabolic Syndrome, Veda Gayatri Sushma Penta

Theses, Dissertations and Capstones

Metabolic syndrome is one of the fastest growing health problems in the world. The medical costs associated with treating this disorder are staggering. Allowed to proceed untreated, metabolic syndrome can lead to a markedly decreased quality of life and a variety of medical conditions including heart and kidney failure. Whether the sodium glucose co-transporter-2 (SGLT-2) inhibitor Empagliflozin can be used to prevent the development of metabolic syndrome is not well understood. This proposal is specifically designed to address this gap in our knowledge. The expected outcomes of this work will identify the time course and degree of interrelatedness between changes …

Destruction, Reconstruction, And Remembrance: Exploring 'Memory' And 'Environment' Through Pennsylvania World War I Memorials In France, Amy Collins

Honors Theses

After examining the substantial efforts at land reclamation and environmental mitigation accompanying the State of Pennsylvania’s construction of memorials after World War I in France, I discovered a strong relationship between post-war memorialization and environmental mitigation in the areas in which the environmental consequences of WWI continue to affect humans and wildlife. My research illuminates how cultural impulses to build memorials that acknowledged the vast losses, acts of valor, and victories heavily influenced mitigation of France’s ecologically damaged Western Front. Many of France’s former battlefields, particularly in the devastated area known as the Red Zone, weren’t accessible to visitors before …

Benchmark Assessment Of Orphaned And Vulnerable Children In Areas Of The Zambia Family (Zamfam) Project—Brief, Michael Mbizvo, Paul C. Hewett

HIV and AIDS

The US Agency for International Development and US President’s Emergency Plan for AIDS Relief (PEPFAR) are supporting the Zambia Family (ZAMFAM) project to strengthen comprehensive, integrated service delivery and support to children living with, affected by, or vulnerable to HIV/AIDS (OVC) in the Lusaka, Copperbelt, Southern, and Central Provinces of Zambia. To inform that effort, Project SOAR conducted a benchmark survey among beneficiaries in the four provinces of the ZAMFAM program. The benchmark survey measured the status and conditions of OVC and their families. This brief provides a summary of the findings outlined in the final report on the needs …

Benchmark Assessment Of Orphaned And Vulnerable Children In Areas Of The Zambia Family (Zamfam) Project, Michael Mbizvo, Paul C. Hewett, Nkomba Kayeyi, Lyson Phiri, Saziso N. Mulenga, Bwalya Mushiki, Mwelwa Chibuye

HIV and AIDS

The US Agency for International Development and US President’s Emergency Plan for AIDS Relief (PEPFAR) are supporting the Zambia Family (ZAMFAM) project to strengthen comprehensive, integrated service delivery and support to children living with, affected by, or vulnerable to HIV/AIDS (OVC) in the Lusaka, Copperbelt, Southern, and Central Provinces of Zambia. To inform that effort, Project SOAR conducted a benchmark survey among beneficiaries in the four provinces of the ZAMFAM program. The benchmark survey measured the status and conditions of OVC and their families. The findings provide a deeper understanding of the needs of OVC families and the gaps in …

Concerning Adding Certified Police Working Horses To The Crime Of Cruelty To A Service Animal Or A Certified Police Working Dog., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Concerning The Continuation Of The Animal Feeding Operation Permit Program Under The Department Of Public Health And Environment, And, In Connection Therewith, Making An Appropriation., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Concerning A Licensed Chiropractor's Ability To Perform Animal Chiropractic On An Animal Patient., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Mechanisms Of Decreased Brainstem Arousal In Limbic Seizures: In Vivo Whole-Cell Recordings, John Paul Andrews

Yale Medicine Thesis Digital Library

Seizures are commonly regarded as disorders of neuronal hyperactivity, but evidence shows that temporal lobe seizures also cause reduced activity in subcortical arousal nuclei, including cholinergic neurons in the pedunculopontine tegmental nucleus (PPT), a key node of the reticular activating system. The synaptic mechanisms underlying the reduced ictal activity of cholinergic neurons in the PPT are unknown. Whole-cell in vivo recordings were made from PPT neurons in head-fixed rats to distinguish active inhibition from withdrawal of excitatory input as the driver of reduced ictal neuronal firing. A subset of PPT neurons exhibited reduced firing and hyperpolarization during seizures and stained …

Money In Politics: Campaign Finance And Its Influence Over The Political Process And Public Policy, 52 Uic J. Marshall L. Rev. 185 (2018), Conrad Foreman

UIC Law Review

Money in politics has risen to the forefront of the public political consciousness in the decade since Citizens United v. FEC. At the root of the issue are deeply flawed Supreme Court rulings on the constitutional protection afforded to political spending and the definition of regulable "corruption," which have exacerbated issues in the American campaign finance system and effectively legalized political bribery. The purpose of this comment is to highlight the impact of campaign finance on public policy and ultimately propose that we, the American people, must amend our Constitution to restore a representative democracy.

Chasing Results From The Chasing Arrows: Strategies For The United States To Stop Wasting Time And Resources When It Comes To Recycling, 52 Uic J. Marshall L. Rev. 147 (2018), Christina Everling

UIC Law Review

The United States is a leader when it comes to creating waste, but not when it comes to disposing of that waste in environmentally conscious ways, such as through recycling. While other countries boast recycling rates over 60 percent, the United States’ recycling rate is an unimpressive 25 percent. Even amidst a “zero waste” movement, there are few national efforts to increase our recycling rate. Some state and local communities have picked up the slack, implementing a variety of strategies to boost their recycling output and reduce waste. These initiatives, such as automatic curbside recycling, landfill bans, mandatory recycling, container …