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2018

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The Moderating Role Of Emotion Regulation In The Relationship Between Stress And Inflammatory Bowel Disease Severity Among Diagnosed Individuals, Sarah M. Ghose Jan 2018

The Moderating Role Of Emotion Regulation In The Relationship Between Stress And Inflammatory Bowel Disease Severity Among Diagnosed Individuals, Sarah M. Ghose

ETD Archive

This study examined whether both perceived and objectively rated chronic stress are contributing external factors to altered Inflammatory Bowel Disease (IBD) disease severity among diagnosed individuals. This study further examined whether emotion regulation (ER) acts as an ameliorative factor within this relationship. Of additional interest to this investigation was whether objectively rated stress (acquired via the UCLA Life Stress Interview) provided a unique contribution to this relationship. Recent investigations suggest that higher levels of perceived stress may result in increased IBD severity. Further, ER deficits may be associated with increased IBD disease activity in response to both chronic and perceived …

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Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron Jan 2018

Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron

ETD Archive

Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by four cardinal motor symptoms including bradykinesia, tremor, rigidity, and postural instability, and non-motor symptoms including cognitive impairment. Daily activities, such as walking and maintaining balance, are impacted due to impairments in motor function, and are further exacerbated with the addition of cognitive loading, or dual-tasking (DT). High-intensity exercise has demonstrated centrally-mediated improvements of PD symptoms, with additional positive effects on overall health. The goal of this project was to identify changes in dynamic balance recovery and gait function under conditions with and without increased cognitive load after a high-intensity exercise intervention …

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Synthesis And Biological Evaluation Of Small Molecular Drug Candidates For The Treatment Of Her2 Overexpressed Breast Cancer, Anran Zhao Jan 2018

Synthesis And Biological Evaluation Of Small Molecular Drug Candidates For The Treatment Of Her2 Overexpressed Breast Cancer, Anran Zhao

ETD Archive

In the US breast cancer is the most common cancer after skin cancer. Currently in the US the average risk of a woman to develop breast cancer in her life is roughly 12%. About 25-30% of breast cancer patients have HER2 overexpressed tumor, and the growth of tumor cell is depend on HER2 pathway. It has been well-documented that patients with over-expressed HER2 are associated with increased disease recurrence, worse prognosis and lower survival. Currently there are two type of HER2 targeting drug. The first group is HER2 monoclonal antibody drugs such as trastuzumab approved by FDA in 1998; the …

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Development Of Bioanalytical Methods For Quantitative Measurement Of Anticancer Agents, Sandeep R. Kunati Jan 2018

Development Of Bioanalytical Methods For Quantitative Measurement Of Anticancer Agents, Sandeep R. Kunati

ETD Archive

The ever-growing need to develop new anticancer agents due to increased incidence of cancer and its recurrence has led to a broad range of investigational efforts in anticancer research. Drug discovery and development processes involve evaluations of pharmacokinetic and pharmacodynamic parameters of potential drug candidates in order to assess their safety, toxicity, and efficacy profiles. By providing sensitivity, assay precision, reliability, and high-throughput, mass spectrometry has become an indispensable tool in quantitative and qualitative analysis, from early-stage drug discovery and development processes to routine laboratory analysis. Development of bioanalytical methods requires knowledge of separation science with instrumentation, data interpretation and …

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Real-Time Assessment And Visual Feedback For Patient Rehabilitation Using Inertial Sensors, Deepa Adinarayanan Jan 2018

Real-Time Assessment And Visual Feedback For Patient Rehabilitation Using Inertial Sensors, Deepa Adinarayanan

ETD Archive

Rehabilitation exercises needs have been continuously increasing and have been projected to increase in future as well based on its demand for aging population, recovering from surgery, injury and illness and the living and working lifestyle of the people. This research aims to tackle one of the most critical issues faced by the exercise administers-Adherence or Non-Adherence to Home Exercise problems especially has been a significant issue resulting in extensive research on the psychological analysis of people involved. In this research, a solution is provided to increase the adherence of such programs through an automated real-time assessment with constant visual …

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Notes On Survival, Despite, Jason Harris Jan 2018

Notes On Survival, Despite, Jason Harris

ETD Archive

In this collection of poems, the issue of damage-based thinking and desire-based thinking is being examined. It is being examined through the use of several different types of poetry techniques. Within the poems, the past, the present, and the future are examined and asks a larger question: How can we, as people take the daily violence that we encounter and find – and/or work our way to – joy.

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Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag Jan 2018

Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag

ETD Archive

Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal epithelia adjacent to a cyst. We hypothesize that in normal epithelia near a cyst, the stabilization of Hypoxia Inducible Factor 1a (HIF1a), a major regulator of cellular response to hypoxia, can cause altered paracellular and transcellular transport, transforming a normal absorptive phenotype to a secretory and paracellularly leaky phenotype, leading to cyst expansion. Using 100 µmol/L cobalt chloride (CoCl2), HIF1a was stabilized in cellular nucleus of a mouse cortical collecting duct cell line (mCCD 1296 …

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Who’S In Charge Here? Exercising Authority In The Organization-Volunteer Relationship, Patricia A. Groble Jan 2018

Who’S In Charge Here? Exercising Authority In The Organization-Volunteer Relationship, Patricia A. Groble

ETD Archive

One facet of being a volunteer is the freedom to choose one’s work and schedule. When this ability to choose conflicts with the organization’s need to ensure that volunteers’ work activities fulfill its mission, it creates tension between staff members and volunteers and presents a challenge to the organization’s ability to exercise authority over its volunteers.

Existing research on volunteerism studies volunteer engagement, motivations, and best practices for managing volunteers, as well as how volunteers can be considered a sustainable resource. The volunteer management literature pays little attention, however, to authority’s role in the relationship between organizations and their volunteers. …

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School Logo Cleveland State University Logo Title Evolutionary Optimization For Safe Navigation Of An Autonomous Robot In Cluttered Dynamic Unknown Environments, Arash Roshanineshat Jan 2018

School Logo Cleveland State University Logo Title Evolutionary Optimization For Safe Navigation Of An Autonomous Robot In Cluttered Dynamic Unknown Environments, Arash Roshanineshat

ETD Archive

We present a path planning approach based on probabilistic methods for a robot to navigate in a cluttered, dynamic, unknown environment. There are dynamic obstacles moving around and static obstacles located in the map. The robot does not have any prior information about them but should be able to navigate through the map beginning from a known starting point and safely ending at a known target point. The only information the robot has is the location of the starting point and the target point and it uses sensory information to collect information about its surroundings. Our method is compared to …

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“The Deepest Blush”: Bodily States Of Emotions In Jane Austen’S Novels, Nadya Abdelfattah Jan 2018

“The Deepest Blush”: Bodily States Of Emotions In Jane Austen’S Novels, Nadya Abdelfattah

ETD Archive

During the eighteenth-century, philosophers gave primacy to rationality specifying that reason could and should control emotions; they observed a friction between thought and feeling, rational and irrational, emotion and cognition, mind and body, which competed and united in a way that influenced the eighteenth-century and nineteenth-century thought and experience on many sides. As an early nineteenth-century novelist, Jane Austen explores the relationship between emotion and cognition. I argue that Austen shows the importance of bodily experience of emotion in moral development. Deploying affect theory will illuminate Austen’s depiction of emotions as a mode of understanding of how the body becomes …

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The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh Jan 2018

The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh

ETD Archive

INTRODUCTION The Naked Mole Rat [ Heterocephalus glaber] is a type of rodent -with the highest average lifespan-30 years-among all the rodent species. It lives underground in sealed burrow systems with little to no exposure to day-night transitions on the surface. It shows polyphasic round the clock activity within its subterranean burrow system. The activity and physiology of most animals are governed by the biological circadian clock. The biological circadian clock is a system that oscillates with a rough periodicity of 24 hours. Environmental zeitgebers regulate the entrainment of the circadian clock to the 24-hour day-night cycle and light is …

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Computational Investigation Of Protein Assemblies, Sm Bargeen Alam Turzo Jan 2018

Computational Investigation Of Protein Assemblies, Sm Bargeen Alam Turzo

ETD Archive

Selective nitrosylation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) at Cys-247 affects gene regulation through the interferon-gamma (IFN- γ) activated inhibitor of translation (GAIT) complex. Oxidized low-density lipoprotein (LDLox) and INF-γ induce assembly of the nitrosylase complex composed of inducible nitric oxide synthase (iNOS), S100A8, and S100A9 proteins. Crystal structure of the complex of GAPDH and S100A8A9 is not known, structural prediction method were employed by protein-protein docking and binding energy calculation with PatchDock and FIREDock respectively. Candidate models were selected, based on a weight factor calculated, from the computational method developed from the "artificial protease" cleavage mapping Fe(III) (s)-1-(p- …

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High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang Jan 2018

High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang

ETD Archive

The U.S Environmental Protection Agency (EPA) launched the Transform Tox Testing Challenge in 2016 with the goal of developing practical methods that can be integrated into conventional high-throughput screening (HTS) assays to better predict the toxicity of parent compounds and their metabolites in vivo. In response to this need and to retrofit existing HTS assays for assessing metabolism-induced toxicity of compounds, we have developed a 384-pillar plate that is complementary to traditional 384-well plates and ideally suited for culturing human cells in three dimensions (3D) at a microscale. Briefly, human embryonic kidney (HEK) 293 cells in a mixture of alginate …

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Atheism And The Effects Of Mortality Salience And Limited Analytic Processing Ability On Religious Faith And Teleological Thinkin, Brett Jordan Waggoner Jan 2018

Atheism And The Effects Of Mortality Salience And Limited Analytic Processing Ability On Religious Faith And Teleological Thinkin, Brett Jordan Waggoner

ETD Archive

The scenario of the atheist in the proverbial foxhole has been a topic of discussion in religious circles for centuries. Building on prior research utilizing terror management theory (TMT), a dual process model of cognition, and previous work suggesting that humans are intuitively wired for teleological and religious concepts, the researchers set out to examine atheist’s religiosity when confronted with the reality of one’s impermanence. To explore this idea, the present experiment recruited a sample of atheists, manipulated their awareness of mortality, manipulated their ability to employ analytic thinking, and measured various intuitive cognitions (e.g., teleological reasoning) alongside religious belief. …

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Color Removal From Combined Dye And Fruit Nectar Wastewater Using Adsorption And Microfiltration, Oluwatobiloba A. Akinwande Jan 2018

Color Removal From Combined Dye And Fruit Nectar Wastewater Using Adsorption And Microfiltration, Oluwatobiloba A. Akinwande

ETD Archive

Pollution of the waterways is a great challenge of the 21st century. Textile effluents contain compounds which have the capacity to cause more harm when ingested. There are many dye removal technologies like coagulation, photo oxidation which help to remove color from dye wastewater. The use of adsorption to remove color from dye wastewater has been used for many centuries. Activated carbon can efficiently remove color from dye wastewater but it is very expensive and so different researches have been conducted to get the adsorption capacity of different forms of adsorbents. These adsorbents can be gotten from agricultural waste, biomass, …

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Drughelp.Care – A Web Application For The Discovery Of Drug Addiction Treatment Facilities, Sachin Hiriyanna Jan 2018

Drughelp.Care – A Web Application For The Discovery Of Drug Addiction Treatment Facilities, Sachin Hiriyanna

ETD Archive

One of the current and biggest problems in the system of emergency care for the drug overdose epidemic, is the failure of information delivery on nearby treatment facilities. Even though some initiatives on the internet tried to solve this issue, they either failed in delivering the information or in providing ease of usability. This thesis research aims to develop a web application which, 1. Delivers a highly accurate, easy-to-understand and targeted information in a timely manner for drug abusers and their well-wishers. 2. Provides an eco-system for the treatment facilities with an easy-to-use backend to constantly update their complex information …

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Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin Jan 2018

Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin

ETD Archive

Colorectal cancer is a disease characterized by abnormal, invasive cell growth beginning in the colon or rectum. The third most common type of cancer worldwide, approximately one million new cases of the disease are diagnosed across the globe annually, resulting in an estimated 700,000+ deaths. One major risk factor associated with development of colorectal cancer is the presence of chronic inflammation in the large intestine, also known as colitis. Inflammation is a complex immune response against harmful stimuli, characterized by symptoms including heat, redness, swelling and pain. One important molecular mediator of this process is interleukin 17 (IL-17), a pro-inflammatory …

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The Effect Of Gender And Racial Stereotypes And Education-Related Beliefs On The Academic And Social Identity Development Of Urban African American Girls, Wanda Marie Shealey Jan 2018

The Effect Of Gender And Racial Stereotypes And Education-Related Beliefs On The Academic And Social Identity Development Of Urban African American Girls, Wanda Marie Shealey

ETD Archive

This qualitative, ethnographic study explores various tensions and struggles around gender and racial stereotypes that three urban teenage African American girls encounter as they try to develop a sense of oneself as an individual and in relation to the world. The purpose of this study was to explore Black high school girls’ experiences in a predominately urban public school in the Midwest. This study is guided by the following research question: In what way do gender and racial bias contribute to the self-perception of African American adolescent girls? Interrogating the multiple standpoints that inform African American female identity and how …

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Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin Jan 2018

Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin

ETD Archive

Colorectal cancer is a disease characterized by abnormal, invasive cell growth beginning in the colon or rectum. The third most common type of cancer worldwide, approximately one million new cases of the disease are diagnosed across the globe annually, resulting in an estimated 700,000+ deaths. One major risk factor associated with development of colorectal cancer is the presence of chronic inflammation in the large intestine, also known as colitis. Inflammation is a complex immune response against harmful stimuli, characterized by symptoms including heat, redness, swelling and pain. One important molecular mediator of this process is interleukin 17 (IL-17), a pro-inflammatory …

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The Sellout By Paul Beatty: “Unmitigated Blackness” In Obama's America, John E. Davies Jan 2018

The Sellout By Paul Beatty: “Unmitigated Blackness” In Obama's America, John E. Davies

ETD Archive

Visibility and invisibility are long-standing tropes in the African-American literary tradition. Frequently they are presented in satiric language. I argue that Paul Beatty's Mann Booker Award-winning novel The Sellout now holds an important role in this tradition. Specifically, The Sellout hearkens specifically to Ralph Ellison's Invisible Man and to Paul Beatty's earlier novel The White Boy Shuffle. Further, The Sellout exposes the ongoing presence and function of racism in an America that has elected its first African-American president, Barack Obama, and that now claims to be "post-racial," even as its spectral reproduction and commodification of blackness persist. By analyzing the …

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Recognition Memory Revisited: An Aging And Electrophysiological Investigation, Elliot C. Jardin Jan 2018

Recognition Memory Revisited: An Aging And Electrophysiological Investigation, Elliot C. Jardin

ETD Archive

This study provides a better understanding of contributing factors to age differences in human episodic memory. A recurrent finding in recognition memory is that older adults tend to have lower overall accuracy and tend to make fewer false-alarm errors in judging new items, relative miss errors (Coyne, Allen & Wickens, 1986; Danziger, 1980; Poon and Fozard 1980). Two possible causes for decline in these abilities include an age-related decrement in speed of processing (Salthouse 1991) and changes in information processing ability due to entropy (Allen, Kaufman, Smitch, & Propper 1998a; Mallik et al., in preparation). Additionally, age differences may be …

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Utah State University - University Libraries Metadata Application Profile For Contentdm Digital Collections, Andrea Payant, Sara Skindelien, Liz Woolcott Jan 2018

Utah State University - University Libraries Metadata Application Profile For Contentdm Digital Collections, Andrea Payant, Sara Skindelien, Liz Woolcott

Library Faculty & Staff Publications

The Utah State University Libraries Digital Collections Application Profile outlines the metadata fields, mappings, definitions, and resources used to assign metadata for digital collections in the USU CONTENTdm repository. Utah State University is a collection partner of the Mountain West Digital Library (MWDL). Therefore, this profile pulls substantially from the MWDL application profile 2.0, which is available at this URL: http://mwdl.org/docs/MWDL_DC_Profile_Version_2.0.pdf

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Drought And Land-Cover Conditions In The Great Plains, Heather Tollerud, Jesslyn Brown, Thomas Loveland, Rezaul Mahmood, Norman Bliss Jan 2018

Drought And Land-Cover Conditions In The Great Plains, Heather Tollerud, Jesslyn Brown, Thomas Loveland, Rezaul Mahmood, Norman Bliss

High Plains Regional Climate Center: Staff Publications

Land–atmosphere interactions play a critical role in the Earth system, and a better understanding of these interactions could improve weather and climate models. The interaction among drought, vegetation productivity, and land cover is of particular significance. In a semiarid environment, such as the U.S. Great Plains, droughts can have a large influence on the productivity of agriculture and grasslands, with serious environmental and economic impacts. Here, we used the vegetation drought response index (VegDRI) drought indicator to investigate the response of vegetation to weather and climate for landcover types in the Great Plains in the United States from 1989 to …

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Landscape Transformation During Ceramic Age And Colonial Occupations Of Barbuda, West Indies, Allison Bain, Anne-Marie Faucher, Lisa M. Kennedy, Allison R. Leblanc, Michael J. Burn, Rebecca Boger, Sophia Perdikaris Jan 2018

Landscape Transformation During Ceramic Age And Colonial Occupations Of Barbuda, West Indies, Allison Bain, Anne-Marie Faucher, Lisa M. Kennedy, Allison R. Leblanc, Michael J. Burn, Rebecca Boger, Sophia Perdikaris

School of Global Integrative Studies: Faculty Publications

This research documented the history of landscape transformation on the island of Barbuda in the Lesser Antilles, Caribbean through cross-disciplinary research approaches. Excavations confirmed a human presence for the seasonal exploitation of conch meat and other mollusks during the Archaic Age (c.3000–500 BC), but more substantial impacts to terrestrial ecosystems likely began during the Ceramic Age (c.500 BC–AD 1500). Our combined sedimentary and charcoal records revealed that human-induced environmental transformations began with Ceramic Age peoples as they cleared vegetation for settlements and gardens with intentional burning. Sedimentary charcoal indicated a dramatic decline in fire during post-Ceramic Age abandonment, continuing through …

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Terror Management Theory: The Effect Of Death On Criminogenic Thought Patterns, Zachary J. Kyle Jan 2018

Terror Management Theory: The Effect Of Death On Criminogenic Thought Patterns, Zachary J. Kyle

Modern Psychological Studies

Terror Management Theory has been applied with judges and juries in the courtroom, but not yet with criminals themselves. The current study looks for an association between criminogenic thought patterns and worldviews of criminal behavior. Thought patterns were assessed with the Measure of Criminogenic Thinking Styles (MOCTS), while worldviews were measured with the associate section of the Measures of Criminal Attitudes and Associates. Results indicated that mortality salience did not increase criminogenic thinking. However, criminogenic thinking scores from the MOCTS were correlated with scores on the associate scale under mortality salience. These findings may suggest that participants with a worldview …

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No. 13: The Growth Of Food Banking In Cities Of The Global South, Daniel N. Warshawsky Jan 2018

No. 13: The Growth Of Food Banking In Cities Of The Global South, Daniel N. Warshawsky

Hungry Cities Partnership

As the number and size of food banks increase globally, it is critical to research how food banks fit into existing food systems and their role in reducing food insecurity and food waste. After examining the political ecology of urban food waste in food systems, this discussion paper examines the globalization of food banking and its growth in the Global South. Through a case study of FoodForward SA, it critically analyzes the roles that urban food banks play in cities of the Global South. Since many countries in the South have both the highest levels of food insecurity and the …

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Nutech Ventures Annual Report 2017-2018 Jan 2018

Nutech Ventures Annual Report 2017-2018

NUtech Ventures: Publications

NUTech Ventures annual report 2017-2018.

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Constructing Rock Cairns: Modifying And Signifying The Alpine Landscape Of Southeast Alaska, Ralph J. Hartley, Amanda Renner, William J. Hunt Jr. Jan 2018

Constructing Rock Cairns: Modifying And Signifying The Alpine Landscape Of Southeast Alaska, Ralph J. Hartley, Amanda Renner, William J. Hunt Jr.

Department of Anthropology: Faculty Publications

The existence and variability of human-made rock cairns in subalpine and alpine settings of Southeast Alaska is increasingly well documented. Whete these features were constructed prehistorically and prorohistorically is a fundamental component to assessing the socioecological role of these modifications to a landscape that is, for the most patt, devoid of other physical manifestations of past human activities. Based on information compiled from investigations in the northern portion of Baranof Island and vicinity, we explore the physical and social environmental conditions that may underlie decisions to create the cairns, some of which are estimated to have been built approximately 500 …

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The Psychological Grotesque In Modern American Literature, Amanda Turnbull Jan 2018

The Psychological Grotesque In Modern American Literature, Amanda Turnbull

Master of Liberal Studies Theses

In his novel Winesburg, Ohio, Sherwood Anderson describes a grotesque as someone who has “snatched up” a “truth,” “called it his truth, and tried to live his life by it” (23-4). This one defining “truth” manifests in the grotesque’s life in the form of a number of significant psychological deformities such as fanaticism, denial of reality, and turning inward upon oneself, isolating the grotesque from those around him and arresting his emotional and psychological growth. Using Anderson’s paradigm, this thesis explores the pervasive use of the psychological grotesque in modern American literature by examining the overlapping features of grotesque characters …

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The Metamodern Man, Nathan R. Arrowsmith Jan 2018

The Metamodern Man, Nathan R. Arrowsmith

Master of Liberal Studies Theses

Abstract The first time I heard the term, “Metamodern Age,” I was actively involved in a discussion about the various themes in Mary Shelley’s Frankenstein. The setting was a Master of Liberal Studies class (Rollins College, MLS 604), entitled “Modernity” taught by Dr. Tom Cook. It was October of 2015. Frankenstein, also known as The Modern Prometheus, is a masterpiece and a solid sample from the Modern Era. Following approximately fifty years of Postmodern Era sludge, we are now in what could be identified as the Metamodern Era. Our Modernity class speculated confidently that the current Age of Metamodernism is …

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