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2018

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Localization Of Sip470, A Plant Lipid Transfer Protein In Nicotiana Tabacum, Shantaya Andrews Dec 2018

Localization Of Sip470, A Plant Lipid Transfer Protein In Nicotiana Tabacum, Shantaya Andrews

Electronic Theses and Dissertations

SABP2-interacting protein 470 (SIP470), a non-specific lipid transfer protein (nsLTP), was discovered in a yeast two-hybrid screening using SABP2 as bait and tobacco leaf proteins as prey. SABP2 is an important enzyme in systemic acquired resistance that converts salicylic acid to methyl salicylate. Localization studies are an important aspect to understanding the biological function of proteins. nsLTPs are generally considered apoplastic proteins and has been localized intracellularly and extracellularly. Transient expression shows highest expression of SIP470-eGFP at 2 days post infiltration into Nicotiana benthamiana. Confocal microscopy showed localization near the periphery of the cell. Subcellular localization using differential centrifugation showed …


Gut Microbiota Regulates The Interplay Between Diet And Genetics To Influence Insulin Resistance, Jeralyn Jones Franson Dec 2018

Gut Microbiota Regulates The Interplay Between Diet And Genetics To Influence Insulin Resistance, Jeralyn Jones Franson

Theses and Dissertations

Insulin resistance and obesity are major public health concerns. The impact of diet and genetics on insulin resistance and obesity is well accepted. Additionally, the gut microbiota has been shown to influence obesity and metabolic disorders. However, much remains to be understood about the role of gut microbiota in the development of insulin resistance and obesity. We utilized a mouse model lacking PAS kinase, a protein involved in cellular metabolism, in order to better understand the relationship between diet, genetics and the gut microbiota. Previous research has shown that mice lacking PAS kinase were protected from the effects of a …


Microbial And Environmental Drivers Of Soil Respiration Differ Along Montane To Urban Transitions, Kerri Ann Russell Dec 2018

Microbial And Environmental Drivers Of Soil Respiration Differ Along Montane To Urban Transitions, Kerri Ann Russell

Theses and Dissertations

In natural ecosystems, like deciduous and coniferous forests, soil CO2 flux or soil respiration is highly variable and influenced by multiple factors including temperature, precipitation, dissolved soil organic carbon (DOC), dissolved organic matter (DOM), and bacterial and fungal biomass and diversity. However, as the human population continues to grow rapidly, so too do urbanized landscapes with unknown consequences to soil respiration. To determine the extent urbanization influences seasonal shifts in microorganisms and environmental drivers alter soil respiration, we evaluated bacterial and fungal communities, soil physiochemical characteristics, and respiration in forested and urbanizing ecosystems in three watersheds across northern Utah, USA. …


The Bird And The Fish: Motion Field-Based Frame Interpolation In The Context Of A Story, Thomas Sterling Ellsworth Dec 2018

The Bird And The Fish: Motion Field-Based Frame Interpolation In The Context Of A Story, Thomas Sterling Ellsworth

Theses and Dissertations

Animating by hand can be a long and challenging process in part because of the necessity of drawing every frame by hand. 3D animation media minimize this problem with the use of automatically interpolated frames, but despite significant research no universally acceptable techniques have been demonstrated for 2 dimensional interpolation. In this paper we explore computer-assisted optimizations to the animation pipeline. Specifically, we utilize 3D motion fields to create more realistic in-between frames for sets of 2D ``key frames.'' We demonstrate our method by using it to create 2D special effects for a 30-second clip of an animated short film.


Repopulation And Stimulation Of Porcine Cardiac Extracellular Matrix To Create Engineered Heart Patches, Silvia Juliana Moncada Diaz Dec 2018

Repopulation And Stimulation Of Porcine Cardiac Extracellular Matrix To Create Engineered Heart Patches, Silvia Juliana Moncada Diaz

Theses and Dissertations

Heart failure is the main cause of death for both men and women in the United States. The only proven treatment for patients with heart failure is heart transplantation. The goal of this research is to create patches of tissue that could mimic the function of the native heart to repair the damaged portions of the heart. In this study, whole porcine hearts were decellularized to create a 3D construct that was recellularized with cardiomyocytes (CM) differentiated from human induced pluripotent stem (IPS) cells. At day 4 of differentiation, IPS-derived CMs were implanted onto cardiac extracellular matrix (cECM) and ten …


An Open-Label Pilot Study To Identify The Usefulness Of Adjuvant Homoeopathic Medicines In The Treatment Of Cerebral Stroke Patients, Aslam Abbas, Md Ali, Hima Ponnam, Divya Taneja, Anil Khurana, Chaturbhuja Nayak, Anil Santapur Dec 2018

An Open-Label Pilot Study To Identify The Usefulness Of Adjuvant Homoeopathic Medicines In The Treatment Of Cerebral Stroke Patients, Aslam Abbas, Md Ali, Hima Ponnam, Divya Taneja, Anil Khurana, Chaturbhuja Nayak, Anil Santapur

Indian Journal of Research in Homoeopathy

Background: Stroke, the third leading cause for neurological morbidity and mortality has a global annual incidence of 0.2–2.5/1000 population. The clinical sequelae of stroke are often devastating with hemiparesis, depression, walking difficulties and aphasia. It is essential to take measures halting the progression of stroke. Homoeopathic literature mentions many medicines for stroke. Till a pilot study was undertaken to study the usefulness of Homoeopathy as an adjuvant therapy to standard conventional care in stroke patients. Materials and Methods: An open-label pilot study was conducted at Princess Durru Shehvar Children's and General Hospital, Hyderabad, in coordination with Extension Clinical Research Unit …


Homoeopathic Drug Dilutions Of Thuja Occidentalis Attenuate Complete Freund's Adjuvant-Induced Arthritis In Wistar Rats, Sachin Patil, Umesh Mahajan, Sameer Goyal, Sateesh Belemkar, Chandragouda Patil Dec 2018

Homoeopathic Drug Dilutions Of Thuja Occidentalis Attenuate Complete Freund's Adjuvant-Induced Arthritis In Wistar Rats, Sachin Patil, Umesh Mahajan, Sameer Goyal, Sateesh Belemkar, Chandragouda Patil

Indian Journal of Research in Homoeopathy

Context: Thuja occidentalis is prescribed in Homoeopathy in treating rheumatoid arthritis. We speculated the anti-arthritic mechanism of Homoeopathic dilutions of Thuja occidentalis against the complete Freund's adjuvant (CFA)-induced arthritis in rats. Materials and Methods: Arthritis was induced (n = 28) by subplantar injection of 0.1 ml CFA in the right hind paw of rats. The oral dose of crude Thuja occidentalis was 30 mg/kg/b. i. d and that of Homoeopathic dilutions was 0.1 ml/b. i. d. Orally administered diclofenac at 5 mg/kg/day served as a standard. The treatments continued for 24 days. The severity of arthritis was determined weekly as …


Republication-Predatory Journals: A Downside On Research And Hampering The Impact And Relevance Of Scientific Outcome, N Jain, Ginu Khan Dec 2018

Republication-Predatory Journals: A Downside On Research And Hampering The Impact And Relevance Of Scientific Outcome, N Jain, Ginu Khan

Indian Journal of Research in Homoeopathy

The advancement of medical knowledge is quintessentially based on the authentic and reliable scientific research and publications. This is in addition to the recently mandated requirement of original research publications in indexed journals to ensure career progression in academic/medical institutions; thus, the need for ‘publications’ in scientific medical scholarly journals has increased substantially. On the other hand, this has given an unparalleled rise in the number of standalone journals and publishers ‘predatory’ is the term, who are ready to process the manuscripts on priority with almost guaranteed publication, at a cost, but having no credibility to the research being published. …


A Multicenter Study To Evaluate Pulmonary Function In Osteogenesis Imperfecta., Allison Tam, Shan Chen, Evan Schauer, Ingo Grafe, Venkata Bandi, Jay R. Shapiro, Robert D. Steiner, Peter A. Smith, Michael B. Bober, Tracy Hart, David Cuthbertson, Jeffrey Krischer, Mary Mullins, Peter H. Byers, Robert A. Sandhaus, Michaela Durigova, Francis H. Glorieux, Frank Rauch, Vernon Reid Sutton, Brendan Lee, Members Of The Brittle Bone Disorders Consortium, Eric T. Rush, Sandesh C S Nagamani Dec 2018

A Multicenter Study To Evaluate Pulmonary Function In Osteogenesis Imperfecta., Allison Tam, Shan Chen, Evan Schauer, Ingo Grafe, Venkata Bandi, Jay R. Shapiro, Robert D. Steiner, Peter A. Smith, Michael B. Bober, Tracy Hart, David Cuthbertson, Jeffrey Krischer, Mary Mullins, Peter H. Byers, Robert A. Sandhaus, Michaela Durigova, Francis H. Glorieux, Frank Rauch, Vernon Reid Sutton, Brendan Lee, Members Of The Brittle Bone Disorders Consortium, Eric T. Rush, Sandesh C S Nagamani

Manuscripts, Articles, Book Chapters and Other Papers

Pulmonary complications are a significant cause for morbidity and mortality in osteogenesis imperfecta (OI). However, to date, there have been few studies that have systematically evaluated pulmonary function in individuals with OI. We analyzed spirometry measurements, including forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1 ), in a large cohort of individuals with OI (n = 217) enrolled in a multicenter, observational study. We show that individuals with the more severe form of the disease, OI type III, have significantly reduced FVC and FEV1 which do not follow the expected trends of the …


Annual Report, Fiscal Year 2017/2018, Tennessee. Department Of Safety & Homeland Security. Dec 2018

Annual Report, Fiscal Year 2017/2018, Tennessee. Department Of Safety & Homeland Security.

Annual Report

No abstract provided.


Lending A Helping Paw: Streamlining A Volunteer Handbook, Andrew Donati Dec 2018

Lending A Helping Paw: Streamlining A Volunteer Handbook, Andrew Donati

Capstone Projects and Master's Theses

Peace of Mind Dog Rescue (POMDR) relies heavily on its volunteers to carry out important operational needs that allow them to fulfill their mission of being a resource and advocate for local senior dogs and senior citizens. From overseeing adoption events to foster care to administrative duties, volunteers serve as the arms-and-legs of the organization. Despite having a volunteer base of over 700 individuals, POMDR faces a challenge in preparing new volunteers for their role within the organization. To address this organizational concern, a digital volunteer handbook was created to provide current and prospective volunteers with an easily accessible resource …


Conozca Sus Derechos Como Rentero, Maria Melgoza-Gaytan Dec 2018

Conozca Sus Derechos Como Rentero, Maria Melgoza-Gaytan

Capstone Projects and Master's Theses

Building Healthy Communities- East Salinas is funded by The California Endowment, which is a statewide nonprofit foundation. The BHC’s main goal is to work alongside residents and community-based organizations to work on community participation and leadership to create a healthier community for the residents of East Salinas. Currently, East Salinas tenants are victims of illegal rental practices. Conozca sus derechos como rentero booklet created, an educational booklet and flyer highlighting tenants’ rights. Factors that contribute to the victimization of the residents include the language barrier, lack of knowledge on laws and their legal status. The goal is to educate tenants …


Overtone Singing: History, Development, And Influence In Contemporary Music, Jocelyn Black Dec 2018

Overtone Singing: History, Development, And Influence In Contemporary Music, Jocelyn Black

Capstone Projects and Master's Theses

Overtone singing also known as Throat singing, is an ancient vocal technique where a soloist produces two different tones through the resonance created by the airflow of sound through the lungs, throat, and mouth. Often associated with the Tuva population of Central Asia, this art form is also practiced by the Inuit women of North America, and in South Africa by women of the Xhosa tribe. Overtone singing is an integral part of each cultural tradition and may vary in style and meaning across cultures. Traditional performances of Overtone singing include: celebratory ceremonies, tribal dances, games, and meditation. In the …


Bringing Meaning Back: Adding Significance To Arts Curriculum, Arturo Ortiz Dec 2018

Bringing Meaning Back: Adding Significance To Arts Curriculum, Arturo Ortiz

Capstone Projects and Master's Theses

A lackluster attitude towards art projects can lead to students that do not value art or creativity. Instilling a reach beyond the school population and completing art projects that hold intrinsic value adds meaning to the works being produced. If time is taken out of other curriculum to focus on the arts, it is in students’ and teachers’ best interests to have that class time have real significance. Staff and parents of Clinton Elementary were interviewed for their views on creating opportunities to imbue meaning to art curriculum. After the data was compiled and analyzed, several action options were created. …


Research Practices And Needs Of Indigenous Studies Scholars At Dartmouth College: A Report Coordinated By Ithaka S+R, Ridie Ghezzi, J. Wendel Cox, Julia W. Logan, Amy L. Witzel Dec 2018

Research Practices And Needs Of Indigenous Studies Scholars At Dartmouth College: A Report Coordinated By Ithaka S+R, Ridie Ghezzi, J. Wendel Cox, Julia W. Logan, Amy L. Witzel

Dartmouth Library Staff Publications

No abstract provided.


Adenosquamous Carcinoma Of The Tongue, Yeshwant B. Rawal, Kenneth M. Anderson Dec 2018

Adenosquamous Carcinoma Of The Tongue, Yeshwant B. Rawal, Kenneth M. Anderson

School of Dentistry Faculty Research and Publications

A 51-year-old white female presented with a painful ulcer of the left ventrolateral tongue. An incisional biopsy confirmed a diagnosis of adenosquamous carcinoma. The adenosquamous carcinoma is an uncommon malignant tumor with histopathological features of a squamous carcinoma and an adenocarcinoma. A definitive diagnosis requires histopathological examination of a deep biopsy involving the submucosal tissue. This malignant tumor shows aggressive behavior with early invasive growth and a poor prognosis. The histopathological findings and differential diagnosis of a case of adenosquamous carcinoma of the tongue are discussed.


Veb-Econ: An Outreach Tool For Designing Vegetative Environmental Buffers, John Tyndall, Jesse Randall, John Vandyk Dec 2018

Veb-Econ: An Outreach Tool For Designing Vegetative Environmental Buffers, John Tyndall, Jesse Randall, John Vandyk

Journal of Extension

Vegetative environmental buffers, or VEBs, are rows of trees and shrubs purposefully planted to mitigate livestock odor. In this article, we present VEB-econ, a free-to-use geographic information system–based decision support tool Extension professionals can implement when working with livestock producers in designing site-specific VEBs. A soil database links tree and shrub species recommendations to soil-based suitability guidelines. VEB-econ estimates annualized cost for tree establishment and management and opportunity costs and factors in potential Natural Resources Conservation Service cost-share payments. Additionally, VEB-econ can be used to design field windbreaks. VEB-econ is designed specifically to be useful to Extension professionals and other …


Good Agricultural Practices Training For Limited-Resource Produce Growers And Extension Educators, Agnes Kilonzo-Nthenge, John C. Ricketts, Dharma Pitchay Dec 2018

Good Agricultural Practices Training For Limited-Resource Produce Growers And Extension Educators, Agnes Kilonzo-Nthenge, John C. Ricketts, Dharma Pitchay

Journal of Extension

We delivered to growers and Extension educators a workshop addressing good agricultural practices (GAP) for produce safety. To assess the workshop's effects as applicable to behavioral intervention theory, we studied past behaviors, behavioral intentions, and changes in knowledge. Workshop participants had been aware of but did not fully understand certain GAP, such as implementing written food safety plans; after the workshop, both groups reported improved understanding of various concepts. Producers were mixed regarding intent to make GAP-related changes after workshop participation, whereas the educators overall were likely to make changes related to teaching GAP. We concluded that producers need more …


Small Science: A Tool And Tips For Converting Food Science Demonstrations Into Public Inquiry Experiences, Catherine E. Vrentas, Thomas M. Zinnen Dec 2018

Small Science: A Tool And Tips For Converting Food Science Demonstrations Into Public Inquiry Experiences, Catherine E. Vrentas, Thomas M. Zinnen

Journal of Extension

Small-scale science activities provide an opportunity for engagement of diverse, large audiences at settings such as 4-H fairs. We present practical information for implementation of small-scale food science experiences in the Extension education context. Our focus is description of a tool for adaptation of activities for inquiry-based learning and tips for miniaturization of activities to save on costs and resources.


Development Of A Food Safety Training For A Prison Farm: Challenges And Solutions, Angela Shaw, Kara Helterbran Dec 2018

Development Of A Food Safety Training For A Prison Farm: Challenges And Solutions, Angela Shaw, Kara Helterbran

Journal of Extension

Workers on prison farms in the United States commonly grow produce and row crops and raise livestock. Teaching good agricultural practices to prisoners and prison staff increases the safety of the food produced and reduces the likelihood of an illness outbreak. We developed a food safety curriculum for use on prison farms in Iowa. In developing the curriculum, we encountered many challenges that resulted in modifications in the content and delivery method. We present the content of the curriculum and provide educators with a better understanding of challenges and potential solutions related to working with prison farms.


Food: A Multicomponent Local Food System Assessment Tool, Mark Uchanski, John Garlisch, J. Michael Patrick, Stephanie Walker Dec 2018

Food: A Multicomponent Local Food System Assessment Tool, Mark Uchanski, John Garlisch, J. Michael Patrick, Stephanie Walker

Journal of Extension

Our goal with this article is to present a visual aid and tool for assessing local food systems. We propose that local food systems comprise four essential components represented by the acronym FOOD: in(F)rastructure, pr(O1)duction, (O2)rganizations, and (D)emand. The FOOD assessment tool provides a visual overview of the statuses of these four essential components relative to a particular food system. It is also useful for comparing one food system to another or for tracking changes over time. Availability of the tool has important implications for U.S. Extension professionals across a variety of disciplines with regard to connecting individual components within …


The Potential Use Of Phytoestrogen Containing The Herb, Pueraria Mirifica, For Bone Healing In Osteoporotic Monkeys, Donlaporn Kittivanichkul, Nan Choisunirachon, Kumpanart Soontornvipart, Suchinda Malaivijitnond Dec 2018

The Potential Use Of Phytoestrogen Containing The Herb, Pueraria Mirifica, For Bone Healing In Osteoporotic Monkeys, Donlaporn Kittivanichkul, Nan Choisunirachon, Kumpanart Soontornvipart, Suchinda Malaivijitnond

The Thai Journal of Veterinary Medicine

Within the last decade, the positive effects of Pueraria mirifica on osteoporosis have been established in rats and monkeys. However, the effect of P. mirifica on bone healing has not been elucidated. In this study, post-menopausal osteoporotic monkeys were subjected to an iliac crest biopsy, divided into two groups (5 animals/group), and fed daily with standard monkey diet alone (PMP0 group) or mixed with 1,000 mg/kg body weight of P. mirifica powder (PMP1000 group) for 16 months. The progression of the bone healing was continuously assessed by X-ray radiography, and three individuals from each group were selected for a computed …


Effectiveness Of Sentinel Rodents For Surveillance Of Exposure To Undocumented Bacterial Pathogens In Animal Research Facility, Shih-Keng Loong, Haryanti-Azura Mohammad-Wali, Nurul-Asma-Anati Che-Mat-Seri, Nur-Hidayana Mahfodz, Dzuzaini Mohd-Ghazali, Pooi-Fong Wong, Sazaly Abubakar Dec 2018

Effectiveness Of Sentinel Rodents For Surveillance Of Exposure To Undocumented Bacterial Pathogens In Animal Research Facility, Shih-Keng Loong, Haryanti-Azura Mohammad-Wali, Nurul-Asma-Anati Che-Mat-Seri, Nur-Hidayana Mahfodz, Dzuzaini Mohd-Ghazali, Pooi-Fong Wong, Sazaly Abubakar

The Thai Journal of Veterinary Medicine

The use of sentinel animals in animal research facilities is the cornerstone of animal health monitoring for exposure to natural pathogens of laboratory animals. This is because infection with these pathogens produces no overt signs of disease yet the infection may affect the outcome of research utilising these animals. One of the important pathogens includes Klebsiella pneumoniae, whose prevalence can be high in laboratory animals. This study sought to document the prevalence of K. pneumoniae and other undocumented bacterial pathogens in laboratory rodents for a 3- year period. K. pneumoniae and Chryseobacterium gleum were isolated from sentinel ICR mice housed …


Estimation Of Knee Kinematics Using Non-Monotonic Nanocomposite High-Deflection Strain Gauges, Adin Douglas Martineau Dec 2018

Estimation Of Knee Kinematics Using Non-Monotonic Nanocomposite High-Deflection Strain Gauges, Adin Douglas Martineau

Theses and Dissertations

Human knee kinematics, especially during gait, are an important analysis tool. The current "gold standard" for kinematics measurement is a multi-camera, marker-based motion capture system with 3D position tracking. These systems are accurate but expensive and their use is limited to a confined laboratory environment. High deflection strain gauges (HDSG) are a novel class of sensors that have the potential to measure kinematics and can be inexpensive, low profile, and are not limited to measurements within a calibrated volume. However, many HDSG sensors can have a non-linear and non-monotonic response. This thesis explores using a nanocomposite HDSG sensor system for …


Optimization-Based Spatial Positioning And Energy Management For Unmanned Aerial Vehicles, Ronald Abraham Martin Dec 2018

Optimization-Based Spatial Positioning And Energy Management For Unmanned Aerial Vehicles, Ronald Abraham Martin

Theses and Dissertations

This research applies techniques from the field of optimization to spatial positioning and energy management in Unmanned Aerial Vehicles (UAVs). Two specific areas are treated: optimization of UAV view plans for 3D modeling of infrastructure, and trajectory optimization of solar powered high-altitude long-endurance (HALE) UAVs. Structure-from-Motion (SfM) is a computer vision technique for creating 3D models from 2D images. View planning is the process of planning image sets that will effectively model a given scene. First, a genetic algorithm based view planning approach is demonstrated. A novel terrain simulation environment is developed, and the algorithm is tested at multiple sites …


Military Working Dogs In The United States Armed Forces From World War I To Vietnam, Tristan J. Kelly Dec 2018

Military Working Dogs In The United States Armed Forces From World War I To Vietnam, Tristan J. Kelly

Boise State University Theses and Dissertations

At the beginning of World War I, the only military working dogs the United States owned were sled dogs. In comparison, European nations in World War I used canines as sentries, messengers, ambulance, and draft dogs. In 1942, members of the American public, created Dogs for Defense Inc. to help recruit dogs for military use. By the end of the Vietnam War, dogs no longer were donated by the American public for use, rather the American military owned the dogs they deployed.

This thesis examines the use of dogs by the American military from World War I to the Vietnam …


Mastering Mycological Mysteries With Explorations Of Harpellales Associated With Culicidae And Other Dipterans In Idaho, Michael Mccormick Dec 2018

Mastering Mycological Mysteries With Explorations Of Harpellales Associated With Culicidae And Other Dipterans In Idaho, Michael Mccormick

Boise State University Theses and Dissertations

Presented is the first field survey and laboratory-based study focused on Harpellales gut fungi found in Culicidae (mosquito) larvae collected from various parts of Idaho. Overall, 34 sites were sampled ranging from urban storm drains and irrigation puddles to pristine stream-side puddles. These sites yielded 17 different species of mosquitoes and three previously described species of gut fungi. Three species of mosquitoes were the first recorded observations as hosts of the following gut fungi: Culiseta alaskaensis was infested with Zancudomyces culisetae (from Renwyck Creek), Culex tarsalis with Smittium culicis (from Cottonwood Creek), and Ochleratus sp. with Smittium minutisporum (from Bear …


Resource Competition Among The Uinta Basin Fremont, Elizabeth A. Hora-Cook Dec 2018

Resource Competition Among The Uinta Basin Fremont, Elizabeth A. Hora-Cook

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Archaeologists describe the Uinta Fremont (A.D. 0 – 1300) as a mixed foraging-farming society that underwent a dramatic social change from A.D. 700 – 1000. Researchers observe through different architectural styles and subsistence activity a change from large, aggregated settlements to more dispersed and defensively oriented villages and hamlets. The Ideal Free Distribution (IFD) model provides an explanatory framework through which to interpret these changes. IFD predicts the order in which people or animals will occupy habitats based on a habitat’s relative suitability and suggests hypothetical behaviors that people or animals might engage in to improve or maintain the relative …


Toward Real-Time Flip Fluid Simulation Through Machine Learning Approximations, Javid Kennon Pack Dec 2018

Toward Real-Time Flip Fluid Simulation Through Machine Learning Approximations, Javid Kennon Pack

Theses and Dissertations

Fluids in computer generated imagery can add an impressive amount of realism to a scene, but are particularly time-consuming to simulate. In an attempt to run fluid simulations in real-time, recent efforts have attempted to simulate fluids by using machine learning techniques to approximate the movement of fluids. We explore utilizing machine learning to simulate fluids while also integrating the Fluid-Implicit-Particle (FLIP) simulation method into machine learning fluid simulation approaches.


Innate Immune Cell Phenotypes Are Dictated By Distinct Epigenetic Reprogramming, Kevin Douglas Adams Dec 2018

Innate Immune Cell Phenotypes Are Dictated By Distinct Epigenetic Reprogramming, Kevin Douglas Adams

Theses and Dissertations

The innate immune system is the first line of host defense against external exposures. During these initial encounters, antigen presenting cells - specifically monocytes and macrophages - modulate further inflammatory responses. Macrophages exist along a spectrum of phenotypic programs; on the inflammatory M1 end they enhance immune activity while on the anti-inflammatory M2 end they suppress further immune activation. Furthermore, within M2 macrophages there exist many subpopulations, namely M2a and M2d, each with specific roles during infection or exposure. We sought to compare the epigenetic profiles of these subpopulations of macrophages to determine key regulatory gene networks and factors that …