Digital Commons Network^™

Evolution And Mutations Predisposing To Daptomycin Resistance In Vancomycin-Resistant Enterococcus Faecium St736 Strains, Guiqing Wang, Weihua Huang, Abhay Dhand, Changhong Yin, Marisa Montecalvo, Nevenka Dimitrova, John T. Fallon

NYMC Faculty Publications

We recently identified a novel vancomycin-resistant Enterococcus faecium (VREfm) clone ST736 with reduced daptomycin susceptibility. The objectives of this study were to assess the population dynamics of local VREfm strains and genetic alterations predisposing to daptomycin resistance in VREfm ST736 strains. Multilocus sequence typing and single nucleotide variant data were derived from whole-genome sequencing of 250 E. faecium isolates from 1994-1995 (n = 43), 2009-2012 (n = 115) and 2013 (n = 92). A remarkable change was noticed in the clonality and antimicrobial resistance profiles of E. faecium strains between 1994-1995 and 2013. VREfm sequence type 17 (ST17), the prototype …

Art As Invitation: The Effects Of Including Art Education In The Curriculum Of A Preschool Classroom Of Refugee Students, Nancy Heckmann Erekson

Master's Theses

This study is about how art constitutes an invitation for marginalized people. Refugees are the uninvited, and often remain on the periphery of host communities. This research examines how artmaking acts as an invitation for refugee preschool students and their families to connect with the broader community. I approached data collection through the method of educational connoisseurship and educational criticism and the theory of relational aesthetics. I analyzed data from observations conducted in a refugee preschool classroom and from interviews with six families. Further, I analyzed observations and surveys from a public exhibit of children’s art. These sources provided data …

Vitality Of Water/Vitalidad Del Agua: Our Sacred Connection To Water And How We Can Interpret The Importance Of Water Through Artistic Inquiry, Jenifer Fogarty

Master's Theses

Water has appeared in the work and study of artists for centuries. There are countless aspects of water to be explored, from the sheer physical qualities of water to the spiritual, political, and practical associations with water. Water is what gives us life, and yet the vitality of this precious resource has been threatened over time. This exploration highlights important aspects of the study of water through art-making. My exploration began in the studio while making my own work. I sought to create a multi-sensory environment where viewers could participate and be immersed in the work itself. The site-specific installation …

Patterns Of Authorship In Ecology And Evolution: First, Last, And Corresponding Authorship Vary With Gender And Geography, Charles W. Fox, Josiah P. Ritchey, C. E. Timothy Paine

Entomology Faculty Publications

The position of an author on the byline of a paper affects the inferences readers make about their contributions to the research. We examine gender differences in authorship in the ecology literature using two datasets: submissions to six journals between 2010 and 2015 (regardless of whether they were accepted), and manuscripts published by 151 journals between 2009 and 2015. Women were less likely to be last (i.e., “senior”) authors (averaging ~23% across journals, years, and datasets) and sole authors (~24%), but more likely to be first author (~38%), relative to their overall frequency of authorship (~31%). However, the proportion of …

Sequential Inference For Hidden Markov Models, Michael Ellis

Graduate Theses and Dissertations

In many applications data are collected sequentially in time with very short time intervals between observations. If one is interested in using new observations as they arrive in time then non-sequential Bayesian inference methods, such as Markov Chain Monte Carlo (MCMC) sampling, can be too slow. Increasingly, state space models are being used to model nonlinear and non-Gaussian systems. The structure of state space models allows for sequential Bayesian inference so that an approximation to the posterior distribution of interest can be updated as new observations arrive. In special cases, the exact posterior distribution can be updated through conjugate Bayesian …

Genetic And Epigenetic Investigations On Pulmonary Hypertension Syndrome In Meat Type- Chickens, Khaloud Alzahrani

Graduate Theses and Dissertations

This dissertation presents a collection of studies that investigate the genetic and epigenetic associations to ascites phenotype in broiler chickens. Ascites is a significant metabolic disease associated with fast-growing meat-type chickens (broilers) and is a terminal result of pulmonary hypertension syndrome PHS. It is a multi-factorial syndrome caused by interactions between genetic, physiological, environmental, and managemental factors. It was estimated that ascites accounts for losses of about US$1 billion annually worldwide and for over 25% of broilers mortality. Although traditional and molecular genetic methods in the selection and in performance improvements, has greatly reduced ascites frequency, yet it has not …

Efficacy Of Antimicrobial Mitigation On Escherichia Coli Cfu And Growth And Development Of Hydroponic Leafy Greens, Nathan J. Eylands

Graduate Theses and Dissertations

The Food and Drug Administration (FDA) have set new standards that apply to agriculturalists producing crops eaten fresh and/or raw by consumers. This new produce safety rule, known as the Food Safety Modernization Act (FSMA), has established science-based standards for all areas of production in agriculture with regards to microbial contamination. Escherichia coli (E. coli) O157:H7 is a particular bacterium of concern under FSMA guidelines. Grower compliance is mandatory and therefore vital to the continuation of any farm. Greenhouse hydroponic growers have shown advantages in efficiency when compared to conventional farming methodology. Those, however, with recirculating hydroponic systems face unique …

The Grotesque Self: Finding Identity Through The Grotesque In The Works Of Carson Mccullers, Colton Greganti

Honors Theses

Historically speaking, the South has maintained rigid, male dominated constructions of gender, which have manifested themselves in almost every aspect of the southern individual’s actions, sense of self, and appearance. While much of southern culture has been centered on this rigid identity, the southern gothic literary tradition strays from this stark binary, especially in its depiction of female characters. Through the use of grotesque representations, these characters are able to form a unique identity and deviate from the phallocentric social norms, though it often comes at the cost of social alienation. However, even when tragedies strike these gothic heroines, their …

Characterization Of Microreactor And Analysis Of Carbonyl Compounds In Exhaled Breath., Qi Li

Electronic Theses and Dissertations

Analysis of trace volatile organic compounds at parts per billion (ppbv) to parts per trillion (pptv) level has become an important research frontier because of the applicability for environmental monitoring and noninvasive diagnosis of diseases. The methods of preconcentration for detection of trace aldehydes and ketones both in ambient air and human exhaled breath have increased considerably over the last decade. However, the majority of these methods are not efficient. In this dissertation, we have improved an innovative microreactor that is suitable for quantitative analysis of volatile carbonyl compounds (VOCs) in ambient air as well as in human exhaled breath. …

Effect Of Grape Components On Periodontal Disease., Juili Subodh Shivde

Electronic Theses and Dissertations

Background: Half of the adult American population (47 %) are victims of periodontitis, a chronic inflammatory disease which leads to destruction of the tissues supporting the tooth. Periodontitis is initiated by periodontal pathogens and caused by excessive or prolonged host mediated inflammation. Porphyromonas gingivalisis one important agent implicated in the etiopathogenesis of chronic periodontitis. Pro-inflammatory cytokines induced by periodontal pathogens can cause alveolar bone loss and periodontitis. Bone loss is caused by the imbalance of bone formation and bone resorption. Osteoclasts are major cells that cause bone resorption. Moreover, periodontal inflammation also leads to bone resorption. Grapes are rich …

The Role Of Aldehyde Dehygrogenase 2 In Liver Injury Caused By Vinyl Chloride And High-Fat Diet., Liya Chen

Electronic Theses and Dissertations

Background. Vinyl chloride (VC) is an abundant environmental contaminant that causes steatohepatitis at high exposure levels. We have shown previously that low concentrations of VC exacerbate high fat diet (HFD)-induced liver injury in mice. The mechanisms involved in the progression of liver injury caused by VC and HFD include oxidative stress, inflammation, metabolic and mitochondrial dysfunction. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) serves as a key line of defense against most reactive aldehydes, including lipid aldehydes (e.g., 4-HNE) and chloroacetaldehyde (VC metabolite). We hypothesize that this defense may play a key role in the interaction between HFD and VC in fatty …

Epidermal Growth Factor-Like Ligands Regulate Dimer Selection., Jamie S. Rush

Electronic Theses and Dissertations

There are thirteen known endogenous EGF-like ligands. We previously reported that Betacellulin (BTC) increases ligand-mediated corneal wound healing more than Epidermal Growth Factor (EGF) [Peterson et al. (2014) IOVS 55(5):2870-80], although the molecular reason for this is unknown. Despite being better at promoting wound healing via enhanced cell migration, BTC has reduced receptor affinity and weaker induction of EGFR phosphorylation. These data indicate that BTC’s response is not due to enhanced affinity or EGFR-kinase activity. Receptor phosphorylation and proximity ligation assays indicate that BTC treatment significantly increases ErbB3 phosphorylation and EGFR:ErbB3 heterodimers. BTC traffics EGFR at a faster rate than …

Particulate Hexavalent Chromium Does Not Induce Centrosome Amplification In Sperm Whale And Bowhead Whale Cells., Jennifer Haruka Toyoda

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] is a widespread environmental and occupational carcinogen. The mechanism of carcinogenesis remains poorly understood, but chromosome instability (CIN) is the dominant theory. How numerical CIN arises is unclear, but it correlates with centrosome amplification. Both phenotypes are hallmarks of cancers, early events in carcinogenesis, and have been shown to occur after Cr(VI) exposure to human skin and lung fibroblasts. In this study, we investigate numerical CIN and centrosome amplification in whale cells. Whales are our closest marine relatives, have long lifespans, and are exposed to environmental Cr(VI). Importantly, they have low cancer rates and cell culture studies …

Freedom Of Expression Or Freedom From Hate: A Canadian Perspective, Rosalie Silberman Abella

Cardozo Law Review

No abstract provided.

Motivations And Satisfaction Of North Dakota Deer Hunters During A Temporal Decline In Deer Populations, Kristen E. Black, William F. Jensen, Robert Newman, Jason Boulanger

Biology Faculty Publications

Achieving state wildlife agency biological goals for deer (Odocoileus spp.) management may often conflict with hunter desires. Concomitantly, better information is needed to optimize agency deer herd management goals with hunters’ social goals. In 2016, we surveyed 3,000 North Dakota, USA, resident deer hunters using a self-administered mail survey to gain a better understanding of motivations, satisfaction, and hunter demographics that may be used to inform hunter recruitment and retention (HRR) efforts during a period of reduced statewide deer populations. With deer-gun license availability strictly limited, we explored the possibility that some gun hunters may have been engaging …

Paying For Performance: Public School Property Taxes And Public-School District Performance In Missouri, Keenan Daniela Kinder

Dissertations

An increase in the property tax rate of a school district creates an increase in local revenues for the district (Missouri Department of Elementary and Secondary Education. [MODESE], 2017). The overarching question becomes: Do increases in the local tax levy compare to improved student performance? The purpose of this quantitative study was to examine the difference between property tax rates of Missouri public school districts to student performance as viewed through the lens of benefit tax theory (Duff, 2004). Secondary data were obtained via the MODESE which included property tax rates and information from the Annual Performance Reports for public …

Extension Fail, Elizabeth Colton

USU Student Folklore Fieldwork

Alex: Have you seen that one meme? Where the guy tries to plug that thing in to itself [points to extension cord, laughing] but wonders why it doesn’t work. and. that thing. over there. [stands up and walks to the extension cord, still laughing, untangling it from Christmas lights]

Sam: What are you…

Alex: Showing you the meme! [tries plugging it into itself, but is laughing so hard she has it upside down and fails. Finally, after multiple tries, plugs it in and holds it out for us to see].

Alex: [starts impersonating a big man]. Hmmm. It’s not working. …

Lapin The Trickster Rabbit, Susan Swan

USU Student Folklore Fieldwork

M: um can you tell me about Lapin? *pronnounces luh-PAN*

J: Lapin? [corrects pronunciation to *LAH-pan*] Uh yeah. Lapin is a trickster rabbit comes from Cajun or Creole southern, actually… actually trickster lapin comes from western Africa and the slaves that were brought to the united states from Africa brought their tradition of the trickster rabbit. So, you have Lapin and Brer rabbit and a couple other uh characters that are that kind of came out of that tradition. Bugs bunny maybe. Uh so Lapin we found lapin in a bookstore there in Logan in downtown Logan. We were walking …

Painted Ferocity: The Social Behaviors Of African Wild Dogs, Threats To Survival, And Resulting Conservation Initiatives, Alexis Valdes

Senior Honors Theses

African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the populations of their prey so that it does not become unhealthy and overgrown. Like many organisms, wild dogs are also in competition with other predators for resources, namely lions and hyenas, who are capable of stealing their kills and occasionally injuring and killing them. Due to the depletion of their wild prey, wild dogs may also prey …

A Phylogenetic Analysis Of Leptogorgia Virgulata And Leptogorgia Hebes In The Northwestern Gulf Of Mexico, Samantha Silvestri

Theses and Dissertations

The use of genetics in recent years has brought to light the need to reevaluate the classification of many gorgonian octocorals. In 2017, Poliseno et al. conducted a comprehensive, phylogenetic study of the genus Leptogorgia and found that it, too, was in need of taxonomic revision. To expand on their study, 25 samples representing two Leptogorgia species—L virgulata and L. hebes —from the northwestern Gulf of Mexico (GOM) were examined. Ten novel, complete mitochondrial genomes were sequenced using Next Generation sequencing and 24 novel mtMutS sequences were obtained from both species. The phylogenies reconstructed from these sequences indicate the …

Ros-Related Mitochondrial Dysfunction In Skeletal Muscle Of An Als Mouse Model During The Disease Progression, Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong Zhou

Faculty and Staff Publications

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93A/cpYFP) that carry human ALS mutation SOD1G93A and mt-cpYFP transgenes, in which mt-cpYFP detects dynamic changes of ROS-related mitoflash events at individual mitochondria level. Compared with wild type mice, mitoflash activity in the SOD1G93A (G93A) mouse muscle showed an increased flashing frequency prior to the onset of ALS symptom (at the age of 2 months), whereas …

Irisin Protects Heart Against Ischemia-Reperfusion Injury Through A Sod2-Dependent Mitochondria Mechanism, Zhen Wang, Ken Chen, Yu Han, Hua Zhu, Xinyu Zhou, Tao Tan, Jing Zeng, Jun Zhang, Yukai Liu, Yu Li, Yonggang Yao, Jianxun Yi, Duofen He, Jingsong Zhou, Jianjie Ma, Chunyu Zeng

Faculty and Staff Publications

Irisin, a muscle-origin protein derived from the extracellular domain of the fibronectin domain-containing 5 protein (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test the hypothesis that irisin contributes to cardioprotection after myocardial infarction by preserving mitochondrial function in cardiomyocytes. Animal model studies show that intravenous administration of exogenous irisin produces dose-dependent protection against ischemia/reperfusion (I/R)-induced injury to the heart as reflected by the improvement of left ventricular ejection fraction and the reduction in serum level of cTnI (n = 15, P < 0.05). I/R-induced apoptosis of cardiomyocytes is reduced after irisin treatment. The irisin-mediated protection has, at least in part, an effect on mitochondrial function because administration of irisin increases irisin staining in the mitochondria of the infarct area. Irisin also reduces I/R-induced oxidative stress as determined by mitochondrial membrane potential evaluation and superoxide FLASH event recording (n = 4, P < 0.05). The interaction between irisin and superoxide dismutase2 (SOD2) plays a key role in the protective process because irisin treatment increases SOD activity (n = 10, P < 0.05) and restores the mitochondria localization of SOD2 in cardiomyocytes (n = 5, P < 0.05). These results demonstrate that irisin plays a protective role against I/R injury to the heart. Targeting the action of irisin in mitochondria presents a novel therapeutic intervention for myocardial infarction.

Aquatic Invasions: Causes, Consequences, And Solutions, Corey Ackerson, Melissa Carmichael, Olivia Carpenter, Hannah Crull, Jillian Henrichon, Maeve Mcgowan, Allison Mills, Nicholas Paolini, Everett Pierce, Nicole Scherer, Nicole Volosin, Kady Winsor, Markus Frederich

Marine Sciences Student Projects

Invasive species represent a global threat to ecosystems, human health, and the economy. A basic knowledge of invasive species biology is crucial to understand current and future impacts and implications. The purpose of this book is to provide a broad background on invasive species, and also details on specific examples through case studies.

The students in the course Aquatic Invasive Species (MAR 442) at the University of New England in Biddeford, Maine, have researched and reviewed scientific literature to educate readers about these issues. The class, comprised of twelve junior and senior Marine Science, Marine Affairs, Applied Mathematics, and Environmental …

Diversity And Inclusion As Essential Elements Of 4-H Youth Development Programs, Rachel Sumner, Andy Turner, Anthony Burrow

Journal of Youth Development

Diversity and inclusion are essential elements of 4-H’s goals related to positive youth development, workforce development, and organizational sustainability. Previous research has examined Cooperative Extension professionals’ attitudes on this topic, demonstrating that most of them recognize the importance of diversity and inclusion in 4-H. Here we present results from a survey of adolescents participating in New York state 4-H programs assessing their endorsement of racial/ethnic diversity and inclusion in 4-H. Results revealed that, overall, youth felt positively toward this kind of diversity and inclusion in 4-H, and endorsement was most strongly predicted by a learning orientation that emphasizes acquiring new …

'Like Pushkin, I': Hugh Macdiarmid And Russia, Patrick Crotty

Studies in Scottish Literature

A detailed discussion of the poetic development of the Scottish poet Hugh MacDiamid (1892-1978), drawing on research for the forthcoming Complete Collected Poems of Hugh MacDiarmid to chart the changing ways in which he encountered, read, and responded to Russian writing, philosophy and culture in different phases of his career.

Understanding Consumer Attitudes Towards Antimicrobial Risk Reducing Practices, Sabrina Gulab

Department of Agricultural Economics: Dissertations, Theses, and Student Research

The emergence and spread of antimicrobial resistance is a natural evolutionary reaction to antimicrobial exposure. However, the misuse and overuse of antimicrobial drugs in human medicine and in agriculture are speeding up the process. Antimicrobials have been used in food-producing animals for therapeutic purposes as well as to promote growth by applying low concentrations in animal feed. Antimicrobial resistant pathogens can enter the food chain through food containing residues of antibiotic-resistant bacteria and cause infections in humans. In the United States, millions of people are infected every year with antimicrobial resistant bacterial diseases causing approximately 23,000 deaths (CDC 2013). This …

Soil Health Effects And Stakeholder Perceptions Of Manure And Woody Biomass Application To Cropland In Nebraska, Linda R. Schott

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Organic products that have historically been viewed as waste products may improve soil health by adding carbon (C) and nutrients to soil. Two such products are woodchips, generated from forest or rangeland management activities, and livestock manure. In Nebraska, eastern redcedar (Juniperus virginiana L.) is a native but invasive tree species inhibiting rangeland productivity. Livestock manure that is underutilized while inorganic fertilizers are imported for crop production presents a water quality risk by contributing to local- and regional-scale nutrient imbalances. Increasing the responsible use of livestock manure in crop fertility programs to improve sustainability of both livestock and crop farms …

A Plausible Resolution To Hilbert’S Failed Attempt To Unify Gravitation & Electromagnetism, Florentin Smarandache, Victor Christianto, Robert Neil Boyd

Branch Mathematics and Statistics Faculty and Staff Publications

In this paper, we explore the reasons why Hilbert’s axiomatic program to unify gravitation theory and electromagnetism failed and outline a plausible resolution of this problem. The latter is based on Gödel’s incompleteness theorem and Newton’s aether stream model.

Montclair Magazine (Fall/Winter 2018), Montclair State University

Montclair: The magazine of Montclair State University

No abstract provided.

Direct And Indirect Effects Of Invasive Cirsium Arvense On Pollination In Southern Appalachian Floral Communities, Jesse Daniels

Electronic Theses and Dissertations

Invasive plants can alter pollination dynamics in invaded communities by disrupting patterns of pollinator visitation, pollen transfer dynamics (conspecific [CP] and heterospecific [HP]), and reproductive success. The direction of invasive effects (competitive, neutral, and facilitative) may be partially determined by spatial scale and species’ floral traits. Here, we investigated pollinator visitation, CP and HP receipt, and pollen tube growth for species in a C. arvense present community and non-present community at two scales. At the community-level, the effect of C. arvense on pollinator visitation varied among species. Floral symmetry seemed to explain this variation. At the floral neighborhood-level, we found …