Digital Commons Network^™

Hla-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared To Hla-Bw4-T-80 And Hla-A-Bw4 Isoforms In Rituximab Or Dinutuximab-Based Cancer Immunotherapy, Amy Erbe, Wei Wang, Patrick Reville, Lakeesha Carmichael, Kyungmann Kim, Mehmet F. Ozkaynak, Paul Sondel

NYMC Faculty Publications

Killer-cell immunoglobulin-like receptors (KIRs) are a family of glycoproteins expressed primarily on natural killer cells that can regulate their function. Inhibitory KIRs recognize MHC class I molecules (KIR-ligands) as ligands. We have reported associations of KIRs and KIR-ligands for patients in two monoclonal antibody (mAb)-based trials: (1) A Children's Oncology Group (COG) trial for children with high-risk neuroblastoma randomized to immunotherapy treatment with dinutuximab (anti-GD2 mAb) + GM-CSF + IL-2 + isotretinion or to treatment with isotretinoin alone and (2) An Eastern Cooperative Oncology Group (ECOG) trial for adults with low-tumor burden follicular lymphoma responding to an induction course of …

Characteristics Of Hiv-Infected Children At Enrollment Into Care And At Antiretroviral Therapy Initiation In Central Africa, A Adedimeji, A Edmonds, Donald R. Hoover, Qiuhu Shi, J Sinayobye, M Nduwimana, P Lelo, D Nash, K Anastos, M Yotebieng

NYMC Faculty Publications

BACKGROUND: Despite the World Health Organization (WHO) regularly updating guidelines to recommend earlier initiation of antiretroviral therapy (ART) in children, timely enrollment into care and initiation of ART in sub-Saharan Africa in children lags behind that of adults. The impact of implementing increasingly less restrictive ART guidelines on ART initiation in Central Africa has not been described. MATERIALS AND METHODS: Data are from the Central Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) pediatric cohort of 3,426 children (0-15 years) entering HIV care at 15 sites in Burundi, DRC, and Rwanda. Measures include CD4 count, WHO clinical stage, age, and …

Pipeline Embolization Device As Primary Treatment For Cervical Internal Carotid Artery Pseudoaneurysms, Arthur Wang, Justin Santarelli, Michael Stiefel

NYMC Faculty Publications

BACKGROUND: Limited data exists on the durability and occlusion rate of treating extracranial cervical internal carotid artery pseudoaneurysms using the pipeline embolization device (PED) flow-diverting stent. METHODS: Three patients presenting with dissecting cervical internal carotid artery pseudoaneurysms were treated with the PED as the sole treatment modality. RESULTS: In all three patients, successful aneurysmal occlusion and parent vessel reconstruction occurred on immediate angiography and continued on 6-month follow-up. No immediate or delayed complications were seen, and all patients remained neurologically intact. CONCLUSION: Complete aneurysmal occlusion and long-term angiographic occlusion can occur after PED treatment of cervical carotid pseudoaneurysms. In select …

Anti-Proliferative Role Of Recombinant Lethal Toxin Of Bacillus Anthracis On Primary Mammary Ductal Carcinoma Cells Revealing Its Therapeutic Potential, Rekha Khandia, Bramhadev Pattnaik, Katherikamem Rajukumar, Atul Pateriya, Sandeep Bhatia, Harshad Murugkar, Anil Prakash, Hare Krishna Pradhan, Kildeep Dhama, Ashol Munjal, Sunil K. Joshi

Bioelectrics Publications

Bacillus anthracis secretes three secretary proteins; lethal factor (LF), protective antigen (PA) and edema factor (EF). The LF has ability to check proliferation of mammary tumors, chiefly depending on mitogen activated protein kinase (MAPK) signaling pathway. Evaluation of therapeutic potential of recombinant LF (rLF), recombinant PA (rPA) and lethal toxin (rLF + rPA = LeTx) on the primary mammary ductal carcinoma cells revealed significant (p < 0.01) reduction in proliferation of tumor cells with mean inhibition indices of 28.0 ±1.37% and 19.6 ± 1.47% respectively. However, treatment with rPA alone had no significant anti-proliferative effect as evident by low mean inhibition index of 3.4 ± 3.87%. The higher inhibition index observed for rLF alone as compared to LeTx is contrary to the existing knowledge on LF, which explains the requirement of PA dependent endocytosis for its enzymatic activity. Therefore, the plausible existence of PA independent mode of action of LF including direct receptor mediated endocytosis or modulation of signal transduction cascade via unknown means is hypothesized. In silico protein docking analysis of other cellular receptors for any plausibility to play the role of receptor for LF revealed c-Met receptor showing strongest affinity for LF (H bond = 19; Free energy = …

Pd-1, Pd-L1 (B7-H1) And Tumor-Site Immune Modulation Therapy: The Historical Perspective, J Wang, R Yuan, W Song, J Sun, Delong Liu, Z Li

NYMC Faculty Publications

The current success of targeted inhibition against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1/Programmed Death Ligand 1 (PD-1/PD-L1, herein collectively referred to as PD) pathways is hailed as a cancer immunotherapy breakthrough. PD-L1, known also as B7 homolog 1 (B7-H1), was initially discovered by Dr. Lieping Chen in 1999. To recognize the seminal contributions by Chen to the development of PD-directed therapy against cancer, the Chinese American Hematologist and Oncologist Network (CAHON) decided to honor him with its inaugural Lifetime Achievement Award in Hematology and Oncology at the CAHON's 2015 annual meeting. This essay chronicles the important discoveries …

Hispanic Use Of Alternative Medicine As Demonstrated In Internet Searches, Elad Yom-Tov, William F. Strong, Lupita Rodriguez Strong

Communication Faculty Publications

Objective: We investigated how cultural shifts occur with respect to the use of traditional medicine for influenza-like illness (ILI) within the Latino population near the US-Mexico border.

Methods: We extracted searches of ILI treatments (modern, traditional western, and traditional Hispanic) to the Bing search engine from 5 US states near the US-Mexico border. The incidence of these searches was correlated with county-level demographic data and ILI incidence.

Results: The fraction of queries related to Hispanic medicines is correlated with the distance from the US-Mexico border (Spearman rho = -0.24), which is a slower decay than that observed in the use …

Vicarious Windfalls, Justin Sevier

Scholarly Publications

The vicarious liability doctrine, which holds third parties responsible for the legal obligations of their duly authorized agents, was designed in part to ensure that tort victims are not undercompensated by insolvent agent wrongdoers. But many legal scholars are highly critical of the doctrine and suggest that fact finders’ systematic biases-particularly with respect to corporate third parties-cause unworthy tort plaintiffs to be overcompensated at the expense of innocent, deep-pocket corporate defendants. These scholars have offered little empirical evidence for these claims and, in fact, behavioral research suggests that their predictions are incorrect.

This Article introduces the concept of the vicarious …

Proponents' Standing To Defend Their Ballot Initiatives: Post-Hollingsworth Work-Arounds?, Nat Stern, John S. Caragozian

Scholarly Publications

No abstract provided.

The Uncertain Case For Appraisal Arbitrage, Jay B. Kesten

Scholarly Publications

No abstract provided.

School Killers Speak: A Comprehensive Examination Of Traditional School Violence Perpetrators In K-12 American Schools, Gordon A. Crews

Criminal Justice Faculty Publications

No abstract provided.

Beren And Luthien, By J.R.R. Tolkien, Edited By Christopher Tolkien. Reviewed By Ryder W. Miller., Ryder W. Miller

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

I Stole You: Stories From The Fae, By Kristen Ringman. Reviewed By M. Sturtevant., M. Sturtevant

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Six Degrees Of Freedom: Kinematics Of The Healthy Ankle Syndesmosis Joint, Veronica A. Hogg-Cornejo

Electronic Theses and Dissertations

Syndesmotic injury, more commonly known as a "high ankle sprain", accounts for over 12% of all ankle sprain incidents in the US; of which, over 25% occur during a sporting activity. Typically, harm to the syndesmosis occurs in sports such as football, soccer, lacrosse, and hockey where it is common for an athlete to experience rapid and extreme dorsiflexion-external rotations of the foot. Severe syndesmotic sprains have been noted by clinicians as the most difficult ankle injury to accurately diagnose and treat, require the most recuperation time, and often results in life-long dysfunction. Even more problematic, 40% of patients suffering …

Improved Characterization And Analysis Strategies For Uv-Lif Bioaerosol Instrumentation: Lab And Field Application, Nicole Justine Savage

Electronic Theses and Dissertations

Atmospheric particles of biological origin, also referred to as bioaerosols or primary biological aerosol particles (PBAP), are important to various human health and environmental systems. There has been a recent steep increase in the frequency of published studies utilizing commercial instrumentation based on ultraviolet laser/light-induced fluorescence (UV-LIF), such as the WIBS (wideband integrated bioaerosol sensor), for bioaerosol detection both outdoors and in the built environment. Significant work over several decades supported the development of these technologies, but efforts to systematically characterize the operation of new commercial sensors has remained lacking. Specifically, there are gaps in the understanding of how different …

Earning A Seat At The Table: How It Departments Can Partner In Organizational Change And Innovation, Robert L. Moore, Nathan Johnson

STEMPS Faculty Publications

Few would argue that the information technology department (ITD) is not an essential part of an organization. It is hard to envision a project that does not need the support of the ITD. Despite this importance, the ITD is not always involved in the management of projects. Often, the ITD is brought into the project late in the planning and development process. In many cases, the inclusion of the ITD in an advanced project stage can result in project failure where early involvement could have prevented it. Why is it that ITDs, while clearly a vital part of project implementation, …

Shifting Ethnic Identities In Spain And Gaul, 500-700: From Romans To Goths And Franks, Erica Buchberger

History Faculty Publications

Traditional scholarship on post-Roman western culture has tended to examine the ethnic identities of Goths, Franks, and similar groups while neglecting the Romans themselves, in part because modern scholars have viewed the concept of being Roman as one denoting primarily a cultural or legal affiliation. As this book demonstrates, however, early medieval 'Romanness' also encompassed a sense of belonging to an ethnic group, which allowed Romans in Iberia and Gaul to adopt Gothic or Frankish identities in a more nuanced manner than has been previously acknowledged in the literature.

Human Services Students Preferences For Master's Level Training, Tammi F. Dice, Mark C. Rehfuss

Counseling & Human Services Faculty Publications

Human Services students close to graduation are seeking employment in the field, but many are also considering their future career paths and the training needed to reach their long-term career goals. Knowing if bachelor's level students desire graduate degrees, which focus they prefer, and how they would like to pursue the degrees may contribute to the decision-making of educators, employers, and students. This exploratory study, therefore, examined human services students' preferences for master's level training. Students' responses reflected preferences for several types of master's programs, direct acceptance, and online delivery. These themes and their implications for educators, employers, and students …

Barriers To Counseling Among Human Service Professionals: The Development And Validation Of The Fit, Stigma, & Value Scale, Edward S. Neukrug, Michael T. Kalkbrenner, Sandy-Ann M. Griffith

Counseling & Human Services Faculty Publications

This study sought to confirm rates of attendance in counseling of human service professionals and validate a 32-item questionnaire designed to identify barriers to counseling seeking behavior among this population. Results indicated that a large percentage of human service professionals attend counseling, with males and females attending at similar rates and non-Caucasians attending at lower rates. A multivariate analysis of variance and descriptive statistics identified the most common barriers to attendance in counseling and examined demographic differences in participants’ sensitivity towards barriers to attendance in counseling. A Principal Factor Analysis (PFA) revealed three subscales (fit, value, and stigma), which we …

Human Service Students' And Professionals' Knowledge And Experiences Of Interprofessionalism: Implications For Education, Kaprea F. Johnson, Narketta Sparkman-Key, Michael T. Kalkbrenner

Counseling & Human Services Faculty Publications

Interprofessionalism is an approach to delivering optimal client care in which providers from multiple professions work collaboratively on care teams. Human Service Professionals (HSPs) are generalists who frequently work together with professionals in related fields. The purpose of this study was to investigate the extent to which HSPs and helping professionals in related fields have engaged in interprofessional experiences. Researchers also investigated the impact that having previous interprofessional experiences had on participants' perceptions of interprofessionalism. Results revealed that professionals and students who had previous interprofessional experiences were significantly more likely to have positive perceptions about interprofessional cooperation. However, results also …

Professional Standards: Embracing Preventive Ethics In Human Services, Chaniece Winfield, Narketta Sparkman-Key, Anthony Vajda

Counseling & Human Services Faculty Publications

Recent updates to the National Organization for Human Services Code of Ethics create an opportunity for further recognition within the field. The next logical step to recognition is the adoption of the concept of preventive ethics, in which ethical codes set the tone for the development of grievance procedures and agency level policies. Fostering an environment of preventive ethics within the human services profession will further establish awareness and recognition within the field. This discussion provides support for the development of a grievance process through the conceptual lens of preventive ethics and suggests a framework for the development of a …

Expert Supervisors' Priorities When Working With Easy And Challenging Supervisees, Gulsah Kemer, L. Dianne Borders, Nedim Yel

Counseling & Human Services Faculty Publications

Using Kemer, Borders, and Willse's ( 2014) concept map as a conceptual model, the authors aimed to understand expert supervisors' priorities with their easy and challenging supervisees. Experts' priorities with easy and challenging supervisees were represented in different parts of the concept map, and they seemed to individualize their work with challenging supervisees.

Black And Latino Fathers Of Students With Autism: Culturally Responsive Support, Michael D. Hannon, Kaprea F. Johnson, Nicole A. Christian, Lachan V. Hannon

Counseling & Human Services Faculty Publications

Perspectives from five Black and Latino fathers of students with autism are shared from this qualitative pilot study. The fathers were asked to describe the most helpful forms of support from school counselors. One-time, semi-structured interviews were conducted and interpreted with the thematic analysis method. Results suggest support from other parents, and specifically from other fathers, with shared experiences is most helpful. Recommendations for school counseling practice and research are shared.

Creative And Novel Approaches To Empathy, Edward Neukrug

Counseling & Human Services Faculty Publications

[Introduction] Near the end of Carl Rogers' life, he wrote a scathing article noting that his conceptualization of empathy had little to do with the popularized notion of empathy that had become known as "reflection of feelings." He may have been particularly angry because there were some apocryphal stories circulating about Rogers' work with clients. One of them goes something like this:

Rogers is seeing a client in his office on the 10th floor of a building. The client tells Rogers that he is really depressed, and Rogers says, "Sounds like you're really depressed." The client goes on to say …

Mandates Of Maternity At A Science Museum, From Should To Must, David H. Lee

Publications and Research

A pregnancy exhibit at a science museum is an opportunity to research how medical advice is communicated and interpreted. This paper is about the Beginning of Life area of an exhibition called The Amazing You at the Tampa Museum of Science and Industry, where exhibits are prescriptive as well as descriptive. Expectant women are urged to deliver full-term, normal birthweight babies, by behaving according to prescribed medical norms. This study provides ethnographic descriptions of the exhibits, as well as insights from museum visitors who were interviewed. The exhibits, which emphasize fetal rights and maternal duties, are interpreted and critiqued by …

Mapping Student Days: Collaborative Ethnography And The Student Experience, Andrew Asher, Jean Amaral, Juliann Couture, Barbara Fister, Donna Lanclos, M. Sara Lowe, Mariana Regalado, Maura A. Smale

Publications and Research

Research on students’ educational experiences demonstrates the importance of a holistic understanding of the complexity of students’ lives in developing library programs, services, and resources that effectively address undergraduate needs. The “A Day in the Life” (ADITL) Project investigated a typical day for over 200 students at eight diverse higher education institutions in the US. Examining the local and individual expressions of student taskscapes – the ensemble of interrelated social activities across time and space – placed each student’s relationship to their library in a larger description of their academic and personal lives. By exploring the whole student experience, this …

Saving The Physics Ii: Who Needs To Be Saved? It Depends On Your Metaphysics, Menas Kafatos

Mathematics, Physics, and Computer Science Faculty Articles and Research

Physics does not need to be saved. If anything, physics was rescued in the early twentieth century with the advancement of both the theories of relativity and quantum mechanics. What needs to be saved is our world outlook or metaphysics because how a society acts and develops depends on what its belief systems are. Here we explore how a new metaphysics where consciousness is fundamental might just be what modern societies need.

Adaptive Orthonormal Systems For Matrix-Valued Functions, Daniel Alpay, Fabrizio Colombo, Tao Qian, Irene Sabadini, Tao Qian

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper we consider functions in the Hardy space Hp×q2 defined in the unit disc of matrix-valued. We show that it is possible, as in the scalar case, to decompose those functions as linear combinations of suitably modified matrix-valued Blaschke product, in an adaptive way. The procedure is based on a generalization to the matrix-valued case of the maximum selection principle which involves not only selections of suitable points in the unit disc but also suitable orthogonal projections. We show that the maximum selection principle gives rise to a convergent algorithm. Finally, we discuss the case of real-valued signals.

Gamifying Quantum Theory, Matthew S. Leifer

Mathematics, Physics, and Computer Science Faculty Articles and Research

"Over the past few years, the trend of gamification has gradually seeped into quantum research, education and outreach, so that we now have a critical mass of games based on quantum mechanics. I thought the time was right to discuss quantum gamification at the APS March meeting[.]"

Review Of Qbism: The Future Of Quantum Physics, Matthew S. Leifer

Mathematics, Physics, and Computer Science Faculty Articles and Research

A review of QBism: The Future of Quantum Physics by Hans Christian von Baeyer.

Piece By Piece Review Of Digitize-And-Lend Projects Through The Lens Of Copyright And Fair Use, Michelle M. Wu

Georgetown Law Faculty Publications and Other Works

Digitize-and-lend library projects can benefit societies in multiple ways, from providing information to people in remote areas, to reducing duplication of effort in digitization, to providing access to people with disabilities. Such projects contemplate not just digitizing library titles for regular patron use, but also allowing the digitized versions to be used for interlibrary loan (ILL), sharing within consortia, and replacing print copies at other libraries. Many of these functions are already supported within the analog world (e.g., ILL), and the digitize-and-lend concept is largely a logical outgrowth of technology, much like the transitioning from manual hand duplication of books …