Digital Commons Network^™

The Dual Faces Of Misery, Arden Moscati

Theses and Dissertations

Major Depression (MD) and Generalized Anxiety Disorder (GAD) are psychiatric disorders that arise from dysfunction of the core human capacities for emotion. Sapience is inextricably bound up with the potential for feelings of regret, worry and concern. When these emotions lead to clinically significant impairment or distress, they may result in one or both of the disorders of MD and GAD. The occurrence of MD and GAD in the same person, known as comorbidity, is remarkably high; substantially higher than would be expected by chance.

MD and GAD have been studied since the mid-20^th century, resulting in a substantial …

Zebrafish (Danio Rerio) As A Model For Orofacial Research, Kevin A. Ghaffari

Theses and Dissertations

Across species, the face and more specifically the mouth, serves as an essential facet of everyday life. Amongst humans the mouth serves as a tool for the ingestion of food, a marker for facial recognition and a medium for communication. In order for the mouth to properly form, a series of precise growth and fusion events are needed. In order to insure that these events are orchestrated properly is a wide array of signals, transcription factors and epigenetic regulators. Due to the needed precision of these events, congenital birth defects of the face such as cleft lip and cleft palate …

The Monstrous Self: Negotiating The Boundary Of The Abject, Katya Yakubov

Theses and Dissertations

Through the lens of the horror film and the fairy tale, this thesis explores the notion of the grotesque as a boundary phenomenon—a negotiation of what is self and what is other. As such, it locates the function that the monstrous and the grotesque have in the formation of a personal and social identity. In asking why we take pleasure in the perverse, I explore how permutations of guilt, victimhood, and desire can be actively rewritten, in order to construct a stable sense of self.

The Fractured Memory Of A Mind’S Eye, Russell G. White

Theses and Dissertations

The work I create is informed by questioning reality/identity, the fractalizing planes

of existence our essence occupies, and the artifacts of memory experience navigating

through space time. While existing in this realm of oversaturated media and neon

glow, I question the effects of pervasive data systems overloading or programming the

mental software we possess. My work includes humor as a means of exploring these

conventions while also displaying psychedelic surrealist imagery to help break away

from the conscious prison this existence births our concept apparatuses within.

Construction Of An Album For Oneself, Maria Tinaut

Theses and Dissertations

My work focuses on the construction and validation of images assembled from fragments of found photographs, generating new narratives that hover between “reality” and fiction. Archive and Fiction: Construction of the past and the self is the result of two years of artwork exploring my family archives and my relationship to my family through them. I understand the family as a place of identity in continuous change, serving as a container of history and memory. Conceiving of my family albums as material allows me to approach my family history as a visitor. Mediated memory and constructed memory intertwine in the …

Adventures Close To Home, Ryan Syrell

Theses and Dissertations

My work articulates experiences of intimacy and porosity with regard to domestic space. I think of these paintings as fields of interrelatedness which work to dismantle the perceived thresholds between things. The following text brings together the research of my studio practice and a survey of artists, writers, and filmmakers who have charted related spaces of the ordinary, domestic, and porous.

Altering A Runner’S Foot Strike Using A Modified Elliptical Trainer, Daniel Shull

Theses and Dissertations

One possible solution to common running related injuries is to transition runners from a rearfoot strike during initial contact to a midfoot strike. Natural rearfoot strike runners were studied to see if a modified elliptical trainer could be used to alter their running pattern to that of a midfoot strike runner. Their results were compared to subjects who ran on a non-modified elliptical trainer. After training on the modified elliptical trainer, subjects demonstrated a decrease in foot angle at initial contact when attempting to run with a midfoot strike. Training did not affect all kinetic metrics or stride frequency. However, …

Positions Of Place: Converging Viewpoints In Visual Communication, Gregory J. Schmidt

Theses and Dissertations

This thesis includes a body of work that explores our visual relationship to the physical spaces and places we inhabit in our everyday lives. Today we live in a complex world where we are bombarded with fragments of information and inundated with distractions. As designers, we are equipped with tools and methods that allow us to experience and interpret our environment through multi-faceted perspectives and from different viewpoints. My approach to graphic design adopts techniques and practices from a mix of different disciplines. The work focuses on a design process that alternates between the parallel depiction of first-person and third-person …

A Dull Soldier And A Keen Guest: Stumbling Through The Falstaffiad One Drink At A Time, Emma Givens

Theses and Dissertations

Theatre history has long interwoven with the production, consumption, and peddling of alcohol. While the seedier aspects of our past generally go unremembered, we can find traces of them in the culture of the times. If we read Shakespeare through the lens of drinking culture, what can we discover about the play and what can that tell us about how to produce his works today? By looking at the rules and customs surrounding alehouses during the English Renaissance I have analyzed the three plays contained within the Falstaffiad (1 Henry IV, 2 Henry IV, and Merry Wives …

Spooky Action At A Distance, Jonathan A. Rehwoldt

Theses and Dissertations

The question posed is “Can I experience remote human intimacy?” This is only posed after a network of computer code, images and entities have worked through the studio apparatus. These objects only materialize after khaos, the gap, the chasm has been recognized and a remote position has been realized. The work is about examining this constellation of objects and processes in their aspiration to answer the stated question in the affirmative. The resulting presentation is an experience of the failures and illuminations of both the material and the work.

Nature Nurtures, Moriah Rhodes

Theses and Dissertations

Richmond, Virginia is defined by our connection to the James River. The James River Park system stretches over 550 acres of natural beauty. The park is broken into 14 different sections from the Huguenot Bridge in the west to a half mile beyond the I-95 Bridge in the east. The James River includes water features that appeal to the young and curious to the most experienced river-adventurer. The James River Park System boasts idyllic shorelines, peaceful meadows, and miles of challenging hiking and biking trails that appeal to the community and guests alike. Every year thousands of people come to …

Wiped Clean, Elizabeth H. Hunter

Theses and Dissertations

It seems that all forms of pain, quotidian and monumental, are catalogued in the same muted and inaccessible space in our memory. In my installation Wiped Clean, I question whether human capacity to externalize physical trauma is aided by a the physical design of our institutions. I examine the architectures and structural mechanisms that mediate traumatic and intimate experiences with our bodies, and explore the potential of self-formation within these conditions.

The Japanese Experience In Virginia, 1900s-1950s: Jim Crow To Internment, Emma T. Ito

Theses and Dissertations

This thesis addresses how Japanese and Japanese Americans may have lived and been perceived in Virginia from 1900s through the 1950s. This work focuses on their positions in society with comparisons to the nation, particularly during the “Jim Crow” era of “colored” and “white,” and after the bombing of Pearl Harbor in 1941. It highlights various means of understanding their positions in Virginia society, with emphasis on Japanese visitors, marriages of Japanese in Virginia, and the inclusion of Japanese in higher education at Roanoke College, Randolph-Macon College, William and Mary, University of Virginia, University of Richmond, Hampden-Sydney College, and Union …

Biochemical Analysis Of Putative Single-Stranded Nucleic Acid Binding Proteins In Porphyromonas Gingivalis, Steve H. Kokorelis

Theses and Dissertations

Proteins that bind to both DNA and RNA embody the ability to perform multiple functions by a single gene product. These nucleic acid binding proteins in prokaryotes can play a vital role in many cellular processes, including replication, transcription, gene expression, recombination, and repair, to name a few. Nucleic acid binding proteins have unique functional characteristics that stem from their structural attributes that have evolved in a widely-conserved manner. In Escherichia coli (E. coli), the highly-conserved histone-like protein, HU, which predominates as a heterodimer of HUα and HUβ, has been found to bind to both dsDNA and ssDNA. …

Nanocomposite Bioelectronics For Biopotential Enabled Prosthesis, Dong Sup Lee

Theses and Dissertations

Soft material-enabled electronics can demonstrate extreme mechanical flexibility and stretchability. Such compliant, comfortable electronics allow continuous, long-term measurement of biopotentials on the skin. Manufacturing of the stretchable electronic devices is enabled by the recent development combining materials transfer printing and microfabrication. However, the existing method using inorganic materials and multi-layered polymers requires long material preparation time and expensive processing cost due to the requirement of microfabrication tools and complicated transfer printing steps. Here, this study develops a new fabrication method of soft electronics via a micro-replica-molding technique, which allows fast production, multiple use, and low cost by avoiding microfabrication and …

The Role Of Mindfulness In The Regulation Of Behavior Among Those Prone To Negative Urgency, Alexandra M. Martelli

Theses and Dissertations

Negative emotions can be challenging to regulate, and for some individuals can lead to failures of behavior regulation. The present study is an initial effort to explore the role that mindfulness may play in fostering effective behavior regulation among those prone to high negative urgency (NU). Eighty undergraduate students were recruited based on their high or low scores of NU. First, participants completed a self-report measure of mindfulness (Mindful Attention Awareness Scale; MAAS), an Emotional Go/No Go task in an fMRI scanner, and then reported alcohol consumption. Results showed that those with high in NU had low levels of mindfulness …

Sound Perception:Encapsulating Intangible Voice Memories In A Physical Memento, Mona Mahmoud Makhlouf

Theses and Dissertations

We live in a very busy world with a variety of sensory stimulation including the olfactory, visual, tactile, and auditory. The five senses are triggered by our surroundings and help us to form meaning about the world.ⅰ Based on where someone grows up, she or he is introduced to various sites and sounds, affecting how they interpret the world. Sounds relate meaning through the association between hearing, memory and an event. Hearing is one of the learning processes, in which individuals give, receive, and store information. We typically rely on our five senses, which contribute to the process of understanding, …

Characterizing The Role Of Key Planar Cell Polarity Pathway Components In Axon Guidance, Grayland W. Godfrey Ii

Theses and Dissertations

An essential process to the development of the neural network of the nervous system is axon guidance. The noncanonical Wnt/Planar Cell Polarity pathway has been identified as an integral component in controlling the projection of axons during axon guidance. Prickle, ROR1 and ROR2 are PCP related proteins that do not have clearly defined roles in the process. This study aims to use zebrafish CoPA neurons as a model to study the roles of Prickle, ROR1, and ROR2 in axon guidance. Using in situ hybridization, morpholino knockdown, and CRISPR/Cas9 loss of function experiments were able to identify ror1, ror2 and …

Quantitative Analysis And Process Of High Speed Live Cell Interferometry Measurements, Daniel Guest

Theses and Dissertations

The application of auto focus, using an optical beam deflection technique, to existing live cell interferometry measurements was developed and examined. The benefit to relevant experiments, currently being performed, is shown as well as its performance across various magnifications. Enough information is given so that the system can be reproduced to fit any end users needs.

Niche Conservatism Or Divergence: Insights Into The Evolutionary Histories Of Pinus Taeda, Pinus Rigida, And Pinus Pungens, Constance E. Bolte

Theses and Dissertations

Environmentally related selective pressures and community interactions are well-documented drivers for niche differentiation, as natural selection acts on adaptive traits best fit for survival. Here, we investigated niche evolution between and within Pinus taeda, Pinus rigida, and Pinus pungens and sought to identify which climate variables contributed to species divergence. We also sought to describe niche differentiation across genetic groupings previously identified for P. taeda and P. rigida. Ecological niche models were produced using Maximum Entropy followed by statistical testing based on a measure of niche overlap, Schoener’s D. Both niche conservatism and niche divergence were …

Effect Of Charged Species On The Gradient Properties, Kayesh Ashraf

Theses and Dissertations

Surface chemical gradients are materials that exhibit continuous, gradually varying chemical or physical properties along and across the length of a substrate. As a result, each point on the gradient surface can represent an individual sample. They are broadly classified as chemical and physical gradients depending upon the properties that the gradient exhibits. A physical gradient involves a continuous variation of physical properties such as surface roughness and film porosity on the micrometer scale. Chemical gradients involve a gradual variation of chemical properties such as polarity, acidity and basicity, etc. Such gradients have found various applications in cell adhesion, nanoparticle …

Re-Exploring My Identity As A Japanese Woman, Fumi Amano

Theses and Dissertations

This document contains reflections on my motivations and the personal decisions made in the realization of selected works leading up to and including my thesis exhibition "Voice". The following text shares the many and varied connections between my life and art-making. My issues in my personal relationships with others has spilled out from my heart and turned into these works. I'm continuously expressing the unsuccessful attempts we make at developing true bonds that bridge the gaps between people.

Combining Noxa-Inducing Drugs With Abt-263 To Efficiently Increase Cell Death In Head And Neck Squamous Cell Carcinoma (Hnscc), Sung Woo Kim

Theses and Dissertations

Head and neck cancer is the sixth leading cancer worldwide. Head and neck squamous cell carcinoma (HNSCC) accounts for more than 90% of incident cases. Despite intense, multimodality treatment regimens for HNSCC including surgery, chemotherapy, and radiation, little progress has been made over the past 30 years in improving overall survival rates. Tumor cell death induced by both conventional and targeted chemotherapy is often mediated by the BCL-2 family-dependent mitochondrial apoptotic pathway. However, initiators of this apoptotic pathway, such as p53, are more than 50% of the time mutated or deleted in HNSCC rendering the disease refractory to treatment. To …

Hydrogen Peroxide And Pharmacological Agent Modulation Of Trpv2 Channel Gating, Tuoxin Cao

Theses and Dissertations

Transient receptor potential vanilloid 2 channel (TRPV2) is a Ca²⁺-permeable ion channel that is highly expressed in leukocytes but is also present in skeletal and cardiac muscle and endocrine cells. The TRPV2 function is implicated in a number of physiological processes, including bacterial phagocytosis, pro-inflammatory cytokine production, cardiac hypertrophy, and cancer development. TRPV2 knockout mice exhibit a high incidence of perinatal mortality, arguing that the channel plays essential roles in physiology. Despite the importance of TRPV2 for normal homeostasis, the mechanisms that control TRPV2 gating in response to pharmacological agonists, heating, membrane stretch, bioactive lipids and reactive oxygen …

Sustainable Adapted Treatments For Eating Disorders: The Role Of Cultural Adaptation In Prevention, Sarah J. Javier

Theses and Dissertations

Despite demonstrating eating disorder rates equivalent to White women, African American and Asian American women are less likely to seek treatment and are more likely to terminate treatment prematurely. One of the most successful programs for eating disorder prevention has only focused on surface-level cultural adaptations. Prevention literature maintains that deep-structure cultural adaptation (e.g., integrating cultural values and beliefs) can enhance outcomes for ethnic minorities. This dissertation examined the feasibility of Sustainable Adapted Treatments for Eating Disorders (SATED), a pilot intervention that included a culturally- targeted pre-treatment to an eating disorder dissonance-based intervention. A sample of 72 women (ages 18-30) …

Negotiating Desire: Resisting, Reimagining And Reinscribing Normalized Sexuality And Gender In Fan Fiction, Charity A. Fowler

Theses and Dissertations

Fan studies has examined how fan fiction resists heteronormativity by challenging depictions of gender and sexuality, but to date, this inquiry has focused disproportionately on slash, to the exclusion of other genres of fan fiction. Additionally, scholars disagree about slash’s subversive effects by setting up a seemingly stable dichotomy—subversive vs. misogynistic—where one does not necessarily exist.

In this project, I examine multiple genres of fan fiction—namely, slash arising from bromances; femslash from female friendships; incestuous fan fiction from dysfunctional familial relationships; and polyamorous fics. I chose fics from four televisions shows—NBC’s Revolution, MTV’s Teen Wolf, the CW’s The …

Tissue Factor Expression, Regulation, And Signaling In Human Airway Cells, Michael D. Davis

Theses and Dissertations

Rationale: Tissue Factor (TF) is a transmembrane glycoprotein that canonically functions as the initiator of the coagulation cascade. Increased levels of TF have been associated with inflammatory airway diseases. Since lipopolysaccharide (LPS) is known to elicit and inflammatory response in airway epithelium, we hypothesized that airway epithelial cells release TF when exposed to LPS. Since TF aids in local wound healing, we also hypothesized that inhibition of TF would decrease NHBE growth. The specific aim of this work was to evaluate the effects of LPS exposure on TF production and release from airway epithelia and determine the signaling pathways involved. …

Short-Term Effects Of Nutrients On A Barrier Island Grassland Community, Ashley Moulton

Theses and Dissertations

Increased nutrient availability globally has the potential to affect community functional composition of plants in nutrient limited environments, such as coastal grassland systems. Stability of these systems are threatened worldwide by urbanization, as well as effects of sea level rise and increased frequency and intensity of storms, and atmospheric N deposition, associated with climate change. Annual net primary productivity (ANPP), species composition, and functional traits (community weighted specific leaf area (CWSLA), leaf area index (LAI), growth form and photosynthetic pathway) were measured across four treatments to assess multiple resource limitation of nitrogen (N) and phosphorus (P) and functional community response …

Sleep Disturbances And Depression: The Role Of Genes And Trauma, Mackenzie J. Lind

Theses and Dissertations

Sleep disturbances and insomnia are prevalent, with around 33% of adults indicating that they experience at least one main symptom of insomnia, and bidirectional relationships exist with common psychopathology, particularly major depressive disorder (MDD). However, genetic and environmental (e.g., traumatic event exposure) contributions to the etiology of these phenotypes are not yet well understood. A genetically informative sample of approximately 12,000 Han Chinese women aged 30-60 (50% with recurrent MDD) was used to address several gaps within the sleep literature. Sleep disturbances were assessed in all individuals using a general item addressing sleeplessness (GS). A sleep within depression sum score …

Protective Factors In The Association Between Child Sexual Abuse And Telomere Length In Adults, David Sosnowski

Theses and Dissertations

The purpose of the present study was to examine if childhood sexual abuse (CSA) was associated with decreases in mean telomere length (TL), and if social support and/or optimism moderated this association. The study included 99 Caucasian female monozygotic twins, ranging in age from 19-48 (M_age = 30.5, SD = 7.8) at Time 1. Linear mixed effects models were employed to test study hypotheses. Analyses with all participants did not detect an effect of CSA exposure or severity on mean TL, nor were there effects with optimism. However, in analyses that only included women exposed to abuse, increases …