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2017

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Gridded Snow Water Equivalent Reconstruction For Utah Using Forest Inventory And Analysis Tree-Ring Data, Daniel Barandiaran, Shih-Yu (Simon) Wang, R. Justin Derose Jan 2017

Gridded Snow Water Equivalent Reconstruction For Utah Using Forest Inventory And Analysis Tree-Ring Data, Daniel Barandiaran, Shih-Yu (Simon) Wang, R. Justin Derose

Plants, Soils, and Climate Faculty Publications

Snowpack observations in the Intermountain West are sparse and short, making them difficult for use in depicting past variability and extremes. This study presents a reconstruction of April 1 snow water equivalent (SWE) for the period of 1850–1989 using increment cores collected by the U.S. Forest Service, Interior West Forest Inventory and Analysis program (FIA). In the state of Utah, SWE was reconstructed for 38 snow course locations using a combination of standardized tree-ring indices derived from both FIA increment cores and publicly available tree-ring chronologies. These individual reconstructions were then interpolated to a 4-km grid using an objective analysis …

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Co-Existence Of Bovine Viral Diarrhea And Border Disease Viruses In A Sheep Flock Suffering From Abortus And Diarrhea, Peli̇n Tuncer Göktuna, Gi̇zem Alpay, Eda Baldan Öner, Kadi̇r Yeşi̇lbağ Jan 2017

Co-Existence Of Bovine Viral Diarrhea And Border Disease Viruses In A Sheep Flock Suffering From Abortus And Diarrhea, Peli̇n Tuncer Göktuna, Gi̇zem Alpay, Eda Baldan Öner, Kadi̇r Yeşi̇lbağ

Turkish Journal of Veterinary & Animal Sciences

Pestivirus infections have a huge economic impact on livestock production. In 2014, an aborted fetus from a sheep flock suffering from abortus and diarrhea was submitted for virological diagnosis. Due to the positive result of the sample for pestivirus and continuing clinical symptoms in the flock, all of the animals were sampled individually. Blood samples for serum and peripheral blood mononuclear cells were collected from 93 animals (5 rams, 26 lambs, and 62 sheep). During sampling 1 ocular and 4 rectal swab samples were obtained from lambs that had a clinical eye problem and diarrhea, respectively. Additionally 5 aborted fetuses …

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Design Of Probiotic Dry Fermented Sausage (Sucuk) Production Withmicroencapsulated And Free Cells Of Lactobacillus Rhamnosus, Emel Ünal, Zerri̇n Ergi̇nkaya, Süleyman Polat, Emi̇r Ayşe Özer Jan 2017

Design Of Probiotic Dry Fermented Sausage (Sucuk) Production Withmicroencapsulated And Free Cells Of Lactobacillus Rhamnosus, Emel Ünal, Zerri̇n Ergi̇nkaya, Süleyman Polat, Emi̇r Ayşe Özer

Turkish Journal of Veterinary & Animal Sciences

The present study was performed to design sucuk production with microencapsulated and free cells of Lactobacillus rhamnosus and to investigate the effect of this production method on probiotic viability and quality characteristics on the final product. L. rhamnosus was microencapsulated with an optimal coating material combination by using response surface methodology and subsequently used in sucuk production as a probiotic culture. Microencapsulation protected L. rhamnosus against gastric and other stress conditions in sucuk composition. Sucuk production with microencapsulated L. rhamnosus was found to be similar to traditional sucuk in terms of textural, physicochemical, and sensorial properties. Novel sucuk production was …

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Fascia Lata Flap To Repair Perineal Hernia In Dogs: A Preliminary Study, Simone Guérios, Juliana Monteiro, Daniella Matos Da Silva Jan 2017

Fascia Lata Flap To Repair Perineal Hernia In Dogs: A Preliminary Study, Simone Guérios, Juliana Monteiro, Daniella Matos Da Silva

Turkish Journal of Veterinary & Animal Sciences

Perineal hernia (PH) in dogs normally requires surgical reconstruction of the pelvic diaphragm. The use of fascia lata grafts has been reported and described in previous studies for the correction of PH after failure of the conventional herniorrhaphy. The purpose of this report is to describe a modified technique of fascia lata flap (FLP) for PH repair in dogs. Six client-owned male dogs with PH were included in the study. PH was repaired with a FLP obtained from the dog's ipsilateral thigh and sutured directly into the perineal defect. Caudal scrotal orchiectomy was performed in all dogs that were not …

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Efficacy Of Repeatedly Used Cidr Device In Cattle Reproduction: A Metaanalysisreview Of Progesterone Concentration And Conception Rate, Muhammad Furqan Asghar Chacher, Armağan Çolak, Armağan Hayirli Jan 2017

Efficacy Of Repeatedly Used Cidr Device In Cattle Reproduction: A Metaanalysisreview Of Progesterone Concentration And Conception Rate, Muhammad Furqan Asghar Chacher, Armağan Çolak, Armağan Hayirli

Turkish Journal of Veterinary & Animal Sciences

n order to reduce estrus synchronization cost, utilization of residual progesterone (P4) in the used controlled internal drug release (CIDR) device upon sanitization can be possible. Two datasets were compiled from 8 and 7 research articles involving 3434 (2653 heifers + 771 lactating cows + 10 ovariectomized cows) and 7301 cattle (3879 heifers + 3422 lactating cows) to evaluate blood P4 concentration and conception rate, respectively, in response to repeatedly used CIDR devices after sanitization via autoclaving and disinfection. As the number of CIDR usages increased, blood P4 concentration decreased linearly (y = -0.484X + 3.135, R2 = 0.99, P < 0.001). Blood P4 concentration (1.52 vs. 2.20 ng/mL; P < 0.002) and conception rate (40.76 vs. 32.96%, P < 0.05) for lactating cows were lower than those for heifers. The sanitization method did not affect blood P4 concentration, but reused CIDR device subjected to disinfection was associated with reduced conception rate. In summary, depending upon the initial P4 load (1.38-1.90 g), the CIDR device could be used twice in lactating cows and four times in heifers after autoclaving to achieve target blood P4 concentrations.

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Comparison Of The Isolation And Inhibition Abilities Ofselective Media Used For Brucella Spp. Isolation, Mustafa Sencer Karagül, Serkan İki̇z Jan 2017

Comparison Of The Isolation And Inhibition Abilities Ofselective Media Used For Brucella Spp. Isolation, Mustafa Sencer Karagül, Serkan İki̇z

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to compare and contrast the isolation ability of selective media developed for Brucella spp. isolation and their inhibition ability against contaminant microorganisms. Fifty-one field strains biotyped from abortion case samples and 25 Brucella spp. negative organ samples were used. Strain suspensions and organ suspensions were prepared separately. The turbidity of the strain suspensions was measured via spectrophotometer. The bacterial density of the strain suspensions was prepared in such a way that the suspensions would have different turbidity values. Inoculation into Farrell, Agrifood Research and Technology Center of Aragon, Jones & Morgan, and Modified Thayer …

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Development Of Multiplex Rt-Pcr For Detection And Differentiationof Foot-And-Mouth Disease Virus O And A Serotypes In Turkey, Beyhan Sareyyüpoğlu, İbrahi̇m Burgu Jan 2017

Development Of Multiplex Rt-Pcr For Detection And Differentiationof Foot-And-Mouth Disease Virus O And A Serotypes In Turkey, Beyhan Sareyyüpoğlu, İbrahi̇m Burgu

Turkish Journal of Veterinary & Animal Sciences

In this study, a two-step multiplex reverse transcription-polymerase chain reaction (mRT-PCR) was developed and evaluated using designed primers for the simultaneous detection and differentiation of Turkish foot-and-mouth disease virus (FMDV) serotypes A and O from clinical samples. In the method, a mix of one universal reverse primer designed from the 2B gene and two serotype-specific forward primers designed from the hypervariable regions of the capsid VP1-1D coding gene of FMDV were used. Totally, 272 FMDV-infected samples collected between 2006 and 2008 constituted the material of the study. mRT-PCR was compared to ELISA in terms of positivity percentage (%) and the …

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Our Gift To All Of Us: Ga(Y)Am: Preface, Frank Loesche, Klara ?Ucznik Jan 2017

Our Gift To All Of Us: Ga(Y)Am: Preface, Frank Loesche, Klara ?Ucznik

More Faculty of Arts, Humanities and Business Research

This special issue of AVANT is all about Cognitive Innovation. It is not about CogNovo, the interdisciplinary and international doctoral training programme that produced three different Off the Lip events. It is not about Off the Lip 2017, the novel sympo

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Comparative Review Of Education Doctorates In Three Countries.., M East, Eb Hajdukova, Me Carr, Wh Evans, G Hornby Jan 2017

Comparative Review Of Education Doctorates In Three Countries.., M East, Eb Hajdukova, Me Carr, Wh Evans, G Hornby

More Faculty of Arts, Humanities and Business Research

No abstract provided.

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The Csnp Scanning And Expression Analysis Of The Duck Fth1 Gene, Yu Zhang, Yiyu Tong, Yang Chen, Zhengyang Huang, Zhen Zhu, Yang Zhang, Qi Xu, Guohong Chen Jan 2017

The Csnp Scanning And Expression Analysis Of The Duck Fth1 Gene, Yu Zhang, Yiyu Tong, Yang Chen, Zhengyang Huang, Zhen Zhu, Yang Zhang, Qi Xu, Guohong Chen

Turkish Journal of Veterinary & Animal Sciences

Ferritin, heavy polypeptide 1 (FTH1) is a kind of ferritin complex that catalyzes the conversion of Fe(II) into Fe(III) to protect the cell from oxidative damage. Recent research has shown that FTH1 is also associated with several disease-related processes, such as inflammation and tumor progression and so on. In this study, the coding sequence (CDS) of FTH1 in Jinding ducks was cloned. The CDS sequence revealed an open reading frame of 546 nucleotides encoding a protein with 181 amino acids. Based on this sequence, the duck FTH1 protein is predicted to have conserved domains typical of eukaryotic ferritin. Only one …

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A Survey Of Ixodid Ticks Feeding On Cattle And Molecular Detectionof Coxiella Burnetii From Ticks In Southeast Iran, Omid Ghashghaei, Saeid Reza Nourollahi Fard, Mohammad Khalili, Hamid Sharifi Jan 2017

A Survey Of Ixodid Ticks Feeding On Cattle And Molecular Detectionof Coxiella Burnetii From Ticks In Southeast Iran, Omid Ghashghaei, Saeid Reza Nourollahi Fard, Mohammad Khalili, Hamid Sharifi

Turkish Journal of Veterinary & Animal Sciences

Ticks are the main hematophagous arthropods and obligatory ectoparasites that are considered a vector of serious pathogens for animals and humans. The aims of the present survey were to assess the prevalence and diversity of ticks in cattle in Southeast Iran and to determine Coxiella burnetii in the ticks. From May 2014 to April 2015, 583 ticks were collected randomly from 257 cattle. Nested trans-PCR was performed to detect C. burnetii. The overall prevalence of hard tick infestation on cattle was 56.8%. In total, seven different species were identified: Rhipicephalus sanguineus sensu lato (32.6%), Hyalomma anatolicum (28.8%), Hyalomma excavatum (19%), …

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Immunohistochemical Expression Of Surfactant Apoproteins In Pneumonic Ovine Lungs, Enver Beytut Jan 2017

Immunohistochemical Expression Of Surfactant Apoproteins In Pneumonic Ovine Lungs, Enver Beytut

Turkish Journal of Veterinary & Animal Sciences

The present study was undertaken to investigate the immunohistochemical expression of pulmonary surfactant proteins (SP-A, SP-B, proSP-C) associated with proliferating cell nuclear antigen (PCNA), thyroid transcription factor-I (TTF-I), and lymphocytic phenotypes (CD3+ T and CD79αcy+ B cells) in ovine lungs with exudative and verminous pneumonia. Pneumonic lungs (n = 50) were classified as presenting fibrinous bronchopneumonia (n = 16), abscessing necrotic bronchopneumonia (n = 10), verminous pneumonia (n = 15), and interstitial pneumonia (n = 9). The lungs with fibrinous bronchopneumonia displayed consolidation of lobes with adhesion to surrounding tissues. The lungs with verminous pneumonia were characterized by lungworm sections …

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Hematological Effects Of Etomidate And Tricaine In Common Carp, Malgorzata Witeska, Beata Teodorczuk, Katarzyna Lugowska Jan 2017

Hematological Effects Of Etomidate And Tricaine In Common Carp, Malgorzata Witeska, Beata Teodorczuk, Katarzyna Lugowska

Turkish Journal of Veterinary & Animal Sciences

Hematological effects of etomidate and tricaine at concentrations causing general anesthesia or sedation of carp juveniles were compared. Recovery of body balance took similar time in the case of both anesthetics, but fish treated with etomidate were depressed for several hours, while those subjected to tricaine immediately regained normal behavior. Immediately after exposure anesthetics caused minor hematological changes; the only statistically significant effects (decrease of hematocrit and plasma glucose) occurred after sedation with etomidate. One week after exposure a significant increase in mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration occurred in all groups of fish compared to the previous …

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Influence Of Dietary Vitamin D3 Supplementation On The Color Changes In Longissimus Lumborum, Vastus Lateralis, Semitendinosus, And Semimembranosus Beef Muscles, Urszula Karolina Rafalska Jan 2017

Influence Of Dietary Vitamin D3 Supplementation On The Color Changes In Longissimus Lumborum, Vastus Lateralis, Semitendinosus, And Semimembranosus Beef Muscles, Urszula Karolina Rafalska

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the effect of dietary vitamin D3 supplementation on changes in color and heme pigment (myoglobin and metmyoglobin) in 4 beef muscles. The muscles came from 48 crossbred bulls that were subjected to supplementation with vitamin D3 at 4 different doses: 0.0 (control group), 3.5, 7.0, and 10.0 x 106 IU. The 3.5 x 106 IU dose was administered daily for 6 days, before the morning feeding. Four days before slaughter, the supplementation was withdrawn. The dose of 7.0 and 10.0 x 106 IU was administered for 3 days and withdrawn 7 days …

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Radiographic Examination Of Hip Joint Geometry In Healthy Sivas Kangal Dogs, Murat Sarierler, Zeynep Bozkan Tatli, İbrahi̇m Akin, Rahi̇me Yaygingül, Onur Özgün Deri̇ncegöz Jan 2017

Radiographic Examination Of Hip Joint Geometry In Healthy Sivas Kangal Dogs, Murat Sarierler, Zeynep Bozkan Tatli, İbrahi̇m Akin, Rahi̇me Yaygingül, Onur Özgün Deri̇ncegöz

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the normal ranges of proximal femoral and acetabular parameters in 26 adult healthy Sivas Kangal dogs (SKDs). Significant differences were observed between the sexes in hip axis length (HAL) of 8.03 ± 0.82 cm and 7.47 ± 0.40 cm, femoral neck axis length-a (FNALa) of 6.40 ± 0.55 cm and 6.09 ± 0.27 cm, FNALb of 5.09 ± 0.47 cm and 4.78 ± 0.31 cm, acetabular width (AW) of 1.62 ± 0.35 cm and 1.37 ± 0.24 cm, femoral shaft diameter (FSD) of 3.11 ± 0.31 cm and 2.88 ± 0.21 cm, …

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Originalism And Level Of Generality, Peter J. Smith Jan 2017

Originalism And Level Of Generality, Peter J. Smith

GW Law Faculty Publications & Other Works

Even if one concedes that the meaning of the Constitution today is its original meaning, at what level of generality should one seek that meaning? In considering whether bans on same-sex marriage violate the Fourteenth Amendment, for example, should we seek to determine how the framers of the Amendment would have answered that question, or should we instead seek to discern the broad principle — perhaps “equality” or “no caste-like discrimination” — that the Amendment objectively incorporated, even if application of that principle today might produce results that the framers would not have anticipated? The level of generality at which …

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Awareness As A First Step Toward Overcoming Implicit Bias, Cynthia Lee Jan 2017

Awareness As A First Step Toward Overcoming Implicit Bias, Cynthia Lee

GW Law Faculty Publications & Other Works

In this book chapter, Cynthia Lee explains that raising awareness of implicit bias is a necessary first step toward eliminating such bias. Lee discusses various ways legal actors can raise awareness about implicit bias, including implicit bias trainings and jury instructions attempting to educate jurors about implicit bias. She concludes that making racial bias (or other types of bias) salient is probably the most effective way to raise awareness of implicit bias in the courtroom setting and discusses the social science literature that supports this conclusion. In light of some studies suggesting that making bias salient may backfire, she suggests …

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Properly Funding The Copyright Office: The Case For Significantly Differentiated Fees, Robert Brauneis Jan 2017

Properly Funding The Copyright Office: The Case For Significantly Differentiated Fees, Robert Brauneis

GW Law Faculty Publications & Other Works

The United States Copyright Office performs a variety of functions crucial to the copyright system. Through its core registration and recordation functions, it provides critical information about the authorship, ownership, and copyright status of millions of works of authorship created over the last century; it also advises Congress, other federal agencies, and the courts on copyright law; conducts studies on various aspects of copyright law; participates in international meetings; produces educational programs and publications; and engages in many other activities relating to the administration of copyright law. However, the Copyright Office is seriously underfunded, compromising all of its functions. The …

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Impression Products, Inc. V. Lexmark International, Inc.: A Glib Rebuke Of The Federal Circuit, Andrew Michaels Jan 2017

Impression Products, Inc. V. Lexmark International, Inc.: A Glib Rebuke Of The Federal Circuit, Andrew Michaels

GW Law Faculty Publications & Other Works

While the result of the Supreme Court's decision in Impression Products is defensible, the opinion's lack of sophistication makes the case seem easier than it was, unnecessarily sowing the seeds of potential future confusion.

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Presidential Politics And Judicial Review, Robert L. Glicksman, David Aldeman Jan 2017

Presidential Politics And Judicial Review, Robert L. Glicksman, David Aldeman

GW Law Faculty Publications & Other Works

This Article assesses the impact of judicial review on one of the nation’s foundational environmental statutes, the National Environmental Policy Act (NEPA). Based on litigation spanning fifteen years, we find that the stringency of judicial review is driven by the interaction of judicial ideology and presidential politics. Our principal findings are two-fold: First, judicial ideology, here defined by political party affiliation, is most influential when NEPA’s environmental goals conflict with the politics of the presidential administration in power. Second, the influence of judicial ideology is mediated by the distribution of cases across federal circuits and the ideological balance of judges …

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Exploring The Meaning Of Experiential Deaning, Margaret Martin Barry, Robert Dinerstein, Phyllis Goldfarb, Peggy Maisel, Linda Morton Jan 2017

Exploring The Meaning Of Experiential Deaning, Margaret Martin Barry, Robert Dinerstein, Phyllis Goldfarb, Peggy Maisel, Linda Morton

GW Law Faculty Publications & Other Works

This article explores the position of associate dean of experiential education in law schools across the country and the central role associate deans play in the changing landscape of legal education. Experiential deans have broad responsibility for overseeing law schools’ experiential education programs. Additional responsibilities differ between institutions, but range from leading efforts to comply with new ABA standards to overseeing the integration of experiential education into the broader curriculum. Analyzing survey data collected from associate experiential deans across the country, the authors find the structure, content, and authority of the position is under-developed. The authors make recommendations on how …

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Directv, Inc. V. Imburgia And The Continued Ascendance Of Federal Common Law: Class-Action Waivers And Mandatory Arbitration Under The Federal Arbitration Act, Michael J. Yelnosky Jan 2017

Directv, Inc. V. Imburgia And The Continued Ascendance Of Federal Common Law: Class-Action Waivers And Mandatory Arbitration Under The Federal Arbitration Act, Michael J. Yelnosky

Roger Williams University Law Review

No abstract provided.

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Franchise Tax Board Of California V. Hyatt: A Split Court, Full Faith And Credit, And Federal Common Law, Jonathan M. Gutoff Jan 2017

Franchise Tax Board Of California V. Hyatt: A Split Court, Full Faith And Credit, And Federal Common Law, Jonathan M. Gutoff

Roger Williams University Law Review

No abstract provided.

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How Adverse Outcome Pathways Can Aid The Development And Use Of Computational Prediction Models For Regulatory Toxicology, Clemens Wittwehr, Hristo Aladjov, Gerald Ankley, Hugh Byrne, Joop Deknecht Jan 2017

How Adverse Outcome Pathways Can Aid The Development And Use Of Computational Prediction Models For Regulatory Toxicology, Clemens Wittwehr, Hristo Aladjov, Gerald Ankley, Hugh Byrne, Joop Deknecht

Articles

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic understanding. The adverse outcome pathway (AOP) framework provides a systematic approach for organizing knowledge that may support such inference. Likewise, computational models of biological systems at various scales provide another means and platform to integrate current biological understanding to facilitate inference and extrapolation. We argue that the systematic organization of knowledge into AOP frameworks can inform and …

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Synthesis And Characterization Of A Multifunctional Gold-Doxorubicin Nanoparticle System For Ph Triggered Intracellular Anti-Cancer Drug Release, Ghanesh Khutale, Alan Casey Jan 2017

Synthesis And Characterization Of A Multifunctional Gold-Doxorubicin Nanoparticle System For Ph Triggered Intracellular Anti-Cancer Drug Release, Ghanesh Khutale, Alan Casey

Articles

A nanoparticle drug carrier system has been developed to alter the cellular uptake and chemotherapeutic performance of an available chemotherapeutic drug. The system comprises of a multifunctional gold nanoparticle based drug delivery system (Au-PEG-PAMAM-DOX) as a novel platform for intracellular delivery of doxorubicin (DOX). Spherical gold nanoparticles were synthesized by a gold chloride reduction, stabilized with thiolated polyethylene glycol (PEG) and then covalently coupled with a polyamidoamine (PAMAM) G4 dendrimer. Further, conjugation of an anti-cancer drug doxorubicin to the dendrimer via amide bond resulted in Au-PEG-PAMAM-DOX drug delivery system. Acellular drug release studies proved that DOX released from Au-PEG-PAMAM-DOX at …

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In Vitro Comparative Cytotoxicity Study Of Aminated Polystyrene, Zinc Oxide And Silver Nanoparticles On A Cervical Cancer Cell Line, Akash Sharma, Brian Gorey, Alan Casey Jan 2017

In Vitro Comparative Cytotoxicity Study Of Aminated Polystyrene, Zinc Oxide And Silver Nanoparticles On A Cervical Cancer Cell Line, Akash Sharma, Brian Gorey, Alan Casey

Articles

Nanoparticles use in nano-biotechnology applications have increased significantly with Aminated polystyrene amine (AmPs NP), Zinc oxide (ZnO NP), and Silver (Ag NP) nanoparticles utilized in wide variety of consumer products. This has presented a number of concerns due to their increased exposure risks and associated toxicity on living systems. Changes in the structural and physicochemical properties of nanoparticles can lead to changes in biological activities. This study investigates, compares, and contrasts the potential toxicity of AmPs, ZnO and Ag NPs on an in vitro model (HeLa cells) and assesses the associated mechanism for their corresponding cytotoxicity relative to the surface …

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Carbon Nanomaterials And Their Application To Electrochemical Sensors: A Review, Aoife Power, Shaneel Chandra, Brian Gorey, James Chapman Jan 2017

Carbon Nanomaterials And Their Application To Electrochemical Sensors: A Review, Aoife Power, Shaneel Chandra, Brian Gorey, James Chapman

Articles

Carbon has long been applied as an electrochemical sensing interface owing to its unique electrochemical properties. Moreover, recent advances in material design and synthesis, particularly nanomaterials, has produced robust electrochemical sensing systems that display superior analytical performance. Carbon nanotubes (CNTs) are one of the most extensively studied nanostructures because of their unique properties. In terms of electroanalysis, the ability of CNTs to augment the electrochemical reactivity of important biomolecules and promote electron transfer reactions of proteins is of particular interest. The remarkable sensitivity of CNTs to changes in surface conductivity due to the presence of adsorbates permits their application as …

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Biofunctionalized Capillary Flow Channel Platform Integrated With 3d Nanostructured Matrix To Capture Circulating Tumor Cells, Shashwat Banerjee, Ganesh Khutale, Vrushali Khobragade, Narendra Kale, Milind Pore, Govind Chate, Archana Jalota-Badhwar, Manoj Dongare, Jayant Khandare Jan 2017

Biofunctionalized Capillary Flow Channel Platform Integrated With 3d Nanostructured Matrix To Capture Circulating Tumor Cells, Shashwat Banerjee, Ganesh Khutale, Vrushali Khobragade, Narendra Kale, Milind Pore, Govind Chate, Archana Jalota-Badhwar, Manoj Dongare, Jayant Khandare

Articles

Circulating tumor cells (CTCs) from peripheral blood account genetic information for cancer diagnosis and overall disease monitoring. Analysis of “liquid biopsy” holds immense promise as it may lead to new approaches for cancer treatment. The study reports effective and continuous flow microchannel system for isolating CTCs using transferrin conjugated 3D matrix synthesized by crosslinking polyethylene glycol-Fe3O4 nanostructures for rapid and efficient capturing of CTCs. The platform provides option of using multiple microchannel units in series that can influence higher cell-capture efficiency due to increasing cell-substrate contact frequency. CTCs are captured with high efficiency even at low concentration of target cells …

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Integration Of Biological Effects, Fish Histopathology And Contaminant Measurements For The Assessment Of Fish Health: A Pilot Application In Irish Marine Waters, Michelle Giltrap, Jenny Ronan, John Bignell, Brett Lyons, Evelyn Collins, Heather Rochford, Brendan Mchugh, Evin Mcgovern, Lorraine Bull, James Wilson Jan 2017

Integration Of Biological Effects, Fish Histopathology And Contaminant Measurements For The Assessment Of Fish Health: A Pilot Application In Irish Marine Waters, Michelle Giltrap, Jenny Ronan, John Bignell, Brett Lyons, Evelyn Collins, Heather Rochford, Brendan Mchugh, Evin Mcgovern, Lorraine Bull, James Wilson

Articles

This study investigates the use of a weight of evidence (WOE) approach to evaluate fish health status and biological effects (BEs) of contaminants for assessment of ecosystem health and discusses its potential application in support of the Marine Strategy Framework Directive (MSFD). External fish disease, liver histopathology and several BEs of contaminant exposure including 7-ethoxy resorufin O-de-ethylase (EROD), acetylcholinesterase (AChE), bile metabolites, vitellogenin (VTG) and alkali labile phosphates (ALP) were measured in two flatfish species from four locations in Ireland. Contaminant levels in fish were generally low with PCBs in fish liver below OSPAR environmental assessment criteria (EAC). There were …

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An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle Jan 2017

An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle

Articles

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte–discocyte–echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring- particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full …

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