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2017

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Studies On Stable Crack Growth, Mohammed Juma Humaid Al-Ghafri Dec 2017

Studies On Stable Crack Growth, Mohammed Juma Humaid Al-Ghafri

Theses

The goal of this work is to experimentally investigate the stable crack growth (SCG) fracture behavior of AISI 4340 alloy steel. A series of mode I and mixed mode SCG fracture tests were carried out on 8 mm thick compact tension (CT) specimens subjected to quasistatic loading. The wire cutting technique was used to introduce a pre-notch/ pre-crack of 0.05 mm root radius to the specimen. Five different loading angles Ψ between the loading axis and the crack surface were employed; 90° (mode I), 75°, 65°, 60° and 50°. Five different ratios of original crack length to specimen width a …

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Neurological Burden In Baluchistan Province, Pakistan, Mohammad Saleem Barech Dec 2017

Neurological Burden In Baluchistan Province, Pakistan, Mohammad Saleem Barech

Pakistan Journal of Neurological Sciences (PJNS)

Total population of Balochistan is about13.16 million, while there are only nine qualified Neurologists in the whole province who look after not only neurological disorders of the province, but also patients from nearby countries like Afghanistan and Iran. The common neurological disorders are Stroke, Neuropathies, Myopathies, Epilepsy, Migraine, SSPE, Multiple Sclerosis, Meningitis, Myasthenia Gravis, Parkinson's disease and infectious diseases especially Tuberculosis, which is very common.

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New Oral Anticoagulants (Noacs) For Cerebral Venous Thrombosis, Maria Khan, Mohammad Wasay Dec 2017

New Oral Anticoagulants (Noacs) For Cerebral Venous Thrombosis, Maria Khan, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Cerebral venous thrombosis (CVT) is a relatively rare condition that results from thrombosis of the superficial or deep venous sinuses of the brain. The first ever reported case of the condition was back in 1825 and this was diagnosed at autopsy. It took more than 150 years before imaging modalities were developed that could diagnose cases earlier. With the advent of CT and MR venogram, the diagnosis has become much easier and is contributing to a larger number of cases being picked up. Despite that the incidence in Western literature stays low at 1.3-1.6 cases per 100,000 people. Middle Eastern …

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Burden And Pattern Of Neurological Diseases Seen In Neurology Department Of A Tertiary Care Hospital In Baluchistan, Wazir Akbar, Noor Ahmed Khosa, Abdul Bari Nasar Dec 2017

Burden And Pattern Of Neurological Diseases Seen In Neurology Department Of A Tertiary Care Hospital In Baluchistan, Wazir Akbar, Noor Ahmed Khosa, Abdul Bari Nasar

Pakistan Journal of Neurological Sciences (PJNS)

Neurologic disorders represent a major burden of disease globally. These are common and represent a major public health problem. The spectrum of diseases ranges from non communicable disorders like stroke and neurodegenerative disorders to central nervous system infections. The burden of neurological diseases may be on the increase especially in developing countries. Improved outcome in these settings may require appreciation of the spectrum of neurological diseases and the impediments to their management.The pattern of neurological admissions in hospital varies amongst different regions of the world and this depends on many factors including the regional burden of neurological disorders.

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Early Electrophysiological Findings In Guillain Barre Syndrome, Hazim Brohi, Rajesh Kumar, Sadia Mubarak, Muhammmad Anees Mumtaz Dec 2017

Early Electrophysiological Findings In Guillain Barre Syndrome, Hazim Brohi, Rajesh Kumar, Sadia Mubarak, Muhammmad Anees Mumtaz

Pakistan Journal of Neurological Sciences (PJNS)

Early electrophysiological testing is more important as early abnormalities can be obtained even in the first week. However the electrical abnormalities may not be that prominently evident for definitive diagnosis in the first 2 weeks. However at times the decision of treatment has to be taken early. Research is required to look at different electrophysiological parameter which could give clue for an earlier diagnosis. The aim of our study is to determine early electrophysiological parameters with in first week to identify GBS at earliest.

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Lefort 1 Access For Juvenile Nasopharyngeal Angiofibroma Treated Without Angiographic Embolization., Shaheen Ahmed, Muhammad Imran, Atiq Ahmed Khan, Anwar Ali, Syed Ijlal Ahmed, Asim Rehmani, Muhammad Faaiq Ali Dec 2017

Lefort 1 Access For Juvenile Nasopharyngeal Angiofibroma Treated Without Angiographic Embolization., Shaheen Ahmed, Muhammad Imran, Atiq Ahmed Khan, Anwar Ali, Syed Ijlal Ahmed, Asim Rehmani, Muhammad Faaiq Ali

Pakistan Journal of Neurological Sciences (PJNS)

To assess and analyze the clinical presentation of Juvenile nasopharyngeal angiofibroma and analyze the complications associated with JNA resection without pre surgical embolization using LeFort 1.

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Dementia Survey Among Attendees Of A Dementia Awareness Event In Karachi, Pakistan, Qurat Ul Ain Khan, Yusra Hanif Khan, Mohammad Zaman Khan, Shireen Najam Dec 2017

Dementia Survey Among Attendees Of A Dementia Awareness Event In Karachi, Pakistan, Qurat Ul Ain Khan, Yusra Hanif Khan, Mohammad Zaman Khan, Shireen Najam

Pakistan Journal of Neurological Sciences (PJNS)

There is little information available about peoples'knowledgeregarding symptoms of dementia, dementia diagnosis, and care arrangementsfor dementia patients in Pakistan. Aims: We aimed to find out if patients with dementia and their caregivers were aware of diagnosis, the most common and most distressing symptoms, and care arrangement for these patients.

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Pharygeal Cervicobrachial Variant Of Guillian -Barre Syndrome, Hazim Brohi, Marium Mustaqeem, Sundus Khan Dec 2017

Pharygeal Cervicobrachial Variant Of Guillian -Barre Syndrome, Hazim Brohi, Marium Mustaqeem, Sundus Khan

Pakistan Journal of Neurological Sciences (PJNS)

Guilain-Barre Syndrome (GBS) is a common cause of Neuro-muscular paralysis with a spectrum of clinical and electrophysiology variants. We present a case of thePharyneo-cervico-brachial type. A 25 yr old male came to the Medical OPD with the complains of one day history of upper limb weakness and decreased flexion of the neck , which was progressively worsening, along-with associated shortness of breath. His systemic inquiry and past medical/surgical histories were insignificant. Physical exam correlated withthe diagnostic criteria of PCB variant of GBS. Diagnosis was confirmed on EMG/NCS,which showed axonal neuropathy involving axillay and musculocutaneousnerve, along with absent F –waves latencies …

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A Rare Case Of Becker Disease In A 7 Year Old Boy, Prem Chand, Rozmeen Badruddin Husein, Fazal M. Arain Dec 2017

A Rare Case Of Becker Disease In A 7 Year Old Boy, Prem Chand, Rozmeen Badruddin Husein, Fazal M. Arain

Pakistan Journal of Neurological Sciences (PJNS)

Becker Disease is an autosomal recessive version of the rare congenital disorder called Myotonia Congenita. Due to the rarity of Becker Disease, the genetic and pathological basis of this disease have not been studied well and possible diagnostic methods and techniques are yet to be explored. The existing method of diagnosis of such a case is predominantly dependent on the clinical examination. More work and studies need to be done on the diagnostic aspect of this disease to discover newer diagnostic methods for this disease, which are more reliable and specific. In order to develop better diagnostic methods for the …

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Epidemiological Data Of Neurological Disorders In Pakistan And Neighboring Countries: A Review, Ghulam Hussain, Azhar Rasul, Haseeb Anwar, Muhammad Umar Sohail, Syed Kashif Shahid Kamran, Shahid Mahmood Baig, Asghar Shabbir, Javed Iqbal Dec 2017

Epidemiological Data Of Neurological Disorders In Pakistan And Neighboring Countries: A Review, Ghulam Hussain, Azhar Rasul, Haseeb Anwar, Muhammad Umar Sohail, Syed Kashif Shahid Kamran, Shahid Mahmood Baig, Asghar Shabbir, Javed Iqbal

Pakistan Journal of Neurological Sciences (PJNS)

Neurological disorders are the impairments of nervous system and are an important and growing cause of morbidity, mortality, and disability. In addition to health costs, those suffering from these conditions are also frequently victimized of stigmatization and discrimination. Stigmatization further minimizes the patients' access to treatment and social activities. These disorders, therefore, require special attention particularly in developing countries where unfortunately, the burden of these disorders remains largely unrecognized. Moreover, the burden imposed by such chronic neurological conditions in general can be expected to be particularly devastating in poor populations. These conditions are emerging as severe public health concerns in …

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5th National Headache Update, Abdul Malik Dec 2017

5th National Headache Update, Abdul Malik

Pakistan Journal of Neurological Sciences (PJNS)

Headache is one of the most common disorders worldwide. On the World Health Organization's ranking of causes of disability, this would bring headache disorders into the 10 most disabling conditions for both genders, and into the five most disabling for women. The prevalence of headache disorders in Pakistan is high, and would be at least on par with that reported in other parts of the world, although a recent epidemiological survey suggests that the prevalence of migraines could be as high as 22%, almost twice that noted in the international literature. Over the years, the Pakistan Headache Society (PHS) has …

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The Interaction Between Operational Flexibility And Financial Flexibility, Onur Boyabatli, Tiecheng Leng Dec 2017

The Interaction Between Operational Flexibility And Financial Flexibility, Onur Boyabatli, Tiecheng Leng

Research Collection Lee Kong Chian School Of Business

This paper examines the interaction between operational flexibility and financial flexibility in a multi-product business unit that makes operational decisions based on financial resources provided by its parent company (or headquarters). We capture operational flexibility through investment in flexible technology and financial flexibility through higher availability of financial resources. We consider the flexible-versus-dedicated technology choice and capacity investment decisions of a two-product business unit under demand uncertainty in the presence of budget constraints. The unit operates under a capital budget for financing the capacity investment, and an operating budget, which is uncertain in the capacity investment stage, for financing the …

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Base Faith, Stefano Harney, Fred Moten Dec 2017

Base Faith, Stefano Harney, Fred Moten

Research Collection Lee Kong Chian School Of Business

The earth moves against the world. And today the response of the world is clear. The world answers in fire and flood. The more the earth churns the more vicious the world’s response. But the earth still moves. Tonika Sealy Thompson might call it a procession. The earth’s procession is not on the world’s calendar. It is not a parade on a parade ground. It is not in the world’s teleology. Nor is the procession exactly a carnival played to mock or overturn this parade, to take over its grounds. A procession moves unmoved by the world. The earth’s procession …

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Hedge Fund Franchises, William Fung, David Hsieh, Narayan Y. Naik, Melvyn Teo Dec 2017

Hedge Fund Franchises, William Fung, David Hsieh, Narayan Y. Naik, Melvyn Teo

Research Collection Lee Kong Chian School Of Business

Duplicate, see https://ink.library.smu.edu.sg/lkcsb_research/5964/. We investigate the growth strategies of hedge fund firms. We find that firms with successful first funds are able to launch follow-on funds that charge higher performance fees, set more onerous redemption terms, and attract greater inflows. Motivated by the aforementioned spillover effects, first funds outperform follow-on funds, after adjusting for risk. The multiple-product growth strategy hurts investors while benefiting hedge fund firms; multiple-product firms underperform single-product firms but harvest greater fee revenues. Investors respond to this growth strategy by redeeming from first funds of firms with follow-on funds that do poorly. Moreover, skilled investors allocate …

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Inventory Management Based On Target-Oriented Robust Optimization, Yun Fong Lim, Chen Wang Dec 2017

Inventory Management Based On Target-Oriented Robust Optimization, Yun Fong Lim, Chen Wang

Research Collection Lee Kong Chian School Of Business

We propose a target-oriented robust optimization approach to solve a multi-product, multi-period inventory management problem subject to ordering capacity constraints. We assume the demand for each product in each period is characterized by an uncertainty set, which depends only on a reference value and the bounds of the demand. Our goal is to find an ordering policy that maximizes the sizes of all the uncertainty sets such that all demand realizations from the sets will result in a total cost lower than a pre-specified cost target. We prove that a static decision rule is optimal for an approximate formulation of …

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Wap Four-Disulfide Core Domain Protein 2 Promotes Metastasis Of Human Ovarian Cancer By Regulation Of Metastasis-Associated Genes, Y Chen, L Huang, S Wang, T Liu, Et Al Dec 2017

Wap Four-Disulfide Core Domain Protein 2 Promotes Metastasis Of Human Ovarian Cancer By Regulation Of Metastasis-Associated Genes, Y Chen, L Huang, S Wang, T Liu, Et Al

Peninsula Medical School

BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis. Higher expression of WFCD2 was also observed in aggressive HO8910-PM cells than in HO8910 cells, and WFCD2 knockdown halted cell migration, invasion, tumorigenicity and metastasis …

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Is Good Clinical Practice Becoming Poor Clinical Care?, S Le Gouill, M Dreyling, Md Caballero, M Andre, Et Al Dec 2017

Is Good Clinical Practice Becoming Poor Clinical Care?, S Le Gouill, M Dreyling, Md Caballero, M Andre, Et Al

Peninsula Medical School

Year after year, clinical research teams and investigating physicians are subjected to an exponential growth in administrative burden, paperwork, and regulation associated with clinical trials. The universal explanation for this ever-increasing workload is that it represents “good clinical practice” and is all about the safety of the patient and the integrity of the research. So whenever an investigator asks the question “Why should I fill out this document again?,” “Why should I write this sentence in the patient’s record again?,” “ Why should I sign all these electronic files?,” “Why should I write the date again,” the answer is immutably …

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Comparative Costs And Activity From A Sample Of Uk Clinical Trials Units, D Hind, Bc Reeves, S Bathers, C Bray, Et Al Dec 2017

Comparative Costs And Activity From A Sample Of Uk Clinical Trials Units, D Hind, Bc Reeves, S Bathers, C Bray, Et Al

Peninsula Medical School

BACKGROUND: The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS: Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, and written justification for, costs associated with CTU activities required to implement an identical protocol. The protocol described a 5.5-year, nonpharmacological randomized controlled trial (RCT) conducted at 20 centres. Direct and indirect costs, the number of full time equivalents (FTEs) and the FTEs attracting overheads were compared and qualitative methods (unstructured interviews …

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The Potentiating Effect Of Mandelate And Lactate On Chemically-Induced Germination In Members Of Bacillus Cereus Sensu Lato., Ah Bishop Dec 2017

The Potentiating Effect Of Mandelate And Lactate On Chemically-Induced Germination In Members Of Bacillus Cereus Sensu Lato., Ah Bishop

School of Biological and Marine Sciences

Endospores of the genus Bacillus can be triggered to germinate by a limited number of chemicals. Mandelate had powerful additive effects on the levels and rates of germination produced in non-heat-shocked spores of Bacillus anthracis strain Sterne, Bacillus cereus, and Bacillus thuringiensis when combined with l-alanine and inosine. Mandelate had no germinant effect on its own but was active with these germinants in a dose-dependent manner at concentrations higher than 0.5 mM. The maximum rate and extent of germination were produced in B. anthracis by 100 mM l-alanine with 10 mM inosine; this was equaled by just 25% of these …

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A Shift In Malware Protection, I Baptista, S Shiaeles Dec 2017

A Shift In Malware Protection, I Baptista, S Shiaeles

School of Engineering, Computing and Mathematics

Irina Baptista and Dr Stavros Shiaeles, both from Plymouth University, discuss why there’s a need for a shift in the way we go about preventing malware.

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Automating Active Stereo Vision Calibration Process With Cobots, A Mohamed, Pf Culverhouse, R De Azambuja, A Cangelosi, C Yang Dec 2017

Automating Active Stereo Vision Calibration Process With Cobots, A Mohamed, Pf Culverhouse, R De Azambuja, A Cangelosi, C Yang

School of Engineering, Computing and Mathematics

Collaborative robots help the academia and industry to accelerate the work by introducing a new concept of cooperation between human and robot. In this paper, a calibration process for an active stereo vision rig has been automated to accelerate the task and improve the quality of the calibration. As illustrated in this paper by using Baxter Robot, the calibration process has been done faster by three times in comparison to the manual calibration that depends on the human. The quality of the calibration was improved by 120% when the Baxter robot was used.

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Fifty Years After The Twenty-Fifth Amendment: Recommendations For Improving The Presidential Succession System, Second Fordham University School Of Law Clinic On Presidential Succession Dec 2017

Fifty Years After The Twenty-Fifth Amendment: Recommendations For Improving The Presidential Succession System, Second Fordham University School Of Law Clinic On Presidential Succession

Fordham Law Review

This Report begins with an overview of the presidential succession system, particularly the Twenty-Fifth Amendment provisions. The remaining Parts describe the Clinic’s recommendations. The first Part of the Clinic recommendations discusses executive branch contingency planning and outlines two steps the White House can take to prepare for presidential inabilities. First, the Clinic recommends that the President determine in advance situations where the Vice President should act as President under the Twenty-Fifth Amendment’s voluntary transfer provision at Section 3. Such a “prospective declaration of inability” would allow for transfers of power during emergencies when the Cabinet is not easily reachable to …

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What To Do If Simultaneous Presidential And Vice Presidential Inability Struck Today, Roy E. Brownell Ii Dec 2017

What To Do If Simultaneous Presidential And Vice Presidential Inability Struck Today, Roy E. Brownell Ii

Fordham Law Review

Dual incapacity is one of three major inability scenarios involving the Vice President that threatens the continuity of the executive branch. The current state of the law in this area, unfortunately, leaves only imperfect options for policymakers. This Article proposes that, in the event of a dual inability, the Speaker, the President pro tempore of the Senate, and the Cabinet should meet and then jointly declare that the Speaker is Acting President until either the President or Vice President regains capacity. At the same time, the Speaker—as the new Acting President—the President pro tempore, and the Cabinet should request that …

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The Bipartisan Bayh Amendment: Republican Contributions To The Twenty-Fifth Amendment, Joel K. Goldstein Dec 2017

The Bipartisan Bayh Amendment: Republican Contributions To The Twenty-Fifth Amendment, Joel K. Goldstein

Fordham Law Review

It is appropriate that Senator Birch Bayh has been widely recognized as the author and person most responsible for the Twenty-Fifth Amendment. His work was indispensable, and he was helped by other Democrats and nonpartisan actors including the American Bar Association and John D. Feerick, among others. Yet the Amendment was also the product of bipartisan cooperation. Important provisions were based on work done during the administration of President Dwight D. Eisenhower, and Eisenhower and his Attorney General, Herbert Brownell, played important roles in supporting Bayh’s proposal as did other Republicans in and out of Congress. Republicans like Representative Richard …

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"A Dr. Strangelove Situation": Nuclear Anxiety, Presidential Fallibility, And The Twenty-Fifth Amendment, Rebecca C. Lubot Dec 2017

"A Dr. Strangelove Situation": Nuclear Anxiety, Presidential Fallibility, And The Twenty-Fifth Amendment, Rebecca C. Lubot

Fordham Law Review

This Article is a revisionist history of the ratification of the Twenty-Fifth Amendment, which establishes procedures for remedying a vice presidential vacancy and for addressing presidential inability. During the Cold War, questions of presidential succession and the transfer of power in the case of inability were on the public’s mind and, in 1963, these questions became more urgent in the shadow of the Cuban Missile Crisis. Traditional legal histories of the Amendment argue that President John F. Kennedy’s assassination was both the proximate and prime factor in the development of the Amendment, but they do not account for the pervasive …

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A Voice For One, Or A Voice For The People: Balancing Prosecutorial Speech Protections With Community Trust, Immanuel Kim Dec 2017

A Voice For One, Or A Voice For The People: Balancing Prosecutorial Speech Protections With Community Trust, Immanuel Kim

Fordham Law Review

Prosecutors, as representatives of the public in the criminal justice system, are the sole advocates for “the People” in a criminal case. Thus, prosecutors are expected to maintain a particular level of integrity that would ensure a fair and just representation of the People. Despite this expectation, the wide discretionary authority prosecutors hold makes it virtually impossible to regulate their conduct. Furthermore, the First Amendment of the U.S. Constitution protects many expressions of viewpoints, and such protections extend—albeit to a limited degree—to prosecutors, thereby giving them even more discretion in how they decide to handle their own cases. Nonetheless, the …

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A Vote For Clarity: Establishing A Federal Test For Intervention In Election-Related Disputes, Ben Klein Dec 2017

A Vote For Clarity: Establishing A Federal Test For Intervention In Election-Related Disputes, Ben Klein

Fordham Law Review

Increasingly, state and federal courts are asked to resolve election-related disputes, as candidates are more likely than ever before to challenge some aspect of the administration of an election in court. Election-related litigation puts judges in the unfavorable position of kingmaker, forcing the court, not the people, to determine the winner of an election. When the court intervenes in an election dispute, the public may perceive the court’s intervention as a political act that decreases the legitimacy of the winning candidate and the election system as a whole. Moreover, research reveals that judicial decision-making at both the state and federal …

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Letting The Electrics Slide: A Constitutional Challenge To State Dealer-Franchise Laws Prohibiting Direct-To-Consumer Car Sales, Thomas Sperber Dec 2017

Letting The Electrics Slide: A Constitutional Challenge To State Dealer-Franchise Laws Prohibiting Direct-To-Consumer Car Sales, Thomas Sperber

Fordham Law Review

Tesla Motors has a business model for its U.S. sales unlike that of all other car manufacturers: Tesla sells cars directly to consumers rather than through a system of independently owned dealers. Most car manufacturers choose not to sell cars this way because most states have dealer laws that ban direct-to-consumer sales. To use this business model, Tesla has had to win narrow exceptions to these dealer franchise laws. It has mostly succeeded with this method and can now sell cars, albeit from a limited number of company stores, in all but six states. Tesla is now suing the state …

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Dedication To Senator Birch E. Bayh, John D. Feerick Dec 2017

Dedication To Senator Birch E. Bayh, John D. Feerick

Fordham Law Review

Former U.S. Senator Birch Bayh of Indiana has been honored many times for his outstanding career in public service. Fordham University School of Law and the Fordham Law Review have been beneficiaries of his selfless service of others.

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Management Of Undernutrition And Failure To Thrive In Children With Congenital Heart Disease In Low- And Middle-Income Countries, Andrew C. Argent, Rakhi Balachandran, Balu Vaidyanathan, Amina Khan, R. Krishna Kumar Dec 2017

Management Of Undernutrition And Failure To Thrive In Children With Congenital Heart Disease In Low- And Middle-Income Countries, Andrew C. Argent, Rakhi Balachandran, Balu Vaidyanathan, Amina Khan, R. Krishna Kumar

Section of Cardiology

Poor growth with underweight for age, decreased length/height for age, and underweight-for-height are all relatively common in children with CHD. The underlying causes of this failure to thrive may be multifactorial, including innate growth potential, severity of cardiac disease, increased energy requirements, decreased nutritional intake, malabsorption, and poor utilisation of absorbed nutrition. These factors are particularly common and severe in low- and middle-income countries. Although nutrition should be carefully assessed in all patients, failure of growth is not a contraindication to surgical repair, and patients should receive surgical repair where indicated as soon as possible. Close attention should be paid …

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