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2017

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Novel Superconducting Phases Of Materials Under Pressure By Evolutionary Algorithm Uspex, Mohammad Mahdi Davari Esfahani Dec 2017

Novel Superconducting Phases Of Materials Under Pressure By Evolutionary Algorithm Uspex, Mohammad Mahdi Davari Esfahani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Making solid metallic hydrogen proved elusive, even at pressures up to nearly 400 GPa. An alternative approach is to use chemical alloying as a means to exert additional pressure on hydrogen atoms. Following the recent breakthrough in predicting and synthesizing hydrogen sulfide with record-high Tc = 203 K [Drozdov et al. | Nature (2015)] and with the motivation of discovering high-temperature superconductors, evolutionary algorithm USPEX is employed to search for all stable compounds in the group-IV hydrides. This method has been successfully used to predict new materials that were confirmed experimentally, e.g. | Zhang et al. | Science (2013), Mannix …

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Soldados Del Infortunio: Sustratos De La Colonialidad En La Literatura Bã©Lica Caribeã±A | Soldados Del Infortunio: Sustratos De La Colonialidad En La Literatura Bélica Caribeña, Rubén González-Jiménez Dec 2017

Soldados Del Infortunio: Sustratos De La Colonialidad En La Literatura Bã©Lica Caribeã±A | Soldados Del Infortunio: Sustratos De La Colonialidad En La Literatura Bélica Caribeña, Rubén González-Jiménez

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation explores the coloniality of being in mid-twentieth century Spanish Caribbean war literature. I examine literature as a means of fostering decolonial thinking, as working to reverse coloniality’s effects. The dissertation takes into account the context that triggered the armed conflicts in which Spanish Caribbean soldiers were involved. It emphasizes the United States’ imperialistic attitude towards the Caribbean, a common factor in threading stories of male affect. In the first chapter, I study four short stories by Emilio Díaz Valcárcel which focus on the participation of Puerto Rican soldiers in the United States Army during the Korean War. In …

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Optimizing Phosphorus Removal In Nitrogen Removing Biofilters, Jeanette Lee Dec 2017

Optimizing Phosphorus Removal In Nitrogen Removing Biofilters, Jeanette Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This study examines the removal of phosphorus in alternative wastewater technologies known as nitrogen removing biofilters (NRB) with focus on the geochemical processes that occur within the sediment and wastewater during septic tank effluent transit through NRBs. Wastewater and lysimeter samples were taken from three NRB systems at the Massachusetts Alternative Septic System Testing Center (MASSTC) from January 2016 to April 2017 for total phosphorus (TP), total dissolved phosphorus (TDP), total particulate phosphorus (TPP), dissolved inorganic phosphorus (DIP), and dissolved organic phosphorus (DOP). Sediment cores were taken from one NRB for sequential extractions to determine bound phosphorus phases, for ammonium …

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The Role Of Submarine Groundwater Discharge (Sgd) On The Water Quality In Jamaica, Stivaly Thalia Paulino Dec 2017

The Role Of Submarine Groundwater Discharge (Sgd) On The Water Quality In Jamaica, Stivaly Thalia Paulino

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Abstract of the Thesis The role of submarine groundwater discharge (SGD) on the water quality in Jamaica by Stivaly Paulino Master of Science in Marine and Atmospheric Science (Marine Geology) Stony Brook University 2017 To aid ecosystem management in fish sanctuaries along the northern coast of Jamaica, West Indies, it is necessary to locate and categorize submarine springs. Continuous shoreline surveys of 222Rn were conducted in Discovery Bay (18.469, -77.415), Turtle Crawl (18.176, -76.422) and Cold Harbour (18.174, -76.404) with simultaneous aerial thermal infrared imagery. Elevated 222Rn activities corresponded with plumes of cooler water at the shoreline indicative of submarine …

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Adaptive Search Algorithms For Simulation Optimization In Discrete And Continuous Domains, Qi Fan Dec 2017

Adaptive Search Algorithms For Simulation Optimization In Discrete And Continuous Domains, Qi Fan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis includes some newly-proposed adaptive search algorithms for simulation optimization in discrete and continuous domains. We first consider the ranking and selection problem of allocating a given simulation budget among a set of design alternatives in order to maximize the probability of correct selection. Previous research used to take static approaches to allocate certain number of simulation budget on different designs, i.e. pre-calculating the allocation plan before simulation, and among them, sequential optimal computing budget allocation (OCBA) shows the best allocation efficiency so far. Our approach, Dynamic Simulation Budget Allocation (DSBA), allocates this sampling budget dynamically by formulating this …

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The Role Of Hemocytes In The Early Interactions Between The Oyster Crassostrea Virginica And Its Alveolate Parasite Perkinsus Marinus, Yuk-Ting Lau Dec 2017

The Role Of Hemocytes In The Early Interactions Between The Oyster Crassostrea Virginica And Its Alveolate Parasite Perkinsus Marinus, Yuk-Ting Lau

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The eastern oyster, Crassostrea virginica, is an economically- and ecologically-valuable species. Both commercial fisheries and ecological services are impacted by disease-associated mortality. Perkinsosis, caused by the protozoan parasite Perkinsus marinus, is one of the major diseases that cause mass mortalities. This dissertation aimed to investigate the role of oyster blood cells (hemocytes) in P. marinus infection. Hemocytes associated with mucosal surfaces lining the pallial (shell) cavity were characterized through functional assays and cell surface epitope labeling in conjunction with flow cytometry. Bi-directional transit of hemocytes across mucosal pallial epithelia was also evaluated using flow cytometry and fluorescence microscopy. In-vitro studies …

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Diet Analysis Of Loggerhead Sea Turtles In New York Waters, Julia Donaton Dec 2017

Diet Analysis Of Loggerhead Sea Turtles In New York Waters, Julia Donaton

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis examines the diet of loggerhead sea turtles (Caretta caretta) in New York between 1995 – 2014 using stomach contents analysis. Loggerheads are one of four sea turtle species that occur in the temperate waters of New York during summer months. Estuaries of Long Island provide foraging habitat for juvenile loggerheads from June to November. In order to quantify loggerhead diet, I examined individual and inter-annual variation in the stomach contents of 123 individual turtles that stranded along Long Island. Prey items were identified to the lowest possible taxonomic level, and the minimum number of prey items was assessed …

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Ice Nucleation Potential And Chemical Composition Of Laboratory-Generated And Field-Collected Organic Particles, Joseph Charnawskas Dec 2017

Ice Nucleation Potential And Chemical Composition Of Laboratory-Generated And Field-Collected Organic Particles, Joseph Charnawskas

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Ice particles are ubiquitous in the atmosphere, either coexisting with supercooled water droplets in mixed-phase clouds or existing as the sole inhabitant of cirrus clouds. Aerosol particles act as heterogeneous ice nucleating particles (INPs) and influence ice crystal formation, affecting both cloud radiative properties and climate. Heterogeneous ice nucleation is not a well understood process and is cause for great uncertainty in climate models. Organic aerosol is ubiquitous in the atmosphere. However, the effect organic aerosols on ice nucleation is not well established. This thesis investigates the propensity of organic aerosol to form ice. Secondary organic aerosol (SOA) particles generated …

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The Coast Isn't Clear: An Economic Model Of Home Values And Water Clarity In Suffolk County, N.Y., Mark Nepf Dec 2017

The Coast Isn't Clear: An Economic Model Of Home Values And Water Clarity In Suffolk County, N.Y., Mark Nepf

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This research analyzes the Suffolk County, New York real estate market to determine if water quality in the three major Long Island water bodies (the Long Island Sound, the South Shore Bays, and the Peconic Estuary System) are affecting home values. Water quality is measured by clarity, as this is the most objective measure of a water body's quality that is readily available to property buyers and sellers. Suffolk County is an ideal location for this study, as water quality has been consistently monitored for more than four decades, and local water bodies regularly experiences dense algal blooms that can …

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Engineering Of Semiconductor Photocatalysts For Solar Water Splitting, Danhua Yan Dec 2017

Engineering Of Semiconductor Photocatalysts For Solar Water Splitting, Danhua Yan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Driven by a strong desire for clean and renewable fuel, effective methods of hydrogen production have been sought after for a long time. Solar water splitting within a photoelectrochemical (PEC) cell has been one of the most promising methods. The key component of a PEC cell, the semiconductor photoelectrode, is responsible for carrier generation through light absorption, which initiates redox reactions in water to produce hydrogen and oxygen. An optimal photoelectrode is believed to meet these requirements: a small semiconductor bandgap for visible solar light absorption, suitable band positions that straddle the water re-dox potentials, and high conversion efficiency of …

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Development Of Next Generation Of Nano-Catalysts Prepared By Novel Methods For Environmental And Energy Applications, Qiyuan Wu Dec 2017

Development Of Next Generation Of Nano-Catalysts Prepared By Novel Methods For Environmental And Energy Applications, Qiyuan Wu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Supported metal nanoparticles (NPs) catalysts play a critical role in modern chemical industries. Catalytic performance of supported metal NPs, including activity, selectivity, and stability, is influenced by many different factors. These factors include properties of NPs and support materials. In the first part of this project, supported Rh nanocatalysts were produced by a novel doping-segregation method. Different ex-situ and in-situ characterization techniques were utilized to systematically investigate the doping-segregation process in order to gain fundamental knowledge on this phenomenon. This knowledge was employed to produce supported Rh nanocatalysts with outstanding catalytic performance. In the second part of this project, supported …

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Glycan Type Specificity In N-Linked Glycosylation: Implications For Highly Glycosylated Viral Surface Proteins, Artem Krantesvich Dec 2017

Glycan Type Specificity In N-Linked Glycosylation: Implications For Highly Glycosylated Viral Surface Proteins, Artem Krantesvich

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Virtually every living cell is covered with glycoproteins. Most mammalian glycoproteins primarily bear N-linked glycans of complex type, having only a small fraction of hybrid glycans and barely any high-mannose glycans. However, some highly glycosylated proteins translated in mammalian cells have an unusually high fraction of high-mannose glycans. The goal of this thesis is to investigate the nature of the mechanisms behind this unusual distribution of glycan types and glycan type specificity for glycosylation sites. A well-studied example of the abnormally glycosylated protein is HIV envelope glycoprotein gp120, which usually has about 24 glycans, approximately half of them being of …

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Improved Methodology Of Dna Fragmentation Using Micro-Patterned Pdms Stamps To Apply Cutting Enzymes, Donald Liu Dec 2017

Improved Methodology Of Dna Fragmentation Using Micro-Patterned Pdms Stamps To Apply Cutting Enzymes, Donald Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The development of sequencing since the Human Genome Project has greatly advanced. Current Next Generation Sequencing (NGS) platforms can produce more cost-effective sequencing in a shorter amount of time by using massively parallel sequencers. However, current NGS platforms have limitations in that only DNA fragments of size 100-300 bases may be analyzed. When producing these fragments of DNA, the positional order is often lost due to random fragmentation. Additionally, with repeats, insertions, and deletions of the genome, it further complicates the construction of contigs. Although companies such as Pacific Biosciences have developed longer-read technologies which sequences longer fragments (10 kilobases), …

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Defining The Rules Of Substrate Recognition For A Mitochondrial Aaa+ Protease, Anthony John Rampello Dec 2017

Defining The Rules Of Substrate Recognition For A Mitochondrial Aaa+ Protease, Anthony John Rampello

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The i-AAA protease is a membrane-anchored ATP-dependent protease that contributes to proteostasis of the mitochondrial inner membrane and intermembrane space. The protease is required to select specific substrates for degradation from among the diverse complement of proteins present in mitochondria, yet the molecular mechanisms of substrate recognition have yet to be fully described. Importantly, dysfunction of the mitochondrial AAA proteases has been implicated in the development of numerous neurodegenerative diseases. Detailed solution studies of these enzymes have been hampered by the requirement for an insoluble transmembrane span to drive hexamerization and thus form the ATPase active sites. By replacing the …

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Brain Activity Instructs New Hippocampal Neuron Addition: Insights From Virtual Reality, Gregory Wohl Kirschen Dec 2017

Brain Activity Instructs New Hippocampal Neuron Addition: Insights From Virtual Reality, Gregory Wohl Kirschen

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adult brains are constantly reshaping themselves from synapses to circuits as we encounter novel experiences from moment to moment. Importantly, this reshaping also includes the addition of newborn hippocampal neurons. However, it remains largely unknown how our circuits encode experience-induced brain activity to govern the addition of new hippocampal neurons. By coupling in vivo Ca2+ imaging of dentate granule neurons with a novel, unrestrained virtual reality system for rodents, we discovered that a new experience rapidly and robustly increased the firing of active dentate granule neurons, and was accompanied by an accumulative enhancement in the addition of new hippocampal neurons. …

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Food From Stein, Christopher Kovarik Dec 2017

Food From Stein, Christopher Kovarik

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The genesis of Food from Stein was a commission from an ensemble in Vancouver, British Columbia. While that concert ultimately did not take place, it nonetheless dictated the instrumentation of the piece: flute, viola, harp and voice. This genesis also informed the structure of the piece. The commission required that the work reflect the concept of biodiversity (the performance was to occur in the Beatty Biodiversity Museum at the University of British Columbia). I chose to do this by using the theory of evolution to determine the work’s basic structure. Sections would be longer at the beginning and become shorter …

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Hegel And Arendt On The French Revolution, Wakagi Takahashi Dec 2017

Hegel And Arendt On The French Revolution, Wakagi Takahashi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Through a close analysis of Hegel’s Phenomenology of Spirit and the Philosophy of Right, this dissertation constructs Hegelian answers to Hannah Arendt’s critique of the French Revolution, according to which the modern subject’s claim to actualize universality in politics necessarily undermines the plurality of freedom. Hegel shows that the modern subject withdraws into illusory innocence and undermines the plurality of freedom only when it embodies universality insufficiently. First, the dissertation demonstrates that Hegel’s “universality” can withstand Arendt’s criticism and that it transcends her view of modern society as emerging from a degeneration of ancient Greek and Roman freedom. Second, the …

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Panorama And Proximity In Levinas And The Stoics, Carlie Anglemire Dec 2017

Panorama And Proximity In Levinas And The Stoics, Carlie Anglemire

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Panorama and Proximity in Levinas and the Stoics is a comparative study of the philosophy of Emmanuel Levinas and the Stoics centered on their shared emphasis on the ethical importance of disinterestedness and putting the ego in its place. The Stoics aim to perfect their self-control in order to reach the imperturbable state of the sage and become impervious to what one cannot change, while Levinas emphasizes the inevitability of the rupture of the self by others who both call us into question and captivate us. Overall, Levinas tends to highlight both the value and inevitability of the dethroning of …

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Ionic Dynamics In Molecular Strong Field Ionization, Arthur Zhao Dec 2017

Ionic Dynamics In Molecular Strong Field Ionization, Arthur Zhao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis studies the dynamics in strong field ionization (SFI) of small molecules, with a focus on the removal of electrons from multiple molecular orbitals, especially the mechanisms underlying the population of excited ionic states. To do this, we ionize molecular systems with ultrafast intense laser pulses ( ~10 fs, > 10 TW/cm2) and measure photoelectrons and photoions in coincidence with velocity map imaging (VMI) detection. The ionization is multiphoton by design, and due to its highly non-linear nature, intense laser pulses provide adequate temporal resolutions for probing molecular dynamics and certain electronic dynamics. VMI measures the momentum distribution of charged …

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Search For The Standard Model Higgs Boson Produced With An Associated W Boson And Decaying To A Pair Of $B$ Quarks At $\Sqrt{S} = 13$ Tev With The Atlas Detector, Alyssa Rae Montalbano Dec 2017

Search For The Standard Model Higgs Boson Produced With An Associated W Boson And Decaying To A Pair Of $B$ Quarks At $\Sqrt{S} = 13$ Tev With The Atlas Detector, Alyssa Rae Montalbano

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

A Higgs boson has been found in multiple decay modes, but not yet in the mode with the largest standard model (SM) branching fraction: $h\rightarrow b\bar{b}$. This thesis details a search for the SM Higgs when produced with an associated $W$ boson. This search is performed with the ATLAS detector using data from Run 2 of the Large Hadron Collider operating at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 36.1 $fb^{-1}$. The final state of the $W$ boson is its leptonic decay with an electron or muon. The measured signal strength relative to the …

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Effect Of Treadmill Training On Recovery Of Lower Urinary Tract And Locomotor Function Following Incomplete Spinal Cord Injury In Adult Rats, Faiza Qureshi Dec 2017

Effect Of Treadmill Training On Recovery Of Lower Urinary Tract And Locomotor Function Following Incomplete Spinal Cord Injury In Adult Rats, Faiza Qureshi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Inability to walk and void efficiently after spinal cord injury (SCI) is associated with secondary health problems that affect quality of life. Individuals with paraplegia rate return of bladder function as one of their top priorities. Recently, studies have begun to investigate the recovery of bladder function after SCI. Additionally, several studies have shown improvements in locomotor function after SCI in human and animal models, however there is a gap of studying the correlation of temporal pattern of recovery of bladder and locomotor function after SCI. The aim of this research was to study the correlation of the temporal pattern …

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Negative Charges At Mek1 Kinase Consensus Sites Downregulate Ndt80 Activity During Budding Yeast Meiotic Prophase Without Affecting Protein Stability, Robert Gaglione Dec 2017

Negative Charges At Mek1 Kinase Consensus Sites Downregulate Ndt80 Activity During Budding Yeast Meiotic Prophase Without Affecting Protein Stability, Robert Gaglione

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Meiotic recombination promotes the formation of crossovers between homologous chromosomes to ensure their proper segregation in Meiosis I. Crossovers are formed by the repair of programmed double strand breaks (DSBs) during meiotic prophase. In budding yeast, the meiotic recombination checkpoint delays meiotic progression until all DSBs have been repaired and is under the control of the meiosis-specific Mek1 kinase. The meiosis-specific transcription factor Ndt80 activates the transcription of hundreds of genes, including those required for prophase exit and the meiotic divisions. Transcription of NDT80 occurs in two stages, mediated first by Ime1 and then by Ndt80 itself. Ime1-transcribed Ndt80 is …

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New Masses Magazine And The Birth Of A New World: Illustrating A Revolution, Stephanie Desimone Dec 2017

New Masses Magazine And The Birth Of A New World: Illustrating A Revolution, Stephanie Desimone

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis takes as its central object of analysis The Birth of a New World – A Cooperative Tribute, an illustration spread featured in the November 1926 issue of New Masses, a notable leftist magazine in the United States during the interwar period of the 1920’s and 1930’s. As a collaborative piece by the artists Hugo Gellert, William Gropper, I. Klein, Louis Lozowick and William Siegel, this illustration demonstrates how a model for artistic collaboration and a collective vision for an alternative society emerged during this period by drawing inspirations from political and artistic revolutions elsewhere. One such source was …

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Asylum To Community And In Between: Examining The Post-Deinstitutionalization Transitional Experiences Of Mentally Disabled Individuals In Suffolk County, Long Island, Cassandra Evans Dec 2017

Asylum To Community And In Between: Examining The Post-Deinstitutionalization Transitional Experiences Of Mentally Disabled Individuals In Suffolk County, Long Island, Cassandra Evans

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This is an ethnographic research project examining the lives of individuals with psychiatric disabilities in Suffolk County, Long Island, New York during September 2015 to July 2017. This research considers key aspects of deinstitutionalization, community-based mental health care, and the transition processes that resulted from people leaving long-term psychiatric care. I argue that spaces such as designated mental health housing and occupations, like mental health “Program,” limit choices and perpetuate a sense of control and containment, or what I term “chosen for” spaces—living sites and vocations that are chosen for people on their behalf, diminishing their agency and autonomy. Alternatively, …

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The Bulgarian Training Manual, Ruth Bonapace Dec 2017

The Bulgarian Training Manual, Ruth Bonapace

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The Bulgarian Training Manual is a comic novel that tells the story of Christina Acqualina Bontempi (a.k.a. Tina) in her quest to find her true parents and jeans that fit. With the help of a mysterious book with magical powers, Tina makes her way from her waterlogged apartment in Hoboken, New Jersey, to a hallucinogenic visit to Bulgaria and back. Our heroine is catalyst for a final contest that is part body-builder pose-off and part poetry slam. The novel is a sly look at self-improvement. Those who follow The Bulgarian Training Manual not only bulk up muscle mass, they become …

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A Day At The Beach: Linking Biological Activity In The Ocean To Chemical Properties Of Sea-Spray Aerosol, Wendy Paula Kilthau Dec 2017

A Day At The Beach: Linking Biological Activity In The Ocean To Chemical Properties Of Sea-Spray Aerosol, Wendy Paula Kilthau

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Recent studies have shown that sea-spray aerosol (SSA) particles are largely composed of inorganic salts and organic matter (OM). It has been suggested that phytoplankton and bacteria and the organic compounds released from cells are a possible origin for this airborne OM. Transparent exopolymer (TEP) and Coomassie stainable particle (CSP) concentrations in the ocean surface increase during phytoplankton bloom conditions. The sea-surface microlayer (SML), the interface for all air-sea interactions can become enriched in these materials and SSA formation. A new system, the Breaker Emulating Aerosol Chamber (BEACH) was developed to study the production of SSAs in a self-contained, controlled …

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The Dependents, Lauren A. Harvey Dec 2017

The Dependents, Lauren A. Harvey

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

At ten years old, Delta, who suffers from a particularly aggressive form of epilepsy, boards a one-way flight to Colorado with her single dad, Tom, after they hear of a life-saving medication for her illness. The medicine—cannabinoid oil—works. As Delta and Tom acclimate to their new environment and learn about the world of medical cannabis, they must overcome the fears and patterns of self-imposed isolation imprinted from the days when an epileptic attack could hit at any moment. Delta meets Reagan, another child with epilepsy, whose recklessness makes Delta question her own preconceived limitations. Without his daughter's illness to distract …

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When The Signals Come Home, Jordan E. Franklin Dec 2017

When The Signals Come Home, Jordan E. Franklin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

“When the Signals Come Home” is a hybrid poetry and prose collection in which I explore complex familial bonds alongside race, gender, culture and community. A majority of the pieces in the manuscript are ekphrastic poems inspired by music, art, film, mythology and literature. The poems, in turn, are broken up by brief memoir pieces, or “interludes.” There are three books that I credit with inspiring the overall conception of the book. They are: 1. Citizen: An American Lyric by Claudia Rankine, which also demonstrates a blending of forms. 2. Boy With Thorn by Rickey Laurentiis uses ekphrastic poetry to …

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Radicals, Gregory Brereton Golaszewski Dec 2017

Radicals, Gregory Brereton Golaszewski

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Radicals is a work of fiction concerning tensions between the police department and political revolutionaries in New York City, told through a series of first-person narrators. | 284 pages

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Base Excision Dna Repair In The Mitochondria Of Differentiated Neuronal Cells, Rachel Audrey Caston Dec 2017

Base Excision Dna Repair In The Mitochondria Of Differentiated Neuronal Cells, Rachel Audrey Caston

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Healthy mitochondria are vital for maintaining neuronal activity over the lifespan of an organism. Since mitochondria contain their own DNA, functional DNA repair pathways in the organelle are necessary for mitochondrial integrity. However, mitochondria do not have the complete complement of DNA repair pathways found in the nucleus. Thus far, base excision DNA repair (BER), mismatch repair, and double-strand break repair have been detected in mitochondria, although these pathways involve fewer proteins than is the case in the nucleus. Of the DNA repair pathways operating in mitochondria, BER acts on small, non-distorting base lesions, the main type of damage expected …

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