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Articles 32131 - 32132 of 32132
Full-Text Articles in Entire DC Network
Mursamacin: A Novel Class Of Antibiotics From Soil-Dwelling Roundworms Of Central Kenya That Inhibits Methicillin-Resistant Staphylococcus Aureus, Ryan Musumba Awori, Peter Njenga Ng'ang'a, Lorine Nanjala Nyongesa, Nelson Onzere Amugune, Daniel Masiga
Mursamacin: A Novel Class Of Antibiotics From Soil-Dwelling Roundworms Of Central Kenya That Inhibits Methicillin-Resistant Staphylococcus Aureus, Ryan Musumba Awori, Peter Njenga Ng'ang'a, Lorine Nanjala Nyongesa, Nelson Onzere Amugune, Daniel Masiga
All Peer-Reviewed Publications
Antibiotic-resistant bacteria, also called " superbugs", can at worst retrogress modern medicine to an era where even sore throats resulted in death. A solution is the development of novel types of antibiotics from untapped natural sources. Yet, no new class of antibiotic has been developed in clinical medicine in the last 30 years. Here, bacteria from insect-killing Steinernema roundworms found in the soils of Central Kenya were isolated and subjected to specific molecular identification. These were then assayed for production of antibiotic compounds with potential to treat methicillin-resistant Staphylococcus aureus infections. The bacteria were identified as Xenorhabdus griffiniae and produced …
Proteoglycan Neofunctions: Regulation Of Inflammation And Autophagy In Cancer Biology., Liliana Schaefer, Claudia Tredup, Maria A. Gubbiotti, Renato V. Iozzo
Proteoglycan Neofunctions: Regulation Of Inflammation And Autophagy In Cancer Biology., Liliana Schaefer, Claudia Tredup, Maria A. Gubbiotti, Renato V. Iozzo
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview, we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes. We will critically discuss the dual role of proteoglycan-driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which …