Digital Commons Network^™

The Evolution Of Natriuretic Peptide Augmentation In Management Of Heart Failure And The Role Of Sacubitril/Valsartan, Srikanth Yandrapalli, Wilbert Aronow, P Mondal, D Chabbott

NYMC Faculty Publications

Heart failure (HF) is one of the leading causes of morbidity, mortality, and health care expenditures in the US and worldwide. For three decades, the pillars of treatment of HF with reduced ejection fraction (HFrEF) were medications that targeted the sympathetic nervous system (SNS) and the renin-angiotensin-aldosterone system (RAAS). Prior attempts to augment the natriuretic peptide system (NPS) for the management of HF failed either due to lack of significant clinical benefit or due to the unacceptable side effect profile. This review article will discuss the NPS, the failure of early drugs which targeted the NPS as therapies for HF, …

Delayed Care And Mortality Among Women And Men With Myocardial Infarction, R Bugiardini, B Ricci, E Cenko, Z Vasiljevic, S Kedev, G Davidovic, M Zdravkovic, D Milicic, M Dilic, O Manfrini, Akos Koller, L Badimon

NYMC Faculty Publications

Background-Women with ST-segment-elevation myocardial infarction (STEMI) have higher mortality rates than men. We investigated whether sex-related differences in timely access to care among STEMI patients may be a factor associated with excess risk of early mortality in women. Methods and Results-We identified 6022 STEMI patients who had information on time of symptom onset to time of hospital presentation at 41 hospitals participating in the ISACS-TC (International Survey of Acute Coronary Syndromes in Transitional Countries) registry (NCT01218776) from October 2010 through April 2016. Patients were stratified into time-delay cohorts. We estimated the 30-day risk of all-cause mortality in each cohort. Despite …

Prolonged Growth Hormone/Insulin/Insulin-Like Growth Factor Nutrient Response Signaling Pathway As A Silent Killer Of Stem Cells And A Culprit In Aging, Mariusz Ratajczak, Andrzej Bartke, Zbigniew Darzynkiewicz

NYMC Faculty Publications

The dream of slowing down the aging process has always inspired mankind. Since stem cells are responsible for tissue and organ rejuvenation, it is logical that we should search for encoded mechanisms affecting life span in these cells. However, in adult life the hierarchy within the stem cell compartment is still not very well defined, and evidence has accumulated that adult tissues contain rare stem cells that possess a broad trans-germ layer differentiation potential. These most-primitive stem cells-those endowed with pluripotent or multipotent differentiation ability and that give rise to other cells more restricted in differentiation, known as tissue-committed stem …

Metabolic Differentiation Of Early Lyme Disease From Southern Tick-Associated Rash Illness (Stari), C Molins, L Ashton, Gary Wormser, B Andre, A Hess, J Belisle

NYMC Faculty Publications

Lyme disease, the most commonly reported vector-borne disease in the United States, results from infection with Borrelia burgdorferi. Early clinical diagnosis of this disease is largely based on the presence of an erythematous skin lesion for individuals in high-risk regions. This, however, can be confused with other illnesses including southern tick-associated rash illness (STARI), an illness that lacks a defined etiological agent or laboratory diagnostic test, and is coprevalent with Lyme disease in portions of the eastern United States. By applying an unbiased metabolomics approach with sera retrospectively obtained from well-characterized patients, we defined biochemical and diagnostic differences between early …

Outcomes Of An Integrated Approach To Speed And Strength Training With An Elite-Level Sprinter, Eric D. Magrum

Electronic Theses and Dissertations

The purpose of this study was to observe changes in sprint velocity, ground contact time, and peak force demonstrated by a competitive sprinter following an integrated approach to speed development and strength training. As part of an ongoing monitoring procedure the participant completed 20m sprint testing through an optical measurement system and isometric-strength testing before and after each phase of training. Sprint velocity, ground contact time and peak force were analysed using Tau-U, smallest worthwhile and percent change statistics. Results indicate sprinting velocity statistically improved while changes in peak force were practically significant and ground contact time remained trivial throughout …

Vulnerability Assessment Of Groundwater To No3 Contamination Using Gis, Drastic Model And Geostatistical Analysis, Adela Beauty Adu Agyemang

Electronic Theses and Dissertations

The study employed Geographical Information System (GIS) technology to investigate the vulnerability of groundwater to NO₃ content in Buncombe County, North Carolina in two different approaches. In the first study, the spatial distribution of NO₃ contamination was analyzed in a GIS environment using Kriging Interpolation. Cokriging interpolation was used to establish how NO₃ relates to land cover types and depth to water table of wells in the county. The second study used DRASTIC model to assess the vulnerability of groundwater in Buncombe County to NO₃ contamination. To get an accurate vulnerability index, the DRASTIC parameters were …

Matter Under Mind, John F. Lause

Electronic Theses and Dissertations

The artist discusses the work for his Masters of Fine Arts exhibition, Mind under Matter, held at the Tipton Gallery in downtown Johnson City, Tennessee. Exhibition dates are from March 27th through April 5th 2017. ‘Matter under Mind’ explores the balance of control and non-control within the art-making process. This technique creates an automatic dialogue resulting in abstraction guided by the subconscious. The title ‘Matter under Mind’ is a slight play on the phrase ‘mind over matter’ emphasizing how matter/material is manipulated by the mind through the making of artwork, and within the mind’s eye or imagination.

The video installation …

Effects Of Lactobacillus Rhamnosus Mrs6an On Intestinal Gpat3 Pathway Involved In The Lipid Transport In Enterocytes, Ayodeji Oludare Ipinmoroti

Electronic Theses and Dissertations

Accumulation of triglyceride (TG) in enterocytes of the small intestine follows two specific absorption pathways: the monoacylglycerol acyltransferase pathway (MGAT) and glycerol acyltransferase pathway (GPAT), the latter (GPAT) is usually found in the small intestine. In this study, we investigated the effects of Lactobacillus rhamnosus MRS6AN, an isolate from “amabere amaruranu” a Kenyan traditional cultured milk, on triglyceride accumulation and expression of GPAT3, I-FABP, MTP and NPC1L1 in Caco-2 cell enterocyte model. Intracellular triglyceride level (TG) of Caco2 cells was significantly reduced by live L. rhamnosus (LB) compared with other bacterial products. MTP expression in Caco2 cells was minimally reduced …

A Study Of Salmonid Growth In Two Southern Appalachian Headwater Streams, Joshua Argo

Electronic Theses and Dissertations

This study sampled salmonid populations in two headwater streams in East Tennessee, Briar Creek and Left Prong Hampton Creek. Length and weight data were used to calculate the growth of these populations to determine if significant variation exists between isolated brook trout populations. Slope comparisons concluded that there was a difference in growth between brook trout populations of these streams (p

Design Co2 Molecule Gas Sensor Based On Surface Plasmon Resonance, Muhamad Abdulla Hamad

Polytechnic Journal

Environmentally damaging gases, such as carbon dioxide (CO2), must be sensed for ecological observing or in the vehicle industry. CO2 gas sensing can be done theoretically through designing a biosensor based on a surface plasmon resonance (SPR) principle. The effect of gas respond can be demonstrated by means of SPR spectra shifting and a change in the utilized light reflectance. In general, The CO2 gas sensor monitors the changes of the air refractive index through measuring the position of the resonance dip value with respect to its position for normal air structure . In addition, a tiny variation in the …

Comparative Phytochemical Screening And Antioxidant Activities Of Calligonum Comosum And Calligonum Crjnitum, Khalfan Mohamed Abdulla Ai Naqbi

Theses

Medicinal plants are vital source of present day prescription and the majority of the recommended modern medications contain their subsidiaries. Calligonum comosum and Calligonum crinitum are perennial shrub plants growing in the United Arab Emirates, and are being utilized as a part of traditional medicinal system of UAE. The aims of proposed study were to evaluate and compare the phytochemical and antioxidant properties of these two plants. The extraction and fractionation were conducted by using petroleum ether, chloroform, ethyl acetate, acetone and methanol. The extracts were tested for their antioxidant activity. Phytochemical studies with total phenolics and flavonoid contents were …

Examining The Role Of Hres On The Regulation Of Opioid Receptor Gene Expression In Neuronal Cells Undergoing Hypoxic Mimic Condition, Alberto Herrera

Seton Hall University Dissertations and Theses (ETDs)

Hypoxia is a condition of inadequate oxygen supply, which can induce cell death. Using human neuronal cells treated with a hypoxia memetic compound, desferoxamine (DFO), a hypoxic cell model system was created. Our lab reported previously that treatment with DFO resulted in the decrease of cell viability. However, there were still surviving neurons. The surviving cells did not exhibit significant morphological changes, as compared to the control cells, under confocal microscopy analysis using annexin-V-FLUOS and propidium iodide staining, indicating that they were not at apoptotic or necrotic stages. These surviving neurons, therefore, developed adaptive responses under hypoxic challenge. Several changes …

Understanding The Predictors Of Posttraumatic Growth Among Those With A History Of A Reproductive Trauma, Moshe Winograd

Seton Hall University Dissertations and Theses (ETDs)

Pregnancy loss, from early miscarriage through full-term stillbirth, is a problem that affects a significant percentage of child bearing women. Such a loss can lead to varied negative psychological outcomes such as depression, anxiety, PTSD, and other adjustment disorders. Posttraumatic growth, the ability to make meaning through the processing of a trauma, is a concept that, while well researched among other trauma populations, has barely been considered in relation to pregnancy loss. This study examined posttraumatic growth among 103 women who had experienced a pregnancy loss. Using a hierarchical regression it examined the role that perinatal grief, family processes, hope, …

A Functional Subnetwork Approach To Designing Synthetic Nervous Systems That Control Legged Robot Locomotion, Nicholas Szczecinski, Alexander J. Hunt, Roger Quinn

Mechanical and Materials Engineering Faculty Publications and Presentations

A dynamical model of an animal’s nervous system, or synthetic nervous system (SNS), is a potentially transformational control method. Due to increasingly detailed data on the connectivity and dynamics of both mammalian and insect nervous systems, controlling a legged robot with an SNS is largely a problem of parameter tuning. Our approach to this problem is to design functional subnetworks that perform specific operations, and then assemble them into larger models of the nervous system. In this paper, we present networks that perform addition, subtraction, multiplication, division, differentiation, and integration of incoming signals. Parameters are set within each subnetwork to …

Spirituality And Contemporary Higher Education, Michael D. Waggoner

Faculty Publications

Though religion played a central role in the founding of U.S. higher education, over the centuries, its influence was diluted by competing secular emphases. In recent decades, religion has seen a resurgence in academic and co-curricular attention on campuses. In addition, a spirituality not based on religion has gained increasing attention. The aim of this article is to provide an overview of the phenomenon of spirituality in contemporary higher education. The author discusses the recent appearance of spiritualty on campus, relates what research says about the potential benefits of and challenges in addressing spirituality in higher education, and examines some …

Plant Size And Competitive Dynamics Along Nutrient Gradients, Deborah E. Goldberg, Jason P. Martina, Kenneth J. Elgersma, William S. Currie

Faculty Work

Resource competition theory in plants has focused largely on resource acquisition traits that are independent of size, such as traits of individual leaves or roots or proportional allocation to different functions. However, plants also differ in maximum potential size, which could outweigh differences in module-level traits. We used a community ecosystem model called mondrian to investigate whether larger size inevitably increases competitive ability and how size interacts with nitrogen supply. Contrary to the conventional wisdom that bigger is better, we found that invader success and competitive ability are unimodal functions of maximum potential size, such that plants that are too …

Using Cognitive Maps Of Mental Models To Evaluate Learning Challenges: A Case Study, Z. Shen, Keng Siau

Research Collection School Of Computing and Information Systems

Mental models are organized knowledge structures that individuals form to make sense of the world around them. Cognitive maps are the externalized portrayals of mental models in graphical format. Mental models and cognitive maps have been used as an instructional design method, an assessment tool, and a learning strategy in college education. In this paper, we propose a novel use of mental models and cognitive maps as a device to elicit students’ challenges in learning course materials. Our case study in an Information Systems class illustrates how cognitive maps are constructed from students’ mental models, how learning challenges are identified …

Why Organic Resources And Current Fertilizer Formulations In Southern Africa Cannot Sustain Maize Productivity: Evidence From A Long-Term Experiment In Zimbabwe, Tongai J. Mtangadura, Florence Mtambanengwe, Hatirarami Nezomba, Jairos Rurinda, Paul Mapfumo

All Peer-Reviewed Publications

Sustainability of maize-based cropping systems is a major challenge for southern Africa, yet the demand for maize as staple food and animal feed in the region continues to increase. A study was conducted on a sandy clay loam (220 g clay kg-1 soil) at Domboshawa in Zimbabwe to investigate the long-term effects of organic resource quality and application rate, and nitrogen (N) fertilization on soil chemical properties and maize (Zea mays L.) productivity. Crotalaria juncea (high quality), Calliandra calothyrsus (medium quality), cattle manure (variable quality), maize stover and Pinus patula sawdust (both low quality) were incorporated into soil at 4.0 …

Time-Aware Conversion Prediction, Wendi Ji, Xiaoling Wang, Feida Zhu

Research Collection School Of Computing and Information Systems

The importance of product recommendation has been well recognized as a central task in business intelligence for e-commerce websites. Interestingly, what has been less aware of is the fact that different products take different time periods for conversion. The “conversion” here refers to actually a more general set of pre-defined actions, including for example purchases or registrations in recommendation and advertising systems. The mismatch between the product’s actual conversion period and the application’s target conversion period has been the subtle culprit compromising many existing recommendation algorithms.The challenging question: what products should be recommended for a given time period to maximize …

A Study On Factors Affecting Sleep During Pregnancy In Clinical Trials, Zihan Yan

Arts & Sciences Graduate Student Theses and Dissertations

Regular sleep is required for sensory processing, learning, and brain plasticity. During pregnancy, poor sleep quality and dysregulation of hormones are all associated with increased risk for diseases like postpartum major depression^[1]. Seventy-eight percent of pregnant women experience sleep problems at some point during pregnancy according to the National Sleep Foundation's 1998 Women and Sleep poll_. Chronodisruption is a frequent sleep disturbance experienced by pregnant women that can be primary or due to co-morbid conditions^[2]. For this reason, chronodisruption, which includes insomnia, is currently regarded as one of the most important factors determining pregnancy outcome. …

Amoral Machines, Or: How Roboticists Can Learn To Stop Worrying And Love The Law, Bryan Casey

Northwestern University Law Review

The media and academic dialogue surrounding high-stakes decisionmaking by robotics applications has been dominated by a focus on morality. But the tendency to do so while overlooking the role that legal incentives play in shaping the behavior of profit-maximizing firms risks marginalizing the field of robotics and rendering many of the deepest challenges facing today’s engineers utterly intractable. This Essay attempts to both halt this trend and offer a course correction. Invoking Justice Oliver Wendell Holmes’s canonical analogy of the “bad man . . . who cares nothing for . . . ethical rules,” it demonstrates why philosophical abstractions like …

Democratizing Criminal Law As An Abolitionist Project, Dorothy E. Roberts

Northwestern University Law Review

The criminal justice system currently functions to exclude black people from full political participation. Myriad institutions, laws, and definitions within the criminal justice system subordinate and criminalize black people, thereby excluding them from electoral politics, and depriving them of material resources, social networks, family relationships, and legitimacy necessary for full political citizenship. Making criminal law democratic requires more than reform efforts to improve currently existing procedures and systems. Rather, it requires an abolitionist approach that will dismantle the criminal law’s anti-democratic aspects entirely and reconstitute the criminal justice system without them.

Racing Abnormality, Normalizing Race: The Origins Of America's Peculiar Carceral State And Its Prospects For Democratic Transformation Today, Jonathan Simon

Northwestern University Law Review

For those struggling with criminal justice reform today, the long history of failed efforts to close the gap between the promise of legal equality and the practice of our police forces and prison systems can seem mysterious and frustrating. Progress has been made in establishing stronger rights for individuals in the investigatory and sanctioning stages of the criminal process; yet, the patterns of over-incarceration and police violence, which are especially concentrated on people of color, have actually gotten worse during the same period. Seen in terms of its deeper history however, the carceral state is no longer puzzling: it has …

Emotion Dysregulation And Functional Connectivity In Children With And Without A History Of Major Depressive Disorder, Katherine Lopez

Arts & Sciences Graduate Student Theses and Dissertations

Recent interest has emerged in understanding the neural mechanisms by which deficits in emotion regulation (ER) may relate to the development of depression. Cortico-limbic alterations reported in emotion dysregulation and depression may be one possible link. We examined the relationships between emotion dysregulation in school age, corticolimbic resting state functional connectivity (rs-FC) in preadolescence, and depressive symptoms in adolescence. Participants were 143 children from a longitudinal preschool onset depression study who completed the Children Sadness Management Scale (CSMS), Child Depression Inventory (CDI), and two resting state MRI scans. We examined rs-FC between four primary regions of interest (ROIs; bilateral dorsolateral …

Stable Isotopes And Radiocarbon Assess Variable Importance Of Plants And Fungi In Diets Of Arctic Ground Squirrels, Erik A. Hobbie, Julee Shamhart, Michael Sheriff, Andrew P. Ouimette, Matt Trappe, Edward A. G. Schuur, John E. Hobbie, Rudy Boonstra, Brian M. Barnes

Faculty Publications

Arctic ground squirrels (Urocitellus parryii) rely primarily on dietary protein derived from plants to fuel gluconeogenesis during hibernation, yet fungal sporocarps may be an important, yet overlooked, protein source. Fungivory levels depend on sporocarp productivity, which varies with the dominant plant species and is higher on acidic than on non-acidic soils. To test whether these factors altered fungal consumption, we used stable isotopes to investigate arctic ground squirrel diets at two sites in northern Alaska, Toolik (primarily moist acidic tundra) and Atigun (primarily moist non-acidic tundra). Radiocarbon estimates can also indicate fungivory levels because ectomycorrhizal fungi assimilate soil-derived organic nitrogen …

In Vivo Evaluation Of Stem Cell Aggregates On Osteochondral Regeneration., Banupriya Sridharan, Amy D. Laflin, Michael A. Holtz, Donna M. Pacicca, Nicholas K. Wischmeier, Michael S. Detamore

Manuscripts, Articles, Book Chapters and Other Papers

To date, many osteochondral regenerative approaches have utilized varied combinations of biocompatible materials and cells to engineer cartilage. Even in cell-based approaches, to date, no study has utilized stem cell aggregates alone for regenerating articular cartilage. Thus, the purpose of this study was to evaluate the performance of a novel stem cell-based aggregate approach in a fibrin carrier to regenerate osteochondral defects in the Sprague-Dawley rat trochlear groove model. Two different densities of rat bone marrow mesenchymal stem cell (rBMSC) aggregates were fabricated by the hanging drop technique. At 8 weeks, the cell aggregates supported the defects and served as …

Effect Of An Aquatic Environment On Dual-Task Performance In Older Adults, Devin Patterson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Background: Older adults tend to have difficulty maintaining balance. It has been suggested that the aquatic environment may provide a safer and more challenging alternative to land for balance training. It has also been suggested that the performance of a dual cognitive-balance task paradigm may increase the competition for cortical resources needed to maintain balance. There is a need to evaluate the influence of an aquatic environment on the performance of a combined cognitive and motor task paradigm in older adults. Purpose: To assess the effects of an aquatic environment on the performance of cognitive and motor tasks in older …

Perception Of Librarians Towards Collaborative Research In Academic Libraries In Nigerian Universities, Dim Chibuzor Livina, Scholastica Ukwoma, Okafor Victoria Nwamaka Dr

Library Philosophy and Practice (e-journal)

Abstract

The study is a survey of librarians’ perception towards collaborative research in South Eastern Nigeria. Four research questions guided the study, the study adopted descriptive survey method. The population of the study consists of 242 librarians in federal and state university in South East Nigeria. The instrument for data collection was questionnaire, the data collected was analysed using percentages and bar chart. The result showed that librarians are involved in collaborative research, majority of them are motivated to embrace collaborative research because of high publishing cost, and need for specialization within certain area. It was also discovered that collaborative …

Towards A Personalized Cancer Gene Therapy: A Case Of Clear Cell Renal Cell Carcinoma, Dumitru Iacobas, Sanda Iacobas

NYMC Faculty Publications

No abstract provided.

Metabolic Regulation Of Cellular Signaling, Rashid John Darbandi

Theses and Dissertations (ETD)

Using the biochemically tractable Xenopus oocyte model system, we have previously characterized a novel metabolic regulation of cell death. We found that glucose-6-phosphate (G6P) via the pentose phosphate pathway leads to increased nicotinamide adenine dinucleotide phosphate (NADPH) levels, a subsequent increase in cytosolic acetyl-coenzyme A and activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII). We recently identified coenzyme A (CoA), derived from the breakdown of acetyl-CoA, as the key metabolic signal that mediates a novel mechanism of calmodulindependent activation of CaMKII. CoA binds directly to the calmodulin (CaM) binding domain (CaMBD) of CaMKII resulting in its activation and downstream inhibitory phosphorylation …