Digital Commons Network^™

Detecting And Accounting For Multiple Sources Of Positional Variance In Peak List Registration Analysis And Spin System Grouping, Andrey Smelter, Eric C. Rouchka, Hunter N. B. Moseley

Molecular and Cellular Biochemistry Faculty Publications

Peak lists derived from nuclear magnetic resonance (NMR) spectra are commonly used as input data for a variety of computer assisted and automated analyses. These include automated protein resonance assignment and protein structure calculation software tools. Prior to these analyses, peak lists must be aligned to each other and sets of related peaks must be grouped based on common chemical shift dimensions. Even when programs can perform peak grouping, they require the user to provide uniform match tolerances or use default values. However, peak grouping is further complicated by multiple sources of variance in peak position limiting the effectiveness of …

Towards An International Right To Claim Innocence, Brandon L. Garrett

Faculty Scholarship

In the past, wrongful convictions were seen as a local problem largely undeserving of national or international attention. Very different legal systems have shared a common approach of emphasizing the finality of criminal convictions, thereby making it very difficult to claim innocence by relying on new evidence uncovered post-trial. While international law guarantees a right to a fair trial, a presumption of innocence, and a right to appeal, no international human rights norms clearly obligate countries to allow defendants to meaningfully assert post-trial claims of innocence. Today, the procedures and attitudes toward claims of innocence that rely on newly discovered …

Cognitive Screening Practices Of Primary Care Providers In Mississippi, Andrea Branch

MSN Research Projects

Cognitive impairment is one of the predominant diagnoses that in its early stages remain undetected in the primary healthcare setting. With Alzheimer's and dementia on the rise, it is paramount that cognitive impairment be detected promptly so preventative measures may be initiated to slow or avert progression of this dreaded disease. The annual wellness visit, a Medicare benefit added by the Affordable Care Act of 2010, recommends primary care providers conduct a screening to detect cognitive impairment during the course of this assessment. The Centers for Medicare and Medicaid services failed to recommend a specific screening tool to be utilized …

College Students’ Knowledge Of Human Papillomavirus, Knowledge Of Human Papillomavirus Vaccination Series, And Their Human Papillomavirus Vaccination Compliance, Shelley Hamblin

MSN Research Projects

Human papillomavirus (HPV) is the most prevalent sexually-transmitted infection in the U.S. Specific types have been linked to 70% of cervical cancers, 90% of genital warts, 65% of vulvar cancers, 35% of penile cancers, and 70% of head and neck cancers (Markowitz et al., 2014). According to the CDC, the most effective way to prevent HPV- associated infections and HPV-related cancer is through vaccination. The purpose of this study was to determine how knowledgeable college students ages 18-26 years are of HPV, HPV vaccine, and vaccination compliance among these students. The Health Promotion Model (HPM) created by Pender (2011) was …

Fluid Manipulations Using A Piezo Electric Transformer For Sensing And Spray Generation Applications, Zeinab Ramshani

Dissertations

A steady effort has been made on the development of fluid manipulation techniques for sensing and actuating systems. Conventional techniques of fluid manipulation for sensing and spray generation purposes, often need trained staff or high input power and they are complicated, time consuming and expensive. Therefore, it is necessary to develop new systems which can overcome these drawbacks.

In this dissertation, the author has developed piezoelectric-based systems for fluid manipulation. The focus of this dissertation involves novel approaches of enhancing the sensing and actuating systems using the piezoelectric devices. This includes designing a system, which theoretically can overcome the limitations …

2017-2018 Faculty Senate Roster, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Annual Report, 2017, University Of Washington School Of Law

Tech Policy Lab

The Tech Policy Lab at the University of Washington has emerged as a leading resource for policymakers interested in wiser and more inclusive technology policy. This year the Lab built on its reputation for excellence in interdisciplinary research, published scholarship and tools to benefit tech policy, and had direct input into policymaking at multiple levels of government.

2017 Utah State University Student Orientation Guide, Utah State University

The Utah Statesman

A special supplemental magazine provided by The Utah Statesman to take a closer look at some of the services and departments available at Utah State University.

Elongation Factor P Interactions With The Ribosome Are Independent Of Pausing, Rodney Tollerson Ii, Anne Witzky, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Bacterial elongation factor P (EF-P) plays a pivotal role in the translation of polyproline motifs. To stimulate peptide bond formation, EF-P must enter the ribosome via an empty E-site. Using fluorescence-based single-molecule tracking, Mohapatra et al. (S. Mohapatra, H. Choi, X. Ge, S. Sanyal, and J. C. Weisshaar, mBio 8:e00300-17, 2017, https://doi.org/10.1128/mBio.00300-17 ) monitored the cellular distribution of EF-P and quantified the frequency of association between EF-P and the ribosome under various conditions. Findings from the study showed that EF-P has a localization pattern that is strikingly similar to that of ribosomes. Intriguingly, EF-P was seen to bind ribosomes more …

Order Restored? Federal Agencies "Accountable" For Nepa, Esa Violations But Project To Proceed: Examining Pub. Emps. For Envtl. Responsibility V. Hopper, Nicole. S. Haiem

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Effects Of Diel-Cycling Hypoxia On The Cardiac Activity And Growth Of Argopecten Irradians, Samuel Jonathan Gurr

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Bottom water oxygen concentrations in coastal environments can oscillate between fully oxygenated and hypoxic conditions on a daily basis. How benthic organisms deal with such drastic changes in oxygen availability is not well understood. Specifically, we do not know the magnitude, duration, and frequency at which diel-cycling hypoxia conditions become harmful. Here we have used non-invasive infrared sensors to measure the cardiac activity of the Atlantic bay scallops, Argopecten irradians, in response to diel-cycling hypoxia in-situ over one-month periods as well as in the laboratory in controlled incubations using animals conditioned to contrasting field conditions. In the field, heartbeat rates …

Influence Of Drill Diameter On Temperature And Time During Slow Drilling Protocol - In Vitro Study, Aekta Patel

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Introduction: Bone drilling causes an increase in bone temperature, and a temperature above 47°C is critical because it causes thermal bone necrosis. Recently the concept of slow-speed drilling (50 rpm) was suggested as an alternative to the conventional implant-bed preparation. Some advantages for slow drilling over high speed drilling like better control, recovery of vital bone, lower heat generation and patient management are claimed. It is critical for the success of dental implants that minimal heat is generated in the bone during the drilling of the implant sites. Bone tissues are very susceptible to thermal injury, and the temperature threshold …

Regulation Of Post-Translational Modifications By The Adenovirus E4-Orf3 Protein, Rebecca Bridges

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adenovirus (Ad) is a human DNA tumor virus that has been used extensively as a model to understand many fundamental cellular processes and host-pathogen interactions. During infection, the Ad type 5 (Ad5) early protein, E4-ORF3, forms unique track-like structures throughout nuclei of infected cells. E4-ORF3 tracks serve to relocalize and sequester many cellular proteins, including Mre11 and Nbs1, two antiviral components of the DNA damage-responsive MRN complex. Relocalization of Mre11 and Nbs1 to E4-ORF3 tracks facilitates their post-translational modification with the small ubiquitin-like modifier, SUMO. SUMOylation is essential to the regulation of many cellular processes, including transcription, replication, and DNA …

Anti-Lgbt Hate Crimes In The Us, Elizabeth Coston

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation provides a comprehensive and theoretically grounded empirical analysis of anti-LGBT hates crimes utilizing national crime data from the Uniform Crime Report and National Crime Victimization Survey. Current accounts of anti-LGBT (lesbian, gay, bisexual, and transgender) hate crimes at the national level typically only discuss prevalence or offer descriptive statistics, and more advanced statistical analyses have used small samples and offer conflicting conclusions across studies. This project utilizes advanced regression techniques with national data to examine the factors that contribute to these crimes, which represents a major methodological advance in the study of anti-LGBT hate crimes. First, the role …

Role And Regulation Of Sphingomyelin Synthase 1 In Leukemia, Sitapriya Moorthi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The Sphingomyelin synthase (SMS1 and SMS2) enzymes constitute a class of transferases, belonging to the sphingolipid pathway and they catalyze the synthesis of sphingomyelin (SM). The role of sphingolipids has transformed, from being vital components of cellular membranes to mediators of various biological processes, such as proliferation, regulation of the cell cycle and differentiation. SMS catalyzes the transfer of the phosphorylcholine moiety from phosphatidylcholine to ceramide (Cer), generating SM and diacylglycerol (DAG). The role of SMS in cancer stems from its ability to regulate the levels of two bioactive lipids, Cer (mediator of anti-proliferative effects) and DAG (a mitogenic lipid), …

Ringtailed Lemur Social Networks And Their Role In Pathogen Transmission, Gena Christine Sbeglia

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Many of the pathogens that cause disease are transmitted through physical contact, which makes patterns of social behavior potential routes of transmission. Questions about socially facilitated transmission are best addressed by combining data on the observed contacts of the host and the haplotype-level genetic differentiation of the pathogen because individuals must harbor the same or related haplotypes of a particular pathogen for transmission to be deduced. However, few studies simultaneously collect data on both the behavior of the host and the genetics of the pathogen and those that do are limited by their use of culture-based methods. Culture-based methods involve …

Dystroglycan Is A Novel And Context-Dependent Regulator Of Notch In The Postnatal Subventricular Zone, Himanshu Sharma

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

While the importance of the subventricular zone (SVZ) in brain development and homeostasis has become more well appreciated over the last few decades, many of the mechanisms regulating SVZ development remain unclear. In particular, the role of extracellular matrix (ECM)-mediated signals in shaping the development and function of the postnatal SVZ remain poorly understood, despite the recognized role of ECM in other stem cell niches. We now report that during the first weeks of postnatal development, ECM is reorganized into laminin-rich "hubs" at the interface between neural stem cells and ependymal cells at the ventricular surface. This ECM is of …

Adam10 Regulates Nsc Properties Via Jam-C/Rap1 Axis, Nadia Mcmillan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In the adult brain, the microenvironment that supports neural stem cell (NSC) properties is known as the subventricular zone (SVZ). The SVZ is organized into an apical compartment adjacent to the ventricular wall and a basal compartment containing a rich vascular network. In this context, quiescent NSCs are arranged at the ventricular wall, while mitotically activated NSCs are found near the basal, vascular region of the SVZ. Expression of extracellular and secreted niche elements are dynamic and tightly controlled to maintain NSC properties, and appear to correlate with NSC positioning within the niche to direct cell intrinsic programs. Despite identification …

Stochastic Modeling Of Cell Dynamics, Mutation Acquisition And Cancer Risk, Mu Tian

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

It is well recognized that cancer results from multi-stage mutation acquisitions. To this end, both intrinsic and extrinsic factors contribute to mutagenesis in cancer and subsequently the risk of cancer. To better understand the process of cancer initiation and the contributions of various risk factors, we build stochastic models for carcinogenesis based on modern cancer stem cell theory with clonal expansion. In our extended risk model, we have incorporated all three types of cell lineages including stem cells, progenitor cells and terminal cells. We have also included major ingredients for cancer development, including general cell behaviors, tissue homeostasis, multi-stage mutation …

Tremblings, August 2017, Western Aspen Alliance

Tremblings

Uphill Battle to Restore Aspen in the Sierra

John-Pascal Berrill

Being a forest owner and manager, I’m interested in topics important to local forest managers: uneven-aged management and restoration. Maybe I just want the complete opposite of the plantation forestry back home in New Zealand. Moving to California satisfied that, with complex disturbance, social, and policy issues surrounding natural resource management of mixed stands. And with tree species that sucker and sprout – a challenge!

Biosorption And Bioreduction's Impact On The Mobility Of Uranium And Cesium, Sarah Tandy Hennessy

All Theses

Microbial interactions with radionuclides in the environment are multi-faceted and play an important role on the fate and the extent of transport of these metals within the biosphere. Understanding how these biotic interactions affect radionuclides could prove useful in developing more suitable waste containment facilities and improve the overall risk management strategies at legacy waste sites around the world. This study investigates two microbial interactions with these metals: biosorption and bioreduction. To elucidate the impact of biosorption on uranium and cesium, active and inactive biomass were analyzed using batch sorption experiments in the presence of complexing ligands, EDTA and citrate, …

Individual Differences In Influenceability And Anti-Influenceability, Rebecca L. Robinson

Psychology Dissertations - Archive

Using a dispositional strategy, two studies investigated individual differences in three types of influenceability and two types of anti-influenceability. Study 1 replicated the majority of consistent results found in Robinson and Ickes (2016) of different personality traits being predictive of different forms of influenceability. Individuals who reported more instances of self-jeopardizing influenceability tended to (1) have an external locus of control, (2) be more other-directed, (3) have a weaker sense of self, and (4) be more prone to dispositional emotional contagion. Individuals who were prone to susceptibility to peer pressure tended to be (1) low in social desirability, (2) more …

F₄₂₀ Cofactor Dependent Enzymes : Kinetic, Mechanistic And Structural Characterization Of F₄₂₀-Dependent Glucose-6-Phosphate Dehydrogenase (Fgd) From Mycobacterium Tuberculosis, Mercy A. Oyugi

Chemistry & Biochemistry Dissertations - Archive

F₄₂₀-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacterium tuberculosis (Mtb) is one of a few enzymes that utilize the unique F₄₂₀ cofactor for catalysis. FGD catalyzes the first committed step of the pentose-phosphate pathway, where it uses the oxidized F₄₂₀ cofactor to convert glucose-6-phosphate (G6P) to 6-phosphogluconolactone. Mtb is the bacteria that causes Tuberculosis (TB), which is currently the world’s deadliest bacterial disease. The pentose-phosphate pathway is important for survival of Mtb, since it provides precursors for nucleic acid synthesis and yields reducing equivalents that are essential for other metabolic pathways. The fact that FGD catalyzes the committed step of the pentose-phosphate …

Development Of Ultrahigh Performance Chiral Phases For Separations Approaching The Speed Of Sensors, Darshan C. Patel

Chemistry & Biochemistry Dissertations - Archive

Chromatography using chiral stationary phases is the most effective and popular technique for qualitative and quantitative analysis of enantiomers in the pharmaceutical, agricultural, and food industry, among many others. Given the prevalence of chirality in nature, creation of new technologies for improving the speed and performance of chiral separations can provide immediate and significant benefits. This dissertation focuses on development of ultrahigh performance chiral phases which can provide separations at speeds that approach the speed of typical sensors and thereby enable chromatography as a real-time analysis tool. A variety of chiral selectors namely macrocyclic glycopeptides (teicoplanin, teicoplanin aglycone, vancomycin), cyclic …

Epigenetic Mechanism Of Regulation Of Hox Genes And Neurotransmitters Via Hormones And Lncrna, Paromita Deb

Chemistry & Biochemistry Dissertations - Archive

Endocrine disrupting chemicals (EDCs) are classes of environmental contaminants whose exposure even at very low concentrations interfere with normal endocrine signaling and induce many adverse health effects including increased risk of birth defects, diabetes, obesity, abnormal reproduction, and cancer. EDC exposure alters the epigenetic programming of cells resulting in altered gene expression and regulation and cell signaling. These EDCs include bisphenol-A (BPA), diethylstilbesterol (DES), polychlorinated biphenyl (PCB), phthalates, phytoestrogens, methoxychlor, fungicides, insecticide, herbicide, and some heavy metals. As a part of my work, I have investigated epigenetic impacts of EDCs on HOX (homeobox containing genes) genes, which are critical players …

Enrichment And Identification Of Disulfide Bonded Peptides By Tandem Mass Spectrometry, Pooja Rajeshbhai Ramanuj

Chemistry & Biochemistry Theses - Archive

Proteins are Comprised of different amino acids which can undergo various modifications known as post-translational modifications (PTMs). Amino acid’s side chains are the most common sites for the PTMs. Cysteine side chain can undergo several PTMs and one very common one is disulfide bond formation. Disulfide bond aids in maintaining protein tertiary structures, its identification is an inevitable aspect in studying protein functions. Furthermore, disulfide bonds are potential targets to develop new protein therapeutics for life-threatening diseases such as cancer. Literature surveys revealed several methods to identify disulfide bonds, which require either high quality sample or are highly laborious. Moreover, …

Toxicity Study Of Cace₂S₄, Wafa Tonny

Chemistry & Biochemistry Theses - Archive

In recent years, rare earth sulfides have received attention for their interesting thermoelectric and optical properties.1 They exhibit a fairly wide range of colors, which makes them promising candidates as pigments.2 The demand for red colored pigments in industrial application is high but the current ones in use are not environmentally friendly. This has garnered attention towards the rare-earth sulfides. Among the rare-earth sulfide compounds, Ce₂S₃ is a highperformance pigment of red color. It is particularly interesting as doping with alkaline earth metal stabilizes the structure of Ce₂S₃ at low temperature and plays a role in tuning its color from …

Change Of Brain Network Connectivity Among Different Human Vigilance States Investigated By Eeg, Yudhajit Das

Bioengineering Theses - Archive

Understanding the brain network connectivity associated with human vigilance states, to investigate the basic neural processes that underlie complex higher-order cognitive operations and functional domains, has become an important topic in biological science research. Also, there is growing concern about the prevalence and effects of sleep deprivation. Given the increasingly fast-paced nature of our society, the focus of the researchers is not only to identify the changes occurring within the brain during sleeping stages, but also to extract meaningful psycho-behavioral reason behind such change patterns which can lead to an improved understanding of brain activity during sleep which may further …

Arthropod Food Webs In Arctic Tundra: Trophic Interactions And Responses To Global Change, Ashley Lila Asmus

Biology Dissertations - Archive

Arctic ecosystems are undergoing rapid change. Terrestrial arctic arthropods (insects, spiders and others) are not only appreciably diverse, but also sensitive to their environment. As such, tundra arthropod communities and food webs could provide critical insight into the ecological consequences of global change in the Arctic. My dissertation explores the underpinnings of arthropod community and food web dynamics in arctic tundra. First, I explore how changes to plant production and plant community composition affect arthropod community composition, trophic structure and food web function. I also explored one key trophic interaction: cannibalism among wolf spiders, the most abundant terrestrial predator in …

Protein/Nucleic-Acid Structure And Sequence Requirements For Specifying Second-Strand Cleavage And Second-Strand Synthesis During The Integration Of The Site-Specific Line R2bm, Aruna Govindaraju

Biology Dissertations - Archive

Long interspersed nucleotide elements (LINEs) are major drivers of genomic landscaping events in many eukaryotic genomes. LINEs encode a multifunctional protein that binds to their own mRNA, recognize and cleave target DNA, and performs target-primed reverse transcription (TPRT). R2 element from Bombyx mori (R2Bm) has served as an important experimental system for the biochemical understanding of the structure, function, and integration of LINEs. First-strand target site cleavage and TPRT in the current model of integration have been well understood both in vitro (using R2Bm) and in vivo (using LINE-1 elements); however, interpretation of factors involved in second-strand cleavage and second- …