Digital Commons Network^™

The Association Of Nov/Ccn3 With Obstructive Sleep Apnea (Osa): Preliminary Evidence Of A Novel Biomarker In Osa, J Weingarten, Lars Bellner, S Peterson, M Zaw, P Chadha, S Singh, Nader Abraham

NYMC Faculty Publications

Obstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk. Ten morbidly obese and 10 healthy lean subjects underwent overnight polysomnography (PSG) and clinical evaluation. Blood samples were analyzed for NOV levels, adiponectin and …

Developing Assessment Criteria And Rubrics For Narrative Medicine Writing, Hung-Chang Liao, Ya-Huei Wang

Journal of Medical Education

Purpose: Narrative medicine writing can help health care students and professionals make empathetic connections with their patients in order to make patient-centered decisions. Nonetheless, though the use of narrative medicine writing exercises within medical-care education and on-the-job training is expanding, the assessment tools to determine narrative medicine writing levels are lacking. Therefore, there is a need for developing assessment criteria and rubrics for evaluating health care students' and professionals' narrative medicine writing. Methods: Extensive literature review and expert panel discussion were used to develop an analytic narrative medicine writing scoring rubric (ANMWSR). Once developed, the scoring rubric was validated through …

A New Teaching Method To Improve Clinical Skills Of Suture Techniques For Undergraduate Medical Students By Introducing Motivation Theory And Flipped Classroom Approach, Hui-Ying Low, Kuo-Shu Huang, Yi-Lun Chen, Hui-Chin Chang, Ming-Che Tsai, Ming-Yu Hsieh

Journal of Medical Education

Background: All doctors need to develop a core of basic surgical skills, whether or not they eventually specialize as surgeons. However, mastering surgical skills requires sustained deliberate practice, usually over several years. Ideally, this training should start early in undergraduate years and be reinforced at intervals. Nowadays, a combination of computer-aided video instruction, flipped classroom and competition is well established in medical education and is ideal for learning surgical techniques and it encourages regular practice, in preparation for supervised clinical experience when the basics have been mastered. Objectives: to evaluate the performance of suture skills including knot-tying techniques of undergraduate …

Instrument Constituencies And Public Policy-Making: An Introduction, Daniel Beland, Michael Howlett, Ishani Mukherjee

Research Collection School of Social Sciences

For many years, policy-making has been envisioned as a process in which subsets of policy actors engage in specific types of interactions involved in the definition of policy problems, the articulation of solutions and their matching or enactment. This activity involves the definition of policy goals (both broad and specific), the creation or identification of the means and mechanisms that need to be implemented to realize these goals, and the set of bureaucratic, partisan, electoral and other political struggles involved in their acceptance and transformation into action. While past research on policy subsystems has often assumed or implied that these …

A Spatial Critique Of Intellectual Property Law And Policy, Peter K. Yu

Washington and Lee Law Review

No abstract provided.

Amblyomma Maculatum Secis Binding Protein 2 And Putative Selenoprotein P Are Indispensable For Pathogen Replication And Tick Fecundity, Khemraj Budachetri, Gary Crispell, Shahid Karim

Faculty Publications

Selenium, a vital trace element, is incorporated into selenoproteins to produce selenocysteine. Our previous studies have revealed an adaptive co-evolutionary process that has enabled the spotted fever-causing tick-borne pathogen Rickettsia parkeri to survive by manipulating an antioxidant defense system associated with selenium, which includes a full set of selenoproteins and other antioxidants in ticks. Here, we conducted a systemic investigation of SECIS binding protein 2 (SBP2) and putative selenoprotein P (SELENOP) by transcript silencing in adult female Gulf-coast ticks (Amblyomma maculatum). Knockdown of the SBP2 and SELENOP genes depleted the respective transcript levels of these tick selenogenes, and …

Ethanol-Induced Stress Response Of Staphylococcus Aureus, Jasmine M. Pando, Richard F. Pfeltz, Jesus A. Cuaron, Vijayaraj Nagarajan, Mukti N. Mishra, Nathaniel J. Torres, Mohamed O. Elasri, Brian J. Wilkinson, John E. Gustafson

Faculty Publications

Transcriptional profiles of 2 unrelated clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates were analyzed following 10% (v/v) ethanol challenge (15 min), which arrested growth but did not reduce viability. Ethanol-induced stress (EIS) resulted in differential gene expression of 1091 genes, 600 common to both strains, of which 291 were upregulated. With the exception of the downregulation of genes involved with osmotic stress functions, EIS resulted in the upregulation of genes that contribute to stress response networks, notably those altered by oxidative stress, protein quality control in general, and heat shock in particular. In addition, genes involved with …

Application Of An Advanced Maximum Likelihood Estimation Restoration Method For Enhanced-Resolution And Contrast In Second-Harmonic Generation Microscopy, Mayandi Sivaguru, Mohammad M. Kabir, Manas Ranjan Gartia, David S.C. Biggs, Barghav S. Sivaguru, Vignesh A. Sivaguru, Glenn A. Fried, Gang Logan Liu, Sakthivel Sadayappan, Kimani C. Toussaint

Faculty Publications

Second-harmonic generation (SHG) microscopy has gained popularity because of its ability to perform submicron, label-free imaging of noncentrosymmetric biological structures, such as fibrillar collagen in the extracellular matrix environment of various organs with high contrast and specificity. Because SHG is a two-photon coherent scattering process, it is difficult to define a point spread function (PSF) for this modality. Hence, compared to incoherent two-photon processes like two-photon fluorescence, it is challenging to apply the various PSF-engineering methods to improve the spatial resolution to be close to the diffraction limit. Using a synthetic PSF and application of an advanced maximum likelihood estimation …

European Starlings, H. Jeffrey Homan, Ron J. Johnson, James R. Thiele, George M. Linz

Wildlife Damage Management Technical Series

European starlings (Sturnus vulgaris, Figure 1) are an invasive species in the United States. The first recorded release of the birds was in 1890 in New York City’s Central Park. Because starlings easily adapt to a variety of habitats, nest sites and food sources, the birds spread quickly across the country. Today, there are about 150 million starlings in North America. Conflicts between people and starlings occur mostly in agricultural settings. Conflicts can occur during winter in urban and suburban environments, especially in business districts.

Starlings damage apples, blueberries, cherries, figs, grapes, peaches, and strawberries. Besides causing direct losses from …

Assessing The Effect Of Nutritional Interventions On Body Composition Changes During Pregnancy In Moderately Malnourished Malawian Women, Megan K. Kitagawa

Master's Theses

Background: Malnutrition can affect the body composition changes that occur in healthy pregnancy, resulting in adverse effects to both the mother and infant. Supplementary foods with high quality protein may result in more favorable changes in lean mass and fat mass in pregnant malnourished women.

Objective: To retrospectively assess changes in body composition in moderately malnourished pregnant Malawian women in response to one of three nutritional interventions.

Methods: Height, weight, MUAC, and TSF were measured in pregnant women with MUAC >20.6 cm and19) were compared using ANOVA. If differences were detected, differences between groups were tested using the Tukey HSD …

Mice Lacking Gpr37 Exhibit Decreased Expression Of The Myelin-Associated Glycoprotein Mag And Increased Susceptibility To Demyelination, Brilee M. Smith, Michelle M. Giddens, Jessica Neil, Sharon Owino, Trang Kimberly T. Nguyen, Duc Duong, Fengqiao Li, Randy A. Hall

Neuroscience: Faculty Publications

GPR37 is an orphan G protein-coupled receptor that is predominantly expressed in the brain and found at particularly high levels in oligodendrocytes. GPR37 has been shown to exert effects on oligodendrocyte differentiation and myelination during development, but the molecular basis of these actions is incompletely understood and moreover nothing is known about the potential role(s) of this receptor under demyelinating conditions. To shed light on the fundamental biology of GPR37, we performed proteomic studies comparing protein expression levels in the brains of mice lacking GPR37 and its close relative GPR37-like 1 (GPR37L1). These studies revealed that one of the proteins …

Diabetes And Coronary Artery Disease: Role Of Functional Imaging, Maseeh Uz Zaman, Nosheen Fatima

Department of Radiology

No abstract provided.

Fallout From Obergefell: The Dissolution Of Unconventional Adoptions To Pave The Way For Same-Sex Marriage Equality, Jodi B. Mileto

West Virginia Law Review

No abstract provided.

Providing For The Safety Of The Participants Of The Criminal Court Proceedings – The Subject Of Cconcern Of Russian Legislator, Government, Scientists And Practicians, Galina Yakovlevna Borisevich

Journal of Digital Forensics, Security and Law

For many decades, the problems of the post-criminal impact onto the witnesses, complainants, other participants of the criminal procedures in Russian Federation has no solution. Criminal procedural Codes of 1922, 1923, 1960 did not mentioned them. Gradually, these problems have gained a widespread importance and interpretation. The fear of reprisal from the criminals, their close neighbourhood, the possibility to reprise led to the witnesses’ and the complainants’ refusal to testify or to changing the testimonies. All that negatively influenced substantiating the circumstances of the criminal cases. The absence of the safety measures in the legislation of the USSR and Russia …

Identification And Characterization Of Preferred Dna-Binding Sites For The Thermus Thermophilus Transcriptional Regulator Fadr, Minwoo Lee, Hyejin Um, Michael W. Van Dyke

Faculty Articles

One of the primary transcriptional regulators of fatty acid homeostasis in many prokaryotes is the protein FadR. To better understand its biological function in the extreme thermophile Thermus thermophilus HB8, we sought to first determine its preferred DNA-binding sequences in vitro using the combinatorial selection method Restriction Endonuclease Protection, Selection, and Amplification (REPSA) and then use this information to bioinformatically identify potential regulated genes. REPSA determined a consensus FadR-binding sequence 5´-TTRNACYNRGTNYAA-3´, which was further characterized using quantitative electrophoretic mobility shift assays. With this information, a search of the T. thermophilus HB8 genome found multiple operons potentially regulated by FadR. …

Bronchoscopic Management Of Prolonged Air Leak, S Keshishyan, A Revelo, Oleg Epelbaum

NYMC Faculty Publications

Bronchopleural fistula (BPF) with prolonged air leak (PAL) is most often, though not always, a sequela of lung resection. When this complication occurs post-operatively, it is associated with substantial morbidity and mortality. Surgical closure of the defect is considered the definitive approach to controlling the source of the leak, but many patients with this condition are suboptimal operative candidates. Therefore there has been active interest for decades in the development of effective endoscopic management options. Successful use of numerous bronchoscopic techniques has been reported in the literature largely in the form of retrospective series and, at best, small prospective trials. …

Oblique Longwave Infrared Atmospheric Compensation, Daniel S. O'Keefe

Theses and Dissertations

This research introduces two novel oblique longwave infrared atmospheric compensation techniques for hyperspectral imagery, Oblique In-Scene Atmospheric Compensation (OISAC) and Radiance Detrending (RD). Current atmospheric compensation algorithms have been developed for nadir-viewing geometries which assume that every pixel in the scene is affected by the atmosphere in nearly the same manner. However, this assumption is violated in oblique imaging conditions where the transmission and path radiance vary continuously as a function of object-sensor range, negatively impacting current algorithms in their ability to compensate for the atmosphere. The techniques presented here leverage the changing viewing conditions to improve rather than hinder …

2017 Bracke Library Retreat.Pdf, Marianne Stowell Bracke

Library Retreat

No abstract provided.

Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review, Wesley C. Van Voorhis, J. Stone Doggett, Marilyn Parsons, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold, Michael W. Riggs, Andrew Hemphill, Daniel K. Howe, Robert H. Mealey, Audrey O. T. Lau, Ethan A. Merritt, Dustin J. Maly, Erkang Fan, Kayode K. Ojo

Veterinary Science Faculty Publications

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites’ survival and proliferation. In this review, we review efficacy against the kinase target, the parasite growth in vitro, and in animal infection models, as well …

Evaluating The Evidence And Assessing Registered Dietitian Nutritionists' Perceptions Of The Complex Renal Dietary Restrictions, Alyssa Lee Welte

Theses and Dissertations

The renal diet is often regarded as challenging to teach and follow, and can easily lead to additional complications, including malnutrition. Recent trends in the literature have suggested a liberalization in the renal diet, though no studies have assessed whether Registered Dietitian Nutritionists (RDNs) are comfortable making this change. An original, cross-sectional survey was created for this study. 187 renal dietitians completed the survey which revealed that only 15.3% of participants felt it is acceptable to liberalize the standard dietary restriction on fruits and vegetables, and 13.6% said the same about the bean and legume restriction. 19.9% are extremely likely …

Connecting The Dots: Stopover Strategies Of An Intercontinental Migratory Songbird In The Context Of The Annual Cycle, Kristina Paxton, Frank R. Moore

Faculty Publications

The phases of the annual cycle for migratory species are inextricably linked. Yet, less than five percent of ecological studies examine seasonal interactions. In this study, we utilized stable hydrogen isotopes to geographically link individual black-and-white warblers (Mniotilta varia) captured during spring migration with breeding destinations to understand a migrant's stopover strategy in the context of other phases of the annual cycle. We found that stopover strategy is not only a function of a bird's current energetic state, but also the distance remaining to breeding destination and a bird's time-schedule, which has previously been linked to habitat conditions experienced …

Microbial Invasion Vs. Tick Immune Regulation, Daniel E. Sonenshine, Kevin R. Macaluso

Biological Sciences Faculty Publications

Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al., 2013). Moreover, …

Immunohistochemistry And Electron Microscopy Of Rat Palatine Glands Development, Zaki Hakami

Master's Theses

No abstract provided.

Tropical Cyclones Disrupt The Relationship Between Tree Height And Species Diversity: Comment, Teng-Chiu Lin, Lixin Wang, Chengyang Zheng, Ryan W. Mcewan, Chung-Te Chang, Jyh-Min Chiang, Chung-Hao Chi

Biology Faculty Publications

In a recent report on the patterns of tree species richness in eastern and western North America, Marks et al. (2016) claimed to have identified an operational indicator of environmental harshness (maximum tree height) and concluded that environmental stressors that limit tree height also act as ecological filters on species richness. Marks et al. (2017) attributed the positive association between species richness and maximum tree height to both the direct effects of environmental harshness on species richness and the indirect effects of environmental harshness on species richness as mediated by maximum tree height.

This finding overlooked the fact that many …

Humanity’S Subtensions: Culture Theory In Us Death Penalty Mitigation, Jesse Cheng

Social and Cultural Sciences Faculty Research and Publications

Criminal law in the United States values conceptual definitiveness in its quest for resolution. But the work of open-ended humanization required of sentencing mitigation advocates in American death penalty cases defies this call for definitiveness. Even as formal legal processes seek to limit the knowledge that can be brought into the courtroom, new theoretical approaches that justify more understanding and fact-finding can help attain tangible goals of defense advocacy. This article provides an ethnographic account of how capital defense practitioners in the United States engage with anthropological theories of culture as a behind-the-scenes advocacy strategy that succeeds by exploiting the …

Reciprocal Effect Of Parental Lines On The Physiological Potential And Seed Composition Of Corn Hybrid Seeds, Juliana F. Santos, Lynnette M. A. Dirk, A. Bruce Downie, Mauricio F. G. Sanches, Roberval D. Vieira

Horticulture Faculty Publications

Obtaining corn hybrid seeds (Zea mays L.) with high vigour depends on the parental lines and the direction of the cross, and this relates to seed desiccation tolerance and composition. This research studied reciprocal crosses between pairs of proprietary, elite parent lines (L1 and L5; L2 and L4) producing hybrid seeds with different qualities attempting to correlate vigour with seed composition, focusing on storage proteins, starch and soluble sugar amounts. Four corn hybrid seed lots produced from reciprocal crosses were compared (HS 15 with HS 51, and HS 24 with HS 42) by assessing germination, vigour, and seedling emergence …

X Chromosome Evolution In Cetartiodactyla, Anastasiya A. Proskuryakova, Anastasia I. Kulemzina, Polina L. Perelman, Alexey I. Makunin, Denis M. Larkin, Marta Farre, Anna V. Kukekova, Jennifer Lynn Johnson, Natalya A. Lemskaya, Violetta R. Beklemisheva, M. Roelke-Parker, June Bellizzi, Oliver A. Ryder, Stephen James O'Brien, Alexander S. Graphodatsky

Biology Faculty Articles

The phenomenon of a remarkable conservation of the X chromosome in eutherian mammals has been first described by Susumu Ohno in 1964. A notable exception is the cetartiodactyl X chromosome, which varies widely in morphology and G-banding pattern between species. It is hypothesized that this sex chromosome has undergone multiple rearrangements that changed the centromere position and the order of syntenic segments over the last 80 million years of Cetartiodactyla speciation. To investigate its evolution we have selected 26 evolutionarily conserved bacterial artificial chromosome (BAC) clones from the cattle CHORI-240 library evenly distributed along the cattle X chromosome. High-resolution BAC …

Address At The Lincoln Charter Of The Forest Conference, Bishop Grosseteste University: The Charter Of The Forest: Evolving Human Rights In Nature, Nicholas A. Robinson

Elisabeth Haub School of Law Faculty Publications

This conference is a singular event, long over due. It has been 258 years since William Blackstone celebrated “these two sacred charters,”1 Carta de Foresta and Magna Carta, with his celebrated publication of their authentic texts. In 2015, the Great Charter of Liberties enjoyed scholarly, political and popular focus. The companion Forest Charter was and is too much neglected.2 I salute the American Bar Association, and Dan Magraw, for the ABA’s educational focus of the Forest Charter, as well as Magna Carta. Today we restore some balance with this conference’s searching and insightful examination of the Forest Charter’s significance.

Geospatial Determinants Of Increased Screening Mammography In U.S. Black Women, Laura Stiel

Loma Linda University Electronic Theses, Dissertations & Projects

Black women have the highest mortality rate due to breast cancer compared to any other racial/ethnic group in the U.S. and are more likely to be diagnosed with late-stage breast cancer compared to White women. Though the causes of these disparities are multifactorial, early detection by mammography, in combination with improved treatment, is related to improved breast cancer survival outcomes. Recently, the rate of Black women reporting having had a screening mammogram in the last two years has increased, and by some accounts surpassed, that of White women. This dissertation assesses this change in mammography among Black women in order …

Factors Associated With Orthodontically Induced Apical Root Resorption Of Maxillary Incisors, Brandon Malan

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Resorption of root apices is a ubiquitous occurrence in orthodontic treatment. Although most occurrence of resorption during orthodontic treatment is clinically inconsequential, a small percentage of patients have a severe amount of root structure that is lost. There are factors that are widely accepted as responsible for apical root resorption (RR), such as heavy compressive forces on the periodontal ligament (PDL). Unfortunately, it is still largely unpredictable if one patient will experience more root loss than what is considered normal. Thus, it is of clinical interest to further study what factors play a role in RR. Purpose: The purpose …