Digital Commons Network^™

Biennial Faculty Activities Report To The Board Of Regents, State Of Iowa, 2017, University Of Northern Iowa, University Of Iowa, Iowa State University

Institutional Effectiveness & Planning Documents

Report of faculty activity broken down by rank and compared to the other Regents institutions.

Wild 540.01: Research Design, Lisa A. Eby

University of Montana Course Syllabi, 2016-2020

No abstract provided.

Wild 595.01: Research Design Lab, Lisa A. Eby

University of Montana Course Syllabi, 2016-2020

No abstract provided.

Substantive Change Prospectus Section 5. Faculty- Final Narrative, Georgia Southern University

Armstrong State & Georgia Southern Consolidation: SACSCOC Prospectus (Archived)

Armstrong State/ Georgia Southern Consolidation SACSCOC Substantive Change Prospectus Section 5

Predicting The Consequence Of Natural And Chemical Dispersion For Oil Slick Size Over Time, Marieke Zeinstra-Helfrich, Wierd Koops, Albertinka Murk

C-IMAGE Publications

Application of dispersants aims to enhance the natural dispersion process in order to reduce the size of the slick and the amount of oil at the surface. This study presents an approach for modeling the development of the surface oil slick as a function of the wind speed, oil viscosity, and dispersant application. We modeled the oil slick mass distribution across a transect through the slick over time taking into account the continuous entrainment of oil, resurfacing process of the different oil droplet size classes and horizontal transport. Outcomes show distinctively different oil slick features, depending on how favorable conditions …

White-Nose Syndrome Fungus In A 1918 Bat Specimen From France, Michael G. Campana, Naoko P. Kurata, Jeffrey T. Foster

KIP Articles

White-nose syndrome, first diagnosed in North America in 2006, causes mass deaths among bats in North America. We found the causative fungus, Pseudogymnoascus destructans, in a 1918 sample collected in Europe, where bats have now adapted to the fungus. These results are consistent with a Eurasian origin of the pathogen.

Development And Validation Of A Novel Lc–Ms/Ms Method For Simultaneous Determination Of Abiraterone And Its Seven Steroidal Metabolites In Human Serum: Innovation In Separation Of Diastereoisomers Without Use Of A Chiral Column, Mohammad Alyamani, Zhenfei Li, Sunil K. Upadhyay, David J. Anderson, Richard J. Auchus, Nima Sharifi

Chemistry Faculty Publications

Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castration-resistant prostate cancer. Abiraterone is metabolized in patients to a more potent analogue, D4A. However, we have recently reported that this analogue is further metabolized to additional metabolites in patients treated with AA. Here, we present a liquid chromatography-tandem mass spectrometry method developed to resolve and detect abiraterone and its seven metabolites in human serum using an AB Sciex Qtrap 5500 mass analyzer coupled with a Shimadzu Nexera UPLC station. Analytes and the internal standard (abiraterone-d4) were extracted from human serum using the liquid–liquid extraction procedure. The …

2017 Grizzly Football Yearbook, University Of Montana--Missoula. Athletics Department

Grizzly Football Yearbook, 1939-2018

Annual yearbook of the University of Montana’s Athletics Department. This volume covers the period from fall 2017 through spring 2018.

Caption This: Police In Pussyhats, White Ladies, And Carceral Psychology Under Trump, Alison R. Reed

English Faculty Publications

No abstract provided.

Fors 333.01: Fire Ecology, Philp Higuera

University of Montana Course Syllabi, 2016-2020

No abstract provided.

Different Types Of Housing And Respiratory Health Outcomes, Wen Qi Gan, Wayne T. Sanderson, Steven R. Browning, David M. Mannino

Preventive Medicine and Environmental Health Faculty Publications

Evidence has shown that housing conditions may substantially influence the health of residents. Different types of housing have different structures and construction materials, which may affect indoor environment and housing conditions. This study aimed to investigate whether people living in different types of housing have different respiratory health outcomes. The data from the 1999–2006 National Health and Nutrition Examination Survey were used for the analyses. The types of housing included houses, townhouses, apartments, and mobile homes. Respiratory symptoms included wheezing, coughing, sputum, and dyspnea; respiratory diseases included asthma, chronic bronchitis, emphysema, and chronic obstructive pulmonary disease (COPD). Multiple logistic regression …

Dna Damage Regulates Direct Association Of Tor Kinase With The Rna Polymerase Ii-Transcribed Hmo1 Gene, Arvind Panday, Ashish Gupta, Kavitha Srinivasa, Lijuan Xiao, Mathew D. Smith, Anne Grove

Faculty Publications

© 2017 Panday et al. The mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient sufficiency and cellular stress. When mTORC1 is inhibited, protein synthesis is reduced in an intricate process that includes a concerted down-regulation of genes encoding rRNA and ribosomal proteins. The Saccharomyces cerevisiae high-mobility group protein Hmo1p has been implicated in coordinating this response to mTORC1 inhibition. We show here that Tor1p binds directly to the HMO1 gene (but not to genes that are not linked to ribosome biogenesis) and that the presence of Tor1p is associated with activation of gene activity. Persistent induction of DNA double-strand …

Parasite Biodiversity Faces Extinction And Redistribution In A Changing Climate, Colin J. Carlson, Kevin R. Burgio, Eric R. Dougherty, Anna J. Phillips, Veronica M. Bueno, Christopher F. Clements, Giovanni Castaldo, Tad A. Dallas, Carrie A. Cizauskas, Graeme S. Cumming, Jorge Doña, Nyeema C. Harris, Roger Jovani, Sergey Mironov, Oliver C. Muellerklein, Heather C. Proctor, Wayne M. Getz

Faculty Publications

Copyright © 2017 The Authors, some rights reserved. Climate change is a well-documented driver of both wildlife extinction and disease emergence, but the negative impacts of climate change on parasite diversity are undocumented. We compiled the most comprehensive spatially explicit data set available for parasites, projected range shifts in a changing climate, and estimated extinction rates for eight major parasite clades. On the basis of 53, 133 occurrences capturing the geographic ranges of 457 parasite species, conservative model projections suggest that 5 to 10% of these species are committed to extinction by 2070 from climate-driven habitat loss alone. We find …

Primers For Castilleja And Their Utility Across Orobanchaceae: Ii. Single-Copy Nuclear Loci, Maribeth Latvis, Sarah J. Jacobs, Sebastian M.E. Mortimer, Melissa Richards, Paul D. Blischak, Sarah Mathews, David C. Tank

Faculty Publications

Premise of the study: We developed primers targeting nuclear loci in Castilleja with the goal of reconstructing the evolutionary history of this challenging clade. These primers were tested across other major clades in Orobanchaceae to assess their broader utility. Methods and Results: We assembled low-coverage genomes for three taxa in Castilleja and developed primer combinations for the single-copy conserved ortholog set (COSII) and the pentatricopeptide repeat (PPR) gene family. These primer combinations were designed to take advantage of the Fluidigm microfluidic PCR platform and are well suited for high-throughput sequencing applications. Eighty-seven primers were designed for Castilleja, and 27 were …

Characteristics Of Ovarian Cancer Detection By A Near-Infrared Fluorescent Probe Activated By Human Nad(P)H: Quinone Oxidoreductase Isozyme 1 (Hnqo1), Yuko Nakamura, Zhenhua Shen, Toshiko Harada, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Peter L. Choyke, Robin L. Mccarley, Hisataka Kobayashi

Faculty Publications

© Nakamura et al. Near-infrared (NIR) fluorescent probes are ideal for in vivo imaging, because they offer deeper tissue penetration by the light and lower background autofluorescence than fluorophores that emit in the visible range. Q3STCy is a newly synthesized, NIR light-emitting probe that is activated by an enzyme commonly overexpressed in tumor cells, human nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase isozyme 1, known as hNQO1 or DT-diaphorase. The purpose of this study is to compare the sensitivity of detecting peritoneal ovarian cancer metastasis (POCM) with Q3STCy and gGlu-HMRG, a green fluorescent probe, upon their surface application. In vitro uptake …

Evolution Of Alu Subfamily Structure In The Saimiri Lineage Of New World Monkeys, Mark Batzer, Jasmine N. Baker, Jerilyn A. Walker, John A. Vanchiere, Kacie R. Philippe, Corey P. St. Romain, Paulina Gonzalez-Quiroga, Michael W. Denham, Jackson R. Mierl, Miriam K. Konkel

Faculty Publications

Squirrelmonkeys,Saimiri,arecommonlyfoundinzoologicalparksandusedinbiomedicalresearch.S.boliviensisisthemostcommon species for research; however, there is little information about genome evolution within this primate lineage. Here, we reconstruct the Alu element sequence amplification and evolution in the genus Saimiri at the time of divergence within the family Cebidae lineage. Alu elements are the most successful SINE (Short Interspersed Element) in primates. Here, we report 46 Saimiri lineage specificAlusubfamilies.RetrotranspositionactivityinvolvedsubfamiliesrelatedtoAluS,AluTa10,andAluTa15.Manysubfamiliesare simultaneously active within the Saimiri lineage, a finding which supports the stealth model of Alu amplification. We also report a high resolution analysis of Alu subfamilies within the S. boliviensis genome [saiBol1].

Alu Insertion Polymorphisms As Evidence For Population Structure In Baboons, Mark Batzer, Cody J. Steely, Jerilyn A. Walker, Vallmer E. Jordan, Thomas O. Beckstrom, Cullen L. Mcdaniel, Corey P. St. Romain, Emily C. Bennett, Arianna Robichaux, Brooke N. Clement, Muthuswamy Raveendran, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeff Rogers, Miriam K. Konkel

Faculty Publications

Male dispersal from the natal group at or near maturity is a feature of most baboon (Papio) species. It potentially has profound effects upon population structure and evolutionary processes, but dispersal, especially for unusually long distances, is not readily documented by direct field observation. In this pilot study, we investigate the possibility of retrieving baboon population structure in yellow (Papio cynocephalus) and kinda (Papio kindae) baboons from the distribution of variation in a genome-wide set of 494 Alu insertion polymorphisms, made available via the recently completed Baboon Genome Analysis Consortium. Alu insertion variation in a mixed …

Integrating Soil Silicon Amendment Into Management Programs For Insect Pests Of Drill-Seeded Rice, James M. Villegas, Michael O. Way, Rebecca A. Pearson, Michael J. Stout

Faculty Publications

© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Silicon soil amendment has been shown to enhance plant defenses against insect pests. Rice is a silicon-accumulating graminaceous plant. In the southern United States, the rice water weevil and stem borers are important pests of rice. Current management tactics for these pests rely heavily on the use of insecticides. This study evaluated the effects of silicon amendment when combined with current management tactics for these rice insect pests in the field. Field experiments were conducted from 2013 to 2015. Rice was drill-planted in plots subjected to factorial combinations of variety (conventional …

Role Of Inward Rectifier Potassium Channels In Salivary Gland Function And Sugar Feeding Of The Fruit Fly, Drosophila Melanogaster, Daniel R. Swale, Zhilin Li, Felix Guerrero, Adalberto A. Pérez De León, Lane D. Foil

Faculty Publications

© 2016 The Authors The arthropod salivary gland is of critical importance for horizontal transmission of pathogens, yet a detailed understanding of the ion conductance pathways responsible for saliva production and excretion is lacking. A superfamily of potassium ion channels, known as inward rectifying potassium (Kir) channels, is overexpressed in the Drosophila salivary gland by 32-fold when compared to the whole body mRNA transcripts. Therefore, we aimed to test the hypothesis that pharmacological and genetic depletion of salivary gland specific Kir channels alters the efficiency of the gland and reduced feeding capabilities using the fruit fly Drosophila melanogaster as a …

Short Communication: Lack Of Support For Socially Connected Hiv-1 Transmission Among Young Adult Black Men Who Have Sex With Men, Kayo Fujimoto, Lyndon M. Coghill, Christopher A. Weier, Lu Yu Hwang, Ju Yeong Kim, John A. Schneider, Michael L. Metzker, Jeremy M. Brown

Faculty Publications

© Copyright 2017, Mary Ann Liebert, Inc. 2017. We explore the phylogenetic relationships among HIV sequences sampled from young adult black men who have sex with men (YAB-MSM), who are connected through peer referral/social ties and who attend common venues. Using 196 viral sequences sampled from the peripheral blood mononuclear cells of 10 individuals, our preliminary phylogenetic results indicate that these socially connected YAB-MSM are infected with distantly related viruses and provide no evidence for viral transmission between network members. Our results suggest that HIV-prevention strategies that target young adult MSM should extend beyond their network members and local community.

An Overview Of Research At University Of Kalyani In Exploring Some Basic Issues Of Homoeopathy, Anisur Khuda-Bukhsh

Indian Journal of Research in Homoeopathy

Homoeopathy has been confronted with certain major issues such as (i) how is medicinal property of homoeopathic drug transferred to and retained by the vehicle; (ii) how can it act in biological system in the absence of any original drug substance in ultra high diluted remedies? and (iii) plausible mechanism and pathways of biological action including mysteries of ‘like cured by likes’. We demonstrated through controlled studies the ability of ultra-highly diluted homoeopathic drugs in rendering protection/repair of cytogenetic damages inflicted by whole-body X-irradiation in mammalian model mice in vivo. We examined cytogenetic damages in arsenic, cadmium, mercury and stannum …

Anti-Inflammatory Homoeopathic Drug Dilutions Restrain Lipopolysaccharide-Induced Release Of Pro-Inflammatory Cytokines: In Vitro And In Vivo Evidence, Umesh Mahajan, Ajit Walke, Mahendra Kardile, Sameer Goyal, Sumit Siddharth, Chanakya Kundu, Shreesh Ojha, Chandragouda Patil

Indian Journal of Research in Homoeopathy

Context: The lipopolysaccharide (LPS)-induced cytokine release and oxidative stress are validated experimental parameters used to test anti-inflammatory activity. We investigated the effects of homoeopathic mother tinctures, 6 CH, 30 CH and 200 CH dilutions of Arnica montana, Thuja occidentalis and Bryonia alba against LPS (1 μg/ml)-induced cytokine release from RAW-264.7 cells and human whole-blood culture. Materials and Methods: For in vivo evaluations, mice were orally treated with 0.1 ml drug dilutions twice a day for 5 days followed by an intraperitoneal injection of 0.5 mg/kg LPS. After 24 h, the mice were sacrificed and serum levels of pro-inflammatory cytokines and …

Efficacy And Safety Of Abatacept, A T-Cell Modulator, In A Randomised, Double-Blind, Placebo-Controlled, Phase Iii Study In Psoriatic Arthritis., Philip Mease, Alice B Gottlieb, Désirée Van Der Heijde, Oliver Fitzgerald, Alyssa Johnsen, Marleen Nys, Subhashis Banerjee, Dafna D Gladman

Articles, Abstracts, and Reports

OBJECTIVES: To assess the efficacy and safety of abatacept, a selective T-cell costimulation modulator, in a phase III study in psoriatic arthritis (PsA).

METHODS: This study randomised patients (1:1) with active PsA (~60% with prior exposure to a tumour necrosis factor inhibitor) to blinded weekly subcutaneous abatacept 125 mg (n=213) or placebo (n=211) for 24 weeks, followed by open-label subcutaneous abatacept. Patients without ≥20% improvement in joint counts at week 16 were switched to open-label abatacept. The primary end point was the proportion of patients with ≥20% improvement in the American College of Rheumatology (ACR20) criteria at week 24.

RESULTS: …

The Potential Impact Of Heir Property On Timber Management In The Southeastern United States, Becky Barlow, Conner Bailey

Professional Agricultural Workers Journal

Abstract

Active timberland management maintains forest health and productivity, which in turn contributes to the sustainability of the resource and wealth of the landowner. However, when land is held as heir property, options for timberland management are often limited. Heir property is owned as an undivided interest among many heirs of an original owner, or multiple generations of owners, who died intestate. This is common among African American landowners in the South. As a result the title is considered “clouded,” limiting access to capital and resources that are beneficial to timberland management. In this paper, the authors hope to improve …

Deep Ancestry Of Programmed Genome Rearrangement In Lampreys, Vladimir A. Timoshevskiy, Ralph T. Lampman, Jon E. Hess, Laurie L. Porter, Jeramiah J. Smith

Biology Faculty Publications

In most multicellular organisms, the structure and content of the genome is rigorously maintained over the course of development. However some species have evolved genome biologies that permit, or require, developmentally regulated changes in the physical structure and content of the genome (programmed genome rearrangement: PGR). Relatively few vertebrates are known to undergo PGR, although all agnathans surveyed to date (several hagfish and one lamprey: Petromyzon marinus) show evidence of large scale PGR. To further resolve the ancestry of PGR within vertebrates, we developed probes that allow simultaneous tracking of nearly all sequences eliminated by PGR in P. marinus and …

Phrynosoma Cornutum (Texas Horned Lizard). Predation., Jennie Mook, Monika Burchette, Brett Degregorio, Victor Bogosian Iii, Eric M. Schauber, Raymond W. Moody

Publications

No abstract provided.

Effect Of Dietary Salt Intake On Epithelial Na+ Channels (Enac) In Vasopressin Magnocellular Neurosecretory Neurons In The Rat Supraoptic Nucleus, Kaustubh Sharma, Masudul Haque, Richard Guidry, Yoichi Ueta, Ryoichi Teruyama

Faculty Publications

© 2017 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Key points: A growing body of evidence suggests that epithelial Na+ channels (ENaCs) in the brain play a significant role in the regulation of blood pressure; however, the brain structures that mediate the effect are not well understood. Because vasopressin (VP) neurons play a pivotal role in coordinating neuroendocrine and autonomic responses to maintain cardiovascular homeostasis, a basic understanding of the regulation and activity of ENaC in VP neurons is of great interest. We show that high dietary salt …

Primers For Castilleja And Their Utility Across Orobanchaceae: I. Chloroplast Primers, Maribeth Latvis, Sebastian M.E. Mortimer, Diego F. Morales-Briones, Samuel Torpey, Simon Uribe-Convers, Sarah J. Jacobs, Sarah Mathews, David C. Tank

Faculty Publications

Premise of the study: Chloroplast primers were developed from genomic data for the taxonomically challenging genus Castilleja. We further tested the broader utility of these primers across Orobanchaceae, identifying a core set of chloroplast primers amplifying across the clade. Methods and Results: Using a combination of three low-coverage Castilleja genomes and sequence data from 12 Castilleja plastomes, 76 primer combinations were specifically designed and tested for Castilleja. The primers targeted the most variable portions of the plastome and were validated for their applicability across the clade. Of these, 38 primer combinations were subsequently evaluated in silico and then validated across …

Rubrobacter Spartanus Sp. Nov., A Moderately Thermophilic Oligotrophic Bacterium Isolated From Volcanic Soil, Jeffrey S. Norman, Gary M. King, Maren L. Friesen

Faculty Publications

© 2017 IUMS. Bacterial strain HPK2-2T was isolated from soil adjacent to the caldera of Kilauea Volcano in Hawaii Volcanoes National Park. HPK2-2T is a chemoorganoheterotroph that shows optimal growth at 50 °C (range 45-55 °C) and pH 8.0 (range 5.0-10.0). Sequence analysis of the 16S subunit of the rRNA gene showed that HPK2-2T is most closely related to the type strain of Rubrobactertaiwanensis (ATCC BAA-406T), with which it shared 94.5% sequence identity. The major fatty acids detected in HPK2-2T were C18:0 14-methyl and C16:0 12-methyl; internally branched fatty acids such as these are characteristic of the genus Rubrobacter. The …

Long-Term Entomological Research On Canopy Arthropods In A Tropical Rainforest In Puerto Rico, T. D. Schowalter

Faculty Publications

No abstract provided.