Digital Commons Network^™

Biology And Impacts Of Leech Infestation In Largemouth Bass (Micropterus Salmoides) In Back Bay, Virginia, Amanda Nicole Pomposini

Biological Sciences Theses & Dissertations

Back Bay is an oligohaline coastal bay in Southeast Virginia, USA. The Oregon Inlet along the Outer Banks of North Carolina is the only significant salinity source to the Bay via the Pamlico and Currituck Sounds of North Carolina. Today Back Bay is considered a brackish ecosystem with salinity of 2004, leeches have been observed in the oral cavities of Largemouth Bass (Micropterus salmoides) in Back Bay. Leeches (Myzobdella lugubris) have previously been documented in the oral cavities of largemouth bass in the Currituck Sound. In 2009, the Virginia Department of Game and Inland Fisheries (VDGIF) …

Synthesis, Characterization And Application Of Sugar-Based Low Molecular Weight Gelators, Ifeanyi Simeon Okafor

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are an interesting class of compound that have gained considerable attention especially because of their potential applications for soft biomaterials. Carbohydrate based low molecular weight hydrogelators and organogelators are able to selfassemble and form ordered supramolecular structures, which are useful for exploring biomedical applications. The resulting gelators are responsive to external stimuli because of the weak noncovalent intermolecular forces and interaction that influences self-assembly. Stimuli-responsive supramolecular organogels with interesting properties in response to external environmental stimuli have gained considerable attention due to their applications in biomaterials, sensors and for drug delivery.

One of the major …

Is Every Tweet Created Equal? A Framework To Identify Relevant Tweets For Business Research, Thad Chee

Information Technology & Decision Sciences Theses & Dissertations

It is a life or death matter for a firm to observe its environment and identify new threats or opportunities quickly. Information technology has increased firm’s speed and agility in responding to environmental changes. Social media offers a vast and timely source of environmental information that firms can readily use gauge public sentiment. Twitter is a high-speed service that allows anyone to “tweet” a message to any interested parties. Firms can access near instantaneous changes in the public mood about any topic by using Sentiment Analysis. These topics range from predicting equities prices to predicting election outcomes. A gap exists …

Infusing Complex Problem-Solving And Systems Thinking In College Leadership Development Programs, Dionicia Mahler-Rogers

Educational Leadership & Workforce Development Theses & Dissertations

Present day leaders grapple with a dynamic environment of evolving challenges. Prior leadership studies have afforded revisions of leadership theories in an attempt to remain relevant with the prominently shifting environment. The leadership models that underscore college leadership development programs should reflect the updated theories and practices which expose student leaders to solving complex problems they will experience. This study explores the knowledge, skills, and abilities needed for college students to be able to conceptualize and address system’s level leadership challenges. Foremost, the study examined instructional tools and methods that students found impactful for improving conceptualization and achievement of systems-level …

Population Structure Of Lethrinus Lentjan (Lethrinidae, Percoidei) Across The South China Sea And The Philippines Is Detected With Lane-Affected Radseq Data, Ellen E. Biesack

Biological Sciences Theses & Dissertations

Southeast Asia includes the Coral Triangle, a marine biodiversity hotspot that supports important fishery resources experiencing varied threats. Patterns of speciation and population structure in the Coral Triangle have been examined to test hypotheses relating to the historical geologic processes that may have influenced this biodiversity phenomenon. This study investigates the genetic population structure of the Pink-ear Emperor Snapper, Lethrinus lentjan (Lacepède, 1802), across the Philippines and the South China Sea. The species is fished throughout the Coral Triangle by subsistence and commercial fishers and their landings have been in decline for several years, which could be indicative of depleted …

Tracing The Genetic Footprints Of The Redbelly Yellowtail Fusilier, Caesio Cuning, Across Multiple Spatial And Evolutionary Scales, Amanda Susanne Ackiss

Biological Sciences Theses & Dissertations

Overfishing is one of the most pervasive threats to coral reef ecosystems, and management of these multi-species resources is hampered by limited species-specific population level information. The reefs in the western tropical Pacific Ocean, including the Coral Triangle, are the most bio-diverse in the world. Home to more than 400 million people, this region contains some of the most threatened coral reef ecosystems. Presented here is the first comprehensive analysis of the genetic structure of Caesio cuning, planktivorous fish inhabiting reefs in the Coral Triangle and western Pacific Ocean. Data from both classical Sanger and next-generation sequencing were analyzed …

Marine Reserves Promote Coral Reef Resilience By Mitigating Human Impacts Through The Restoration Of Parrotfish Populations, Increasing Their Reproductive Output And Seeding Neighboring Overfished Reefs, Brian L. Stockwell

Biological Sciences Theses & Dissertations

Coral reefs are some of the most productive ecosystems on the planet, providing fisheries resources for over a billion people with billions of dollars in revenue from tourism for developing nations. Coral reefs are under threat from overfishing and water pollution, resulting in less productive algae dominated reefs. Marine reserves are widely expected to promote the resilience of reefs by protecting and increasing the abundance of herbivorous fishes that can graze on algae, therefore directly or indirectly preventing coral to algal phase shifts. However, the ability of marine reserves to mitigate human impacts, restore herbivorous fish populations and seed nearby …

Efficient Machine Learning Approach For Optimizing Scientific Computing Applications On Emerging Hpc Architectures, Kamesh Arumugam Karunanithi

Computer Science Theses & Dissertations

Efficient parallel implementations of scientific applications on multi-core CPUs with accelerators such as GPUs and Xeon Phis is challenging. This requires - exploiting the data parallel architecture of the accelerator along with the vector pipelines of modern x86 CPU architectures, load balancing, and efficient memory transfer between different devices. It is relatively easy to meet these requirements for highly-structured scientific applications. In contrast, a number of scientific and engineering applications are unstructured. Getting performance on accelerators for these applications is extremely challenging because many of these applications employ irregular algorithms which exhibit data-dependent control-flow and irregular memory accesses. Furthermore, these …

Healthcare Outcomes And Resource Utilization Associated With Neonatal Hypoglycemia: Analysis Of Data From The Hcup Kid’S Inpatient Database, Brook T. Alemu

Health Services Research Dissertations

Neonatal hypoglycemia is the most common metabolic abnormality in infants and is associated with neurological damage and death. The risk of developing hypoglycemia among infants born from diabetic mothers is even higher. Although much work has been performed addressing issues for treatment and care, research related to neonatal hypoglycemia has been focused on the clinical or individual level risk factors. Contextual risk factors such as hospital characteristics, neighborhood economic status, and regional variations were not considered in earlier studies. Additionally, although healthcare resources utilization of hypoglycemia has been adequately addressed in the adult population, this topic has not been studied …

Lifespan Communication And Career Development Of Black Teachers: A Socio-Ecological Approach, Veronica Whinnett Hurd

Communication & Theatre Arts Theses

This thesis unlocks the lifespan story of nine Black participants as they reflected on the communicative practices that guided their career journey towards becoming a teacher. Through the lens of Bronfenbrenner’s (1979) socio-ecological development model, the microsystem, mesosystem, exosystem, macrosystem, and chronosystem were examined to understand the content of career-related memories and with whom or what the communicative experiences occurred with across the participants’ lifespan. This study also takes an in-depth look at how the content of the memories evolved across Erikson’s (1964) childhood, adolescence, and young adulthood developmental periods, and the influence of the proximal and distal socio-ecological environments …

Thermally Assisted Pulsed Electric Field Ablation For Cancer Therapy, James Michael Hornef

Biomedical Engineering Theses & Dissertations

Pulsed Electric Fields (PEF) have promised improved treatment results in a variety of cancer types including melanoma, pancreatic and lung squamous cancer. Recent studies show that PEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. Experiments were performed to design, calibrate and implement a feedback-looped infrared laser irradiation system that could maintain specified temperatures during the treatment. The exact treatment area, penetration depth and thermal distribution of a 980-nm laser fiber were quantified using several methods, including the knife-edge technique and a tissue optical property study. In vivo and in vitro experiments using …

Using Optimality Theory And Reference Points To Improve The Diversity And Convergence Of A Fuzzy-Adaptive Multi-Objective Particle Swarm Optimizer, Amit A. Kulkarni

Mechanical & Aerospace Engineering Theses & Dissertations

Particle Swarm Optimization (PSO) has received increasing attention from the evolutionary optimization research community in the last twenty years. PSO is a metaheuristic approach based on collective intelligence obtained by emulating the swarming behavior of bees. A number of multi-objective variants of the original PSO algorithm that extend its applicability to optimization problems with conflicting objectives have also been developed; these multi-objective PSO (MOPSO) algorithms demonstrate comparable performance to other state-of-the-art metaheuristics. The existence of multiple optimal solutions (Pareto-optimal set) in optimization problems with conflicting objectives is not the only challenge posed to an optimizer, as the latter needs to …

Effects Of Carboxylated Nanodiamonds On Macrophages During And After Differentiation, Maisoun E. Bani Hani

Biological Sciences Theses & Dissertations

Nanodiamonds (ND) are a carbon-based nanomaterial that are increasingly being proposed for developing novel imaging techniques, as carriers of biomolecules and therapeutic drugs, as coatings for implants, and for other biomedical applications. The exceptional chemical, mechanical, and optical properties of ND make this material suitable in a wide range of fields. The application of ND in the biomedical field is attractive but requires more in-depth investigation into the safety of ND and its interactions with different cells and systems. The effects of ND on the immune system are not fully understood or investigated and there are several controverting reports regarding …

Life History And Management Methods For Blueline Tilefish (Caulolatilus Microps) From The United States Mid-Atlantic Region, Michael A. Schmidtke

OES Theses and Dissertations

Blueline tilefish (Caulolatilus microps) have recently undergone an increase in landings from waters off the US Mid-Atlantic region (Virginia-Massachusetts). Currently, life history characteristics of blueline tilefish in this area are undescribed. Additionally, appropriate indices of population abundance are not available for this region, necessitating the use of data-limited management methods to set restrictions for harvest of blueline tilefish in this area. This dissertation describes growth and reproductive characteristics of blueline tilefish caught off the coast of Virginia and explores improvements of data-limited management methods that have been applied to blueline tilefish in the US Mid-Atlantic. Blueline tilefish from …

Selenium Distribution And Cycling In The Eastern Equatorial Pacific Ocean, Zoe Wambaugh

OES Theses and Dissertations

Oxygen minimum zones in oceanic waters have become increasingly important to the marine environment and society. Low oxygen waters affect not only the distribution and abundance of marine organisms, but also impact the solubility and transport of trace elements that are of biological importance, with the chemical speciation and solubility depending on the actual redox poise of the waters. One redox sensitive trace element of interest is selenium, which can be both toxic and essential for organisms, depending on its chemical speciation. In 2013, the US GEOTRACES program completed the GP16 transect from Peru to Tahiti, going through the oxygen …

Exploring The Relationship Between Media Influence And Policy Output: A State Comparative Study, Stephanie Savas Joannou Menefee

School of Public Service Theses & Dissertations

Through the years, various forms of media have become political institutions able to influence the public policy agenda. Analyzing policy helps to promote a better understanding of how the policy process works, how problems appear on the political agenda, and why governments choose to act or not to act on particular policy problems. This research utilizes Baumgartner and Jones’s (1993) Theory of Punctuated Equilibrium (PET) to examine the ways in which media attention influenced public policy on marijuana in the states of Kentucky, Massachusetts, and Vermont between 1996 and 2016.

Using qualitative research methods, the researcher conducted an exploratory, comparative …

Increased Habenular Connectivity In Opioid Users Is Associated With An Α5 Subunit Nicotinic Receptor Genetic Variant, Kaylah Curtis, Humsini Viswanath, Kenia M Velasquez, David L Molfese, Mark J Harding, Eduardo Aramayo, Philip R Baldwin, Elisa Ambrosi, Alok Madan, Michelle Patriquin, B Christopher Frueh, J Christopher Fowler, Thomas R Kosten, David A Nielsen, Ramiro Salas

Staff and Researcher Publications

Background and objectives: Opioid use disorder (OUD) is a chronic disorder with relapse based on both desire for reinforcement (craving) and avoidance of withdrawal. The aversive aspect of dependence and relapse has been associated with a small brain structure called the habenula, which expresses large numbers of both opioid and nicotinic receptors. Additionally, opioid withdrawal symptoms can be induced in opioid-treated rodents by blocking not only opioid, but also nicotinic receptors. This receptor co-localization and cross-induction of withdrawal therefore might lead to genetic variation in the nicotinic receptor influencing development of human opioid dependence through its impact on the aversive …

Ormeloxifene Suppresses Prostate Tumor Growth And Metastatic Phenotypes Via Inhibition Of Oncogenic Β-Catenin Signaling And Emt Progression, Bilal B. Hafeez, Aditya Ganju, Mohammed Sikander, Vivek K. Kashyap, Zubair Bin Hafeez, Neeraj Chauhan, Shabnam Malik, Andrew Massey, Manish Tripathi, Fathi T. Halaweish, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

Ormeloxifene is a clinically approved selective estrogen receptor modulator, which has also shown excellent anticancer activity, thus it can be an ideal repurposing pharmacophore. Herein, we report therapeutic effects of ormeloxifene on prostate cancer and elucidate a novel molecular mechanism of its anticancer activity. Ormeloxifene treatment inhibited epithelial-to-mesenchymal transition (EMT) process as evident by repression of N-cadherin, Slug, Snail, vimentin, MMPs (MMP2 and MMP3), β-catenin/TCF-4 transcriptional activity, and induced the expression of pGSK3β. In molecular docking analysis, ormeloxifene showed proficient docking with β-catenin and GSK3β. In addition, ormeloxifene induced apoptosis, inhibited growth and metastatic potential of prostate cancer cells and …

Sustainable Solutions

Sustainable Solutions Newsletter (2016-2021)

• Director's Message
• Campus Opportunities
• 3rd Annual Pallet Challenge
• Sustainability Seminar: Dr. Vandana Shiva
• Apartment Gardening 101 Workshop
• After School Garden Program
• Green Ambassadors- a Green Student Organization
• Tailgate Game- day Recycling
• Bee-Well Workshop
• Environmental Community Cinema: Life Off Grid
• Residence Hall Recycling Incentive Program
• Individual Student and Organization Mini-Grants
• Adopt-A-Stream volunteers needed
• NC's Vermiculture Conference

Sustainable Solutions, Georgia Southern University

Sustainable Solutions Newsletter (2016-2021)

• Campus Opportunities
• GreenFest
• 3rd Annual Pallet Challenge
• Sustainability Seminar: Dr. Vandana Shiva
• Environmental Community Cinema Presents: The True Cost
• Sustainability Social
• Georgia Southern Sustainability Network Annual Conference
• After School Garden Program
• Green Ambassadors- a Green Student Organization
• Tailgate Game-day Recycling
• Residence Hall Recycling Incentive Program
• Campus in the Spotlight
• Lunch and Learn with the Botanic Garden at Georgia Southern
• Adopt-A-Stream volunteers needed
• Georgia Conservancy: Sapelo Island Service Weekend
• Georgia Conservancy: Yellow River & Paddle Jame
• Forest Therapy Retreat
• Conferences
• EPA: Campus RainWorks Challenge
• Sustainability related Study Abroad
• Webinars
• Jobs/Internships
• FIRST Green Carpet Fashion Awards, Italia
• Green Tip

Genetic Moderation Of Cocaine Subjective Effects By Variation In The Tph1, Tph2, And Slc6a4 Serotonin Genes, Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielsen

Staff and Researcher Publications

Objective: This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine.

Methods: Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration of saline or cocaine (-15 min) to up to 20 min after infusion. Self-report ratings on the visual analog scale ranged from 0 (no effect) to 100 (greatest effect). Participants were genotyped for the TPH1 rs1799913, TPH2 rs4290270, and SLC6A4 5-HTTLPR variants. Repeated-measures analysis of covariance was used …

A Phenomenological View Of Teacher Efficacy As Experienced By Secondary Teachers Engaged In The Process Of Instructional Coaching, Shaftina Fiesta Snipes

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological was to describe teacher efficacy in the lived experiences of secondary teachers actively engaged in the instructional coaching process. The theoretical framework guiding this study was Albert Bandura’s (1992) social cognitive theory as it expounds upon the role efficacy plays in human agency as it encompasses teacher’s individual beliefs and past experiences, as well as, the extrinsic motivations. Teacher efficacy, the confidence a teacher holds regarding their abilities to enact student learning, can be influenced by interactions with instructional coaches. Criterion-based sampling was used to select instructional coaches (n=2) and teachers (n=10) to participate …

24-Hour Blood Pressure Variability Assessed By Average Real Variability: A Systematic Review And Meta-Analysis, Luis J. Mena, Vanessa G. Felix, Jesus D. Melgarejo, Gladys E. Maestre

School of Medicine Publications

Background-—Although 24-hour blood pressure (BP) variability (BPV) is predictive of cardiovascular outcomes independent of absolute BP levels, it is not regularly assessed in clinical practice. One possible limitation to routine BPV assessment is the lack of standardized methods for accurately estimating 24-hour BPV. We conducted a systematic review to assess the predictive power of reported BPV indexes to address appropriate quantification of 24-hour BPV, including the average real variability (ARV) index.

Methods and Results-—Studies chosen for review were those that presented data for 24-hour BPV in adults from meta-analysis, longitudinal or cross-sectional design, and examined BPV in terms …

Relative Sea-Level Variability During The Late Middle Pleistocene: New Evidence From Eastern England, N. L.M. Barlow, A. J. Long, W. R. Gehrels, M. H. Saher, R. G. Scaife, H. J. Davies, K. E.H. Penkman, D. R. Bridgland, A. Sparkes, C. W. Smart, S. Taylor

School of Geography, Earth and Environmental Sciences

© 2017 The Authors Unravelling patterns of relative sea-level change during previous interglacials enhances our understanding of ice sheet response to changing climate. Temperate-latitude estuarine environments have the potential to preserve continuous records of relative sea level from previous interglacial (warm) periods. This is important because, currently, we typically only have snapshots of sea-level highstands from low-latitude corals and raised palaeoshoreline indicators while the (continuous) deep-sea oxygen isotope record only provides indirect evidence of sea-level changes. Here, we focus on the Nar Valley in eastern England, in which is preserved evidence of a late middle-Pleistocene marine transgression more than 20 …

Characterization Of Atrial Fibrillation Adverse Events Reported In Ibrutinib Randomized Controlled Registration Trials, Jr Brown, J Moslehi, S O’Brien, P Ghia, Et Al

Peninsula Medical School

The first-in-class Bruton's tyrosine kinase inhibitor ibrutinib has proven clinical benefit in B-cell malignancies; however, atrial fibrillation (AF) has been reported in 6-16% of ibrutinib patients. We pooled data from 1505 chronic lymphocytic leukemia and mantle cell lymphoma patients enrolled in four large, randomized, controlled studies to characterize AF with ibrutinib and its management. AF incidence was 6.5% [95% Confidence Interval (CI): 4.8, 8.5] for ibrutinib at 16.6-months versus 1.6% (95%CI: 0.8, 2.8) for comparator and 10.4% (95%CI: 8.4, 12.9) at the 36-month follow up; estimated cumulative incidence: 13.8% (95%CI: 11.2, 16.8). Ibrutinib treatment, prior history of AF and age …

Subcutaneous Rituximab For The Treatment Of B-Cell Hematologic Malignancies: A Review Of The Scientific Rationale And Clinical Development, A Davies, C Berge, A Boehnke, A Dadabhoy, Et Al

Peninsula Medical School

UNLABELLED: Rituximab (MabThera®/Rituxan®), a chimeric murine/human monoclonal antibody that binds specifically to the transmembrane antigen CD20, was the first therapeutic antibody to enter clinical practice for the treatment of cancer. As monotherapy and in combination with chemotherapy, rituximab has been shown to prolong progression-free survival and, in some indications overall survival, in patients with various B-cell malignancies, while having a well-established and manageable safety profile and a wide therapeutic window. As a result, rituximab is considered to have revolutionized treatment practices for patients with B-cell malignancies. A subcutaneous (SC) formulation of rituximab has been developed, comprising the same monoclonal antibody …

Reclassification Of Thiomicrospira Hydrogeniphila (Watsuji Et Al. 2016) To Thiomicrorhabdus Hydrogenophila Comb. Nov., With Emended Description Of Thiomicrorhabdus (Boden Et Al., 2017), Rich Boden, Kathleen M. Scott, Alexander W. Rae, Lee P. Hutt

School of Biological and Marine Sciences

The genus Thiomicrorhabdus (Tmr) in the Piskirickettsiaceae in the Thiotrichales of the Gammaproteobacteria contains four species of sulfur-oxidising obligate chemolithoautotroph with validly published names, all previously classified as Thiomicrospira (Tms) species. Here we demonstrate that Thiomicrospira hydrogeniphila, a recently published hydrogen-utilising chemolithoautotroph closely related to Thiomicrorhabdus frisia (type species of Thiomicrorhabdus) should be classified as a member of the genus Thiomicrorhabdus and not Thiomicrospira, as Thiomicrorhabdus hydrogeniphila comb. nov., on the basis of comparative physiology and morphology as well as 16S rRNA (rrs) gene identity of Tms. hydrogeniphila MAS2^T being closer to that of Tmr. frisia JB-A2^T (99.1 …

Lack Of Consensus Among Sentiment Analysis Tools: A Suitability Study For Sme Firms, A Connelly, M Palomino, V Kuri

School of Engineering, Computing and Mathematics

Small and medium-sized enterprises (SMEs) are a large and integral part of the UK’s economy, with over 99% of all Britain’s businesses classified as small or medium. Supporting the needs of SMEs across the UK has become crucial, while the demands for software tools placed by such businesses keep growing. We are particularly interested in the case of tools for sentiment analysis, because such tools have emerged lately as a good prospect for SMEs to turn data into opportunities. We have compared five of the most well-regarded sentiment analysis tools, and have concluded that none of them is sufficiently reliable …

Prescribing Anti-Epileptic Drugs For People With Epilepsy And Intellectual Disability, Rohit Shankar, Lance Watkins, Regi T. Alexander, J. Devapriam, Jennifer Dolman, Anjana Hari, Richard Laugharne, Brendan Mclean, Howard Ring, Ashok Roy, Josemir W. Sander, Mark Scheepers, Reena Tharian, Phil Tittensor, Matthew C. Walker, Robert Winterhalder

Peninsula Medical School

This report addresses the extremely important area of epilepsy in the field of intellectual disability (ID), also known as learning disability. Epilepsy and ID are two conditions that carry stigma and can lead to social isolation. An individual who experiences both these problems faces huge challenges. This report aims to provide epileptologists, psychiatrists, doctors and clinicians working with people with ID and epilepsy an overview of good practice prescribing. Its focus is on using current evidence and applying it to support practical prescribing for people with ID. The document is not a substitute for recognised prescribing guides such as the …

Bringing Farm Advisors Into The Sustainability Conversation: Results From A Nitrogen Workshop In The U.S. Midwest, Julie E. Doll, Adam Reimer

Journal of Extension

Increasingly, farmers are looking to private sector advisors to inform their nitrogen decisions, but little is known about these important actors. We held a Sustainable Nitrogen Roundtable workshop to bring together important groups—private sector farm advisors, Extension educators, scientists, and farmers—to discuss new research and more sustainable use of nitrogen in midwestern cropping systems. We gained important insights by reaching outside academia and including private sector farm advisors as valued participants. Ninety percent of participants found that their understanding of varied viewpoints on nitrogen management improved, and an equal proportion would recommend such a workshop to a colleague.