Digital Commons Network^™

Carpenter V. United States And The Fourth Amendment: The Best Way Forward, Stephen E. Henderson

William & Mary Bill of Rights Journal

We finally have a federal ‘test case.’ In Carpenter v. United States, the Supreme Court is poised to set the direction of the Fourth Amendment in the digital age. The case squarely presents how the twentieth-century third party doctrine will fare in contemporary times, and the stakes could not be higher. This Article reviews the Carpenter case and how it fits within the greater discussion of the Fourth Amendment third party doctrine and location surveillance, and I express a hope that the Court will be both a bit ambitious and a good measure cautious.

As for ambition, the Court …

Impact Of Flow Direction On Local Flow Behavior In Biologically-Inspired Flow Passages, Derrick Dewayne Herrin

Honors College Theses

ABSTRACT

A computational fluid dynamics model was utilized to study the effect of flow direction on local flow behavior in biologically-inspired microscale flow networks. Biologically-inspired flow networks have been found to offer numerous advantages when compared with parallel flow networks, particularly in thermal management applications. Flow behavior was examined for a range of bifurcation angles and laminar inlet Reynolds numbers. The computational model was validated with existing theoretical solutions and verified for grid independence. As the bifurcation angle increased, the pressure drop, and thus pumping power, across the biologically-inspired flow networks increased. In addition, as the inlet Reynolds number increased, …

Persuasive Kinship: Human–Plant Relations In Southwest Amazonia, Fabiana Maizza

Tipití: Journal of the Society for the Anthropology of Lowland South America

Based on my ethnographic research with the Jarawara people, an indigenous society in the Southwest Amazonia, the article explores the idea of thinking kinship as persuasion. Among the Jarawara, children can have more than one father, which is well known in Americanist literature, but there would exist as well an original practice what we could call "multi-maternity". I also observe that the Jarawara can have diverse parental relations - some of their children are human, while others are plants. This occurs in a system of raising (nayana) in which children and plants are raised by a father and/or a mother …

Cosmology Performed, The World Transformed: Mimesis And The Logical Operations Of Nature And Culture In Myth In Amazonia And Beyond, Deon Liebenberg

Tipití: Journal of the Society for the Anthropology of Lowland South America

By analyzing myths from around the world to build an argument regarding the relation between cosmology and community, Amazonian myths are set within a broader set of mythic imageries. Lévi-Strauss showed how a structural description of myth should fully incorporate the entire set of variant arrangements through which its elements or terms could be related to one another. Despite the criticism to which his approach has been subject, the notion that certain kinds of logical operations could be gleaned in the organization of myth continues to yield valuable insights. In this paper, I contend that the mimetic representation of empirically …

The Role Of Yes-Associated Protein 1 In Ovarian Physiology And Pathology, Xiangmin Lv

Theses & Dissertations

Ovarian granulosa cells are the major somatic components of the ovarian follicle. Proper proliferation and differentiation of ovarian granulosa cells are essential for successful follicle development. Accumulating evidence indicates that the Hippo-YAP signaling pathway plays critical roles in both development and tumorigenesis of several organs. The present study aims to investigate the role of Yes-associated protein 1 (YAP) in ovarian granulosa cell proliferation, differentiation, and malignant transformation. At first, we found that nuclear YAP (active) was highly expressed in proliferative granulosa cells, whereas cytoplasmic YAP (inactive) was detected mainly in terminally-differentiated luteal cells. Further studies suggested that endogenous YAP activity …

Novel Therapeutic Approaches For Juvenile Neuronal Ceroid Lipofuscinosis (Cln3), Megan Elizabeth Bosch

Theses & Dissertations

Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a lysosomal storage disease caused by autosomal recessive mutations in CLN3. Neuronal loss is thought to occur via glutamate excitotoxicity; however, little is known about neuron-astrocyte glutamate regulation in JNCL. We discovered that Cln3^Δex7/8 astrocytes have significantly lower basal spontaneous Ca²⁺ oscillations and decreased responses to glutamate, indicating a disrupted signaling network. Cln3^Δex7/8 astrocytes also displayed significantly lower basal mitochondrial respiration and ATP production, suggesting impaired metabolic functions. Concurrent with diminished astrocyte metabolism and Ca²⁺ signaling, Cln3^Δex7/8 neurons were hyper-responsive to glutamate stimulation. These studies suggest that CLN3 …

Transcriptome Profiling Of Cleft Palate Intgf-Beta3 Knockout Mice Alleles: Rna-Seq Analysis Of Tgf-Beta3 Mice, Kelsey White

Theses & Dissertations

Background: Orofacial clefts are the most common craniofacial birth defect with a complex, combinatorial etiology. Tgf-b3 regulates palatal fusion in mice; Tgf-b3 knockout mice have cleft palate (CP) lacking other major deformities. The genes downstream of Tgf-b3 during palatogenesis remain largely unexplored. Our objective was to analyze the global transcriptome changes and their contribution to CP and identify novel Tgf-b3 associated genes involved in formation of CP. We used RNA-sequencing to analyze and compare the whole transcriptome of Tgf-b3 alleles during palatal growth and fusion in mice.

Results: …

In-Vitro And In-Vivo Models Of Bile Acid Metabolism And Transport, Rhishikesh Thakare

Theses & Dissertations

All biomedical research is conducted in animal models first. In addition, the Food and Drug Administration requires extrapolation from animal data to predict human responses. There are ongoing scientific and regulatory challenges translating interspecies comparisons and predictions. Metabolic pathways are a cornerstone to understanding drug metabolism and toxicities and the liver is a key organ in this process. Bile acids (BAs) play a central role in the hepatobiliary toxicities of chemicals, toxins, and biological reagents. BAs have many physiological functions including regulation of genes involved in cholesterol and glucose metabolism and BA homeostasis. However, BAs also have several pathological effects …

A Translational Evaluation Of Renewal Of Inappropriate Mealtime Behavior, Vivian Ibañez, Cathleen C. Piazza, Kathryn M. Peterson

Theses & Dissertations

The term renewal describes the recurrence of previously extinguished behavior that occurs when the intervention context changes. Renewal has important clinical relevance as a paradigm for studying treatment relapse because context changes are necessary for generalization and maintenance of most intervention outcomes (Podlesnik, Kelley, Jimenez-Gomez, & Bouton, 2017). The effect of context changes are particularly important during intervention for children with feeding disorders because children eat in a variety of contexts, and extinction is an empirically supported and often necessary intervention. Therefore, we used an ABA arrangement to test for renewal during intervention with 3 children diagnosed with a feeding …

The Effect Of Mechanical Vibration On Pain And Rate Of Tooth Movement During Initial Orthodontic Alignment, Leslie Ellingson

Theses & Dissertations

Purpose: The purpose of this investigation was to evaluate the effect of mechanical vibration on pain experienced and rate of tooth movement (OTM) during the initial alignment phase of orthodontic treatment.

Materials and Methods: Participants were randomly allocated to control, low frequency or high frequency. An electric toothbrush was modified to provide high frequency vibration. A low frequency vibration device was acquired from a commercial vendor. Experimental groups applied vibration to the dentition for 20 minutes daily. All participants completed questionnaires using visual analog scales at five time points. Pain experience was measured in millimeters (mm) with the scale measuring …

Role Of Transforming Growth Factor (Tgf) – Β Signaling In Craniofacial Development, Malignancies And Regeneration, Jingpeng Liu

Theses & Dissertations

The transforming growth factor (TGF) – β signaling pathway regulates a diversity of fundamental cellular processes such as cell growth and proliferation, cell differentiation, migration, apoptosis and other biological functions, both during embryogenesis and in adult tissue homeostasis. TGF-β is known to play a critical role in palatal development as in TGF-β knockout murine models, TGF-β deficiency causes cleft palate, a common craniofacial deformity in humans due to the abnormality of growth, elevation or fusion of the two palatal shelves. In order to investigate the mechanisms of how TGF-β regulates palatogenesis, we generated TGF-β3 knockout (-/-) murine models, performed systematic …

Effective Training Modalities To Teach The Use Of Naloxone Nasal Spray, Dominick V. Zurlo

Individual, Family, and Community Education ETDs

This paper examines the use of four different modalities to teach the correct assembly and administration method to use a naloxone nasal device. Naloxone is a medication which can reverse an opioid overdose when administered correctly. This specific device has been used for over a decade, and has been instrumental in opioid prevention educational programs to bystanders and individuals who use substances (NMDOH, 2017). Prior research studies utilizing naloxone nasal devices, have included outcome data collected from programs which train individuals who use opioids, and distribute the naloxone nasal device (Kerr, 2008). Others have included examination of curriculum content with …

Board Of Trustees Meeting Minutes, December 15, 2017

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 15, 2017.

Health Starts In The Home: An Assessment Of Efforts To Improve Occupant Health Through Healthy Building Materials In San Francisco’S Affordable Housing, Staci Hoell

Master's Projects and Capstones

Americans spend 90% of their lives indoors, and much of this time is spent at home, surrounded by building materials that typically have added chemicals like flame retardants, highly fluorinated compounds, and antimicrobials. Recent research has linked these chemicals to adverse health outcomes such as asthma, endocrine disruption, cancer, neurodevelopmental issues, and reproductive problems (Bayer et al., n.d.; Green Science Policy Institute). Furthermore, these chronic health conditions disproportionately affect low-income populations. Fortunately, substantial efforts in research, practice, and policy are working to reduce the use of these potentially harmful chemicals in building materials, particularly in San Francisco’s affordable housing sector. …

Habitat Selection, Survival, And Movement Ecology Of The American Woodcock (Scolopax Minor) In Louisiana Usa, Elisa Constancia Elizondo

LSU Master's Theses

The American Woodcock (Scolopax minor) is a migratory upland game species occurring across much of eastern North America. Across its breeding range in the northern U.S. and southern Canada, this species has experienced significant, pervasive declines over the last half century. As woodcock populations continue to decline, active habitat management for this species has become increasingly important.

The state of Louisiana has substantial amounts of woodcock habitat and receives wintering birds from across the woodcock range. However, few data exist regarding survival rates, habitat utilization, and movement patterns across the state.

In order to better manage for woodcock …

Design And Analysis Of Bio-Inspired Nacelle For Current Energy Turbine, Michael Coe

Master's Theses

he world’s oceans contain a substantial amount of energy, stored in ocean currents and waves. Ocean current energy can be extracted using similar principles to existing wind energy platforms. A problem with such extraction methods is that the velocity of the fluid in ocean currents is too low for efficient energy generation. A potential solution to this problem is the use of a concentrator or diffuser to increase fluid velocity to the blades, but this carries with it extra costs. A more cost effective solution to this problem is presented by the use of a down flow current turbine in …

A Role For Δ-Catenin In Synaptic Regulation, Li Yuan

Theses & Dissertations

The cadherin-catenin complex regulates cell-cell adhesion and signal transduction in epithelial cells. It is becoming increasingly evident that components of the complex regulate various aspects of neuronal architecture and function. δ-catenin is a cytosolic component of the cadherin-catenin complex and is predominantly expressed in the central nervous system. Loss of CTNND2, which encodes δ-catenin, is associated with intellectual disability and mutations in CTNND2 have been identified in autism, suggesting that δ-catenin is a critical component of the molecular machinery underlying neural circuit function. We have previously demonstrated that δ-catenin regulates multiple aspects of synaptic and dendritic development, including dendritic …

Cpap-Mad Combination Therapy For Cpap Intolerant Patients With Moderate To Severe Osa, Jacob Stadiem

Theses & Dissertations

The treatment of obstructive sleep apnea (OSA) allows for a multidisciplinary approach between dentistry and medicine. Continuous positive airway pressure (CPAP) is the gold standard for OSA treatment, but the non-adherence rates are high. The mandibular advancement device (MAD) has a higher acceptance rate than the CPAP, however the efficacy is much lower in cases of moderate to severe OSA. This thesis attempted to evaluate if there was a change in compliance when a MAD was added as a combination therapy to moderate to severe OSA subjects that were currently non-compliant with their CPAP. In addition, the change in air …

Dreams: A Unified Theory Approach, Chance Mcdermott

Dissertations, 2014-2019

Henriques (2011) proposed a new unified theory of psychology (UT) which he argued could assimilate and integrate divergent lines of thought into a coherent whole. An implication of this claim is that the system can be applied to phenomena that was not addressed in the original work and the current work tests this proposition. Specifically, the current work utilized the UT and its components to examine the dream literature, especially psychodynamic, physiological and evolutionary approaches. Following a brief introduction, the project reviews the various lines of research and interpretations of why we dream and what they may mean for us. …

Color-Grapheme Synesthesia: A Study Of Population Prevalence, Christopher Hill

Dissertations, 2014-2019

Given the current state of the literature and weaknesses of many previous prevalence studies, the primary purpose of this research study was to gather base-rate data of color-grapheme synesthesia in a general population sample. Over a period of seven months, 502 participants enrolled in the study on Mechanical Turk and completed the online Synesthesia Battery. The primary data collected was the participant’s score on the synesthesia test, whereby a score of a one or below is deemed by the battery to be indicative of someone with a color-grapheme synesthetic ability. Of the 502 participants, eight percent (0.082) of the population …

Cascaded Uuv Trajectory Tracking Control Based On Model Predictive And Sliding Mode Control, Bing Sun, Wenyang Gan, Man Mei, Daqi Zhu, Simon X Yang

Journal of Marine Science and Technology–Taiwan

This paper describes a cascaded dynamic trajectory tracking control approach based on model predictive control (MPC) and sliding mode control for unmanned underwater vehicles (UUVs). The proposed method combines kinematic and dynamic controllers to achieve robust control. First, MPC is employed to realize tracking control kinematically. The MPC algorithm is proposed as a solution to the speed jump problem. Considering the computational burden for nonlinear UUV dynamic models, the MPC method is used in conjunction with sliding mode control to achieve dynamic tracking control, which solves problems of modeling uncertainty and external disturbances. Experimental results showed that the proposed method …

Multiscale Imaging Of The Mouse Cortex Using Two-Photon Microscopy And Wide-Field Illumination, Jonathan Richard Bumstead

McKelvey School of Engineering Graduate Student Theses & Dissertations

The mouse brain can be studied over vast spatial scales ranging from microscopic imaging of single neurons to macroscopic measurements of hemodynamics acquired over the majority of the mouse cortex. However, most neuroimaging modalities are limited by a fundamental trade-off between the spatial resolution and the field-of-view (FOV) over which the brain can be imaged, making it difficult to fully understand the functional and structural architecture of the healthy mouse brain and its disruption in disease. My dissertation has focused on developing multiscale optical systems capable of imaging the mouse brain at both microscopic and mesoscopic spatial scales, specifically addressing …

Untangling The Mechanics Of Co-Entangled Cytoskeletal Networks, Shea Ricketts

Undergraduate Honors Theses

Active networks of interlinked protein filaments comprising the cytoskeleton largely control cellular mechanics and cell architecture. By forming cytoskeleton networks that combine motile, semiflexible actin with rigid, supportive microtubules, cells maintain structural integrity and shape while being able to flow and move. To elucidate the complex mechanical processes that arise between interacting networks of actin and microtubules within cells, we create a suite of randomly-oriented, well mixed networks of actin and microtubules by co-polymerizing varying ratios of both proteins in situ. We use optical tweezer microrheology in order to characterize the nonlinear mesoscale mechanics of in vitro co-entangled actin-microtubule composites. …

Next Generation Sequencing Technologies For Real-Time Genotyping And Targeted Sequencing For Precision Medicine, Priyanka Rawat

Biomedical Engineering ETDs

Astounding success of Human genome project and accelerating success of sequencing technologies have enabled $ 1000 genome goals possible. But, this is still far-fetched from the reach of many resource refrained populations with high genetic variations causing lethal genetic diseases. Based on present technology principles, I have developed prototypes for affordable, scalable and customizable point-of-care genotyping and targeted sequencing. Ion-sensitive field effect transistors with novel read-out and signal amplification techniques are used for laying foundation of possible ISFET based allele-arrays. Sequencing-by-synthesis based full-fledge sequencer is made with novel immobilization, flow-cell and data acquisition methods for massive sequenciing.

The Processing And Polarization Reversal Dynamics Of Thin Film Poly(Vinylidene) Fluoride, Noel Mayur Dawson

Nanoscience and Microsystems ETDs

Many ferroelectric devices benefit from the ability to deposit thin ferroelectric layers. Poly(vinylidene) fluoride (PVDF) is the prototypical ferroelectric polymer, but processing of thin film ferroelectric PVDF remains a challenge due to the formation of large voids in the film during traditional thin film processing. The research described in this dissertation starts by investigating the origin of these voids. The cause of these voids is found to be caused by vapor induced phase separation (VIPS). Guided by the thermodynamics of VIPS, a process is then designed to produce void-free ferroelectric PVDF thin films on polar and non-polar substrates. The films …

Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu

Computer Science: Faculty Publications

Pebble game rigidity analysis is a combinatorial method, implemented in our free web server KinariWeb, for extracting protein rigidity and flexibility information without performing costly molecular dynamics simulations. Due to the idiosynchrasies of the data in the Protein Data Bank (PDB), Kinari succeeds only on a fraction of the available files. Motivated by large scale applications, aiming at processing almost all the PDB files, we have recently developed a faster and more robust version, the phased pebble game algorithm. It is specifically designed to take advantage of the sequential structure of biopolymers. However, the structural data available in the Protein …

Repairing Gaps In Kinari-2 For Large Scale Protein And Flexibility Analysis Applications, Magdalena Metlicka, Mojtaba Nouri Bygi, Ileana Streinu

Computer Science: Faculty Publications

Pebble game rigidity analysis is a combinatorial method, implemented in our free web server KinariWeb, for extracting protein rigidity and flexibility information without performing costly molecular dynamics simulations. Due to the idiosynchrasies of the data in the Protein Data Bank (PDB), Kinari succeeds only on a fraction of the available files. Motivated by large scale applications, aiming at processing almost all the PDB files, we have recently developed a faster and more robust version, the phased pebble game algorithm. It is specifically designed to take advantage of the sequential structure of biopolymers. However, the structural data available in the Protein …

Serum Amyloid A3 Is A High Density Lipoprotein-Associated Acute-Phase Protein, Lisa R. Tannock, Maria C. De Beer, Ailing Ji, Preetha Shridas, Victoria P. Noffsinger, Laura Den Hartigh, Alan Chait, Frederick C. De Beer, Nancy R. Webb

Internal Medicine Faculty Publications

Serum amyloid A (SAA) is a family of acute-phase reactants. Plasma levels of human SAA1/SAA2 (mouse SAA1.1/2.1) can increase ≥ 1,000-fold during an acute-phase response. Mice, but not humans, express a third relatively understudied SAA isoform, SAA3. We investigated whether mouse SAA3 is an HDL-associated acute-phase SAA. Quantitative RT-PCR with isoform-specific primers indicated that SAA3 and SAA1.1/2.1 are induced similarly in livers (∼2,500-fold vs. ∼6,000-fold, respectively) and fat (∼400-fold vs. ∼100-fold, respectively) of lipopolysaccharide (LPS)-injected mice. In situ hybridization demonstrated that all three SAAs are produced by hepatocytes. All three SAA isoforms were detected in plasma of LPS-injected mice, although …

Diet And Activity Patterns Of Five Bat Species In North-Central Kansas, Holly G. Wilson

Master's Theses or Doctor of Nursing Practice

My study focuses on six bat species that occur in north-central Kansas. Although each species is widely distributed, information about their diet and activity patterns is lacking, especially within Kansas. Increased knowledge about bat species in Kansas can provide a baseline for future studies and conservation efforts for the species included in my study; big brown bat (Eptesicus fuscus), eastern red bat (Lasiurus borealis), hoary bat (Lasiurus cinereus), northern myotis (Myotis septentrionalis), evening bat (Nycticeius humeralis), and tricolored bats (Perimyotis subflavus) were captured and fecal samples were examined for diet diversity. I captured bats in mist nets in the Kansas …

Privileging Autistics Of Color: A Human Rights Approach To Applied Behavior Analysis (Aba) Therapy, Rebecca Rubey

Master's Projects and Capstones

This field project examines the social construction of autistic people of color through the pathology paradigm and the associated human rights violations. The purpose of the project is to disrupt the pathology paradigm by privileging voices of autistic people of color in professional development workshops for ABA therapy providers. The workshops aim to help ABA therapy providers understand the historical context of ABA, how it fits into the wider systems of white supremacy and ableism, and how these dynamics are re-enacted in every day practice with autistic people of color.